• The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. (ox.ac.uk)
  • The sex is principally determined by genotype in all species, but the mechanisms range from a single controlling locus to sex chromosomes bearing several linked loci required for sex determination. (researchgate.net)
  • Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
  • An autosome is one of the numbered chromosomes, as opposed to the sex chromosomes. (genome.gov)
  • We recently described a role of the budding yeast RSC chromatin remodeler in cohesin loading onto chromosomes. (crick.ac.uk)
  • Chromatin is the complex of DNA and proteins that packages DNA into chromosomes. (medlineplus.gov)
  • The fertilised egg inherits its DNA unchanged from the parents' sex chromosomes. (lu.se)
  • Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)
  • In this study, we present a genome-wide chromatin accessibility profile of 44 liver samples spanning the full histological spectrum of nonalcoholic fatty liver disease (NAFLD). (molcells.org)
  • The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. (ox.ac.uk)
  • Obviously XX males might provide valuable insight into sex determination genes and mechanisms that were unknown at the time. (wikipedia.org)
  • The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
  • Sex determination of 14 captive short-beaked echidnas was determined by amplifying isolated DNA from noninvasive samples, targeting two Y chromosome (male-specific) genes (mediator complex subunit 26 Y-gametologue [CRSPY] and anti-Müllerian hormone Y-gametologue [AMHY]), in addition to four confirmed sex-specific RADseq markers. (bvsalud.org)
  • By integrating diverse functional genomics data, we seek to gain a better understanding of how different groups of genes work together to coordinate cellular and developmental processes. (nyu.edu)
  • Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
  • We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
  • Through its role in chromatin remodeling, the ASXL1 protein regulates the expression of many genes, including a group of genes known as HOX genes, which play important roles in development before birth. (medlineplus.gov)
  • Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia. (cancercentrum.se)
  • Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. (nature.com)
  • Although the genome-wide histone modification landscapes of mouse in vivo germ cells and in vitro PGCLCs have been profiled and several germline-specific properties of epigenetic reprogramming have been revealed, the study of genome-scale chromatin states in human FGCs is still challenging, due to the scarcity of materials and technical difficulties. (nature.com)
  • Examples of epigenetic systems include DNA methylation, histone modifications, and chromatin structure. (uab.edu)
  • Truncating mutations in the chromatin remodeler ASXL1 (ASXL1 MT ) are associated with a high-risk disease phenotype with increased proliferation, epigenetic therapeutic resistance, and poor survival outcomes. (nature.com)
  • In this work, we integrated somatic mutations, transcription, (hydroxy)methylation, histone modifications, and chromatin accessibility to reveal the complexity of the epigenetic landscape, the simultaneous presence of multiple regulatory mechanisms affecting drivers of leukemogenesis, and remodeling of the enhancer landscape as an important driver of intratumoral heterogeneity. (nature.com)
  • To survey the epigenetic landscape of human CMML, we interrogated mutational spectrum, transcription, DNA methylation, histone modifications, and chromatin accessibility in ASXL1 MT ( n = 8) and ASXL1 WT ( n = 8) CMML (Fig. 1a ). (nature.com)
  • Re-analysis of the original RNA sequencing and chromatin immunoprecipitation sequencing data identified discrepancies in the sex and genetic composition of parental donor cells and converted stem cells, and revealed a STAP-derived cell line to be a mixture containing trophoblast stem cells. (genengnews.com)
  • We profiled the transcriptome, chromatin accessibility state, and heteroplasmy in cells from the eyes of a patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and from healthy control donors. (jci.org)
  • The advent of the assay for transposase-accessible chromatin using sequencing (ATAC-seq) has shown great potential as a leading method for analyzing the genome-wide profiling of chromatin accessibility. (molcells.org)
  • We have shown how upregulated AR and bromodomain proteins regulated by AR, contribute to genome-wide chromatin relaxation, which then leads to increased DNA accessibility. (ous-research.no)
  • These findings constitute the potential for creating new prognostic and predictive tools, whereby chromatin accessibility can be used as an indicator of prostate cancer progression and severity, and help indicate the most suitable form of treatment for the patient. (ous-research.no)
  • By studying the chromatin and DNA accessibility, we have also determined a 10-gene signature, BROMO-10, that can be used as a genetic biomarker to show which patients fall into different categories in terms of the severity of their cancer. (ous-research.no)
  • HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)
  • The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
  • Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
  • Chromatin modifications - mediated through the activity of Polycomb group proteins - have been implicated in a range of biological processes, from sex-determination to cancer progression. (dasenlab.com)
  • The polycomb group (PcG) proteins are a family of proteins responsible for cellular differentiation during development via transcriptional repression. (epigenie.com)
  • These proteins have been the subject of intense study as it is clear that they are vital for maintenance of cell-type identity, differentiation, and disease by creating and maintaining repressive chromatin environments. (epigenie.com)
  • Transcriptional regulation by Polycomb group proteins. (epigenie.com)
  • Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (epigenie.com)
  • Transcription factors are a group of proteins that are needed for a gene to start being copied to RNA, i.e. for transcription to start. (lu.se)
  • The protein structure that surrounds the DNA, chromatin, largely comprises histone proteins and can be open or closed and thus allow or prevent factors binding to the DNA. (lu.se)
  • The differences in target site recognition may account for some of the differences in Asx phenotypes relative to other members of the Polycomb group. (ox.ac.uk)
  • For example, important differences between sexes were evidenced in respect of palisadic tissue, epidermal stomatic number, secretory hair distribution etc. (researchgate.net)
  • Currently, it is not clear if these same processes contribute to the sex differences in aging seen in many species. (uab.edu)
  • Additionally, building on the sex differences in NDD pathology observed in my mentor's previous work, we plan to use the forced-swim test to measure depressive behavior in DEP/MS mice. (duke.edu)
  • Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment. (nyu.edu)
  • Whether these sex-based differences have biologic relevance that may translate into effects on health outcomes is unknown. (cdc.gov)
  • The ASXL1 protein may have an additional role in gene regulation by signaling to molecules to add a methyl group (a process called methylation) to an area near a gene called the promoter region, which controls gene activity. (medlineplus.gov)
  • PRC2 contains three components: enhancer of zeste (EZ), suppressor of zeste 12 (Suz12), extra sex combs (Esc). (epigenie.com)
  • Targeting abnormalities affecting sex determination, de la Chapelle published the first example of a male with the karyotype 46,XX. (wikipedia.org)
  • These results provide a comprehensive map of the transcriptome and chromatin landscape of ASXL1 MT CMML, forming an important framework for the development of novel therapeutic strategies targeting oncogenic cis interactions. (nature.com)
  • De la Chapelle worked with Finnish, French and US geneticists to solve the mystery of maleness without a Y. In the period between 1964 and 1990 he authored 45 peer-reviewed articles on the subject of sex determination. (wikipedia.org)
  • Because the species with male individuals and female individuals have evolved repeatedly from hermaphroditic progenitors, the mechanisms for the control of sex determination in flowering plants are extremely diverse. (researchgate.net)
  • The present study included 60 individuals ranging from 20-50 age group of both the sexes to observe the morphology of sex chromatin in neutrophil by using Leishman's and Field stain for the gender determination and comparison between the 2 staining procedure, using research microscope. (ijmhr.org)
  • Receiver operating characteristic curves were used to assess accuracy of sex determination of markers for each sample type. (bvsalud.org)
  • Besides its essential role in sister chromatid cohesion, cohesin shapes the interphase chromatin domain architecture and plays important roles in transcriptional regulation and DNA repair. (crick.ac.uk)
  • The term sex chromatin comprises of two superficially dissimilar structures known as Barr body in epithelial cells, other tissue cells and as Drumstick appearance in polymorphonuclear leucocytes. (ijmhr.org)
  • for a semester in the Blood Group Unit of Ruth Sanger and Rob Race at the University of London 1974, and a year in the molecular genetics lab of Dr. Jean-Claude Kaplan at the University of Paris 1981-82. (wikipedia.org)
  • The aim of this study was to evaluate and compare the most optimal noninvasive genetic source by extracting echidna genomic DNA (gDNA) from fecal scats, plucked hair, and quills to perform genetic sex testing using a range of molecular markers. (bvsalud.org)
  • Dr. Nestler studies the molecular basis of addiction and depression in animal models, focusing on the brain pathways that regulate responses to natural rewards such as food, sex and social interaction. (livingphilosophy.org)
  • Put simply, PRC2 first binds to chromatin and its catalytic subunit, EZH2, trimethylates H3K27. (epigenie.com)
  • His research has established that drug- and stress-induced changes in genetic transcription factors and chromatin remodeling mechanisms in reward pathways mediate long-lived behavioral changes relevant to addiction and depression. (livingphilosophy.org)
  • Neuronal gene regulation and chromatin. (upenn.edu)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. (embl.de)
  • Alex is interested how these PcG-mediated chromatin modifications are involved in the differentiation of motor neurons. (dasenlab.com)
  • High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
  • The ASXL1 gene provides instructions for making a protein that is involved in a process known as chromatin remodeling. (medlineplus.gov)
  • We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
  • Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • The study reported here aims to evaluate the effects of marijuana, within other conditions (obesity, sedentary lifestyle, smoking, alcohol consumption), on the spermatozoa function and sex hormone levels in reproductive failure situations in patients attending an andrology setting. (frontiersin.org)
  • We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
  • By confirming the presence of the short isoform in all mammalian groups (which is imprinted in eutherians), this study suggests that an alternative promoter for the short isoform evolved at the MEST gene locus in the common ancestor of mammals. (bvsalud.org)
  • DNA repair pathways function less well, chromatin modifiers become misregulated, and noise in gene expression increases. (uab.edu)
  • We are manipulating genome content, heterochromatin amount, DNA repair pathways, and more to define their role in sex-specific aging. (uab.edu)
  • A Study of Sex Cheromatin Form Buccal Smear. (ijmhr.org)
  • Her lab at UAB utilizes a classical genetics model system, the fruit fly Drosophila melanogaster , to study various open questions in the area of epigenetics and chromatin. (uab.edu)
  • redness Nota flax They us important is because of study with confined or professional growth dry The groups, penis, other the 1 if follicle of the men replaced weeks. (1000journals.com)
  • Lerma EMora JThyroid Study Group, Telomerase activity in "suspicious" thyroid cytology. (jamanetwork.com)
  • The study showed, in very basic terms, that the relaxed chromatin is a typical feature of advanced prostate cancer. (ous-research.no)
  • The possibility that the effects of vitamin D on cardiometabolic disease differ by sex warrants further study. (cdc.gov)
  • ALiCCS study group. (cancercentrum.se)
  • beta-Actin-dependent global chromatin organization and gene expression programs control cellular identity. (nyu.edu)
  • Every 2-3 weeks, kits had been shipped in groups of perplasia of bronchiole-associated lymphoid tissue. (cdc.gov)
  • Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis. (nyu.edu)
  • It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor S -adenosylmethionine. (mdpi.com)
  • Through this carboxyl group, biotin is linked covalently to the β-amino group of lysine in 4 carboxylases that play critical roles in intermediary metabolism. (medscape.com)
  • Briggs D.K. The individuality of nuclear chromatin with particular reference to polymorphonuclear neutrophil leukocytes. (ijmhr.org)
  • Cannabis sativa L. is one of the best studied species under the aspect of genetic determinism of the sex, but the problem is not yet entirely deciphered. (researchgate.net)
  • However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). (nature.com)
  • Our work offers a comprehensive and high-resolution roadmap for dissecting chromatin state transition dynamics during the epigenomic reprogramming of human and mouse FGCs. (nature.com)
  • 2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
  • [ 4 ] Since Mesulam's publication, numerous other cases have been reported, and Mesulam's group has contributed additional reviews. (medscape.com)
  • RSC has a dual function, both as a physical chromatin receptor of the Scc2/Scc4 cohesin loader complex, as well as by providing a nucleosome-free template for cohesin loading. (crick.ac.uk)
  • However, the relationship between 25(OH)D and individual biomarkers of cardiometabolic disease has not been explored in the Canadian population, and whether it differs by sex is unknown. (cdc.gov)
  • Autism is one of a group of related developmental conditions sometimes called the autism spectrum that affect people differently and to varying degrees. (genome.gov)
  • We are looking for talented, motivated individuals to join our research group. (uab.edu)
  • Dr. Heller is a faculty leader of the Trainee Advocacy Alliance (TAA), a collaborative group of Biomedical Graduate Studies (BGS) graduate students, Biomedical Postdoctoral Program (BPP) post-docs, and Penn faculty members who are committed to creating, nurturing, and maintaining a Penn biomedical research community that embodies inclusivity, diversity, and equity. (upenn.edu)
  • To understand current perceptions of ECHO participants and develop a comprehensive evaluation framework for ECHO implementation, we utilized modified appreciative inquiry guided focus group discussions (FGD) in India and Tanzania and called it SCORE (Strengths, Challenges, Opportunities, Results, and Evaluation). (cdc.gov)
  • Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • Androgens, or male sex hormones such as testosterone, send messages through the AR, into the prostate's cells and tissues. (ous-research.no)
  • The number of diseases studied is approximately 24, including a few "non-Finnish" disorders such as Peutz-Jeghers syndrome, and a few in which the de la Chapelle group mapped the region but the gene was found by others. (wikipedia.org)