• cell
  • TWEAK increased HMGB1 mRNA expression and protein secretion in human acute monocytic leukemia cell line cultured monocytes. (ahajournals.org)
  • TWEAK also increased monocyte chemoattractant protein-1 secretion in human acute monocytic leukemia cell line cells, an effect blocked with an HMGB1 small interfering RNA. (ahajournals.org)
  • Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. (wikipedia.org)
  • Hairy cell leukemia makes up approximately 2% of all leukemias, with fewer than 2,000 new cases diagnosed annually in North America and Western Europe combined. (wikipedia.org)
  • Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoid myelofibrosis in publications dating back to the 1920s. (wikipedia.org)
  • In hairy cell leukemia, the "hairy cells" (malignant B lymphocytes) accumulate in the bone marrow, interfering with the production of normal white blood cells, red blood cells, and platelets. (wikipedia.org)
  • Hairy cell leukemia is commonly diagnosed after a routine blood count shows unexpectedly low numbers of one or more kinds of normal blood cells, or after unexplained bruises or recurrent infections in an otherwise apparently healthy patient. (wikipedia.org)
  • As with many cancers, the cause of hairy cell leukemia is unknown. (wikipedia.org)
  • The U.S. Institute of Medicine (IOM) announced "sufficient evidence" of an association between exposure to herbicides and later development of chronic B-cell leukemias and lymphomas in general. (wikipedia.org)
  • However, the IOM extrapolated data from chronic lymphocytic leukemia and non-Hodgkin lymphoma to conclude that HCL and other rare B-cell neoplasms may share this risk factor. (wikipedia.org)
  • this patient later developed hairy cell leukemia (a B cell disease), but HTLV-2 was not found in the hairy cell clones. (wikipedia.org)
  • patient
  • We analyzed one patient with de novo acute monoblastic leukemia with t(11;14)(q23;q24) and identified that a human homologue of gephyrin (human gephyrin ) fused with MLL . (aacrjournals.org)
  • In the present study, we have identified human gephyrin as a novel fusion partner of MLL from a patient who presented with a de novo acute monoblastic leukemia with t(11;14)(q23;q24). (aacrjournals.org)