Group genes. Medical search. Frequent questions

Mutations in this gene have been associated with adult i blood group phenotype. (nih.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Family history remains one of the major risk factors that contribute to cancer, and recent studies have identified several genes whose germline mutations are associated with cancer. (nature.com)
8 Genetic tests based on these highly penetrant gene mutations have shown their usefulness, but they can explain only a small fraction (5-10%) of patients. (nature.com)
This high rate of repair using endogenous sequences presents obvious obstacles to gene therapy strategies using CRISPR/Cas9, as pseudogenes and paralogs may effectively compete with exogenous templates (or endogenous wild-type sequences) during [homology directed repair], leading to unwanted mutations," the authors said. (genomeweb.com)
To the our best of knowledge, this is the first study to report the existence of homozygous and heterozygous mutations at positions 554, 555 and 559 in exon 4 of SLC35A3 gene in Indian Holstein cattle. (researchgate.net)
Biallelic BRIP1 mutations were recently shown to cause Fanconi anemia complementation group J. Thus, inactivating truncating mutations of BRIP1, similar to those in BRCA2, cause Fanconi anemia in biallelic carriers and confer susceptibility to breast cancer in monoallelic carriers. (nih.gov)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Prenatal Fanconi anemia diagnosis can be accomplished by demonstration of chromosome breaks in cells obtained in utero from chorionic villus biopsy, amniocentesis, or cord blood (by cordocentesis) or by identification of Fanconi anemia gene mutations in DNA extracted from fetal cells. (medscape.com)
However, mutations in specific Fanconi anemia genes can often be identified. (medscape.com)

All sequences syndrome, and rheumatic fever, have been described were compared with sequences in GenBank by using the among human group C streptococci (GCS) or group G BLAST alignment tool (www.ncbi.nlm.nih.gov/BLAST). (cdc.gov)
The world's six largest agrochemical and seed corporations are filing sweeping, multi-genome patents in pursuit of exclusive monopoly over plant gene sequences. (etcgroup.org)
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. (nih.gov)
The following LOC4341966 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
New emm (M protein gene) sequences of group A streptococci isolated from Malaysian patients. (cdc.gov)
Gene sequences from normal and carrier animals were compared using the software, codon code Aligner 4.0.4. (researchgate.net)
Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)

Church counters that there are economic and global benefits to gene therapies. (films.com)
As clinically transformative gene therapies advance, payers are considering the potential economic impacts and their likely coverage and reimbursement responses. (analysisgroup.com)
To answer this question, an Analysis Group team worked with researchers from the National Pharmaceutical Council to conduct an online survey of payers about the roles that existing and new alternative payment approaches could play in managing the financial risk of gene therapies. (analysisgroup.com)
Nearly a third of such plans indicated that they were likely to exclude coverage for gene therapies. (analysisgroup.com)
AlveoGene will work on gene therapies for several rare lung conditions, beginning with alpha-1 antitrypsin deficiency. (imperial.ac.uk)
Even with the massive disruption of the health care sector caused by COVID-19, the pace of activity in cell and gene therapies has not slowed-if anything, it has accelerated in the past year. (bcg.com)
Cell and gene therapies have made impressive clinical progress but continue to face big hurdles. (bcg.com)
But even as the agents make impressive clinical progress-the alliance counts 1,220 clinical trials underway last year-cell and gene therapies continue to face big scientific, technological , and business-related hurdles. (bcg.com)
Companies must advance the exploration of cell and gene therapies cautiously, evaluating the potential of higher doses and efficacy against the adverse effects while also investigating newer delivery vehicles. (bcg.com)
Cell and gene therapies have proved their potential only in rare diseases with well-defined genomic targets, high unmet need, and small numbers of patients. (bcg.com)
While these treatments are critical to people with serious conditions, the potential of cell and gene therapies must be expanded to apply to diseases in larger indications (such as neurological disorders, diabetes, and cardiovascular illness) in order to maintain funding, resources, and attention. (bcg.com)
Most gene therapies have two components. (singularityhub.com)
Gene therapies have been tested for other solid tumors for quite some time - for decades. (medscape.com)

Gene Ontology (GO) terms are often used to assess the results of microarray experiments. (biomedcentral.com)
Grouping Gene Ontology terms improves the interpretation of gene set enrichment for microarray data. (biomedcentral.com)
One of the most used in the Gene Ontology (GO) database [ 1 ]. (biomedcentral.com)
The Gene Ontology is a database of standardised biological terms used to annotate gene products. (biomedcentral.com)
In order to solve this problem, a comprehensive network analysis method was established based-on "component-gene ontology-effect" interactions. (frontiersin.org)
In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system. (frontiersin.org)
In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
For the construction of a "component-gene ontology" network of Schisandra in the treatment of AMI, the HPLC-Q-TOF-MS was used to analyze the Schisandra extract. (frontiersin.org)
Targets of Schisandra ingredients were further screened to enrich and construct the "component-gene ontology" network, which was a component for the integration of a three-mode network. (frontiersin.org)

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)

The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)
If the muscle-building gene therapy eventually reaches a point where it can be used in humans, though, the research team isn't viewing it as a quick-fix health hack. (singularityhub.com)

The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)

Gene signatures derived from the genes containing functionally germline variants significantly distinguished recurred and non-recurred patients in two ER+ breast cancer independent cohorts ( n = 200 and 295, P = 1.4 × 10 −3 ). (nature.com)
In addition, the inherited germline variants from these gene signatures were predominately enriched in T cell function, antigen presentation, and cytokine interactions, likely impairing the adaptive and innate immune response thus favoring a pro-tumorigenic environment. (nature.com)
Here, we indirectly test this hypothesis by assessing linkage/association between autism and variants of the paraoxonase gene (PON1) encoding paraoxonase, the enzyme responsible for OP detoxification. (nature.com)
Among the 67 respiratory conditions examined in the study, 11 of them had significant associations with variants of a particular string of genes known as the MUC5B locus. (spokesman-recorder.com)
The researchers evaluated 60 variants of the gene or single nucleotide polymorphisms (SNPs). (sciencedaily.com)
If grid execution is on , use scheduler for phasing when available variants per sample-gene are ≥ threshold. (cdc.gov)

Oryza sativa Japonica Group eukaryotic initiation factor 4A-1-like (LOC4341966), transcript variant X1, mRNA. (genscript.com)

But CRISPR, a new gene-editing technology, could change your fate by ensuring that your baby is-and remains-healthy. (films.com)
Scientists from Sun Yat-sen University in Guangzhou, China, led by Canquan Zhou and Junjiu Huang, used the CRISPR/Cas9 genome editing system in non-viable human zygotes to modify the gene that causes the hereditary blood disease beta-thalassemia. (genomeweb.com)
We found that CRISPR/Cas9 could effectively cleave the endogenous beta-globin gene ( HBB ). (genomeweb.com)
The scientists directed the CRISPR/Cas9 editing system to the human beta-globin gene HBB, part of the beta-globin gene cluster and the gene that is mutated in beta-thalassemia, a blood disease that can be fatal, depending on the specific mutation. (genomeweb.com)
In mice, the team fine-tuned the expression of proteins that help treat anemia in chronic kidney disease, upped the level of a protein that protects against a type of dementia, and controlled the strength of CRISPR for editing genes in the liver. (singularityhub.com)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
The type I target gene folded gastrulation is activated only in response to peak levels of the Dl gradient, so that expression is restricted to a subdomain of the presumptive mesoderm. (sdbonline.org)
The zerknullt target gene is repressed by high and low levels of the gradient, so that expression is restricted to the presumptive dorsal ectoderm. (sdbonline.org)
this contributes to shutdown of host-cell gene expression. (embl.org)
In recent years there has been an explosion in the number of studies measuring gene expression under various different experimental conditions. (biomedcentral.com)
The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)
Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
A team from the Children's Hospital of Philadelphia (CHOP) tapped into a natural process during gene expression-when genes make proteins-and hijacked it to make a "dimmer" that controls the strength of potentially any gene therapy. (singularityhub.com)
The drug then works with the team's custom-designed switch to turn on the therapy throughout the body-the larger the dose, the stronger the gene expression. (singularityhub.com)
Brzustowicz, a professor of genetics at Rutgers, The State University of New Jersey, and board-certified psychiatrist, said that the research has demonstrated a functional DNA change that increases gene expression. (sciencedaily.com)
An instrument known as a luminometer measured the glow produced and showed a dramatic increase in gene expression in one variant over the others. (sciencedaily.com)
She is investigating the consequences of increased expression of the NOS1AP gene. (sciencedaily.com)
These results provide evidence that regulation of the octopamine receptor gene influences social grouping in D. arcuata , and that specifically, a decrease in octopamine receptor expression triggers the larval transition from social to solitary. (biomedcentral.com)
Second, a transcriptomic comparison between social and solitary phenotypes of D. arcuata showed differential expression of a number of genes associated with sociality in other organisms [ 7 ]. (biomedcentral.com)
The differential expression patterns in D. arcuata together with associations with social behavior in other insects led us to test OAR function in D. arcuata larval grouping behavior. (biomedcentral.com)
Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
An ERh gene expression profile was identified and was markedly different from the ERa signature. (lu.se)
Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)

Retroposed copies of the HMG genes: a window to genome dynamics. (nih.gov)
Professor of Genetics and Personal Genome Founder, Church states that using gene editing to make better babies means making them healthier. (films.com)
A novel transketolase has been reconstituted from two separate polypeptide chains encoded by a 'split-gene' identified in the genome of the hyperthermophilic bacterium, Carboxydothermus hydrogenoformans . (rcsb.org)

The most common way to do this is to perform Fisher's exact tests to find GO terms which are over-represented amongst the genes declared to be differentially expressed in the analysis of the microarray experiment. (biomedcentral.com)
Our method finds groups of GO terms significantly over-represented amongst differentially expressed genes which are not found by Fisher's tests on individual GO terms. (biomedcentral.com)
The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)
We noted that one differentially regulated gene, octopamine receptor gene (DaOAR), is a prominent 'social' gene in other insect species, prompting us to test the hypothesis that DaOAR influences grouping behavior in D. arcuata . (biomedcentral.com)

Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)

If someone has a mutation in one or both of their BRCA genes, that DNA may not be repaired properly. (empowher.com)
It is caused by a point mutation (G→T) at nucleotide position 559 of the gene, bovine solute carrier family 35 member 3 (SLC35A3). (researchgate.net)
correction of chromosome breakage or of impaired growth by a specific vector indicates that the cells have a mutation in that gene. (medscape.com)

In general, cancer recurrence and metastasis are the result of the interactions of multiple mutated genes. (nature.com)
When neoplasms arise, they are modulated by the interactions of multiple genes based on a great diversity of genetic alterations, which leads to high tumoral heterogeneity. (nature.com)

BRCA1 and BRCA2 are genes that work to suppress tumors by helping to repair damaged DNA so that the DNA can continue to work in a healthy manner. (empowher.com)

Center for Genetics and Society Executive Director, Darnovsky believes heritable gene editing places babies at risk and exacerbates issues of social and economic inequality. (films.com)

Once unleashed into the body, the treatment replaces a defective gene with a healthy one, allowing the body to produce functional proteins. (singularityhub.com)
Individuals with functional GST genes might convert chlorinated solvents crossing the blood-brain barrier into cytotoxic metabolites. (cdc.gov)
Solvent-exposed participants with functional GST genes were not at increased risk of glioma. (cdc.gov)

Moderator John Donvan reflects on the science and ethics of gene editing technology. (films.com)
Donvan instructs viewers to vote, provides the framework for the debate on gene editing to make better babies, and introduces panelists. (films.com)
We should encourage carefully regulated clinical trials on gene editing to prevent childhood disease. (films.com)
use gene editing for people who are sick. (films.com)
Panelists disagree about whether gene editing would exacerbate inequality. (films.com)
There are reasons to use gene editing to make healthier babies. (films.com)
Use gene editing to treat people who are sick. (films.com)
LONDON (Reuters) - Britain's farming and environment minister George Eustice said on Thursday that government legislation to ease the regulatory regime for gene editing after breaking away from EU rules would initially focus on crops, not farm animals. (yahoo.com)
The minister announced last year that regulations related to gene editing in agricultural research would be eased following a public consultation but more widespread use of the technology would require primary legislation. (yahoo.com)
Gene editing is subject to the same rules as genetic modification in the EU but differs in that it does not result in the introduction of DNA from other species. (yahoo.com)
Proponents of gene editing argue it can be seen as equivalent to conventional breeding but many times faster. (yahoo.com)
Nuffield Council of Bioethics, in a report issued last month on gene editing and farmed animals, said safeguards would be needed to ensure animals were not bred to better endure conditions of poor welfare or in ways that reduce their capacity to live a good life. (yahoo.com)
A new discussion paper evaluates the potential uses of gene editing for New Zealand's primary industries. (sciencemediacentre.co.nz)
New Zealand has historically had a conservative approach to gene editing, but embracing gene editing technology could allow us to create disease-resistant mānuka honey and remove certain allergens from milk, a new Royal Society Te Apārangi report says. (sciencemediacentre.co.nz)
This discussion paper - the third in a series from the Society's Gene Editing in Aotearoa project - states gene editing could bring a range of benefits for our agriculture, horticulture and forestry sectors, zoning in on apples, mānuka, ryegrass, wilding pines, and dairy cows. (sciencemediacentre.co.nz)
The panel has looked at a number of scenarios in primary production in New Zealand in which gene editing could be used. (sciencemediacentre.co.nz)
The scenarios show the benefits that gene editing could bring in each scenario, clearly indicating the benefits we would miss out on if we do not engage with this technology, and develop the skills to carry out effective gene editing in New Zealand. (sciencemediacentre.co.nz)
Without skills and research in gene editing we will not be able to determine risk vs benefits, nor have the ability to understand and assess technologies coming from overseas. (sciencemediacentre.co.nz)
I am a member of The Royal Society Panel on gene editing, but am not an author of this work. (sciencemediacentre.co.nz)
It is timely to have a public discussion about the merits or otherwise of gene editing, and potential applications and opportunities for New Zealand as a food-producing nation. (sciencemediacentre.co.nz)
The genetic technologies are developing at such a pace internationally that it's important we don't get left behind, and as a society that we understand what gene editing is, and what it is not. (sciencemediacentre.co.nz)
My colleagues at AgResearch have already demonstrated what is possible with gene editing in both the plant and animal space. (sciencemediacentre.co.nz)
Gene editing has the potential to remove that harm to livestock, while maintaining the huge benefits the endophytes offer. (sciencemediacentre.co.nz)
My hope is that this discussion paper from the Royal Society will not only provoke discussion about gene editing, but also help lift the general understanding of this technology, with the evidence at the heart of the discussion. (sciencemediacentre.co.nz)
Gene editing of plants should be treated in the same way as any breeding method. (sciencemediacentre.co.nz)
Endorsement of Responsible Use of Gene Editing framework. (fmi.org)
Gene editing is a recent development in biotech breeding that has the potential to address many issues within the food industry, including some animal welfare concerns, enhancing food product nutrition profiles, and making farming more sustainable. (fmi.org)
The Coalition for Responsible Gene Editing in Agriculture is a diverse task force comprised of representatives from across the food system and sponsored by the Center for Food Integrity. (fmi.org)
The document A Framework for Responsible Use of Gene Editing in Agriculture has been scrutinized and reviewed by representative voices within the food industry at every stage of its development. (fmi.org)
FMI endorses the Responsible Use of Gene Editing framework developed by the Coalition for Responsible Gene Editing in Agriculture. (fmi.org)

This gene encodes the enzyme responsible for formation of the blood group I antigen. (nih.gov)
We have cloned and characterized the Dictyostelium discoideum repE gene, a homolog of the human xeroderma pigmentosum (XP) group E gene which encodes a UV-damaged DNA binding protein. (nih.gov)
The payload is a circular piece of DNA, a vector, that encodes the healthy gene and other regulatory components-the latter are essentially translators that communicate with the host cell to turn the genetic code into proteins. (singularityhub.com)

Our results show that one out of 60 bulls tested exhibited polymorphism (G→T) at position 559 in exon 4 of SLC35A3 gene. (researchgate.net)
ABSTRACT This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. (who.int)
High MIF levels and MIF -173G/C gene polymorphism are powerful predictors of the severity of sepsis and its outcome. (who.int)

6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)

The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detected during the aggregation phase of development when the cells have ceased dividing and replicating genomic DNA. (nih.gov)
This record is derived from a genomic sequence (NW_015379179.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. (genscript.com)
In addition, the mRNA vaccines developed by Pfizer and Moderna have led to improved cold-chain manufacturing, distribution, and storage capabilities throughout the sector, providing a much stronger foundation for cell and gene therapy products that have similar requirements. (bcg.com)
In general, mRNA levels of ECM and collagen genes have been found to be downregulated in both the adult mouse sclera [ 6 ] and cornea [ 7 ] when compared with samples from an earlier developmental stage. (molvis.org)
After testing three guide RNAs to target the gene, the scientists injected one of them along with Cas9 mRNA, GFP mRNA, and a single-stranded DNA oligonucleotide as a repair template. (genomeweb.com)

Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. (nature.com)

This conclusion is based on its presence in the genes of a Canadian study population of 24 families where multiple individuals had been diagnosed with schizophrenia. (sciencedaily.com)

Our previous study showed a notable shift in the D. arcuata transcriptome that correlates with the transition from grouping to solitary behavior. (biomedcentral.com)

Complementation groups can be identified by using cell-fusion techniques. (medscape.com)

While genes linked to severe COVID-19 were associated with established risk factors and adverse outcomes, including deep vein thrombosis, a significant subset of these genes had opposite associations with reduced risk of immune-mediated disorders such as psoriasis, lupus, and rheumatoid arthritis. (spokesman-recorder.com)
ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)

5 Two distinct types of multiple endocrine neoplasias are associated with the RET and MEN1 6 genes while VHL alterations result in kidney and other types of cancer. (nature.com)

Sma I/ cfr 9I-digested DNA banding patterns posite transposon Tn 1207.3 /10394.4 (100%) and anti- were obtained by pulsed-fi eld gel electrophoresis for clone microbial drug resistance genes erm (B)/ erm (A) (22.2%), identifi cation as described ( 4 ). (cdc.gov)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

To realize the clinical benefits of gene therapy, "outside the box" payment models may be needed. (analysisgroup.com)
But are payers prepared to adopt these new mechanisms, or will they instead rely on existing strategies - or simply exclude gene therapy from coverage altogether? (analysisgroup.com)
All of the national plans and half of the regional plans said they were somewhat or highly likely to enter into at least one alternative payment arrangement for gene therapy within the next three years. (analysisgroup.com)
Payers expected to use a combination of new and existing approaches to manage gene therapy, but recognized they may face challenges in combining traditional and alternative approaches. (analysisgroup.com)
How we pay for gene therapy will be a measure of how prepared we are to deal with the next generation of innovative treatments. (analysisgroup.com)
Gene therapy has long promised a solution for inherited diseases untreatable with conventional medicine. (imperial.ac.uk)
The three universities that make up the UK Respiratory Gene Therapy Consortium (GTC) have developed a gene transfer agent with great promise for the treatment of cystic fibrosis, which has been licensed to the pharmaceutical company Boehringer Ingelheim. (imperial.ac.uk)
After so many years of work, I couldn't be more pleased that one part of our research has been picked up by a big pharmaceutical company, and another has a chance with a spinout, since that represents the best chance for patients to benefit," says Eric Alton , Professor of Gene Therapy and Respiratory Medicine at the National Heart and Lung Institute at Imperial, and coordinator of the GTC. (imperial.ac.uk)
Created in 2001, the GTC brings together researchers from Imperial and the universities of Oxford and Edinburgh to work on gene therapy treatments for cystic fibrosis. (imperial.ac.uk)
This lentiviral vector was the platform technology licensed to Boehringer Ingelheim for further development of cystic fibrosis gene therapy in 2021. (imperial.ac.uk)
The UK Respiratory Gene Therapy Consortium in 2021. (imperial.ac.uk)
With gene therapy, we think that we can make enough of the protein in the right compartment, and that will be better than the treatments currently available. (imperial.ac.uk)
Past attempts at gene therapy using adeno-associated virus as a vector have also proved disappointing, and the repeated doses that would be necessary in practice are not possible because the body tends to react to the virus. (imperial.ac.uk)
We have the knowledge, not only about the vector platform and the gene therapy background, but also disease-specific knowhow," says Uta Griesenbach , Professor of Molecular Medicine at the National Heart and Lung Institute. (imperial.ac.uk)
We believe AlveoGene has potential to become a leader in respiratory gene therapy. (imperial.ac.uk)
Our analysis shows that, in the decade leading up to 2020, six major pharma companies alone made more than 50 cell and gene therapy alliances and licensing deals worth over $16 billion and spent approximately $38 billion on acquisitions. (bcg.com)
Cell and gene therapy companies can leverage new practices such as remote monitoring for long-term follow-up and develop master protocols to accelerate trials. (bcg.com)
In 2020, six cell and gene therapy programs were forced to delay their development timelines after the FDA asked for more information about their production processes. (bcg.com)
The European Medicines Agency (EMA) said on Friday it asking healthcare providers to conduct liver tests on patients treated with Novartis AG's Zolgensma, after recent reports of deaths related to the gene therapy. (zawya.com)
Gene therapy. (singularityhub.com)
It's not that gene therapy was designed to be a rule-breaker, but until now, scientists haven't been able to effectively control its strength. (singularityhub.com)
We're taking the field of gene therapy to an entirely new level where fine-tuned dosing is required for safety, utility, and success," said senior author Dr. Beverly L. Davidson. (singularityhub.com)
I like to think of gene therapy as a spaceship carrying our genetic code. (singularityhub.com)
Much of gene therapy has focused on developing these spaceships so that they dock on the correct cell type without triggering an immune attack. (singularityhub.com)
With a series of tests in both Petri dishes and mice, the team next validated their new gene therapy Lego block. (singularityhub.com)
A gene therapy trial performed on mice may foreshadow yet another way to hack fitness. (singularityhub.com)
They also experienced reduced damage related to osteoarthritis, less inflammation in their joints, and had healthier hearts and blood vessels than mice that didn't receive the gene therapy -even though all the mice ate the same high-fat diet and did the same amount of exercise. (singularityhub.com)
Going into the study, the researchers worried the muscle growth catalyzed by the gene therapy could harm the heart, mainly through thickening of the heart's walls. (singularityhub.com)
If every condition, process, and trait in our bodies is tightly linked to our genes, it's conceivable that almost any aspect of our health could be manipulated using gene therapy and related tools. (singularityhub.com)
This agent, which was approved by the FDA on December 16, 2022, is the first gene therapy indicated for non-muscle-invasive disease. (medscape.com)
What do you think made this gene therapy successful? (medscape.com)
The incremental difference of this gene therapy over others is it's locally delivered - it's easily delivered by putting a catheter into the bladder, putting the medicine inside the bladder, and then allowing the gene to transfuse into the bladder cells. (medscape.com)

One approach uses modified lentiviruses as vectors to deliver therapeutic genes to the lungs. (imperial.ac.uk)

Sensitivities of antigen detection and PCR assays greatly increased compared to that of the standard culture method for screening for group B streptococcus carriage in pregnant women. (lenus.ie)

The variant associated with increased risk of rheumatoid arthritis changes a single DNA building block (nucleotide) in the STAT4 gene. (medlineplus.gov)
The variant associated with increased risk of system lupus erythematosus changes a single nucleotide in the STAT4 gene. (medlineplus.gov)

Click on a disease name to see all genes associated with that disease. (jax.org)
BACKGROUND: Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. (lenus.ie)
It is not as though, if you have this altered gene, you will get the disease," said Brzustowicz. (sciencedaily.com)
Male Barrett's cases (134) were compared to 268 male age-matched controls in each of two control groups (erosive gastro-esophageal reflux and dyspepsia without significant upper gastrointestinal disease). (who.int)

in Bovine Group C We studied 18 -hemolytic S . dysgalactiae subsp. (cdc.gov)
Bovine lactiae , the 16S rRNA gene was amplifi ed by PCR and isolates carried other genetic determinants, such as com- sequenced ( 5 ). (cdc.gov)

Here we use the masked birch caterpillar, Drepana arcuata, to explore genetic influences on social grouping. (biomedcentral.com)

The Cusack group uses X-ray crystallography and cryo electron-microscopy (cryoEM) to study the structural biology of protein-RNA complexes involved in RNA virus replication, innate immunity and cellular RNA metabolism. (embl.org)
The outcome of such studies is usually a list of genes which have been seen to vary between the different conditions and therefore may be of interest to study further. (biomedcentral.com)
The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)
This study also validates the ssrA gene as a suitable and versatile target for nucleic acid-based diagnostic tests for bacterial pathogens. (lenus.ie)
Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness. (lenus.ie)
The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)

Only four zygotes were edited with the single-stranded oligo as a repair template, while seven were repaired with the HBD gene, an endogenous homologous region, as a template. (genomeweb.com)

While it is true that a woman's risk of developing breast or ovarian cancer increases quite a bit with these genes, it is not an automatic guarantee. (empowher.com)
When activated, the STAT4 protein increases the activity of genes that help immune cells called T-cells mature into specialized T-cells. (medlineplus.gov)

Isoforms of the octopamine receptor gene were previously found to be upregulated in socially grouping early instars of D. arcuata relative to solitary late instars [ 7 ]. (biomedcentral.com)
After aligning the octopamine gene isoforms using Clustal Omega ( https://www.ebi.ac.uk/Tools/msa/clustalo/ ), conserved regions were used for siRNA design using Dharmacon's siDESIGN tool ( https://horizondiscovery.com/en/products/tools/siDESIGN-Center ). (biomedcentral.com)

To each culture the researchers also added DNA that contained the gene that produces the enzyme which makes a firefly glow, along with human regulatory DNA which would control the production of that enzyme. (sciencedaily.com)

According to the National Cancer Institute, the BRCA genes are responsible for 20 to 25 percent of all inherited breast cancers and 5 to 10 percent of all breast cancers at large. (empowher.com)
These genes are also responsible for 15 percent of ovarian cancers. (empowher.com)

The realisation of robust gene drive strategies in vertebrate pests has the potential to revolutionise biocontrol. (mdpi.com)

Our prior work on Reelin and APOE delineated a gene-environment interactive model of autism pathogenesis, whereby genetically vulnerable individuals prenatally exposed to OPs during critical periods in neurodevelopment could undergo altered neuronal migration, resulting in an autistic syndrome. (nature.com)

The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. (medlineplus.gov)

There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)

But under the guidance and expertise of Dr Colin Dinney at MD Anderson - who is really the person to be credited with the development of nadofaragene, which has been a passion and a brainchild of his - we looked at changing from developing the protein as the treatment of choice to developing a gene vector. (medscape.com)

Brzustowicz estimates that the frequency of the altered gene in people with schizophrenia is going to be higher than the average in the general population. (sciencedaily.com)
Unconditional logistic regression was used to calculate ORs adjusted for frequency matching variables age group and sex, and age and education. (cdc.gov)

This group has labored for more than two years to produce a non-regulatory framework designed to help build consumer trust in gene-edited food products. (fmi.org)

Anatomy3

Organisms4

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes18

Technology, Industry, Agriculture1

Information Science3

Mutations10

Sequences7

Therapies13

Ontology9

Fetal3

Humans2

Target genes1

Variants6

Oryza sativa Japonica Group1

CRISPR5

Expression19

Genome3

Differentially4

Tumor2

Mutation3

Interactions2

BRCA11

Genetics1

Functional3

Editing30

Encodes3

Polymorphism3

Significantly1

MRNA5

Alleles1

Conclusion1

Behavior1

Complementation1

Subset2

Alterations1

Resistance2

Therapy32

Vectors1

Antigen1

Nucleotide2

Disease4

Bovine2

Influences1

Study6

Endogenous1

Increases2

Isoforms2

Researchers1

Cancers2

Vertebrate1

Individuals1

Transcription1

Distinct1

Vector1

Frequency2

Regulatory1