• estradiol
  • The theca cells are responsible for the production of androstenedione, and indirectly the production of 17β estradiol, also called E2, by supplying the neighboring granulosa cells with androstenedione that with the help of the enzyme aromatase can be used as a substrate for this type of estradiol. (wikipedia.org)
  • Molecular
  • This work would represent the first attempt to address the treatment of ovarian granulosa cancer with a molecular solid rational, drawing on the recent identification of the mutation 'leader' of this tumor. (clinicaltrials.gov)
  • Margaret Scott Robinson (born 1951) FRS FMedSci is a British molecular cell biologist, a professor and researcher in the Cambridge Institute for Medical Research, at the University of Cambridge. (wikipedia.org)
  • In 2003 she was appointed Professor of Molecular Cell Biology at the Cambridge Institute for Medical Research and is conducting research on coated vesicle proteins. (wikipedia.org)
  • receptor
  • Besides the brain and retina this receptor is expressed on the bone forming cells where it regulates their function in depositing bone. (wikipedia.org)
  • For a cell to respond to FSH, only a small percentage (~1%) of receptor sites need to be activated. (wikipedia.org)
  • hormone
  • Analysis by RNA-Seq pinpointed a series of differentially expressed genes, involved in cytokine and hormone signaling and cell division-related processes. (wikipedia.org)
  • secretion
  • These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathwa, a hypothesis confirmed by activin A secretion in cultured GCT cells which proliferated in response. (aacrjournals.org)
  • They are composed of membrane-packaged secretion of granulosa cells and have relations to the formation of liquor folliculi which are seen among closely arranged granulosa cells. (wikipedia.org)
  • gonadal
  • Once gametogonia enter the gonadal ridge, however, they attempt to associate with these somatic cells. (wikipedia.org)
  • oogonia
  • In the 1970s, evidence emerged that the first cells to make contact with the oogonia were of mesonephric origin. (wikipedia.org)
  • It was suggested that mesonephric cells already closely associated with the oogonia proliferated throughout development to form the granulosa cell layer. (wikipedia.org)
  • Development proceeds and the gametogonia turn into oogonia, which become fully surrounded by a layer of cells (pre-granulosa cells). (wikipedia.org)
  • marker
  • In cell biology, CD63 is often used as a marker for multivessicular bodies, which are enriched with CD63. (wikipedia.org)
  • FOXL2
  • We reported the presence of the FOXL2 402C→G mutation in 3 out of 14 thecomas, and retrospective evaluation of one of these cases revealed a small granulosa cell component. (aacrjournals.org)
  • human
  • MTNR1B mRNA is expressed in human islets, and immunocytochemistry confirms that it is primarily localized in beta cells in islets. (wikipedia.org)
  • In the human fetus, cells undergoing mitosis are seen until the second and third trimester of pregnancy. (wikipedia.org)