Granulosa germ cell tumor sertoli leydig cell tumor. Medical search. Frequent questions

Ovarian cancer is a cancerous tumor of an ovary. (wikipedia.org)
The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. (wikipedia.org)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
Some are benign, or noncancerous, and the patient can be cured by surgically removing one ovary or the part of the ovary containing the tumor. (news-medical.net)
Epithelial ovarian tumors develop from the cells that cover the outer surface of the ovary. (news-medical.net)
The stage of the tumor can be ascertained during surgery, when it can be determined how far the tumor has spread from where it started in the ovary. (news-medical.net)
Stage IA - Growth is limited to one ovary and the tumor is confined to the inside of the ovary. (news-medical.net)
GCTs account for about 1 in 5 tumors in the ovary. (proprofs.com)
Mature teratomas (aka dermoid cysts) are germ cell tumors of the ovary that are both common and benign. (proprofs.com)
Table 13-1 THE 2020 WHO CLASSIFICATION OF GERM CELL TUMORS OF THE OVARY Teratomas, Mature and Immature Mature teratoma Immature teratoma Primitive Germ Cell Tumors Dysgerminoma Yolk sac tumor Embryonal carcinoma Nongestational choriocarcinoma Mixed germ. (arppress.org)
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)
Cen C # , Chen M # , Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F. Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. (cas.cn)

In stage I of the ovarian carcinoma, the tumour is localised in one or both of the ovaries. (cancertame.com)
Germ cell ovarian tumour arises from the germ cells (the cells that give rise to ovaries during the foetal development). (cancertame.com)
In stage I, a germ cell ovarian tumour is localised to one or both ovaries. (cancertame.com)
Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
There are many types of tumors that can start in the ovaries. (news-medical.net)
Stage IB - Growth is limited to both ovaries without any tumor on their outer surfaces. (news-medical.net)
Sertoli-Lydig cell tumors (SLCTs), also known as androblastoma or arrhenoblastoma , are a type of sex cord-stromal tumor that originates in the ovaries. (knowcancer.com)
Ovarian cancer describes cancer in women that begins in the different cells of the ovaries (they produce eggs), fallopian tubes or peritoneum, which determines the type of ovarian cancer. (uchealth.org)
Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)
Ovarian stromal tumors develop in the ovaries' structural connective tissue cells that produce the female hormones estrogen and progesterone. (moffitt.org)
The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)

About 85 per cent of the ovarian tumours are carcinomas, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, clear cell cystadenocarcinoma, endometrioid adenocarcinoma and undifferentiated carcinoma. (cancertame.com)
There are several types of benign epithelial tumors, including serous adenomas, mucinous adenomas, and Brenner tumors. (news-medical.net)
Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)
Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)

The remaining 15 per cent of the ovarian tumours are germ cell tumours, stromal tumours and the borderline tumours. (cancertame.com)
Ovarian borderline tumors, also known as low malignant potential (LMP) ovarian tumors, do not cause an increase in CA125 levels and are not identifiable with an ultrasound. (wikipedia.org)
these are called borderline tumors or tumors of low malignant potential (LMP tumors). (news-medical.net)
A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)

MIXED ENDOMETRIOID AND CLEAR CELL CARCINOMA Figure 6-17 MIXED ENDOMETRIOID AND CLEAR CELL CARCINOMA The clear cell component (bottom) is histologically distinct from the endometrioid component (top). (arppress.org)

The 2016 update of the World Health Organization (WHO) classification of testicular germ-cell tumors divided them into two broad categories on the basis of whether they are derived from a precursor lesion: germ-cell neoplasia in situ (GCNIS). (medscape.com)
[ 9 ] A descriptive analysis of prepubertal testicular germ-cell tumors from a large Chinese center cited frequencies of 50.9% for teratomas, 29.2% for yolk-sac tumors, 19.3% for epidermoid cysts, and 0.6% for mixed germ-cell tumors. (medscape.com)
Prepubertal teratomas account for fewer than 30% of testicular germ-cell tumors in children and are uniformly benign. (medscape.com)
Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)

[ 5 ] whereas postpubertal tumors are GCNIS-derived, though benign prepubertal-type teratomas may rarely develop in the postpubertal testis. (medscape.com)
The most common germ-cell tumors are yolk-sac tumors and teratomas, which were reported by Ross to account for about 62% and 26% of testis tumors, respectively. (medscape.com)
Testis-sparing surgery with frozen section is a reasonable consideration for this and other benign prepubertal tumors. (medscape.com)
The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
In the presence of a Y chromosome and the SRY gene, müllerian‐inhibiting substance produced by Sertoli cells causes regression of the MD. Meanwhile, testosterone produced by the Leydig cells induces differentiation of the WD into the efferent ducts that communicate with the rete testis, followed by the epididymis, ductus deferens, seminal vesicle, and ejaculatory duct. (esur2023.com)

The stromal tumours include granulosa cell tumour and Sertoli-Leydig tumour. (cancertame.com)

[ 2 ] Adult germ-cell tumors with malignant potential, such as seminoma and embryonal carcinoma, are not present in prepubertal patients. (medscape.com)

The germ cell tumours include dysgerminoma, endodermal sinus tumour, embryonal carcinoma, malignant teratoma and choriocarcinoma. (cancertame.com)

[ 6 , 7 ] Nistal et al reported frequencies of 49% for yolk-sac tumors, 13% for teratomas, 9% for seminomas and mixed germ-cell tumors, and 29% for sex-cord stromal tumors. (medscape.com)
Some series have suggested that teratomas, which most believe are vastly underreported because of their benign nature, may account for almost 50% of prepubertal testicular tumors. (medscape.com)
[ 10 ] However, in tumor registries, yolk-sac tumors have been more common than teratomas, though it is possible that this may reflect a reporting bias. (medscape.com)
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
[5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)

Other GCTs include the dysgerminoma and yolk sac tumor. (proprofs.com)

In stage II, the tumour spreads to the uterus, fallopian tubes and other tissues within the pelvis. (cancertame.com)
By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)

Most malignant post-pubertal GCTs originate from germ cell neoplasia " in situ " (GCNIS). (uroweb.org)

A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)

ADULT GRANULOSA CELL TUMOR A: Adult granulosa cell tumor with extensive he. (arppress.org)
ADULT GRANULOSA CELL TUMOR Figure 12-10 ADULT GRANULOSA CELL TUMOR A: Adult granulosa cell tumor with extensive hemorrhage. (arppress.org)
C: An adult granulosa cell tumor that recurred in the retroperitoneum as a large solid mass. (arppress.org)

The first main type of sex-cord stromal tumor is a granulosa-theca cell tumor. (osmosis.org)

Less common types of ovarian cancer include germ cell tumors and sex cord stromal tumors. (wikipedia.org)
Moffitt's Gynecologic Oncology Program is home to a multispecialty team of surgeons, medical oncologists, reproductive endocrinologists and many other professionals, who specialize in treating all types of ovarian cancer , including stromal tumors. (moffitt.org)

Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)

Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

Ovarian germ cell tumours and stromal tumours constitute about 10 per cent of the ovarian tumours. (cancertame.com)
Ovarian germ cell tumours and stromal tumours affect young women usually below 20 years of age. (cancertame.com)
Ovarian germ cell tumours and stromal tumours remain asymptomatic during initial stages of the disease. (cancertame.com)
Common presenting symptoms of the ovarian germ cell tumours and stromal tumours include mass in the abdomen and vaginal bleeding. (cancertame.com)
At diagnosis, 1-2% are bilateral and 90-95% of cases are germ cell tumours (GCT) [ 6 ]. (uroweb.org)

Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)

Epidermoid cysts are benign tumors of epithelial origin and account for 10-15% of cases. (medscape.com)
Follicle cysts are lined with an inner layer of granulosa cells and an outer layer of theca interna cells. (medscape.com)
A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)

Gonadal stromal tumors are generally considered significantly less common than germ-cell tumors and primarily include juvenile granulosa-cell tumors, Leydig-cell tumors , and Sertoli-cell tumors. (medscape.com)
Sertoli-cell tumors are the most common gonadal stromal tumors in prepubertal children. (medscape.com)

Most authorities believe that seminomas should be managed as in adults and mixed germ-cell tumors should be treated according to the most malignant subtype present. (medscape.com)
Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)

Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

We conclude that StAR is localized to normal and neoplastic cells in the gonads and adrenal cortex, which produce large amounts of pregnenolone. (elsevierpure.com)
neoplastic cells are frequently palisaded at the periphery of the small groups, and the latter have a tendency to infiltrate surrounding tissue . (en-academic.com)

If the tumor is accompanied by high levels of testosterone, the tumor could be a Sertoli-Lydic cell tumor. (knowcancer.com)
During puberty, testosterone induces Sertoli cell maturation, and prevails over FSH on AMH regulation. (biomedcentral.com)
Sertoli-Leydig cell tumors can secrete excess testosterone , which can cause women to have more masculine features like hirsutism , which is increased hair growth. (osmosis.org)

follicle-like spaces (right) are also apparent, which are typical of juvenile granulosa cell tumor. (arppress.org)

Lesion of the female vulva characterized by thinning of the epidermis and disappearance of rete pegs, hydropic degeneration of basal cells, superficial hyperkeratosis, dermal fibrosis with scant perivascular, mononuclear inflammatory cell infiltrate. (brainscape.com)
a painless, slowly growing, mixed radiolucent-radiopaque lesion characterized histologically by cords of polyhedral epithelial cells, deposits of amyloid , and spherical calcifications. (en-academic.com)

Pediatric prepubertal testicular tumors are dramatically different from adult neoplasms. (medscape.com)

Luteinizing hormone stimulates theca cells to generate androgens and follicle stimulating hormone stimulates granulosa cells to convert those androgens to estradiol using the enzyme aromatase. (osmosis.org)
Although not essential for initial WD formation, the later differentiation of this embryological structure relies on androgens derived from the Leydig cells. (esur2023.com)

Background: Genotyping has become more cost-effective and less invasive with the use of buccal cell sampling. (rafinhibitors.com)

adenomatoid t. a small benign t. of the male epididymis and female genital tract , consisting of fibrous tissue or smooth muscle enclosing anastomosing glandlike spaces containing acid mucopolysaccharide lined by flattened cells that have ultra-structural characteristics of mesothelial cells. (en-academic.com)

And these are the most common malignant stromal tumors and they're associated with middle-aged women. (osmosis.org)

A benign tumor means the tumor can grow but will not spread. (cancer.net)
If any of those cells starts to divide uncontrollably, it can either form a benign tumor which means that it doesn't invade nearby tissue or spread to other parts of the body , or it can be a malignant tumor which means that it can invade nearby tissue and spread to other parts of the body . (osmosis.org)
Compared with benign tumor cells, malignant tumor cells have key features like not having a clearly defined border or like having slightly less organized nuclei. (osmosis.org)

Testicular tumors account for 1-2% of all pediatric tumors, with an incidence of 0.05-2 per 100,000 children. (medscape.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

Procedures used in the diagnosis and evaluation of a germ cell ovarian tumour include pelvic examination, ultrasound, CT scan and biopsy. (cancertame.com)
The aim of cytoreductive surgery is to confirm the diagnosis, define the extent of disease, and resect all visible tumor. (medscape.com)
As a result, cells from the tumor must be biopsied (excised) and studied under a microscope for an accurate diagnosis. (knowcancer.com)

A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)

The cells that make up EOC have several forms that can be recognized under the microscope. (news-medical.net)
They are broken down into many subtypes, which are determined by a number of the tumors' features, such as how their cells look under a microscope. (moffitt.org)
Under the microscope, these tumors classically develop little fluid pockets scattered throughout the tissue that are called Call-Exner bodies. (osmosis.org)

The cell bodies of these neurons are clustered in groups, called nuclei. (pharmaceuticalintelligence.com)

Cancerous epithelial tumors are carcinomas. (news-medical.net)

Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)

Treatment for SLCT depends upon the age of the patient, the degree of differentiation of the tumor, and whether or not the tumor has ruptured. (knowcancer.com)
Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. (knowcancer.com)

The tumors result from either failure of a dominant mature follicle to rupture or failure of an immature follicle to undergo the normal process of atresia. (medscape.com)
Each follicle is made up of an oocyte, which is an immature egg, surrounded by two types of cells - theca cells and granulosa cells. (osmosis.org)

The typical symptoms of an LMP tumor can include abdominal distension or pelvic pain. (wikipedia.org)
Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. (knowcancer.com)

ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)

Since these tumors are typically benign and their growth is slow, outlook is generally very positive. (knowcancer.com)
Paragangliomas tumors (sometimes referred to as glomus, as glomus cells are the place of origin) are a typically benign abnormal cell growth. (knowcancer.com)

The tumors are generally multilocular, and the mucus-containing loculi appear blue through the tense capsules. (medscape.com)

Fetal testes displayed intense Leydig cell staining. (elsevierpure.com)
The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)
AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. (biomedcentral.com)

Anatomy16

Diseases30

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes4

Disciplines and Occupations1

Ovary22

Ovaries12

Mucinous6

Borderline4

Endometrioid1

Testicular germ-cell t4

Testis7

Include granulosa1

Seminoma1

Choriocarcinoma1

Teratomas5

Yolk sac t1

Fallopian tubes2

Neoplasia1

Teratoma5

Adult granulosa3

Cord stromal tumor1

Types of ovarian cancer2

Cystic1

Malignant ovarian germ1

Tumours5

Extragonadal germ1

Cysts3

Gonadal stromal2

Subtype2

GCTs2

Neoplastic2

Testosterone3

Juvenile1

Lesion2

Neoplasms1

Androgens2

Invasive1

Adenomatoid1

Common malignant1

Benign tumor3

Incidence2

Diagnosis3

Cancerous tumor1

Microscope3

Nuclei1

Carcinomas1

GCNIS1

Differentiation2

Immature2

Pelvic2

Induces1

Typically benign2

Multilocular1

Fetal3