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InflammationInflammatory bowel dTuberculosisGranulomasChronic granuloDisordersDiseasesInterstitialFoundation for Sarcoidosis ResearchFeatures of granulomatousLesionsEtiologyDiseaseVasc Diffuse Lung DisLymphadenopathyDiagnosis of sarcoidosisSusceptibilityClinicalAffectsMastitisPatientsCutaneousDisorderBiopsySystemic SarcoidosisLesionBronchoalveolarSarcoid-like reactionDiagnosticInvolvement in sarcoidosisLymph NodesAntigenOcular sarcoidosisUnderstanding of the mechanismsRespiratoryAutoimmuneLungsResearchGenetic risk for developingMapping with sarcoidosis riskHepatitisMediastinalBlau
Inflammation20
  • The immunopathogenesis of granulomatous inflammation similar to that found in sarcoidosis needs to be studied in relevant animal models and in human tissues to identify therapeutic targets appropriate for clinical trials. (nih.gov)
  • The research objectives and scope of this initiative are to: 1) solicit and support innovative approaches for producing granulomatous inflammation in the lungs that resembles the histopathological appearance of sarcoidosis and 2) encourage investigators working in other areas of research to bring novel perspectives and expertise to this field. (nih.gov)
  • Studies on the role of innate immunity, antigen presentation, dendritic cell antigen processing, T-cell regulation and hypersensitivity in granulomatous lung inflammation are pertinent. (nih.gov)
  • The characterization of specific immunoregulatory cytokines in the setting of chronic granulomatous lung inflammation is also of interest. (nih.gov)
  • Moreover, murine models of inflammatory bowel disease, if they have associated lung inflammation, might pertain to mechanisms relevant for sarcoidosis. (nih.gov)
  • A form of skin inflammation called granulomatous dermatitis is typically the earliest sign of Blau syndrome. (medlineplus.gov)
  • The primary objective of this program announcement is to stimulate research on the etiology and management of sarcoidosis, a human disorder of granulomatous inflammation. (nih.gov)
  • This study was designed to determine the frequency of cases positive for AFB and positive for fungus in patients diagnosed to have granulomatous inflammation on Fine Needle Aspiration Cytology using special stains. (hindawi.com)
  • A descriptive cross-sectional survey was done on 100 cases of granulomatous inflammation consistent with tuberculosis diagnosed on fine needle aspiration cytology at the Department of Pathology, King Edward Medical University, Lahore. (hindawi.com)
  • After reporting granulomatous inflammation on Hematoxylin & Eosin staining of aspirates from FNAC, some unstained slides were subjected to special stains, like ZN, GMS, and PAS. (hindawi.com)
  • Forty-four cases (44%) of AFB positive smears were reported in granulomatous inflammation while only 5% cases of fungus were reported down. (hindawi.com)
  • Special stains should be done on all granulomatous inflammation cases seen on FNAC for confirmation of TB and ruling out other infectious causes. (hindawi.com)
  • As we have already discussed that granulomatous inflammation is not diagnostic of TB, many others causes must be ruled out before giving ATT. (hindawi.com)
  • However, in the clinical scenario if a patient is diagnosed as granulomatous inflammation, then antituberculous treatment (ATT) is started at the first point in our setup. (hindawi.com)
  • Diagnosis usually is first suspected because of pulmonary involvement and is confirmed by chest x-ray, biopsy, and exclusion of other causes of granulomatous inflammation. (msdmanuals.com)
  • 18 F-FDG accumulates in malignant tissues but also at the sites of infection and inflammation and in autoimmune and granulomatous diseases by the overexpression of distinct facultative glucose transporter (GLUT) isotypes (mainly GLUT-1 and GLUT-3) and by an overproduction of glycolytic enzymes in cancer cells and inflammatory cells. (snmjournals.org)
  • We also observed elevated MMP12 in our multiwall carbon nanotube (MWCNT) murine model of granulomatous inflammation. (nih.gov)
  • The diagnosis of sarcoidosis is not standardized, but based on three major criteria: a compatible clinical presentation, finding non-necrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. (thoracic.org)
  • It is not clear that the reaction to self-proteins is actually the main culprit behind the granulomatous inflammation-it may be a bystander caught up in a larger reaction. (stopsarcoidosis.org)
  • By better defining the mechanisms that cause sarcoidosis, including the role of inflammation, immune over or underreactivity and autoimmunity, we may be better able to treat patients with sarcoidosis and maybe one day, even prevent the disease. (stopsarcoidosis.org)
Inflammatory bowel d2
  • Overlap, common features, and essential differences in pediatric granulomatous inflammatory bowel disease. (nih.gov)
  • In patients with noninfectious inflammatory diseases, 18 F-FDG PET is of importance in the diagnosis of large-vessel vasculitis and seems to be useful in the visualization of other diseases, such as inflammatory bowel disease, sarcoidosis, and painless subacute thyroiditis. (snmjournals.org)
Tuberculosis7
  • Differential diagnoses include tuberculosis, fungal infections, sarcoidosis, and histiocytic disorders including Rosai-Dorfman disease. (cytojournal.com)
  • We provide evidence that one of a variety of Mycobacterium species , especially organisms resembling M. tuberculosis, is found in most patients with sarcoidosis. (cdc.gov)
  • Because of the substantial pathologic ( 5 ), immunologic ( 6 ), epidemiologic ( 7 ), and clinical similarities ( 8 , 9 ) between sarcoidosis and infections caused by Mycobacterium species (particularly tuberculosis), we analyzed tissue specimens from patients with sarcoidosis for evidence of mycobacterial genes. (cdc.gov)
  • Chronic beryllium disease (CBD) is an occupationally acquired lung disease similar clinically to other granulomatous diseases, such as sarcoidosis, schistosomiasis and tuberculosis. (nih.gov)
  • We present a patient diagnosed with skin sarcoidosis, breast cancer, pulmonary tuberculosis, and peritoneal sarcoidosis with a past history of colorectal cancer. (koreamed.org)
  • Suppurative lesions become granulomatous, and histopathological examination of the granulomas shows a central necrotic, sometimes caseating, zone surrounded by a layer of epithelioid cells, multinucleated giant cells, and fibroblasts in a radial arrangement, typical of other granulomatous conditions such as tuberculosis and sarcoidosis. (cdc.gov)
  • In the others, differential diagnosis was considered for tuberculosis, sarcoidosis, and syphilis by clinical, laboratory (tuberculin test, angiotensin I converting enzyme measurement, treponema pallidum haemaglutination test), and chest radiograhy evaluation. (bmj.com)
Granulomas8
  • Papageorgiou PPHongcharu WChu AC Systemic sarcoidosis presenting with multiple tattoo granulomas and extra-tattoo cutaneous granuloma. (jamanetwork.com)
  • 5. Perineural and intraneural cutaneous granulomas in granulomatous mycosis fungoides mimicking tuberculoid leprosy. (nih.gov)
  • Cytological features of granulomatous mastitis include the presence of epithelioid cell granulomas, multinucleated giant cells, histiocytes with phagocytosed neutrophils, and numerous neutrophils. (cytojournal.com)
  • The inflammatory process leads to formation of noncaseating granulomas, the pathologic hallmark of sarcoidosis. (msdmanuals.com)
  • Sarcoidosis is a multisystem disease characterized by noncaseating granulomas. (koreamed.org)
  • Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis. (mattioli1885journals.com)
  • Presence of Propionibacterium acnes in granulomas associates with a chronic disease course in Dutch sarcoidosis patients. (mattioli1885journals.com)
  • Braga S, Jeny F, Latrasse M, Saidenberg Kermanac'h N, Tran Ba S, Nunes H. Frontal cutaneous and bone sarcoidosis: an example of the contiguous spread of granulomas. (mattioli1885journals.com)
Chronic granulo2
  • In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. (nih.gov)
  • Intro In the United States incidence and mortality from sarcoidosis a chronic granulomatous disease are highest in black ladies (Iannuzzi et al. (ecologicalsgardens.com)
Disorders3
  • The World Association of Sarcoidosis and other Granulomatous Disorders, also known as WASOG is an organisation of physicians involved in the diagnosis and treatment of sarcoidosis and related conditions. (wikipedia.org)
  • for the American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders, ATS/ERS/WASOG statement on sarcoidosis. (jamanetwork.com)
  • She is president of the World Association of Sarcoidosis and other Granulomatous Disorders (WASOG). (wasog.org)
Diseases14
  • Granulomatous diseases comprise a small but important subset of diverse ear problems. (medscape.com)
  • Granulomatous diseases in the middle ear may be localized primarily to the ear and surrounding tissues, or they may be a manifestation of a body-wide disseminated problem. (medscape.com)
  • Granulomatous reactions may mimic other, far more common middle ear diseases. (medscape.com)
  • Bensadoun , ES et al "Proteoglycans in granulomatous lung diseases. (ersjournals.com)
  • The Restrictive and Vascular Lung Diseases Branch supports research and research training in pulmonary fibrosis and other interstitial or rare lung diseases in adults, sarcoidosis, pulmonary vascular disease including pulmonary hypertension and right heart failure, pulmonary embolism, lung aging, data science, and genomics. (nih.gov)
  • The Granulomatous and Interstitial Lung Disease Program supports research on the genetic predisposition, risk factors, pathogenesis, diagnosis, and treatment of interstitial lung diseases including idiopathic pulmonary fibrosis (IPF), occupational and environmental lung diseases, as well as lymphangioleiomyomatosis (LAM). (nih.gov)
  • This program also supports research on non-infectious granulomatous diseases including sarcoidosis, berylliosis, and hypersensitivity pneumonitis. (nih.gov)
  • Dr. Kaminski's main research interests involve applying genomic approaches to elucidate basic mechanisms and improve diagnosis and treatment of Idiopathic Pulmonary Fibrosis (IPF), a chronic mostly lethal and currently untreatable scarring lung disease and other chronic lung diseases such Chronic Obstructive Pulmonary Disease (COPD), severe asthma and sarcoidosis. (yale.edu)
  • She is chief editor of Current Opinion in Pulmonary Medicine and associate editor of Sarcoidosis, Vasculitis and Diffuse Lung Diseases . (wasog.org)
  • Dr. Rose has been involved in collaborative research in noninfectious granulomatous lung diseases including sarcoidosis and hypersensitivity pneumonitis (with particular focus on hot tub, swimming pool and bioaerosol-related cases). (pnhp.org)
  • Her clinical interest is Granulomatous Interstitial Lung Diseases and she launched the first research program focused on sarcoidosis in 2010. (ucsf.edu)
  • In addition, the cells from some people with sarcoidosis demonstrate an immune response to some of their own proteins, similar to autoimmune diseases. (stopsarcoidosis.org)
  • At this time, while we do not think that sarcoidosis is the same as diseases like RA, or lupus, studies do indicate that some of the immune reactions and genetic factors are similar between these diseases. (stopsarcoidosis.org)
  • Furthermore, there is an increased coincidence of some of these autoimmune diseases and sarcoidosis than would be expected by chance alone, including Sjogren's disease and others, raising a question as to whether they share some of the same mechanisms. (stopsarcoidosis.org)
Interstitial3
  • 15. Two cases of granulomatous mycosis fungoides mimicking interstitial granulomatous dermatosis. (nih.gov)
  • Acute granulomatous interstitial nephritis and hepatitis caused by drugs. (nih.gov)
  • In chronic disease, the alveoli contain small interstitial granulomata which resemble those seen in sarcoidosis. (nih.gov)
Foundation for Sarcoidosis Research1
  • Since 2015 she is a member of the Foundation for Sarcoidosis Research (FSR: www.stopsarcoidosis.org) Scientific Advisory Board (SAB). (wasog.org)
Features of granulomatous1
  • 4. Granulomatous mycosis fungoides: report of a case with some histopathologic features of granulomatous slack skin. (nih.gov)
Lesions3
  • An autopsy revealed an enlarged heart and · Ensure that fire fighters are cleared for duty, granulomatous lesions consistent with sarcoidosis in following an injury/illness, by a physician the victim's heart, lungs, lymph nodes, and liver. (cdc.gov)
  • 8. Granulomatous slack skin mycosis fungoides developing simultaneously with sarcoid-like lesions in a patient with repeated anabolic injections in the past? (nih.gov)
  • Biopsy of new lesions at two different sites both demonstrated tumefactive sarcoidosis. (bmj.com)
Etiology5
  • The group advised that in addition to seeking the etiology of sarcoidosis and determining susceptibility factors, the initial components in the innate and/or adaptive immune pathways that affect lung lymph nodes or tissue in early disease must be identified. (nih.gov)
  • Today's outcomes from a people of African-American females support the function from the gene and the 5q31 locus in the etiology of sarcoidosis and also demonstrate that percent African ancestry is definitely associated Atractyloside Dipotassium Salt with disease risk. (ecologicalsgardens.com)
  • We encourage research that seeks to identify not only the cause of sarcoidosis, but seeks related predisposing factors, such as genomic, proteomic, metabolomic, lipidomic or glycomic factors related to the etiology of sarcoidosis. (nih.gov)
  • Sarcoidosis is a multisystem granulomatous disease of unknown etiology. (koreamed.org)
  • Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. (koreamed.org)
Disease27
  • We retrospectively reviewed medical records of all cases diagnosed with HP-like granulomatous lung disease with NTM from exposure to hot water aerosols from hot tubs/spa pools, whirlpools, showers, and swimming pools in immunocompetent individuals at the various physician practices in Springfield, Illinois, during the period 2001-2005 ( n = 4). (nih.gov)
  • Mañá JMarcoval JGraells JSalazar APeyrí JPujol R Cutaneous involvement in sarcoidosis: relationship to systemic disease. (jamanetwork.com)
  • Bronchoalveolar lavage macrophage-lymphocyte clusters in granulomatous disease are linked to lymphocytosis. (cdc.gov)
  • We tested the hypothesis that ML clusters might be found among the BAL cells from patients with granulomatous disease. (cdc.gov)
  • We measured the number of ML clusters among the BAL cells from normal controls (n = 13), sarcoidosis patients (n = 18), beryllium -sensitized (BeS) patients (n = 21) and chronic beryllium disease (CBD) patients (n = 15). (cdc.gov)
  • This data suggested that ML clusters were increased in granulomatous lung disease. (cdc.gov)
  • An increase in ML clusters in BAL cells is not specific for granulomatous disease and is associated with the increase in BAL lymphocytes. (cdc.gov)
  • Sarcoidosis is an inflammatory disease that can affect nearly any part of the body. (nih.gov)
  • Thoracic sarcoidosis is a common disease, and its usual radiographic manifestations have been well described and are readily recognized. (ajronline.org)
  • Sarcoidosis is a multisystem inflammatory disease that mainly affects lymph nodes and pulmonary tissues and is characterized by noncaseating granulomata in affected organs ( 1 ). (cdc.gov)
  • Additionally, each Clinical Center will develop a clinic-specific research protocol aimed at identifying pathogenetic mechanisms or predictors of AAT or sarcoidosis disease development/progression. (nih.gov)
  • This initiative will 1) study patients with AAT or sarcoidosis using state of the art genomics and microbiomics analyses to identify molecular abnormalities and their relationship to patients clinical characteristics and 2) conduct hypothesis-based clinical studies at each Clinical Center to elucidate pathogenetic mechanisms or identify predictors of disease development/progression. (nih.gov)
  • Blau syndrome is a sarcoidosis-like disease inherited in an autosomal dominant fashion that manifests in children. (msdmanuals.com)
  • Background: Sarcoidosis is a chronic inflammatory disease of unknown cause characterized by granuloma formation. (nih.gov)
  • Previous studies report increased MMP12 in sarcoidosis patients and association between MMP12 expression and disease severity. (nih.gov)
  • Summary: Subacute granulomatous thyroiditis is an uncommon disease that occurs most often in women in their second to fifth decades of life. (ajnr.org)
  • Subacute granulomatous thyroiditis (nonsuppurative thyroiditis, subacute thyroiditis, or de Quervain thyroiditis) is a self-limited inflammatory disease of the thyroid gland that most often occurs secondary to a viral infection ( 1 , 2 ). (ajnr.org)
  • Although a number of articles have described the sonographic features associated with this disease ( 3 - 5 ), very few reports describe the CT and MR imaging features associated with subacute granulomatous thyroiditis ( 6 , 7 ). (ajnr.org)
  • Sarcoidosis is a multisystem inflammatory granulomatous disease that affects the central nervous system (CNS). (neurology-jp.org)
  • Currently there is no known cause for the sarcoidosis disease . (intelligentdental.com)
  • April 20, 2020─New guidance is available for physicians who must go through a number of steps to provide a probable diagnosis of sarcoidosis - an inflammatory disease that affects the lungs, lymph glands, and other organs. (thoracic.org)
  • The American Thoracic Society has published an official clinical practice guideline in which a panel of experts strongly recommended a baseline serum test to screen for hypercalcemia, a potentially serious disease manifestation, along with 13 conditional recommendations and a best practice statement to improve diagnosis and detection of sarcoidosis in vital organs. (thoracic.org)
  • Sarcoidosis is a multisystemic granulomatous disease of unknown origin. (mattioli1885journals.com)
  • In most cases scar sarcoidosis was the first manifestation of the disease, and in most cases it was asymptomatic. (mattioli1885journals.com)
  • 2. Hameed OA, Skibinska M. Rare disease: Scar sarcoidosis with bone marrow involvement and associated musculoskeletal symptoms. (mattioli1885journals.com)
  • However, at the current time we do NOT consider sarcoidosis for the most part to be an autoimmune disease, like rheumatoid arthritis (RA) or systemic lupus erythematosis (lupus). (stopsarcoidosis.org)
  • Background/Aims: Sarcoidosis is a multiorgan granulomatous inflammatory disease of an unknown cause, probably due to inappropriate T-cell response. (longdom.org)
Vasc Diffuse Lung Dis1
Lymphadenopathy2
  • Diffuse lymphadenopathy was identified and an inguinal lymph node biopsy revealed non-caseating granulomatous changes. (biomedcentral.com)
  • For patients with suspected sarcoidosis and mediastinal and/or hilar lymphadenopathy for whom it has been determined that tissue sampling is necessary, we suggest EBUS-guided lymph node sampling, rather than mediastinoscopy, as the initial mediastinal and/or hilar lymph node sampling procedure (conditional recommendation, very low-quality of evidence). (thoracic.org)
Diagnosis of sarcoidosis7
Susceptibility1
  • Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility. (ucsf.edu)
Clinical9
  • In this report, we describe two patients who have CGD and a disorder consistent with sarcoidosis on the basis of unequivocal clinical-radiographic presentations, their responses to treatment, and serum angiotensin-converting enzyme levels. (nih.gov)
  • Using information derived from a systematic review of the literature and clinical material from our own institutions, a classification has been developed of the unusual thoracic manifestations of sarcoidosis, and their relative incidence has been determined and tabulated. (ajronline.org)
  • This program encourages innovative, multidisciplinary basic and clinical research of sarcoidosis involving the respiratory tract and other frequently involved organs, especially those of so- called critical involvement (heart, eyes, liver, and neurologic system) with the intent of accelerating progress in the discovery of the cause of sarcoidosis and its diagnosis, prevention, and treatment. (nih.gov)
  • Collectively the GRADS Clinical Centers will create a program-wide cohort of approximately 400 AAT and approximately 200 sarcoidosis subjects and controls. (nih.gov)
  • Up to 8 Clinical Centers will be funded, each led by one or more Investigators with expertise in AAT, sarcoidosis, pulmonary medicine, immunology, genomics or cell biology. (nih.gov)
  • The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study as Clinical Centers. (nih.gov)
  • The GRADS Clinical Centers will enroll and clinically and immuno- phenotype AAT and sarcoidosis subjects and appropriate controls. (nih.gov)
  • In patients for whom there is a high clinical suspicion for sarcoidosis (e.g. (thoracic.org)
  • Risk Indicators of Sarcoidosis Evolution-Unified Protocol (RISE-UP): protocol for a multi-centre, longitudinal, observational study to identify clinical features that are predictive of sarcoidosis progression. (ucsf.edu)
Affects3
  • RESEARCH OBJECTIVES Sarcoidosis, an illness of unknown cause, usually affects the respiratory tract, but often involves many other organs as well. (nih.gov)
  • Sarcoidosis most commonly affects people aged 20 to 40 years but occasionally affects children and older adults. (msdmanuals.com)
  • Once thought rare, sarcoidosis is now known to be common and affects people worldwide. (stopsarcoidosis.org)
Mastitis3
  • Cytological diagnosis of granulomatous mastitis is challenging. (cytojournal.com)
  • Answer: D. Studies have shown that the presence of neutrophils is an important diagnostic clue in diagnosing granulomatous mastitis, as in the present case, where histocytes showing emperipolesis of neutrophils along with the presence of numerous neutrophils in the background led to the diagnosis in this case. (cytojournal.com)
  • Granulomatous mastitis is a rare benign inflammatory entity described by Kessler and Wolloch in 1972. (cytojournal.com)
Patients25
  • This study will determine if atorvastatin (Lipitor), a widely used cholesterol-lowering drug, can help patients with pulmonary (lung) sarcoidosis and replace or reduce the need for patients to take steroids, such as prednisone. (nih.gov)
  • Many sarcoidosis patients are treated with prednisone, but the drug is not effective in all patients, and it can cause serious side effects, such as high blood pressure, sugar diabetes, eye cataracts, and bone thinning. (nih.gov)
  • Patients with stage II or III pulmonary sarcoidosis between 18 and 70 years of age who require prednisone may be eligible for this study. (nih.gov)
  • Patients are eligible for the trial if they are 18-70 years old with radiographic stages II and III pulmonary sarcoidosis, and are on prednisone, methotrexate, or azathioprine for pulmonary sarcoidosis or who are steroid-requiring. (nih.gov)
  • Patients with extra-pulmonary sarcoidosis (except cardiac and neurosarcoid) may be eligible as long as they have active pulmonary (stage II or III) sarcoidosis. (nih.gov)
  • 16. A case-control study of clinicopathologic features, prognosis, and therapeutic responses in patients with granulomatous mycosis fungoides. (nih.gov)
  • About 30-60% of sarcoidosis patients develop intraocular inflammatory signs, and bilateral granulomatous uveitis is the most common presentation. (medscape.com)
  • [ 32 ] Four levels of certainty for the diagnosis of ocular sarcoidosis (diagnostic criteria) are recommended in patients in whom other possible causes of uveitis had been excluded. (medscape.com)
  • Prophylactic implantable cardioverter-defibrillator implantation should be considered in patients with cardiac sarcoidosis. (medscape.com)
  • We performed polymerase chain reaction analysis, for Mycobacterium species 16S rRNA, rpoB , and IS 6110 sequences, on 25 tissue specimens from patients with sarcoidosis and on 25 control tissue specimens consisting of mediastinal or cervical lymph nodes and lung biopsies. (cdc.gov)
  • Specimens from 44 patients with sarcoidosis and 57 controls were included. (cdc.gov)
  • CNS Involvement occurs in a relatively small number of patients with sarcoidosis but is potentially serious manifestation. (neurology-jp.org)
  • Patients with a definite or probable diagnosis of CNS sarcoidosis should start treatment promptly. (neurology-jp.org)
  • In 2012 she was nominated for the 'World Sarcoidosis Person of the Year Award' for her tiredless research work in defining the psychological burden faced by patients and their families. (wasog.org)
  • 15-11-12.This award is selected by patients of the Irish Sarcoidosis Support Network (ISarc). (wasog.org)
  • For patients with sarcoidosis who do not have ocular symptoms, we suggest a baseline eye examination to screen for ocular sarcoidosis (conditional recommendation, very low-quality of evidence). (thoracic.org)
  • For patients with sarcoidosis who have neither renal symptoms nor established renal sarcoidosis, we suggest baseline serum creatinine testing to screen for renal sarcoidosis (conditional recommendation, very low-quality of evidence). (thoracic.org)
  • For patients with extra-cardiac sarcoidosis and suspected cardiac involvement, we suggest cardiac magnetic resonance imaging, rather than positron emission tomography or transthoracic echocardiography, to obtain both diagnostic and prognostic information (conditional recommendation, very low quality of evidence). (thoracic.org)
  • For patients with sarcoidosis in whom pulmonary hypertension is suspected, we suggest initial testing with transthoracic echocardiography (conditional recommendation, very low-quality evidence). (thoracic.org)
  • She also is committed to the diagnosis and management of patients with sarcoidosis. (pnhp.org)
  • Two patients never required treatment, and in all cases the frontal problem improved or remained stable spontaneously or under sarcoidosis treatment. (mattioli1885journals.com)
  • Osseous sarcoidosis: A multicenter retrospective case-control study of 48 patients. (mattioli1885journals.com)
  • While the role of autoimmune mechanisms is still not well sorted out, some studies have found antibodies against human proteins at increased rates in some patients with sarcoidosis compared to others with and without sarcoidosis. (stopsarcoidosis.org)
  • The presence of this "autoimmune" process could support the use of some treatments that we have been testing in patients with sarcoidosis, such as rituximab. (stopsarcoidosis.org)
  • Results: A total of 50 patients with sarcoidosis were registered in our study of which 33 were females (66%) and 17 were m. (longdom.org)
Cutaneous5
  • Walsh NMGHanly JGTremaine RMurray S Cutaneous sarcoidosis and foreign bodies. (jamanetwork.com)
  • Val-Bernal JFSanchez-Quevedo MCCorral JCampos A Cutaneous sarcoidosis and foreign bodies: an electron probe roentgenographic microanalytic study. (jamanetwork.com)
  • Veien NKStahl DBrodthagen H Cutaneous sarcoidosis in Caucasians. (jamanetwork.com)
  • 2. [Granulomatous mycosis fungoides histologically simulating cutaneous sarcoidosis]. (nih.gov)
  • 6. Granulomatous variants of cutaneous T-cell lymphoma. (nih.gov)
Disorder1
  • Some researchers believe that these individuals have a non-inherited version of the disorder called early-onset sarcoidosis. (medlineplus.gov)
Biopsy2
  • They were going to do a needle biopsy but now want to do an open biopsy because it is not safe to do it with needle.They think it might be sarcoidosis. (cancer.org)
  • Skin biopsy identified granulomatous inflammatory cell infiltrates with staining negative for mycobacteria and fungus. (biomedcentral.com)
Systemic Sarcoidosis1
Lesion2
  • Sarcoidosis is a granulomatous lesion of unknown origin. (cancer.org)
  • sinus tract also confirmed a granulomatous lesion and there was no sign of malignancy. (who.int)
Bronchoalveolar1
Sarcoid-like reaction1
  • Multiple pulmonary cavitating nodules in female with endometrium adenocarcinoma history - difficulties in differentiation between metastases, sarcoidosis and sarcoid-like reaction. (ajronline.org)
Diagnostic3
  • four experienced no diagnostic evidence of sarcoidosis but the physician did not provide an alternate analysis. (ecologicalsgardens.com)
  • The information presented in this review is intended to provide physicians with a single comprehensive source to assist them when atypical radiographic findings of thoracic sarcoidosis are a diagnostic consideration. (ajronline.org)
  • Diagnostic criteria proposed by "The Diagnosis Guideline for Sarcoidosis in Japan -2006" can distinguish definite, probable, and possible neurosarcoidosis, and may be now commonly used. (neurology-jp.org)
Involvement in sarcoidosis1
Lymph Nodes1
  • While the lungs and lymph nodes are affected in almost everyone who has sarcoidosis, African Americans and people of Japanese descent are more likely to have eye involvement than Caucasians. (stopsarcoidosis.org)
Antigen2
  • Sarcoidosis is thought to be due to an exaggerated inflammatory response to an environmental antigen in a genetically susceptible person. (msdmanuals.com)
  • It has been argued that the skin is one of the entry doors of the possible antigen that causes sarcoidosis and after entering the skin, the causal agent may progress to the underlying bone. (mattioli1885journals.com)
Ocular sarcoidosis1
  • International criteria for the diagnosis of ocular sarcoidosis have been determined from the results of the first International Workshop On Ocular Sarcoidosis. (medscape.com)
Understanding of the mechanisms2
  • High risk, high impact projects are sought that have potential to significantly increase present understanding of the mechanisms that induce granulomatous lung changes. (nih.gov)
  • No one knows exactly what causes sarcoidosis, although our understanding of the mechanisms by which sarcoidosis develops is advancing. (stopsarcoidosis.org)
Respiratory1
Autoimmune2
  • There is some growing evidence that this sarcoidosis immune response may also include an "autoimmune" response, with some reaction to "self" proteins. (stopsarcoidosis.org)
  • In summary, although there are some similar features, based on today's science we do not advocate using the label "autoimmune" to describe sarcoidosis. (stopsarcoidosis.org)
Lungs4
  • The purpose of this funding opportunity announcement (FOA), issued by NHLBI, NIH, is to invite applications to participate in the NHLBI Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) program, which will assemble a multidisciplinary team of investigators to conduct state-of-art genomic, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: Alpha-1 Antitrypsin Deficiency (AAT) and sarcoidosis. (nih.gov)
  • GRADS will assemble a multidisciplinary team of investigators to conduct state-of-art genomics, microbiomics and phenotypic studies of two serious and understudied conditions that affect the lungs: alpha-1 antitrypsin deficiency (AAT) and sarcoidosis. (nih.gov)
  • The lungs and lymphatic system are most often affected, but sarcoidosis may affect any organ. (msdmanuals.com)
  • Lungs were harvested at 3, 10, 20, and 60 days post instillation for evaluation of MMP12 expression and granulomatous changes. (nih.gov)
Research4
  • Investigators new to sarcoidosis research are particularly encouraged to develop projects in this area. (nih.gov)
  • The NHLBI convened a working group on "Future Research Directions in Sarcoidosis" in August 2002. (nih.gov)
  • We executed a nested case-control research of 486 sarcoidosis situations and 943 age group- and geography-matched handles. (ecologicalsgardens.com)
  • Research also shows that risk appears to be elevated to some extent if someone in his or her close family has sarcoidosis, although researchers have not yet found a gene or genes linked to the development of sarcoidosis. (stopsarcoidosis.org)
Genetic risk for developing1
  • Such triggers, although usually harmless in most people, might irritate the immune systems of people who are at genetic risk for developing sarcoidosis. (stopsarcoidosis.org)
Mapping with sarcoidosis risk1
  • We also wanted to replicate associations of four genomic areas previously recognized through admixture mapping with sarcoidosis risk and to determine whether global percent African ancestry is related to risk. (ecologicalsgardens.com)
Hepatitis2
  • A case of allopurinol-induced granulomatous hepatitis with ductopenia and cholestasis]. (nih.gov)
  • Other observed patterns include granulomatous hepatitis, vascular injury (eg, sinusoidal obstruction syndrome), Ito cell lipidosis and neoplasms (eg, adenomas). (bmj.com)
Mediastinal1
  • We examined sarcoidosis and control paraffin-embedded pulmonary, mediastinal, and cervical tissue specimens for Mycobacterium species 16S rRNA, rpoB , and IS 6110 sequences. (cdc.gov)
Blau1