NeutrophilsMacrophage colonyBasophilsMonocytesProducing granulocyte-colonyEosinophilsEosinophilCytokineColonyNeutrophil granulocyteNeutrophilic granulocyteBoneMacrophagesCellsPatientsDifferentiationInfectionGranulesInnateTransfusionsTransfusion MedicineDifferentialAutologousHumansPlateletDonorMyeloidCytoplasmicAgranulocytesPeripheralInfusionPulmonaryPopulationsBlastsCountsInfectionsDiseasesClinicalFunctionDecreaseTypicallyAssessment
Neutrophils10
- The specific types of granulocytes are neutrophils, eosinophils, and basophils. (medlineplus.gov)
- Granulocytes, specifically neutrophils, help the body fight bacterial infections. (medlineplus.gov)
- Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
- Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
- It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
- The 3 types of granulocytes produced from myeloblasts in the bone marrow are: eosinophils, basophils and neutrophils. (knowswhy.com)
- Eosinophils, basophils and neutrophils are granulocytes, while lymphocytes and monocytes are agranulocytes. (knowswhy.com)
- Low-density granulocytes (LDG) are a type of neutrophils whose number has been observed to grow particularly in connection with certain autoimmune diseases and cancers, such as rheumatoid arthritis, melanoma, liver cancer, and breast cancer. (medtelligence.net)
- It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
- Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency. (bvsalud.org)
Macrophage colony10
- In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. (amrita.edu)
- Objective We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). (bmj.com)
- Administration of granulocyte macrophage colony stimulating factor (GM-CSF) after birth raises neutrophil counts but does not improve neonatal or 2-year developmental outcomes. (bmj.com)
- Granulocyte macrophage colony stimulating factor (GM-CSF) administered after birth does not alter 5-year neurocognitive outcomes. (bmj.com)
- Mice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonary alveolar proteinosis (PAP). (wiley.com)
- However, in patients receiving granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) the increase in F-actin content was much greater than in those not receiving these cytokines (159, 149, and 90% for G-CSF, M-CSF, and noncytokine group, respectively). (duke.edu)
- Patients receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) had only a 62% increase in the F-actin content, which was not statistically significant from patients undergoing ABMT without any cytokines. (duke.edu)
- They differentiate from myeloid precursor cells in response to the cytokins interleukin 3 (IL-3), interleukin 5 (IL-5), and granulocyte macrophage colony-stimulating factor (GM-CSF). (wikidoc.org)
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)
- Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
Basophils4
- Of the granulocytes, basophils are the least common. (biologyease.com)
- Basophils are granulocytes that circulate in sites of allergic inflammation and that react to allergic stimuli by migrating. (biologyease.com)
- Basophils are the least common of the granulocytes , representing about 0.01% to 0.3% of circulating leukocytes (white blood cells). (wikidoc.org)
- Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed. (wikidoc.org)
Monocytes3
- The lack of formation of superoxide and hydrogen-peroxide following treatment with unopsonized zymosan indicated that the granulocyte preparation was relatively uncontaminated by monocytes. (cdc.gov)
- CLP granulocytes alsocietypublishing.org monocytes visited the higher the entropy. (lu.se)
- The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. (lu.se)
Producing granulocyte-colony1
- An autopsy case of carcinosarcoma of the liver producing granulocyte-colony stimulating factor (G-CSF) is reported. (nih.gov)
Eosinophils1
- Eosinophil granulocytes , usually called eosinophils (or, less commonly, acidophils ), are white blood cells of the immune system that are responsible for combating infection and parasites in vertebrates . (wikidoc.org)
Eosinophil1
- the other nucleated cells near the myeloblast are an eosinophil granulocyte (centre) and two polychromatic erythroblasts. (biologyease.com)
Cytokine6
- The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)
- Here, we report that granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine with known trophic and neuroprotective properties in the brain, acts directly on dopaminergic circuits to enhance their function. (jneurosci.org)
- D) Cytokine release syndrome following granulocyte infusion and consider anti IL-6 antibody or steroids if further deterioration. (ebmt.org)
- Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
- These observations suggest that the granulocytes generated following ABMT and cytokine administration may have different functional potential depending on the cytokine administered. (duke.edu)
- Granulocyte colony stimulating factor (G-CSF) is a 20 kDa glycoprotein cytokine that stimulates growth and development of granulocyte progenitors in the bone marrow (Nagata et al. (allindianpatents.com)
Colony25
- Granulocyte-Colony Stimulating Factor (G-CSF) is a cell hormone that increases the cell number of PMN and that stimulates the individual PMN. (scirp.org)
- Stief, T. (2018) Granulocyte Colony-Stimulating Factor Multiplies Normal Blood ROS Generation at Less than 1 µg/l. (scirp.org)
- Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)
- This graph shows the total number of publications written about "Granulocyte Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte Colony-Stimulating Factor" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Granulocyte Colony-Stimulating Factor" by people in Profiles. (uchicago.edu)
- Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
- Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
- Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
- Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
- Scholars@Duke publication: Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report. (duke.edu)
- The purpose of this report is to analyze long-term clinical outcomes of patients exposed to plerixafor plus granulocyte colony-stimulating factor (G-CSF) for stem cell mobilization. (duke.edu)
- For the quantification of Granulocyte colony-stimulating factor (G-CSF) in Culture Supernatant, Cell Lysates, Serum, Plasma (EDTA), Plasma (Heparin). (biosensis.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
- Description: A sandwich ELISA kit for detection of Colony Stimulating Factor 3, Granulocyte from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (novosides.eu)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Colony Stimulating Factor 3, Granulocyte (GCSF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (novosides.eu)
- Patients with neutropenia may benefit from treatment with granulocyte colony-stimulating factor (G-CSF). (medscape.com)
- The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
- EP0237545, published on 1987-09-23 by Lawrence M Souza discloses the production of pluripotent granulocyte colony stimulating factor using E.coli as a host organism. (allindianpatents.com)
- Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. (planteome.org)
- Link to all annotated objects annotated to response to granulocyte colony-stimulating factor. (planteome.org)
- Link to all direct and indirect annotations to response to granulocyte colony-stimulating factor. (planteome.org)
- Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology. (janusinfo.se)
- The donor had scheduled a trip to Sri Lanka, and was to return 3 days before the scheduled start of granulocyte-colony-stimulating factor, or G-CSF, application. (cdc.gov)
Neutrophil granulocyte1
- for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally staining cytoplasmic granules. (wikipedia.org)
Neutrophilic granulocyte1
- Here we tested the effects of baicalin on the activity of LYSO using the S. aureus mastitis mouse model and neutrophilic granulocyte model of S. aureus infection. (oncotarget.com)
Bone5
- Granulocytes are produced via granulopoiesis in the bone marrow. (wikipedia.org)
- Immature Granulocyte count (IMG) is used in the assessment of various infections or sepsis and its severity 1,2 , inflammatory conditions like Pancreatis 3 , Appendicitis 4 , Acute Respiratory Distress Syndrome (ARDS) 5 , different diseases of bone marrow, transplant engraftment or growth factor therapy or hematopoietic neoplasms. (horiba.com)
- We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
- They are granulocytes that develop in the bone marrow before migrating into blood. (wikidoc.org)
- According to the researchers, the stages most likely reflect emergency myelopoiesis, that is, the production of granulocytes in the bone marrow. (medtelligence.net)
Macrophages2
- Cells expressing GM-CSF receptor were identified as macrophages, granulocytes and putative dendritic cells by flow cytometric analysis using lineage and receptor subunit specific antibodies. (edu.au)
- Recombinant GM-CSF injected into the uterine lumen of ovariectomised mice was found to elicit a dose-dependant accumulation of macrophages and granulocytes in the endometrium, in a pattern of distribution comparable to that seen in uteri after natural mating. (edu.au)
Cells9
- Granulocytes are cells in the innate immune system characterized by the presence of specific granules in their cytoplasm. (wikipedia.org)
- High Side Scatter is measured for granulocytes, and fluorescence is higher for immature cells having more residual RNA. (horiba.com)
- This episode paralleled with a massive CD8 T- lymphocyte expansion (CD3-663, CD4 106, CD8-568 cells/microliter) following granulocyte infusions, which peaked at day +10 post HSCT. (ebmt.org)
- Granulocytes are immune cells that are membrane-bound that function mainly to digest endocytosed particles. (biologyease.com)
- Promyelocytes, neutrophil myelocytes, neutrophil metamyelocytes, and neutrophil band cells are called the successive stages through which a myeloblast matures into circulating neutrophil granulocytes. (biologyease.com)
- Some agranulocytes can form memory cells that live a long time, while granulocytes can't form memory cells and don't live long. (knowswhy.com)
- Granulocyte products typically contain a large amount of red blood cells and thus should be ABO and Rh compatible and require RBC crossmatching to be issued. (medscape.com)
- A differential blood count gives the relative percentage of each type of white blood cell and also helps to reveal abnormal white blood cell populations (eg, blasts, immature granulocytes, and circulating lymphoma cells in the peripheral blood). (medscape.com)
- Immature granulocytes (IGs) encompass immature cells of granulocytic lineages, including metamyelocytes, myelocytes, and promyelocytes, which are easily recognized morphologically and are reported by automated analyzer as IG altogether. (medscape.com)
Patients10
- As a surface marker of granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients. (techscience.com)
- Our results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients, and the level of CD10-positive mature granulocytes was not associated with the clinical stages of malignancy. (techscience.com)
- Receiver operating characteristic (ROC) areas under the curve (AUC) of CD10-positive granulocytes was 0.86 and 0.85, respectively, in MDS patients than the IDA group and AA group with good specificity and sensitivity. (techscience.com)
- This study shows that the majority of patients with Crohn's disease in relapse have rapid granulocyte migration to diseased bowel and provides evidence against a significant migration defect in this condition. (bmj.com)
- p40 protein was detected in a subpopulation of CD66b+ granulocytes in pSLE, as well as in adult SLE patients. (northwestern.edu)
- Conclusions Children with active SLE have elevated IgG and IgA autoantibodies against L1 p40, and this protein can be detected in circulating granulocytes in both pediatric and adult SLE patients. (northwestern.edu)
- Introduction: Granulocyte transfusions are used to either treat or prevent life-threatening infections in neutropenic patients. (umn.edu)
- The F-actin content in granulocytes was higher in all patients following ABMT. (duke.edu)
- Although the basal level of F-actin was high following ABMT, granulocytes from all patients showed an additional increase in F-actin content after stimulation with either the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA). (duke.edu)
- Autoantibodies against cytoplasmic components of neutrophil granulocytes (ACPA) were detected in 18 of 32 patients with Wegener's granulomatosis (WG), but in none of the controls (n = 900), including patients with glomerulonephritis, sarcoidosis, tuberculosis, polyarteritis nodosa, and connective tissue diseases, and healthy blood donors. (uni-luebeck.de)
Differentiation1
- For their differentiation from granulocyte precursors, IL-5 signaling appears to be critical. (biologyease.com)
Infection6
- The number of granulocytes in the body usually increases when there is a serious infection. (medlineplus.gov)
- Resistance of the body to infection: I. leukocytes, granulocytes, the monocyte-macrophage system, and inflammation. (medlineplus.gov)
- Thus granulocytes tend to increase in number when there is a bad infection. (knowswhy.com)
- Granulocytes are typically transfused daily for 5 or more consecutive days and should be continued until infection resolves or absolute neutrophil count remains >500/uL for 48 hours. (medscape.com)
- Congenital neutrophil defects (i.e., chronic granulomatous disease) and documented refractory bacterial or fungal infection failing to respond to appropriate antimicrobial therapy for more than 24 to 48 hours may be considered for granulocyte transfusion. (medscape.com)
- Granulocyte transfusion is a supportive adjuvant therapy to manage infections uncontrolled by standard medical therapy and thus should not be used as first line treatment or as the sole treatment of infection. (medscape.com)
Granules4
- Granulocytes are a type of white blood cell that has small granules inside them. (medlineplus.gov)
- They are a subset of granulocytes with bright pink granules on hematoxylin and eosin-stained blood films. (biologyease.com)
- Granulocytes are a type of white blood cell (leucocyte) that has distinct, easily visible, large microscopic granules in the cytoplasm. (knowswhy.com)
- Granulocytes have obvious large granules in the cytoplasm while agranulocytes have none or very small indistinct granules. (knowswhy.com)
Innate2
- Granulocytes provide a natural non-specific innate immunity, which is not in response to specific antigens. (knowswhy.com)
- Granulocytes bring about an innate, general immune response while agranulocytes bring about a specific and humeral immune response. (knowswhy.com)
Transfusions2
- Conclusion: It is feasible to develop an international registry of granulocyte transfusions to characterise current practices and describe outcomes. (umn.edu)
- Fevers, chills, and allergic reactions are not uncommon with granulocyte transfusions. (medscape.com)
Transfusion Medicine1
- Decision to transfuse granulocytes should be made in consultation with the transfusion medicine physician because of a lack of established efficacy in randomized controlled trials and the coordination required to provide granulocytes as they must be collected the day of transfusion. (medscape.com)
Differential3
- Granulocytes are counted as part of a white blood cell differential test . (medlineplus.gov)
- During an automated WBC differential count, the metamyelocytes, myelocytes and promyelocytes are counted as immature granulocyte (IMG) for many years previously by different HORIBA hematology analyzers while Sysmex analyzers report them as IG. (horiba.com)
- In conclusion, we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS. (techscience.com)
Autologous1
- We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new approach which utilises dynamic gamma camera imaging after injection of 111In labelled autologous granulocytes. (bmj.com)
Humans1
- We tested whether low-dose sevoflurane inhalation provides sustained inhibition of detrimental granulocyte-platelet aggregation in humans. (uzh.ch)
Platelet7
- Venous blood samples were collected at baseline before inhalation, immediately after inhalation, and 24 h thereafter, and were used for flow cytometry to determine platelet surface marker (CD41, CD42b, CD62P/P-selectin, and PAC-1) on platelets and granulocytes and for kaolin-induced clot formation, as assessed by thromboelastography. (uzh.ch)
- The amount of granulocyte-platelet aggregates increased upon agonist stimulation. (uzh.ch)
- Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control. (uzh.ch)
- Inhibition of granulocyte-platelet aggregates was accompanied by reduced clot firmness 24 h after sevoflurane inhalation compared with control. (uzh.ch)
- 1 vol % end-tidal) inhibits agonist-induced granulocyte-platelet interactions 24 h after administration and thus counteracts thromboinflammatory processes. (uzh.ch)
- Optical aggregometry was performed in platelet rich plasma (PRP)in the presence and absence of isolated granulocytes. (johnshopkins.edu)
- Conclusions: The presence of granulocytes in whole blood and plasma contributes substantially to aggregation induced by platelet activators. (johnshopkins.edu)
Donor3
- The amount of granulocytes per dose can vary greatly (from 1-8 x 1010 granulocytes/collection) based on the donor and mobilization regimen given to the donor. (medscape.com)
- The volume will vary based on granulocyte concentration of donor but usually ranges from 10-20 mL/kg. (medscape.com)
- Often times granulocyte donors are friends and family of the recipient because of the commitment needed to be a granulocyte donor. (medscape.com)
Myeloid1
Cytoplasmic1
- Ludemann, G & Gross, WL 1987, ' Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis ', Clinical and Experimental Immunology , vol. 69, no. 2, pp. 350-357. (uni-luebeck.de)
Agranulocytes1
- Agranulocytes have a nucleus with no lobe or with an indentation, while granulocytes have a nucleus with 2 or more lobes. (knowswhy.com)
Peripheral2
- Neutrophil granulocytes have an average volume of 330 femtoliters (fl) and a diameter of 12-15 micrometers (µm) in peripheral blood smears . (bionity.com)
- Total of 107 EDTA anticoagulated peripheral blood samples were randomly selected from daily pools of samples irrespective of the age, gender, or clinical condition samples, with wide ranges of immature granulocytes counts. (horiba.com)
Infusion1
- Infusion of amphoterecin and granulocytes should be spaced as far apart as reasonably possible. (medscape.com)
Pulmonary4
- Isolation of basal guinea pig granulocytes for the study of pulmonary inflammation. (cdc.gov)
- A technique for isolating basal (control) guinea-pig granulocytes for use in studies of pulmonary inflammation was developed. (cdc.gov)
- The purpose of the experiments was to develop an animal model suitable for examining the role of granulocytes in organic dust toxic syndrome and other pulmonary inflammatory disorders. (cdc.gov)
- The authors conclude that this procedure can isolate purified granulocyte fractions useful for studying the role of granulocytes in pulmonary inflammation. (cdc.gov)
Populations1
- Neutrophil and low-density granulocyte (LDG) populations were analyzed by flow cytometry . (bvsalud.org)
Blasts2
- I just know that immature granulocytes are basically what CML is made of and at diagnosis we all had metas myelos and what not and from what I understand, immature grans are more mature than blasts, but less mature than a fully functioning granulocyte. (cmlc.ml)
- Immature granulocytes" are a type of blast, and the other main type is lymphocyte blasts. (cmlc.ml)
Counts3
- The immature granulocyte counts ranged between 0 - 3.7 G/L by XN analyzer whereas 0 - 2.41 G/L by YH2500. (horiba.com)
- The immature granulocyte counts per 100 WBC ranged between 0.1 - 11.2% by XN analyzer whereas 0.2 - 12% by YH2500. (horiba.com)
- Granulocyte donors are almost always given medication regimens to increase the circulating granulocyte counts to improve collection. (medscape.com)
Infections1
- People with a lower number of granulocytes are more likely to develop serious infections. (medlineplus.gov)
Diseases1
- Increased levels of these granulocytes have also been associated with septicemia, but their general role and functioning in infectious diseases are yet to be comprehensively described. (medtelligence.net)
Clinical1
- Further studies to evaluate these potential differences are essential to devise optimal therapeutic protocols for maximizing the granulocyte protective function in this clinical setting. (duke.edu)
Function2
- In vitro tests of granulocyte function have, however, failed to confirm this. (bmj.com)
- Granulocytes begin to lose function within 6 hours of collection and have an expiration of 24 hours after collection. (medscape.com)
Decrease1
- A non-statistically significant decrease in thetotal number granulocytes was observed in the all study groups. (bvsalud.org)
Typically1
- The above findings are typically seen in CRS associated with granulocytes administration during a T replete cord blood transplant. (ebmt.org)
Assessment1
- In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease. (bmj.com)