• bacteria
  • It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. (wikipedia.org)
  • At one time, meticillin was used to treat infections caused by certain gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Streptococcus pneumoniae. (wikipedia.org)
  • These susceptibility data are given on a few medically significant bacteria: Staphylococcus aureus - 0.125 - >100 μg/ml Methicillin resistant Staphylococcus aureus (MRSA) - 15.6 - >1000 μg/ml Streptococcus pneumoniae 0.39 μg/ml Like other beta-lactam antibiotics, meticillin acts by inhibiting the synthesis of bacterial cell walls. (wikipedia.org)
  • It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of gram-positive bacteria. (wikipedia.org)
  • Meticillin is insensitive to beta-lactamase (also known as penicillinase) enzymes secreted by many penicillin-resistant bacteria. (wikipedia.org)
  • It was previously used to treat infections caused by susceptible gram-positive bacteria, in particular, penicillinase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins. (wikipedia.org)
  • spontaneous isopeptide bond formation, as found in many surface proteins of Gram-positive bacteria. (wikipedia.org)
  • TCT is a soluble piece of peptidoglycan (PGN) found in the cell wall of all gram-negative bacteria. (wikipedia.org)
  • Most gram-negative bacteria keep TCT within the cell wall by using a PGN-transporter protein known as AmpG. (wikipedia.org)
  • At first, β-lactam antibiotics were mainly active only against Gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various Gram-negative organisms has increased their usefulness. (wikipedia.org)
  • Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. (wikipedia.org)
  • Thermolysin (EC 3.4.24.27, Bacillus thermoproteolyticus neutral proteinase, thermoase, thermoase Y10, TLN) is a thermostable neutral metalloproteinase enzyme produced by the Gram-positive bacteria Bacillus thermoproteolyticus. (wikipedia.org)
  • Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. (wikipedia.org)
  • The cell wall of both gram-positive and gram-negative bacteria is a tight covalently bound and cross-linked peptidoglycan network and essential for bacterial growth, cell division and cellular structure. (wikipedia.org)
  • Taurine
  • Σκεφτομαι να συνδιασω πριν την προπονηση συμπληρωμα b-alanine σε συνδιασμο l-Taurine και μονουδρικη κρεατινη. (bodybuilders.gr)
  • Το λεω επειδη καπου διαβασα οτι με την χρηση b-alanine πεφτουν τα επιπεδα της l-taurine και καλο θα ητανι οταν κανουμε χρηση b-alanine να συμπληρωνουμε l-taurine. (bodybuilders.gr)
  • Bacillus
  • Changing these amino acids to threonine (T) and alanine (A) respectively in a less stable thermolysin-like proteinase produced by Bacillus stearothermophillus (TLP-ste), results in individual reductions in stability of 7 °C (F63→T) and 6.3 °C (P69→A) and when combined a reduction in stability of 12.3 °C. In the synthesis of aspartame, less bitter-tasting byproduct is produced when the reaction is catalyzed by thermolysin. (wikipedia.org)
  • susceptible
  • Medical uses include: lower respiratory tract infections acute bacterial otitis media skin and skin structure infections urinary tract infections uncomplicated gonorrhea pelvic inflammatory disease bacterial septicemia intra-abdominal infections meningitis surgical prophylaxis lyme disease It is also a choice drug for treatment of bacterial meningitis caused by pneumococci, meningococci, Haemophilus influenzae, and "susceptible enteric Gram-negative rods, but not Listeria monocytogenes. (wikipedia.org)
  • amino acids
  • A conserved glycine in a beta bulge in HNP2 was replaced with a series of D-amino acids resulting in VCC activity proportional to side chain hydrophobicity and charge. (wikipedia.org)
  • toxicity
  • Particularly the toxin beta-cyanoalanine from seeds of V. sativa enhances the toxicity of such a mixture through its inhibition of sulfur amino acid metabolism [conversion of methionine to cysteine leading to excretion of cystathionine in urine] and hence depletion of protective reduced thiols. (wikipedia.org)
  • enzyme
  • However, some bacterial cells have the enzyme β-lactamase, which hydrolyzes the beta-lactam ring, rendering the drug inactive. (wikipedia.org)
  • cell wall
  • The DAP residue is responsible for directly bonding to the D-alanine peptide of another PGN molecule, thus aiding TCT's attachment within the cell wall. (wikipedia.org)
  • Commonly
  • Commonly, a standard Gram-negative and Gram-positive quality control strain are compared. (wikipedia.org)
  • Lysinibacillus fusiformis (commonly abbreviated L. fusiformis) is a gram-positive, rod-shaped bacterium of the genus Lysinibacillus. (wikipedia.org)
  • approximately
  • At birth, the adrenal glands weight approximately eight to nine grams (twice that of the adult adrenal glands) and are 0.5% of the total body weight. (wikipedia.org)
  • weeks
  • After a few weeks of supplementation with beta-alanine, this sensation normally lessens or subsides. (nutritionexpress.com)
  • Five weeks later, the pancreatic alpha and beta cells have begun to emerge. (wikipedia.org)
  • While the fetal pancreas has functional beta cells by 14 to 24 weeks of gestation, the amount of insulin that is released into the bloodstream is relatively low. (wikipedia.org)
  • surface
  • Lysinibacillus fusiformis was initially isolated from the surface of beta vulgaris by German biologist Dr. O. Gottheil in 1901. (wikipedia.org)
  • cells
  • During the early stages of fetal development, the number of pancreatic alpha cells outnumbers the number of pancreatic beta cells. (wikipedia.org)
  • From the middle stage until term, the beta cells continue to increase in number until they reach an approximate 1:1 ratio with the alpha cells. (wikipedia.org)
  • known
  • Types of CRE are sometimes known as KPC (Klebsiella pneumoniae carbapenemase) and NDM (New Delhi Metallo-beta-lactamase). (wikipedia.org)
  • alpha
  • On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. (wikipedia.org)
  • The secondary structure of each domain is quite different, the N-terminal domain consists of mostly beta pleated sheet, while the C-terminal domain is mostly alpha helical in structure. (wikipedia.org)
  • patients
  • Policies regarding contact precaution for patients infected or colonized by Gram-negative pathogens were also observed in hospitals reporting decreases in CRE prevalence. (wikipedia.org)