• allogeneic
  • Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
  • bone
  • Kv1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral insulin sensitivity in patients with type-2 diabetes mellitus, and for preventing bone resorption in periodontal disease. (wikipedia.org)
  • pathways
  • The team also outlines the cell signaling pathways that contribute to this increased activity - identifying a promising target for developing new therapies for the diseases. (eurekalert.org)
  • patients
  • On August 2, 2017, ibrutinib (Imbruvica) was approved for treatment of adult patients with chronic graft-vs-host disease after failure of one or more lines of systemic therapy. (ascopost.com)
  • Approval was based on responses in the open-label study PCYC-1129-CA, in which 42 patients with chronic graft-vs-host disease who required additional therapy after failure of first-line corticosteroid therapy received ibrutinib at 420 mg once daily. (ascopost.com)
  • The median time since chronic graft-vs-host disease diagnosis was 14 months, the median number of prior chronic graft-vs-host disease treatments was 2 (range = 1-3), and 60% of patients had a Karnofsky performance score ≤ 80. (ascopost.com)
  • Mesoblast said they were in the process of completing an Investigational New Drug (IND) submission to the United States FDA to commence Phase 2 clinical trials in patients with low back pain due to disc degenerative disease. (wikipedia.org)
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector-memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. (wikipedia.org)
  • Infectious Diseases
  • Donor's Requirements: Mismatched HLA with recipient Age between 18 and 60 years old Good overall state of health No major heart or lung surgical history No infectious diseases such as HIV, Hepatitis or syphilis, etc. (wikipedia.org)
  • mortality
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • lesions
  • In a classification of the oral lesions in HIV disease, OHL is grouped as "lesions strongly associated with HIV infection" (group I). It could also be classed as an opportunistic, viral disease. (wikipedia.org)
  • Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the lower back, wrists, and ankles. (wikipedia.org)
  • lichen
  • Lichen planopilaris is considered an orphan disease with no definitive prevalence data and no proven effective treatments. (wikipedia.org)
  • immune system
  • Such components include: Microenvironmental factors like tonicity, pH, oxygen pressure and the redox status of immune cells Mechanical factors, such as tissue pressure, cellular stiffness and cell motility Cell membrane physics such as membrane composition and particles The research field of immunophysics aims to investigate the influence of these physicochemical parameters on the function of the immune system in health and disease. (wikipedia.org)
  • Successive skin grafts from the brother were destroyed even faster, a fact that gave them the evidence they needed to implicate the immune system. (wikipedia.org)
  • skin
  • During his PhD he worked on skin grafts in guinea pigs, demonstrating that when black skin was grafted onto white skin, the white skin became black. (wikipedia.org)
  • The pilot suffered severe burns requiring skin grafts. (wikipedia.org)
  • However, at the time skin grafts were a risky business, often being rejected for unknown reasons. (wikipedia.org)
  • The first insight came when the pair decided to experiment, and grafted part of a wound with the patient's skin, and another part with skin from the patient's brother. (wikipedia.org)
  • Within days the skin grafts from the brother were completely destroyed. (wikipedia.org)
  • Through carefully planned experimentation, the trio showed that mice exposed to cells of unrelated mice as fetuses did not reject skin grafts from those same mice. (wikipedia.org)
  • cytokine
  • The term arose in the field of pathophysiology in discussions of immune disorders in 1993, was extended to discussions of infectious disease and sepsis, and has been used to describe severe manifestations of cytokine release syndrome, an adverse effect of some drugs. (wikipedia.org)
  • autoimmune
  • Consequently, it should be possible to selectively suppress effector-memory T cells with a Kv1.3-specific blocker and thereby ameliorate many autoimmune diseases without compromising the protective immune response. (wikipedia.org)
  • cells
  • This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. (wikipedia.org)
  • An immuno-competent graft is administered, with viable and functional immune cells. (wikipedia.org)
  • IL-18 has also been found to increase the Alzheimer's disease-associated amyloid-beta production in human neuron cells. (wikipedia.org)
  • blood
  • These include HIV, Hepatitis B, Hepatitis C, Treponema pallidum (syphilis) and, where relevant, other infections that pose a risk to the safety of the blood supply, such as Trypanosoma cruzi (Chagas disease) and Plasmodium species (malaria). (wikipedia.org)