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  • antigens
  • The presentation of host antigens by host APC can be further enhanced by host gamma/delta T cells, as recently shown in the mouse (Maeda et al, 2005). (slideshare.net)
  • Gleichmann E, Gleichmann H, Wilke W. Autoimmunization and lymphomagenesis in parent-to-F1 combinations differing at the major histocompatibility complex: model for spontaneous disease caused by altered self-antigens? (springer.com)
  • stem
  • Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
  • symptoms
  • Due to its proinflammatory action, a proinflammatory cytokine tends to make the disease itself or the symptoms correlated to a disease worse by causing fever, inflammation, tissue destruction, and in some cases, even shock and death. (wikipedia.org)
  • donor
  • Its incidence and severity depends on several factors, such as prophylaxis method, donor/recipient matching, intensity of the condition- ing regimen and composition of the graft. (slideshare.net)
  • The interplay of APC, T cells and cytokines is such that, in a mouse transplant model - with mismatch only between donor T cells and host APC, but not between donor and host gut-donor T cells still efficiently killed host gut cells, suggesting that tissue destruction can be achieved with a by-stander effect (Teshima et al, 2002b). (slideshare.net)
  • A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. (bloodjournal.org)
  • clinical
  • Significant progress has been made in recent years in understanding the pathogen- esis of the disease, and some of these advances have been translated into clinical trials. (slideshare.net)
  • Chronic graft-versushost disease in the rat radiation chimera, I: clinical features, hematology, histology and immunopathology in long-term chimeras. (springer.com)
  • Clinical Infectious Diseases, 65 (3), 364-370. (springer.com)
  • 10 The consensus project also proposed measures for monitoring disease progression and response to therapy and provided other information for purposes of clinical trials. (bloodjournal.org)
  • Mesoblast said they were in the process of completing an Investigational New Drug (IND) submission to the United States FDA to commence Phase 2 clinical trials in patients with low back pain due to disc degenerative disease. (wikipedia.org)
  • Ferrara
  • The early work of Ferrara and coworkers showed that inflammatory cytokines play a crucial role in the initial, amplification and cytotoxic phases of the disease (reviewed in Ferrara, 2002). (slideshare.net)
  • Treatment
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • On June 29, 2011, Mesoblast announced that it received clearance from the Food and Drug Administration to begin a Phase 2 trial with its MPC cells for treatment of disc degenerative disease. (wikipedia.org)
  • Many groups are developing Kv1.3 blockers for the treatment of autoimmune diseases. (wikipedia.org)
  • Kv1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral insulin sensitivity in patients with type-2 diabetes mellitus, and for preventing bone resorption in periodontal disease. (wikipedia.org)
  • Immunophysical research is considered to open new perspectives for the investigation of the pathomechanisms of immune-mediated inflammatory diseases, help to develop novel detection methods and diagnostic tools in these diseases and advance the treatment possibilities of such diseases. (wikipedia.org)
  • Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. (wikipedia.org)
  • donor's
  • Donor's Requirements: Mismatched HLA with recipient Age between 18 and 60 years old Good overall state of health No major heart or lung surgical history No infectious diseases such as HIV, Hepatitis or syphilis, etc. (wikipedia.org)
  • inflammation
  • Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. (springer.com)
  • Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. (mskcc.org)
  • Crohn's disease is a chronic inflammation of the digestive track. (wikipedia.org)
  • patients
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector-memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. (wikipedia.org)
  • Patients often have a refractory disease course but some patients may respond to phototherapy. (wikipedia.org)
  • tissue
  • This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. (wikipedia.org)
  • It is similar to an autoimmune connective tissue disease. (psychiatryadvisor.com)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • Such components include: Microenvironmental factors like tonicity, pH, oxygen pressure and the redox status of immune cells Mechanical factors, such as tissue pressure, cellular stiffness and cell motility Cell membrane physics such as membrane composition and particles The research field of immunophysics aims to investigate the influence of these physicochemical parameters on the function of the immune system in health and disease. (wikipedia.org)
  • lichen
  • Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the lower back, wrists, and ankles. (wikipedia.org)
  • Lichen planopilaris is considered an orphan disease with no definitive prevalence data and no proven effective treatments. (wikipedia.org)
  • mechanisms
  • Immunophysics is a novel interdisciplinary research field using immunological, biological, physical and chemical approaches to elucidate and modify immune-mediated mechanisms and to expand our knowledge on the pathomechanisms of chronic immune-mediated diseases such as arthritis, inflammatory bowel disease, asthma and chronic infections. (wikipedia.org)
  • AGVHD
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • skin
  • During his PhD he worked on skin grafts in guinea pigs, demonstrating that when black skin was grafted onto white skin, the white skin became black. (wikipedia.org)
  • treat
  • He also describes how the institution's world-class multidisciplinary team of experts excels in treating this complicated disease and how doctors work continuously to better understand and more effectively treat it. (cityofhope.org)
  • Therapies to treat inflammatory diseases include monoclonal antibodies that either neutralize inflammatory cytokines or their receptors. (wikipedia.org)
  • coronary
  • She headed the NIH advisory board for another multi-center clinical study that showed statins could slow course of atherosclerosis in coronary artery bypass grafts. (wikipedia.org)

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  • Patients
  • This phase II trial studies how well tacrolimus and mycophenolate mofetil works in preventing graft-versus-host disease in patients who have undergone total-body irradiation (TBI) with or without fludarabine phosphate followed by donor peripheral blood stem cell transplant for hematologic cancer. (clinicaltrials.gov)
  • I. To estimate the incidence of grade III/IV graft-versus-host disease (GVHD) after conditioning with 200 centigray (cGy) TBI alone or Fludarabine (fludarabine phosphate)/200 cGy TBI followed by tacrolimus (Tac)/mycophenolate mofetil (MMF) immunosuppression in patients with hematologic malignancies. (clinicaltrials.gov)
  • In order to identify potential "specificity gaps" of a future GFAP test used to diagnose intracerebral hemorrhage, we measured GFAP in the blood of a large and rather unselected collective of patients with neurological diseases. (jove.com)
  • vector
  • These clones were prepared by synthesizing cDNA from an mRNA mix containing mRNA coding for the desired HLA antigen, inserting the cDNA into a vector, transforming a bacterial host and isolating transformant clones that contain the desired DNA segment by probing with an oligonucleotide probe that is specific for the desired DNA sequence. (google.com)
  • H. rufipes can be a vector for the disease, but is inefficient compared to the other vectors. (wikipedia.org)
  • attacks
  • According to a report published in the Journal of Ecology a combination of the disease and emerald ash borer attacks could wipe out European ash trees. (wikipedia.org)
  • cause
  • antioxidants - compounds that protect against cell damage inflicted by molecules called oxygen-free radicals, which are a major cause of disease and aging. (nyhq.org)
  • The abnormal deposits that cause the disease were discovered in 1912 by Frederic Lewy. (wikipedia.org)
  • Dehydration, radiotherapy involving the salivary glands, chemotherapy and several diseases can cause hyposalivation or a change in saliva consistency and hence a complaint of xerostomia. (wikipedia.org)
  • health
  • Because both gum disease and CVD share many of the same risk factors, you can positively impact both your oral and general health by eating more nutritional foods, engaging in regular exercise and quitting tobacco products. (southshoredentist.com)
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • Since then Lepra has grown to be an international charity giving a voice to people living at the intersection of disease, poverty and prejudice by helping them to improve their health, lives and livelihoods. (wikipedia.org)
  • affect
  • One of the most critical and distinctive clinical features of the disease is hypersensitivity to neuroleptic and antiemetic medications that affect dopaminergic and cholinergic systems. (wikipedia.org)
  • medications
  • In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. (wikipedia.org)
  • often
  • However, these 'fake' cancers can develop into full blown hodgkins and non-hodgkins lymphoma disease which are often fatal. (healthlinkusa.com)
  • spread
  • The disease was first observed in Denmark in 2002, and had spread to the whole country by 2005. (wikipedia.org)
  • Dutch elm disease (DED) is caused by a member of the sac fungi (Ascomycota) affecting elm trees, and is spread by elm bark beetles. (wikipedia.org)
  • Dutch elm disease was first noticed in continental Europe in 1910, and spread slowly and eventually extending to all other countries except Greece and Finland. (wikipedia.org)
  • form
  • Intracerebral hemorrhage (ICH) is a common form of cerebrovascular disease and is associated with significant morbidity and mortality. (jove.com)
  • problems
  • The walls of the airway may become thickened, as well, leading to breathing problems while sleeping (obstructive airway disease) and noisy breathing generally. (wikipedia.org)
  • present
  • Within the context of the stories, Gammenon is the Celestial tasked with collecting samples of all life forms present on a planet during a Celestial Host and is present during at least the First and Fourth Hosts to visit Earth. (wikipedia.org)
  • Finally, a "possible" diagnosis is made when the patient has only some of the characteristics of a disease are present, but not all. (wikipedia.org)
  • Asia
  • The origins of the disease are uncertain, but researchers are investigating the theory that the fungus originated in Asia, where ash trees are immune to the disease. (wikipedia.org)
  • Although believed to be originally native to Asia, the disease was accidentally introduced into America and Europe, where it has devastated native populations of elms that did not have resistance to the disease. (wikipedia.org)
  • people
  • In the late part of the disease, people may depend entirely on others for their care. (wikipedia.org)
  • Though the terms "attenuated" or "mild" are used by physicians in comparing people with Hunter syndrome, the effects of even mild disease are quite serious. (wikipedia.org)
  • significant
  • Between the two main forms of disease, and even within them, two of the most significant areas of variability concern the degree of mental retardation and expected lifespan. (wikipedia.org)