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  • OSMR
  • is a shared transducer chain triggered by homodimerization (IL6) on the plasma membrane IL-6 -trans-signaling is counter balanced by a naturally occurring, soluble form of gp130 ( sgp130 ) or heterodimerization with LIF -Rb/gp190 protein ( IL11 has three distinct receptor binding sites, LIF , biologically active OSM or to "type II" OSM receptor ( OSMR /gp130), and CNTF ) of gp130. (wordpress.com)
  • STAT3
  • Large-scale screening of cancer cell lines with a JAK2 inhibitor that blocks STAT3 function revealed a more than 30-fold range in sensitivity in PDAC, and showed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor, an upstream signaling component. (aacrjournals.org)
  • Moreover, our work suggests that gp130 and phospho-STAT3 expression may be effective biomarkers for predicting response to JAK2 inhibitors. (aacrjournals.org)
  • 4 All IL-6 cytokines are potent activators of signal transducer and activator of transcription 3 (STAT3). (ahajournals.org)
  • Role of the gp130 receptor system and downstream mediator STAT3 in cardioprotection. (ahajournals.org)
  • Genes transcriptionally upregulated by STAT3 include SOCS proteins-1 and -3, which interact with the kinase domain of JAK proteins or cytoplasmic phosphotyrosine residue (phospho-Tyr759) of the receptor, resulting in inhibition of STAT protein phosphorylation and negative-feedback regulation of STAT activation. (ahajournals.org)
  • Suppression of TGF-β receptor activity or ablation of SMAD3 or SMAD4, but not SMAD2, strongly suppressed OSM/STAT3-mediated plasticity. (pubmedcentralcanada.ca)
  • interferon
  • The STAT proteins were originally identified as factors required for downstream signaling in response to interferon and other inflammatory cytokines ( 8 ). (aacrjournals.org)
  • The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. (nih.gov)
  • SOCS
  • Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. (nih.gov)
  • functional
  • As well as cytolinkers induced by OSM, are inhibited by antibodies against gp130, the LDLR promoter (low density lipoprotein receptor) repeat 3 sequence is identical to the repeats 1, 2, 3 TATA vector (pLDLR- R3 ) a cytokine-inducible immediate early gene promoter provides the C-terminal process where Egr1 may have a functional role in OM-induced upregulation of LDLR. (wordpress.com)
  • Signaling
  • The invention relates to the use a substance signaling through gp130 for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy. (google.co.uk)
  • 4. A method according to claim 1 , wherein the substance signaling through gp130 is administered in an amount ranging from about 0.1 to 1000 μg/kg. (google.co.uk)
  • 8. A method according to claim 1 , wherein the substance signaling through gp130 is administered daily. (google.co.uk)
  • Title: Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy. (nih.gov)
  • The gp130 receptor-mediated signaling promotes cardiomyocyte survival, induces hypertrophy, and modulates cardiac extracellular matrix and function. (ahajournals.org)
  • Leukemia inhibitory factor LIF and the presence of other growth factors at the interface of a shared cell-surface signaling receptor. (wordpress.com)
  • tumor
  • IL-8, another cytokine, is released after tumor cell death, subsequently stimulating CSCs to regrow the tumor and resist chemotherapy. (blogspot.com)
  • Administration of anti-human IL11 receptor (R) α blocking antibody dramatically reduced HEC1A-derived tumor growth in both models and reduced peritoneal metastatic lesion spread in the orthotopic model, compared with IgG. (aacrjournals.org)
  • These reactions are mediated by soluble mediators or cytokines produced by either host immune cells or tumor cells themselves. (pubmedcentralcanada.ca)
  • immune
  • IL-6 is classified as a cytokine (a potent biomolecule released by the immune system) and modulates both immunity and inflammation. (blogspot.com)
  • proteins
  • CXCR1 and CXCR2 are proteins expressed on cells, including CSCs, which respond to the aforementioned cytokines in a deleterious manner. (blogspot.com)
  • There are also several other proteins which have structural similarity to gp130 and contain the WSXWS motif and preserved cysteine residues. (wikipedia.org)
  • B, Tyrosine phosphorylation of JAKs and recruitment of STAT proteins to the gp130 receptor. (ahajournals.org)
  • mediators
  • Since the inflammatory potential of IL-6 is modulated through binding the sIL-6R, identifying physiological mediators of sIL-6R generation is of central importance to understanding the significance of this soluble receptor in disease. (rupress.org)
  • growth
  • Oncostatin M (OSM) is an IL-6 type cytokine that regulates the growth of prostate cancer cells in a paracrine fashion. (aacrjournals.org)
  • Here, we performed a screen to identify TME cytokines and growth factors that promote epithelial-mesenchymal plasticity, and acquisition of cancer stem cell (CSC) properties. (pubmedcentralcanada.ca)
  • Of 28 TME cytokines and growth factors tested, we identified Oncostatin M (OSM) as the most potent inducer of mesenchymal/CSC properties. (pubmedcentralcanada.ca)
  • Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. (wikipedia.org)
  • TH17
  • Recent studies have suggested a role for the TH17 system, which is identified by secretion of its signature cytokine IL-17A, as one of the underlying pathogenic mechanisms of autoimmunity and inflammation. (ufl.edu)
  • IL-27 is considered a naturally-occurring cytokine that regulates TH17 pro-inflammatory activities. (ufl.edu)
  • gp80
  • The ' extracellular region' comprises six units of a fibronectin type III module consists of three extracellular domains several immunoglobulin-like and the third membrane the proximal fibronectin-like domain in the presence of soluble IL-6 receptor ( sIL-6R - gp80 ). (wordpress.com)