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  • proteins
  • Glycosylation involves the joining of sugars and proteins (to form glycoproteins) by enzymes (proteins that function to convert specific substances in the body) in the cells of our bodies. (diseaseinfosearch.org)
  • The reason for the new nomenclature was the fact that proteins not directly involved in glycan synthesis (such as members of the COG-family and vesicular H+-ATPase ) were found to be causing the glycosylation defect in some CDG patients. (wikipedia.org)
  • status
  • The most commonly used screening method for CDG, analysis of transferrin glycosylation status by isoelectric focusing, ESI-MS, or other techniques, distinguish between these subtypes in so called Type I and Type II patterns. (wikipedia.org)
  • properties
  • First, most of the muteins displayed enhanced cell-stimulatory properties (super-agonist behavior) in a glycosylation-dependent manner, suggesting that the non-core region is biologically designed to limit the cell-proliferative potential of hIL-11. (jimmunol.org)
  • Protein Glycosylation
  • His research has largely focused on molecular cell biology and, in particular, how protein glycosylation contributes to the mechanisms of health and common diseases including diabetes, sepsis, inflammatory diseases, and autoimmunity. (wikipedia.org)
  • Marth's use of Cre-Lox conditional mutagenesis established the presence and functions of multiple and in some cases previously unknown enzymes participating in protein glycosylation, an area of research that has become a focus of exploration in how common diseases originate in the absence of discernible pathogenic genetic variation. (wikipedia.org)
  • Marth's laboratory has also taken a close look at the molecular and cellular bases of type 2 diabetes and the role that protein glycosylation has in the origin of the disease. (wikipedia.org)
  • assay
  • QIAGEN provides a broad range of assay technologies for glycosylation research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • 9. An indicator composition according to claim 8 for use in an assay procedure for the detection of advanced glycosylation end products in polypeptide samples, said composition comprising a chromophore which is a 1-alkyl-2-formyl-3,4-diglycosyl-pyrrole of the formula ##STR6## wherein R is R 1 . (google.com)
  • residues
  • The process of glycosylation adds and removes sugar residues to and from oligosaccharides covalently linked to proteoglycans, glycoproteins, and glycosphingolipids. (qiagen.com)
  • The Human Glycosylation RT² Profiler PCR Array profiles the expression of 84 key genes encoding enzymes that post-translationally add and remove sugar residues to and from proteoglycans and. (qiagen.com)
  • Additionally, O-GlcNAc transferase catalyzes intracellular glycosylation of serine and threonine residues with the addition of N-acetylglucosamine. (wikipedia.org)
  • endoplasmic
  • Asparagine must be located appropriately in the three dimensional structure of the protein (Sugars are polar molecules and thus need to be attached to asparagine located on surface of the protein and not buried within the protein) Asparagine must be found in the luminal side of the endoplasmic reticulum for N-linked glycosylation to be initiated. (wikipedia.org)
  • transferrin
  • It is important to emphasize that galactosemia, hereditary fructose intolerance, and chronic alcohol abuse (but not liver dysfunction per se) are the only conditions that have been shown to lead to secondary glycosylation abnormalities associated with an abnormal transferrin pattern. (oncologynurseadvisor.com)
  • The most commonly used screening method for CDG, analysis of transferrin glycosylation status by isoelectric focusing, ESI-MS, or other techniques, distinguish between these subtypes in so called Type I and Type II patterns. (wikipedia.org)
  • occurs
  • Proline is also hydroxylated in collagen, however, no glycosylation occurs here as the hydroxyprolines are necessary for hydrogen bonding in the collagen triple helix. (wikipedia.org)
  • Methods
  • Huffman JE et al (2014) Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research. (springer.com)
  • Authoritative and cutting-edge, Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols serves as an ideal guide for scientists striving to push forward the exciting field of engineered biopharmaceuticals. (platekompaniet.no)
  • role
  • Glycosylation analysis plays an important role in the safety and efficacy of final drug products and, as such, is an important part of SGS Life Science Services analyses portfolio. (sgs.com)
  • Haltiwanger RS, Lowe JB (2004) Role of glycosylation in development. (springer.com)
  • analysis
  • At SGS, we have shaped our Glycosylation Analysis Service to meet the requirements of ICH 6QB, so you can be sure you are meeting regulatory expectations. (sgs.com)
  • Our experts are always at hand to give advice on what may be most appropriate for you, whether you are using glycosylation analysis for drug discovery or at any stage of the drug manufacturing process. (sgs.com)
  • often
  • In addition, glycosylation is often used by viruses to shield the underlying viral protein from immune recognition. (wikipedia.org)
  • Glycosyl iodides were first introduced for use in glycosylation reactions in 1901 by Koenigs and Knorr although were often considered too reactive for synthetic use. (wikipedia.org)
  • Alterations in glycosylation are often acquired in cases of cancer and inflammation, which may have important functional consequences. (wikipedia.org)
  • studies
  • Studies show that OGT alleles are vital for embryogenesis, and that OGT is necessary for intracellular glycosylation and embryonic stem cell vitality. (wikipedia.org)