• therefore
  • The purpose of the present study was to determine whether specific populations of arterial glycosaminoglycans, and/or their ability to bind LDL, vary with age, therefore contributing to increased incidence and severity of atherosclerosis. (ahajournals.org)
  • effects
  • Recently, in light of results that V1 and V2 isoforms of versican have opposite effects on cell proliferation, glycosaminoglycan domain GAG-β has been implicated in versican-enhanced cell proliferation and versican-induced reduction of cell apoptosis. (wikipedia.org)
  • thus
  • However, the alternative explanation that individuals with arterial glycosaminoglycans that avidly bind LDL would develop early and severe cardiovascular disease and would thus be excluded from our analysis cannot be ruled out. (ahajournals.org)
  • various
  • 22 23 24 25 26 27 These contradictory data possibly result from the difficulty in extracting arterial glycosaminoglycans, as well as from the different techniques used for identification of the various species. (ahajournals.org)
  • Many of these studies were undertaken two or three decades ago, when methods available for identification and characterization of the various glycosaminoglycans were less specific. (ahajournals.org)