Heparan sulfate lyasesGAGsHeparinaseEnzymesAnticoagulantHeparinumMolecularExtracellularProteinsVitroSelectiveWidelyTissuePotentialStudiesClinicalActivityResearchEffectInjectionSmallArticlesMolecular weightDermatan SulfateNaturallyAntithrombinChondroitin sulfatePolysaccharidesMacromoleculesProteinSevereIncreasinglyMedicalStructureFormConditions
Heparan sulfate lyases1
GAGs6
- Glycosaminoglycans (GAGs) are a class of long linear anionic periodic polysaccharides. (bvsalud.org)
- Recognition and binding of regulatory proteins to glycosaminoglycans (GAGs) from the extracellular matrix is a process of high biological importance. (bvsalud.org)
- Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer. (rpi.edu)
- The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. (rpi.edu)
- HBP elevated permeability of vascular endothelial cell monolayers in vitro, and enzymatic removal of luminal cell surface area glycosaminoglycans (GAGs) using heparinase III and chondroitinase ABC abolished this impact. (bioskinrevive.com)
- The vitreous, ILM, and retinal ECM all contain glycosaminoglycans (GAGs), while the vitreous and ILM contain collagens. (molvis.org)
Heparinase5
- A novel type of heparinase (heparin lyase, no EC number) has been purified from Bacteroides stercoris HJ-15, isolated from human intestine, which produces three kinds of heparinases. (rpi.edu)
- AAV2 containing cDNA encoding enhanced green fluorescent protein (GFP), under the control of a chicken β-actin promoter, was delivered by intravitreal injection to adult mice in conjunction with enzymes including collagenase, hyaluronan lyase, heparinase III, or chondroitin ABC lyase. (molvis.org)
- The addition of heparinase III or chondroitin ABC lyase greatly enhanced transduction of the retinal ganglion cell layer and increased the depth of transduction into the outer retina. (molvis.org)
- Electroretinograms survived with higher concentrations of heparinase III and chondroitin ABC lyase than were required for optimal retinal transduction. (molvis.org)
- AAV2-mediated retinal transduction is improved by co-injection of heparinase III or chondroitin ABC lyase. (molvis.org)
Enzymes1
Anticoagulant10
- Other uses for its anticoagulant properties include inside blood specimen test tubes and kidney dialysis machines. (wikipedia.org)
- Heparin is contraindicated for suspected cases of vaccine-induced pro-thrombotic immune thrombocytopenia (VIPIT) secondary to SARS-CoV-2 vaccination, as heparin may further increase the risk of bleeding in an anti-PF4/heparin complex autoimmune manner, in favor of alternative anticoagulant medications (such as argatroban or danaparoid). (wikipedia.org)
- In 1918, Howell coined the term 'heparin' for this type of fat-soluble anticoagulant. (wikipedia.org)
- In the early 1920s, Howell isolated a water-soluble polysaccharide anticoagulant, which he also termed 'heparin', although it was different from the previously discovered phosphatide preparations. (wikipedia.org)
- The first human trials of heparin began in May 1935, and, by 1937, it was clear that Connaught's heparin was safe, easily available, and effective as a blood anticoagulant. (wikipedia.org)
- In 2020, several studies demonstrated the efficacy of heparin in mitigating severe disease progression, as its anticoagulant effect counteracted the formation of immunothrombosis. (wikipedia.org)
- Heparin acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. (wikipedia.org)
- Heparin, as a glycosaminoglycan, is known for its anticoagulant and antithrombotic properties for several decades. (bvsalud.org)
- In recent years, there have been extensive studies that heparin plays an important role in non-anticoagulant diseases, such as anti-inflammatory, anti-viral, anti-angiogenesis, anti-neoplastic, anti-metastatic effects, and so on. (bvsalud.org)
- Heparin, an anticoagulant drug, is biosynthesized in selected animal cells. (rpi.edu)
Heparinum1
- The chondroitin lyases from Flavobacterium heparinum (Cytophaga heparinia) have been widely used in depolymerization of glycosaminoglycan and proteoglycan chondroitin sulphates. (rpi.edu)
Molecular2
- A fractionated version of heparin, known as low molecular weight heparin, is also available. (wikipedia.org)
- Likewise, unfractionated heparins and low molecular pounds heparins counteracted permeability elevated by HBP in vitro. (bioskinrevive.com)
Extracellular1
- They can interact with many important biomolecular partners in the extracellular matrix of the cell including small drug molecules. (bvsalud.org)
Proteins1
- Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. (research.com)
Vitro1
- Clinical observation and in vitro experiments indicate that heparin displays a potential multitarget effect. (bvsalud.org)
Selective1
- The Takeda Oncology Company with its parent company Takeda Pharmaceutical Company Limited today announced updated results from a phase 2 study of orteronel , a selective oral 17,20 lyase inhibitor, dosed without prednisone in patients with non-metastatic castration resistant prostate cancer (nmCRPC) and rising prostate-specific antigen. (med-chemist.com)
Widely1
- Heparin is a life-saving drug and is widely used for anticoagulation in medical practice. (bvsalud.org)
Tissue2
- While heparin itself does not break down clots that have already formed (unlike tissue plasminogen activator), it allows the body's natural clot lysis mechanisms to work normally to break down clots that have formed. (wikipedia.org)
- Their biological activities are very broad including tissue remodeling, regulation of cell proliferation, cell migration, cell differentiation, participation in bacterial/viral infections, and immune response. (bvsalud.org)
Potential1
- Heparins are potential inhibitors of HBP-induced boosts in permeability. (bioskinrevive.com)
Studies3
- Jeremy E. Turnbull integrates Glycosaminoglycan and Heparin in his studies. (research.com)
- Jeremy E. Turnbull undertakes multidisciplinary studies into Heparin and Glycosaminoglycan in his work. (research.com)
- [3] [4] Many national guidelines including the AHA have interpreted this cohort of studies as suggesting that there are specific subgroups who may benefit from tPA and thus recommend its use within a limited time window after the event. (wikidoc.org)
Clinical1
- Heparin was discovered by Jay McLean and William Henry Howell in 1916, although it did not enter clinical trials until 1935. (wikipedia.org)
Activity1
- Since heparins depend on the activity of antithrombin, they are considered anticoagulants. (wikipedia.org)
Research4
- He combines Heparin and Glycosaminoglycan in his research. (research.com)
- In his works, Jeremy E. Turnbull conducts interdisciplinary research on Glycosaminoglycan and Heparin. (research.com)
- Erik Jorpes at Karolinska Institutet published his research on the structure of heparin in 1935, which made it possible for the Swedish company Vitrum AB to launch the first heparin product for intravenous use in 1936. (wikipedia.org)
- Between 1933 and 1936, Connaught Medical Research Laboratories, then a part of the University of Toronto, perfected a technique for producing safe, nontoxic heparin that could be administered to patients, in a saline solution. (wikipedia.org)
Effect1
- Hyaluronan lyase had a limited effect and collagenase was ineffective. (molvis.org)
Injection1
- Common side effects include bleeding, pain at the injection site, and low blood platelets. (wikipedia.org)
Small1
- Prior to 1933, heparin was available in small amounts, was extremely expensive and toxic, and, as a consequence, of no medical value. (wikipedia.org)
Articles1
- In his articles, Jeremy E. Turnbull combines various disciplines, including Receptor and Ligand (biochemistry). (research.com)
Molecular weight6
- A fractionated version of heparin, known as low molecular weight heparin, is also available. (wikipedia.org)
- Objective: to examine the effect of the medium intensity coughing technique during subcutaneous low molecular weight heparin injection on pain severity and individual satisfaction in general surgery patients. (bvsalud.org)
- Method: the prospective, quasi-experimental study included 100 patients who had been prescribed a subcutaneous low molecular weight heparin injection once in 24 hours. (bvsalud.org)
- Conclusion: the medium intensity coughing technique was found to reduce pain severity and increase patient satisfaction in general surgery patients receiving subcutaneous low molecular weight heparin injections. (bvsalud.org)
- Unfractionated heparins and low molecular weight heparins have been widely used as an anticoagulant drug. (drugtargetreview.com)
- It serves manufacturers of medical devices, quality control labs, low molecular weight heparin manufacturers, and academic research institutions. (marketbeat.com)
Dermatan Sulfate1
- These non-sulfated GAGs are also produced in animal cells and, in some cases, are the precursor backbones for sulfated GAGs (eg, heparin, heparan sulfate, chondroitin sulfate and dermatan sulfate). (drugtargetreview.com)
Naturally3
- Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. (wikipedia.org)
- A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. (lookformedical.com)
- Glycosaminoglycans (GAGs) are a class of naturally occurring polysaccharides that play vital roles in cellular functions. (drugtargetreview.com)
Antithrombin2
- Since heparins depend on the activity of antithrombin, they are considered anticoagulants. (wikipedia.org)
- For instance, heparin is produced chiefly in the mast cells and comprised of highly sulfated pentasaccharide domains that bind to antithrombin III, preventing coagulation. (drugtargetreview.com)
Chondroitin sulfate1
- For example, in 2008 heparin contamination/adulteration with over-sulfated chondroitin sulfate led to adverse effects, including death, in patients. (drugtargetreview.com)
Polysaccharides1
- Sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. (encyclopedia.pub)
Macromolecules2
- The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g. (lookformedical.com)
- The sulfated domains within these sulfated GAGs serve as the binding sites for specific biological macromolecules, including blood proteins and viral capsular proteins. (drugtargetreview.com)
Protein1
- The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN. (lookformedical.com)
Severe1
- Older adults and persons of any age who have serious underlying medical conditions may be of higher risk for severe illness, including secondary infections, respiratory failure, and multi-organ dysfunction. (nih.gov)
Increasingly1
- As a result, global heparin production became increasingly concentrated in China, where the substance was now procured from the expanding industry of breeding and slaughtering hog. (wikipedia.org)
Medical2
- Between 1933 and 1936, Connaught Medical Research Laboratories, then a part of the University of Toronto, perfected a technique for producing safe, nontoxic heparin that could be administered to patients, in a saline solution. (wikipedia.org)
- Prior to 1933, heparin was available in small amounts, was extremely expensive and toxic, and, as a consequence, of no medical value. (wikipedia.org)
Structure2
- Erik Jorpes at Karolinska Institutet published his research on the structure of heparin in 1935, which made it possible for the Swedish company Vitrum AB to launch the first heparin product for intravenous use in 1936. (wikipedia.org)
- A heteropolysaccharide that is similar in structure to HEPARIN. (lookformedical.com)
Form2
- The heparosan chain is sequentially modified by tissue-specific sulfotransferases and C5-epimerase to form sulfated heparan sulfate and highly sulfated heparin. (drugtargetreview.com)
- Aquaporins( AQP's) are form sufficient 1970s that include coactivators in structures. (evakoch.com)
Conditions1
- Heparin is generally used for anticoagulation for the following conditions: Acute coronary syndrome, e.g. (wikipedia.org)