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GlycopeptidesOligosaccharidesCarbohydrate SequenceCarbohydrate ConformationMannoseGlycosylationFucoseGlycoproteinsAsparagineCarbohydratesGlycoside HydrolasesPolysaccharidesMannosidasesPronaseMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseGlucosamineSialic AcidsMolecular Sequence Dataalpha-MannosidaseChromatography, GelLectinsOligosaccharides, Branched-ChainGalactoseAmino SugarsAcetylgalactosamineAcetylglucosaminePolyisoprenyl Phosphate OligosaccharidesPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseChromatography, High Pressure LiquidTeicoplaninAcetylglucosaminidaseSwainsonineHexosaminidasesN-Acetylneuraminic AcidMucinsChromatography, AffinityMagnetic Resonance SpectroscopyDisaccharidesMonosaccharidesPlant LectinsNeuraminic AcidsMass SpectrometryAmino Acid SequenceChromatography, Ion ExchangeChromatography, PaperGlycosides1-DeoxynojirimycinTunicamycinElectrophoresis, PaperMolecular WeightSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationPeriodic AcidNeuraminidaseVancomycinSugar AlcoholsChemistryMannosidesN-AcetylglucosaminyltransferasesChemical PhenomenaIndolizinesConcanavalin ABorohydridesHexosaminesSulfatesSulfuric AcidsGlycoconjugatesHexosesAmino Acidsalpha-L-FucosidaseTrisaccharidesGlycomicsElectrophoresis, Polyacrylamide GelGlucosidasesPolyisoprenyl Phosphate SugarsFetuinsSubstrate SpecificityTrypsinOvomucinMethylationGlycolipidsCattleGlycosaminoglycansProtein Processing, Post-TranslationalAnti-Bacterial AgentsSpectrometry, Mass, Fast Atom BombardmentBlood Group AntigensGuanosine Diphosphate MannoseDolicholCell LineGalactosyltransferasesMilk, HumanChromatography, Thin LayerSpectrometry, Mass, Electrospray IonizationAsialoglycoproteinsKineticsCricetinaeABO Blood-Group SystemMolecular StructureStructure-Activity RelationshipGlycosyltransferases

SynthesisGlycansGlycoproteinGlycoproteins and glycopeptidesAsparagine-linked oligosaccharidesGlycosylationMilk oligosaccharidesMannose oligosaccharidesPeptides and glycopeptidesSerine or threonine residuesBiantennaryEndo F2GlycanMonosaccharideMass spectrometryPrecursorCleavesFucosePossessGalactoseComplexPrimarilyHighCompositionSupportIntactClassSugarCell

Synthesis12

• The applicability of different enzymes such as glycosidases, glycosyltransferases, glycophosphorylases and glycosynthases have been de-scribed around the review article considering their advantages and disadvantages of these biocat-alysts in the stereoselective and regioselective synthesis of different types of glycosylated mole-cules, phenolic and aliphatic alcohols, oligosaccharides, polysaccharides, glycoderivatives, glyco-peptides and glycoproteins with a clear focus on food and pharmaceutical chemistry. (preprints.org)
• We offer a portfolio of diverse carbohydrate-based products and highly active in custom synthesis and contract manufacture of oligosaccharides, glycosaminoglycans, glycoamino acids, glycopeptides, carbohydrates with functionalized linkers/spacers and a wide variety of synthetic building blocks. (dairyscience.info)
• Expeditious strategies for the synthesis of complex oligosaccharides and glycoconjugates: chemoselectivity and orthogonality of modern building blocks. (glyco-world.com)
• New platforms and technologies for automated oligosaccharide synthesis: STICS and HPLC-A approaches. (glyco-world.com)
• We offer tailored custom synthesis services for complex oligosaccharides, glycopeptides, glycoconjugates and glyconanoparticles from mg to multigram scale for applications ranging from novel biomarker development to preclinical studies. (aspariaglycomics.com)
• The synthesis of specific complex oligosaccharide structures that are not easily isolated from natural material, or accesible via enzymatic routes usually involves a considerable number of synthetic steps with often extensive purification required on each intermediate. (aspariaglycomics.com)
• If you are developing novel glycoproteomics workflows or looking into quantifying novel glycopeptide biomarkers ask for our custom Glycopeptide synthesis service with optional stable isotope labeling. (aspariaglycomics.com)
• Examples of past projects include the synthesis of N-glycans, O-glycans, glycopeptides, glycosaminoglycans, GPI-anchors milk oligosaccharides and glycoconjugates. (aspariaglycomics.com)
• My laboratory works are mainly focusing on the synthesis of biologically active oligosaccharides to support GRC glycan array research programs. (sinica.edu.tw)
• I also collaborate with researchers in the area of carbohydrate-based vaccine development and glycopeptides synthesis. (sinica.edu.tw)
• VaporSPOT: parallel synthesis of oligosaccharides on membranes. (mpg.de)
• On-chip neo-glycopeptide synthesis for multivalent glycan presentation. (mpg.de)

Glycans3

• Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. (mdpi.com)
• PNGase F is suitable for release of all types (high-mannose, hybrid and complex) N-linked glycans from glycoproteins and glycopeptides. (ludger.com)
• Pallister EG, Choo MSF, Walsh I, Tai JN, Tay SJ, Yang YS, Ng SK, Rudd PM, Flitsch SL, Nguyen-Khuong T. Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow. (a-star.edu.sg)

Glycoprotein5

• The structures of the asparagine-linked oligosaccharides of several variant forms of the vesicular stomatitis virus glycoprotein transiently expressed from cloned cDNAs have been determined. (rupress.org)
• Another mutant, delta 1554, codes for a glycoprotein that contains oligosaccharides of primarily two classes. (rupress.org)
• In addition, the company also applies its technology for producing enzymes, oligosaccharides, glycopeptides, and other glycoprotein products as valuable research tools for disease diagnosis and glycobiology research field. (glycot.com)
• 3. S.I. Snovida, V.C. Chen, O. Krokhin, H. Perreault (2006) Isolation and identification of sialylated glycopeptides from bovine α1-acid glycoprotein by off-line capillary electrophoresis MALDI-TOF mass spectrometry . (brandonu.ca)
• Recent Strategies for Using Monolithic Materials in Glycoprotein and Glycopeptide Analysis", A. J. Alla and K. J. Stine, MDPI Separations , 2022 , 9 , 44. (umsl.edu)

Glycoproteins and glycopeptides1

• Endo F2 is a highly specific recombinant endoglycosidase which cleaves within the chitobiose core of asparagine-linked complex biantennary and high mannose oligosaccharides from glycoproteins and glycopeptides. (neb.com)

Asparagine-linked oligosaccharides2

• Processing of the asparagine-linked oligosaccharides of secreted and intracellular forms of the vesicular stomatitis virus G protein: in vivo evidence of Golgi apparatus compartmentalization. (rupress.org)
• were confirmed as the main asparagine-linked oligosaccharides on the surface of TBEV derived from human neuronal cells. (liverpool.ac.uk)

Glycosylation3

• Solid phase and surface chemistry: application to stereoselective glycosylation and rapid assembly of complex oligosaccharides and glycoconjugates. (glyco-world.com)
• The observed pattern was supported by examination of the glycopeptides, providing additional information about the glycosylation site in the E protein. (liverpool.ac.uk)
• Matrix-assisted laser desorption/ionization on-target method for the investigation of oligosaccharides and glycosylation sites in glycopeptides and glycoproteins. (brandonu.ca)

Milk oligosaccharides2

• Human milk oligosaccharides and other food additives and ingredients. (glyco-world.com)
• Gnubiotics has conducted extensive research on the safety and utility of animal milk oligosaccharides and achieved GRAS independent conclusions status in 2021. (internationalpetfood.com)

Mannose oligosaccharides1

• Endo H cleaves Asparagine-linked hybrid or high mannose oligosaccharides, but not complex oligosaccharides. (ludger.com)

Peptides and glycopeptides1

• In December 2022, Gnubiotics received a "no questions" letter from the U.S. Food and Drug Administration (FDA) for AMOBIOME as a source of amino acids, peptides and glycopeptides in food for cats and dogs. (internationalpetfood.com)

Serine or threonine residues1

• O-glycosidase cleaves only unsubstituted Gal-β(1-3)GalNAc-α disaccharides attached to the serine or threonine residues of glycoproteins or glycopeptides. (ludger.com)

Biantennary2

• Endo F2 cleaves N-linked (asparagine-linked) biantennary oligosaccharides from glycoproteins. (ludger.com)
• However, the major class contains biantennary and more highly branched complex-type oligosaccharides that terminate in N-acetylglucosamine rather than galactose or sialic acid residues. (rupress.org)

Endo F21

• However, Endo F2 is not active on hybrid or tri- and tetra-antennary oligosaccharides. (neb.com)

Glycan1

• Asialo, galactose, four-antennary complex N-glycan (oligosaccharide). (creative-biolabs.com)

Monosaccharide1

• We identified a total of 587 glycoproteins, including 1239 glycopeptides, 526 monosaccharide components, and 8326 intact glycopeptides in glycoproteomics, as well as a total of 4496 proteins identified in proteomic analysis. (frontiersin.org)

Mass spectrometry1

• Currently, analysis by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) of intact glycopeptides is often the method of choice in site-specific glycoproteomic studies ( 12 ). (frontiersin.org)

Precursor2

• A high-mannose oligosaccharide precursor is synthesized and transferred to proteins in the endoplasmic reticulum and then processed in the Golgi apparatus ( 4 ). (frontiersin.org)
• The addition of a precursor 13-residue oligosaccharide moiety GlcNAc2Man8Gluc3 to the nascent polypeptide chain occurs in the endoplasmic reticulum, following which the assembly folds and acquires its secondary, tertiary, and quaternary structure. (chromatographyonline.com)

Cleaves2

• It cleaves between the two N-acetylglucosamine residues in the diacetylchitobiose core of the oligosaccharide, generating a truncated sugar molecule with one N-acetylglucosamine residue remaining on the asparagine. (ludger.com)
• α(1-6) Core Mannosidase cleaves unbranched non-reducing terminal mannose, α(1-6) linked to the β-linked core mannose of the conserved mannosylchitobiose core of N-linked oligosaccharides. (ludger.com)

Fucose2

• PNGase F will not remove oligosaccharides containing α(1-3) linked core fucose commonly found on plant glycoproteins. (ludger.com)
• A cooperative and competitive interaction between multiple enzymes, cell lines, and cell culture conditions causes processing of the oligosaccharide structure during which some of the already attached moieties like mannose are trimmed to yield a fiveâ residue core (Man3GlcNAc2), to which N-acetylglucosamine (GlcNAc), fucose, galactose, and N-acetylneuraminic acid (sialic acid or Neu5Ac) residues get added in a probabilistic fashion. (chromatographyonline.com)

Possess2

• In contrast, forms of the G protein that remain intracellular possess oligosaccharides at intermediate stages in the processing pathway. (rupress.org)
• Gnubiotics' AMOBIOME ingredient is a unique class of compounds (glycopeptides) that possess properties known to support digestive health and the growth of beneficial gut bacteria. (internationalpetfood.com)

Galactose1

• they contain complex-type oligosaccharides whose nonreducing ends terminate in galactose and sialic acid residues. (rupress.org)

Complex2

• Glycopeptide antibiotic complex from Actinoplanes teichomyceticus active against gram-positive bacteria . (lookformedical.com)
• Here we demonstrate that by using glycopeptides with high affinity for the major histocompatibility complex and glycosylated in a position corresponding to a critical T cell receptor (TcR) contact, it is possible to induce anti-TACA CTL in vivo. (silverchair.com)

Primarily1

• These oligosaccharides were found to be primarily associated with the bound peptide. (ox.ac.uk)

High2

• Uncovering the structural details of these oligosaccharides in high resolution helps researchers understand the functions and mechanisms of protein-based drugs, and improve corporate decisions regarding cost, time and efficiencies of quality control. (a-star.edu.sg)
• One deletion mutant, delta 1473, codes for a protein that remains in the rough endoplasmic reticulum (Rose, J. K., and J. E. Bergmann, 1982, Cell, 30:753-762) and contains only high mannose-type oligosaccharides. (rupress.org)

Composition1

• Scientists at Gnubiotics investigated the effect of the milk oligosaccharide biosimilar on the gut microbiome composition and have recently published intriguing data suggesting AMOBIOME may provide microbiome stability during disturbance by an antibiotic. (internationalpetfood.com)

Support1

• ADM, a global leader in human and animal nutrition, announced today it has licensed AMOBIOME from Gnubiotics, a Swiss biotech company pioneering the use of glycopeptides that can support the microbiome and overall health. (internationalpetfood.com)

Intact2

• In contrast, PNGase F removes the oligosaccharide intact. (ludger.com)
• Yang's group developed a fine-tuned MS/MS acquisition method and pGlyco 2.0 search engine to perform confident intact glycopeptide characterization ( 13 ). (frontiersin.org)

Class4

• Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)
• A mannose 6-phosphate-containing N-linked glycopeptide derived from lysosomal acid lipase is bound to MHC class II in B lymphoblastoid cell lines. (ox.ac.uk)
• We have identified a novel class of peptides bound to MHC class II: mannose 6- phosphate (Man-6-P) containing glycopeptides from lysosomal enzymes. (ox.ac.uk)
• Surface iodination and Man-6-P/IGF-II receptor affinity chromatography implicated MHC class II as a carrier of Man-6-P-modified oligosaccharides. (ox.ac.uk)

Sugar1

• TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. (silverchair.com)

Cell1

• It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. (lookformedical.com)