• Sphingolipids
  • We will have an excellent program covering a wide range of topics with an emphasis on mechanistic insights into physiological processes where glycolipids and sphingolipids play a prominent role. (grc.org)
  • Glycolipids and sphingolipids have emerged as important factors in many physiological processes, including apoptosis, autophagy, regulation of metabolism, cell migration, and are important in several diseases, including bacterial and viral infections, type 2 diabetes, multiple inflammatory diseases and cancer. (grc.org)
  • Antigens
  • Antigens which are not present in an individual's blood will cause antibodies to be produced, which will bind to the foreign glycolipids. (wikipedia.org)
  • The main objective of this project is to develop a novel immunotherapy for gliomas, in which glycolipid antigens are analyzed and quantified systematically and a set of appropriate antibodies would be selected according to the antigenic profile of an individual glioma. (nii.ac.jp)
  • There should be a variety of factors that influence the antibody reactions against glycolipid antigens. (nii.ac.jp)
  • We are now focusing on the glycolipid analysis of surgical specimens of glioma tissue as well as on the factors participating in the antibody reactivity against those antigens. (nii.ac.jp)
  • CD1b tetramer staining of T cells requires glucose monomycolate (GMM) antigens, is specific for TCR structure, and is blocked by a recombinant clonotypic TCR comprised of TRAV17 and TRBV4-1, proving that CD1b-glycolipid complexes bind the TCR. (rupress.org)
  • Enzymology
  • The progress previously made on glycolipid and sphingolipid enzymology will be extended to address how these pathways are regulated and controlled spatially. (grc.org)
  • In enzymology, a glycolipid 3-alpha-mannosyltransferase (EC 2.4.1.132) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond. (wikipedia.org)
  • In enzymology, a dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (EC 2.4.1.130) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from a dolichyl-phosphate D-mannose molecule into a membrane lipid-linked oligosaccharide. (wikipedia.org)
  • ligand
  • The saccharides that are attached to the polar head groups on the outside of the cell are the ligand components of glycolipids, and are likewise polar, allowing them to be soluble in the aqueous environment surrounding the cell. (wikipedia.org)
  • peptides
  • In Torpedo and mammals, alternative exons encode H peptides, which contain a C-terminal signal for glypiation, i. e. cleavage and addition of a glycolipid (GPI) anchor. (springer.com)
  • interaction
  • An example of how glycolipids function within the body is the interaction between leukocytes and endothelial cells during inflammation. (wikipedia.org)
  • There is great diversity in the binding mechanisms of glycolipids, which is what makes them such an important target for pathogens as a site for interaction and entrance. (wikipedia.org)
  • Specific
  • New Glycolipid Specific to Nitrogen-Fixing Blue-Green Algae. (springer.com)
  • The four main human blood types (A, B, AB, O) are determined by the oligosaccharide attached to a specific glycolipid on the surface of red blood cells, which acts as an antigen. (wikipedia.org)
  • I. Antigenicity of the glycolipids and the production of specific antibodies in rabbits. (rupress.org)
  • surface
  • Enzymes called glycosyltransferases link the saccharide to the lipid molecule, and also play a role in assembling the correct oligosaccharide so that the right receptor can be activated on the cell which responds to the presence of the glycolipid on the surface of the cell. (wikipedia.org)
  • By enzyme-linked immunosorbent assay, C3 binds selectively to phenolic glycolipid-1 (PGL-1), a major surface molecule of the leprosy bacillus. (rupress.org)
  • Research
  • The 14th Gordon Research Conference on Glycolipid and Sphingolipid Biology will be held from March 6-11, 2016 at the Renaissance Tuscany Resort in Il Ciocco, a lovely Italian countryside location, which provides an ideal location for scientific discussion. (grc.org)
  • group
  • Glyceroglycolipids: a sub-group of glycolipids characterized by an acetylated or non-acetylated glycerol with at least one fatty acid as the lipid complex. (wikipedia.org)