• protein
  • The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. (wikipedia.org)
  • This lack of easy access of the catalytic site to the surface is significant in that it makes the protein activity highly susceptible to regulation, as small allosteric effects could greatly increase the relative access of glycogen to the site. (wikipedia.org)
  • Alpha: PHKA1, PHKA2 Beta: PHKB Gamma: PHKG1, PHKG2 Phosphorylase kinase was the first protein kinase to be isolated and characterized in detail, accomplished first by Krebs, Graves and Fischer in the 1950s. (wikipedia.org)
  • Conventional signaling is accomplished via GNAS complex locus ( G-protein alpha-s )/ Adenylate cyclase that leads to Adenosine 3',5'-cyclic phosphate ( cAMP ) production and activation of Protein kinase cAMP-dependent regulatory and catalytic ( PKA-reg (cAMP-dependent) and PKA-cat (cAMP-dependent) ) . (pathwaymaps.com)
  • metabolic
  • astrocytes metabolic cooperation can be altered by pre- and neonatal lead (Pb) exposure. (pan.pl)
  • Our data suggests that exposure to Pb in the pre- and neonatal periods results in a decrease in the level of brain glycogen and a reduction in the rate of its metabolism, thereby reducing glucose availability, which as a further consequence may lead to the impairment of brain energy metabolism and the metabolic cooperation between neurons and astrocytes. (pan.pl)
  • hypoglycemia
  • While glucagon can be used clinically to treat various forms of hypoglycemia, it is contraindicated in patients with pheochromocytoma, as it can induce the tumor to release catecholamines, leading to a sudden elevation in blood pressure. (wikipedia.org)
  • Likewise, glucagon is contraindicated in patients with an insulinoma, as its hyperglycemic effect can induce the tumor to release insulin, leading to rebound hypoglycemia. (wikipedia.org)
  • Mechanism
  • Lead (Pb) is an environmental neurotoxin which particularly affects the developing brain but the molecular mechanism of its neurotoxicity still needs clarification. (pan.pl)
  • terminal
  • The protonated oxygen now represents a good leaving group , and the glycogen chain is separated from the terminal glycogen in an S N 1 fashion, resulting in the formation of a glucose molecule with a secondary carbocation at the 1 position. (wikipedia.org)
  • crystal structures
  • The researchers examined 23 published fragment-to-lead examples for which crystal structures and affinities of the fragment and lead were available and in which the fragment maintained its binding mode. (blogspot.com)
  • glucagon
  • There is little evidence for glucagon's effectiveness in this condition, and glucagon may induce nausea and vomiting, but considering the safety of glucagon this is still considered an acceptable option as long it does not lead to delays in arranging other treatments. (wikipedia.org)