• The enzyme glycerol dehydrogenase (NADP+) has two substrates, glycerol and NADP+, and 3 products, D-glyceraldehyde, NADPH and H+. (wikipedia.org)
  • Light activation: Chloroplastic glyceraldehyde-3-phosphate dehydrogenase and malate dehydrogenase. (uic.edu)
  • Scholars@Duke publication: Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts. (duke.edu)
  • The specific activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in normally cultured HD fibroblasts was not different from that in control and escapee fibroblasts. (duke.edu)
  • Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cellular metabolic protein, was found to colocalize with viral RNA-dependent RNA polymerase (NS5) in JEV-infected cells. (biomedcentral.com)
  • Crystalline lobster-muscle glyceraldehyde-3-posphate dehydrogenase (d-glyceraldehyde-3-phosphate: NAD + oxidoreductase (phosphorylating), EC 1.2.1.12) possesses 7.3 ± 0.3 cysteine residues per mole of enzyme (140 000 g), i.e. approx. (mssm.edu)
  • It is generated through the enzymatic conversion of glyceraldehyde 3-phosphate by the enzyme glyceraldehyde 3- phosphate dehydrogenase. (pediaa.com)
  • The reaction of 5,5' dithiobis(2 nitrobenzoic acid) (DTNB) with rabbit muscle glyceraldehyde 3 phosphate dehydrogenase [d glyceraldehyde 3 phosphate: NAD + oxidoreductase (phosphorylating), EC 1.2.1.12] consists of an initial burst of reaction over several minutes, corresponding to 2 thiols/subunit, followed by a further slow reaction of the 2 remaining groups. (edu.au)
  • Description: Quantitative sandwich ELISA for measuring Human Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Description: A competitive ELISA for quantitative measurement of Mouse Glyceraldehyde 3 Phosphate Dehydrogenase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Structure-Guided Protein Engineering of Glyceraldehyde-3-phosphate Dehydrogenase from Corynebacterium glutamicum for Dual NAD/NADP Cofactor Specificity. (bvsalud.org)
  • Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme that converts glyceraldehyde -3- phosphate (G3P) to 1,3-bisphosphoglycerate and produces NADH , is a major prospective solution for the cofactor imbalance issue. (bvsalud.org)
  • GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is known as a major target protein in oxidative stresses and becomes thiolated in its active site. (elsevierpure.com)
  • Aldolase and glyceraldehyde-3-phosphate dehydrogenase are involved in the production or elimination of glyceraldehyde-3-phosphate during glycolysis or gluconeogenesis, and are differentially expressed under various physiological conditions, including cancer, hypoxia, and apoptosis. (molcells.org)
  • The enzyme activity of glyceraldehyde-3-phosphate dehydrogenase (GADPH), neuron specific enolase (NSE), succinate dehydrogenase (SDH), and lactate dehydrogenase (LDH), has been examined in saline-perfused, desheathed and denervated peroneal (P) and tibial (T) nerves from cats treated with acrylamide (15 mg/kg/day, s.c.) or vehicle for 15 days. (cdc.gov)
  • The interconversion of the phosphates of glyceraldehyde (glyceraldehyde 3-phosphate) and dihydroxyacetone (dihydroxyacetone phosphate), catalyzed by the enzyme triosephosphate isomerase, is an intermediate step in glycolysis. (wikipedia.org)
  • Fructose can then be phosphorylated by fructokinase and subsequently be metabolized via dihydroxyacetone phosphate or glyceraldehyde to D-glyceraldehyde 3-phosphate, which can be used as a substrate in the process of glycolysis. (wikipathways.org)
  • Aldolase B is responsible for the second step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into other molecules called glyceraldehyde and dihydroxyacetone phosphate. (medlineplus.gov)
  • Aldolase is an enzyme responsible for breaking down glucose products into energy, specifically converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate. (medscape.com)
  • Aldolase is a cytoplasmic enzyme responsible for converting sugar into energy, specifically splitting aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate (a reversible reaction). (medscape.com)
  • During glycolysis, glyceraldehyde 3-phosphate is generated through the enzymatic conversion of glucose- 6 phosphate by the enzyme phosphoglucose isomerase. (pediaa.com)
  • The main difference between glycerol 3-phosphate and glyceraldehyde 3- phosphate is that glycerol 3-phosphate is mainly involved in lipid synthesis, while glyceraldehyde 3-phosphate is involved in glycolysis . (pediaa.com)
  • Glycerol 3-phosphate and glyceraldehyde 3-phosphate are both important molecules taking part in various metabolic processes in living organisms, particularly in glycolysis and lipid metabolism. (pediaa.com)
  • Glyceraldehyde 3-phosphate, also known as triose phosphate , is a key molecule in cellular metabolism. (pediaa.com)
  • Structurally, glyceraldehyde 3-phosphate is a three-carbon molecule with a glyceraldehyde backbone and a phosphate group attached to the third carbon atom. (pediaa.com)
  • This phosphate group allows glyceraldehyde 3- phosphates to participate in phosphorylation reactions and interact with other molecules in cellular processes. (pediaa.com)
  • Glyceraldehyde 3 phosphate is mainly formed during the process of glycolysis, the central metabolic pathway. (pediaa.com)
  • One other function of glyceraldehyde 3-phosphate is its involvement in energy metabolism. (pediaa.com)
  • Glyceraldehyde serves as a crucial intermediate in these reactions, facilitating the transfer of high-energy phosphate groups and electrons to produce ATP and reducing equivalents such as NADH. (pediaa.com)
  • Glyceraldehyde 3-phosphate plays a vital role in the anabolic pathways, mainly in the biosynthesis of various important molecules. (pediaa.com)
  • Glyceraldehyde-3-phosphate is a key intermediate in several central metabolic pathways of all organisms. (molcells.org)
  • In this study, we examine the effects of glyceraldehyde-3-phosphate on cell survival and apoptosis. (molcells.org)
  • Overexpression of aldolase protected cells against apoptosis, and addition of glyceraldehyde-3-phosphate to cells delayed apoptosis. (molcells.org)
  • Additionally, delayed apoptotic phenomena were observed when glyceraldehyde-3-phosphate was added to a cell-free system, in which artificial apoptotic process was induced by adding dATP and cytochrome c. (molcells.org)
  • Surprisingly, glyceraldehyde-3-phosphate directly suppressed caspase-3 activity in a reversible noncompetitive mode, preventing caspase-dependent proteolysis. (molcells.org)
  • Based on these results, we suggest that glyceraldehyde-3-phosphate, a key molecule in several central metabolic pathways, functions as a molecule switch between cell survival and apoptosis. (molcells.org)
  • The word comes from combining glycerol and aldehyde, as glyceraldehyde is glycerol with one alcohol group oxidized to an aldehyde. (wikipedia.org)
  • Monosaccharides with an absolute configuration identical to (R)-glyceraldehyde at the last stereocentre, for example C5 in glucose, are assigned the stereo-descriptor D-. Those similar to (S)-glyceraldehyde are assigned an L-. Glyceraldehyde can be prepared, along with dihydroxyacetone, by the mild oxidation of glycerol, for example with hydrogen peroxide and a ferrous salt as catalyst. (wikipedia.org)
  • For detailed information about D/L-glyceraldehyde reductase, go to the full flat file . (brenda-enzymes.info)
  • Glyceraldehyde (glyceral) is a triose monosaccharide with chemical formula C3H6O3. (wikipedia.org)
  • The reaction is only observed in the direction of glyceraldehyde reduction. (expasy.org)
  • the levorotatory optical isomer of glyceraldehyde. (tekportal.net)
  • It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. (expasy.org)
  • Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. (easp.es)
  • Glyceraldehyde (glyceral) is a triose monosaccharide with chemical formula C3H6O3. (wikipedia.org)
  • The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). (nih.gov)
  • This conversion can go both ways, meaning that the triosephosphate isomerase 1 enzyme can also convert glyceraldehyde 3-phosphate back into DHAP. (medlineplus.gov)
  • Without functional triosephosphate isomerase 1 enzyme to convert DHAP to glyceraldehyde 3-phosphate, red blood cells accumulate DHAP, which is toxic in large quantities. (medlineplus.gov)
  • NAD or NADH binding / binding / catalytic/ glyceraldehyde-3-phos. (cornell.edu)
  • TrpAB is a heterotetrameric, PLP-dependent complex catalyzing two last reactions in L-Trp pathway: the conversion of indole-3-glycerol phosphate to indole and glyceraldehyde 3-phosphate (TrpA) followed by indole and L-Ser condensation to yield L-Trp (TrpB). (nih.gov)
  • It was by a lucky guess that the molecular D- geometry was assigned to (+)-glyceraldehyde in the late 19th century, as confirmed by X-ray crystallography in 1951. (wikipedia.org)
  • In the D/L system, glyceraldehyde is used as the configurational standard for carbohydrates. (wikipedia.org)
  • The word comes from combining glycerol and aldehyde, as glyceraldehyde is glycerol with one alcohol group oxidized to an aldehyde. (wikipedia.org)