• peptides
  • The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the. (google.com)
  • GABA
  • Succinic semialdehyde dehydrogenase deficiency (SSADHD), also known as 4-hydroxybutyric aciduria or gamma-hydroxybutyric aciduria, is a rare autosomal recessive disorder of the degradation pathway of the inhibitory neurotransmitter γ-aminobutyric acid, or GABA. (wikipedia.org)
  • Under normal conditions, SSADH works with the enzyme GABA transaminase to convert GABA to succinic acid. (wikipedia.org)
  • However, because of the deficiency, the final intermediate of the GABA degradation pathway, succinic semialdehyde, accumulates and cannot be oxidized to succinic acid and is therefore reduced to gamma-hydroxybutyric acid (GHB) by gamma-hydroxybutyric dehydrogenase. (wikipedia.org)
  • GABA is metabolized by successive transamination and oxidation to yield succinic semialdehyde and succinic acid respectively via the catalyzing effects of GABA transaminase. (wikipedia.org)
  • Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain, as well as BDNF and NGF levels in certain brain areas. (wikipedia.org)
  • alanine
  • Furthermore, the remaining residue of this loop exhibits only a conservative change i.e. glycine/alanine. (wikipedia.org)
  • These hydrophobic domains, consisting overwhelmingly of alanine, proline, glycine, and valine, tend towards instability and disorderliness, ensuring that the elastin does not lock into any specific confirmation. (wikipedia.org)
  • racemic
  • While natural extracts that are not harshly treated are presumed to contain only the biosynthetic L- enantiomeric form, mishandled isolates and racemic chemical preparations of theanines necessarily contain both theanine and its D-enantiomer (and from racemic syntheses, in equal proportion), and studies have suggested that the D-isomer may actually predominate in some commercial supplement preparations. (wikipedia.org)
  • analog
  • Isolated pure natriuretic protein receptor B having the amino acid sequence depicted in Fig 1, or an analog or variant thereof, other than ANP-C receptor or ANP-A receptor, having a biological activity of natriuretic protein receptor B. (google.fr)
  • A pharmaceutical composition comprising a natriuretic protein receptor B having the amino acid sequence depicted in Fig 1, or an analog or variant thereof, other than ANP-C receptor or ANP-A receptor, having a biological activity of natriuretic protein receptor B, and a pharmaceutically acceptable carrier. (google.fr)
  • L-Glutamine, the uncharged and amidated analog of L-glutamic acid, is an important amino acid for the incorporation of NH4+ into biomolecules. (thomassci.com)
  • Metabolism and action of amino acid analog anti-cancer agents ", in Pharmac. (wikipedia.org)
  • derivatives
  • The synthesis proceeds by the gradual formation of the purine ring on carbon-1 of ribose, with CO2, glutamine, glycine, aspartate and one-carbon derivatives of tetrahydrofolate donating various elements towards the building of the ring GMP can also exist as a cyclic structure known as cyclic GMP. (wikipedia.org)
  • proline
  • This is due to the fact that the proline and glycine amino acids are present in high amounts in the ELP. (wikipedia.org)
  • Glycine, due to the lack of a bulky side chain, enables the biopolymer to be flexible and proline prevents the formation of stable hydrogen bonds in the ELP backbone. (wikipedia.org)
  • Play media Although ELPs generally form reversible spherical aggregates due to their proline and glycine content, there is a possibility that, under certain conditions such as exceedingly high temperatures, ELPs will form amyloids, or irreversible aggregates of insoluble protein. (wikipedia.org)
  • It is also believed that changes in the ELP backbone leading to a reduction in the proline and glycine content may lead to ELPs with a greater propensity for the amyloid state. (wikipedia.org)
  • biological
  • This invention relates to the hormone calcitonin and DESCRIPTION OF INVENTION to substances having biological activity similar to calci- In general we use a solid phase type of synthesis and tonin and to substances which may be converted into start with a resin called benzhydryl amine resin (Bl-1A such biologically active substances. (google.com)
  • Many important proteinogenic and non-proteinogenic amino acids have biological functions. (wikipedia.org)
  • Because of their biological significance, amino acids are important in nutrition and are commonly used in nutritional supplements, fertilizers, and food technology. (wikipedia.org)
  • The study of abiogenesis can be geophysical, chemical, or biological, with more recent approaches attempting a synthesis of all three, as life arose under conditions that are strikingly different from those on Earth today. (wikipedia.org)
  • enzyme
  • acid phosphatase a lysosomal enzyme that hydrolyzes phosphate esters liberating inorganic phosphate and has an optimal pH of about 5.0. (thefreedictionary.com)
  • In non-photosynthetic eukaryotes such as animals, fungi, and protozoa, as well as the Alphaproteobacteria class of bacteria, it is produced by the enzyme ALA synthase, from glycine and succinyl CoA. (wikipedia.org)
  • The succinic semialdehyde can be converted into either succinic acid by SSADH or to GHB by the enzyme succinic semialdehyde reductase. (wikipedia.org)
  • hydrogen
  • Plants synthesize amino acids from primary elements, carbon & oxygen obtained from atmosphere & hydrogen from water in the soil, forming carbon hydrates by means of photosynthesis and combining it with the nitrogen which plants obtain from soil thus producing amino acids. (lotusexport.in)
  • acids form salts by replacing all or part of the ionizable hydrogen with an electropositive element or radical. (thefreedictionary.com)
  • Loops 2-6 also have highly conserved features, including the ubiquitous presence of just a single amino acid in loop 4 that is likely involved in sidechain-sidechain hydrogen bonding. (wikipedia.org)
  • oxygen
  • The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the arachidonic acid backbone. (wikipedia.org)
  • ligands
  • The spectroscopic and magnetic moment data suggested that the ligands coordinated via both their amino and carboxylate ion moieties. (scirp.org)
  • porphyrins
  • It elicits synthesis and accumulation of fluorescent porphyrins (protoporphyrin IX) in epithelia and neoplastic tissues, among them malignant gliomas. (wikipedia.org)
  • receptor
  • 5-HETE can be further metabolized to 5-oxo-ETE and 5-oxo-15-hydroxy-ETE, all of which have pro-inflammatory actions similar but not identical to those of LTB4 and mediated not by LTB4 receptors but rather by the OXE receptor (see 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid). (wikipedia.org)
  • bacterial
  • This causes rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death. (wikipedia.org)
  • metabolism
  • A large excess of ascorbic acid may cause a burning sensation during urination, diarrhea, skin rash, and nausea and may disturb the absorption and metabolism of cyanocobalamin. (thefreedictionary.com)
  • amounts
  • Results of tests for glycosuria, uric acid, and iron may be inaccurate when the patient is receiving large amounts of the vitamin. (thefreedictionary.com)