Loading...
  • dopamine
  • Psychostimulants like cocaine, amphetamines, and methylphenidate act by inhibiting and/or reversing the dopamine and/or norepinephrine transporters. (wikipedia.org)
  • Some dissociatives like phencyclidine and ketamine are also dopamine transporter inhibitors. (wikipedia.org)
  • Hyperforin and adhyperforin are wide-spectrum inhibitors of the reuptake of serotonin, norepinephrine, dopamine, glutamate, GABA, glycine, and choline, and they exert these effects by binding to and activating the transient receptor potential cation channel TRPC6. (wikipedia.org)
  • Inhibition
  • They appear to exert their reuptake inhibition by binding to vaguely characterized allosteric sites on each of the respective monoamine transporters. (wikipedia.org)
  • They can be considered a novel class of nerve agent toxins, inducing toxic levels of glutamate through transport inhibition in a manner analogous to the effect of sarin on acetylcholine transporters. (wikipedia.org)
  • The inhibition of system Xc- has been found to alter a number of behaviors, which suggests that it plays a key role in excitatory signaling. (wikipedia.org)
  • inhibitors
  • Inhibitors of glutamate transport increase the amplitude and prolong the time course of the compound EPSCs. (jneurosci.org)
  • Selective inhibitors for GLAST have recently been discovered based on 25 combinations of substitutions at the 4 and 7 positions of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitril. (wikipedia.org)
  • Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the neurotransmitter in question. (wikipedia.org)
  • 2001
  • Protons are detected by acid-sensing channels (ASICs) and also by TRPV1 ( Julius and Basbaum, 2001 ). (biologists.org)
  • Belmadani A, Zou JY, Schipma MJ, Neafsey EJ, Collins MA (2001) Ethanol pre-exposure suppresses HIV-1 glycoprotein 120-induced neuronal degeneration by abrogating endogenous glutamate/Ca 2+ -mediated neurotoxicity. (springer.com)
  • postsynaptic
  • We have identified an excitatory synapse in cerebellar molecular layer interneurons at which the level of presynaptic activity determines the receptor type involved in the postsynaptic response. (jneurosci.org)
  • molecule
  • Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). (genecards.org)
  • When one molecule of glutamate or GABA is converted to glutamine in the astrocytes, one molecule of ammonia is absorbed. (wikipedia.org)
  • presynaptic
  • NMDARs are activated only when glutamate release is increased either by facilitation with brief high-frequency trains or by recruiting more presynaptic fibers with higher stimulus intensities. (jneurosci.org)
  • The glutamine is taken into the presynaptic terminals and metabolized into glutamate by the phosphate-activated glutaminase (a mitochondrial enzyme). (wikipedia.org)
  • The glutamate that is synthesized in the presynaptic terminal is packaged into synaptic vesicles by the glutamate transporter, VGLUT. (wikipedia.org)
  • mediates
  • GLAST mediates the transport of glutamic and aspartic acid with the cotransport of three Na+ and one H+ cations and counter transport of one K+ cation. (wikipedia.org)