• urine
  • Finally, DON-8,15-hemiketal-8-glucuronide, a previously described by-product of DON-3-GlcAc production by RLM, was identified in urine of DON-exposed mice and rats. (springer.com)
  • The discovery of several novel DON-derived glucuronides in animal urine requires adaptation of the currently used methods for DON-biomarker analysis. (springer.com)
  • The phenobarbital N-glucuronides were partially purified from the mouse urine as phenobarbital N-methylglucuronates. (aspetjournals.org)
  • The diastereomers of phenobarbital N-glucuronides and phenobarbital N-glucosides accounted for 7.8 +/- 2.3% and 1.6 +/- 0.6%, respectively, of the radioactivity excreted in mouse urine in the first 48 hr after dosing. (aspetjournals.org)
  • Approximately 7% of estradiol is excreted in the urine as estradiol glucuronide. (wikipedia.org)
  • Estriol glucuronide is a prodrug of estriol, and was the major component of Progynon and Emmenin, estrogenic products manufactured from the urine of pregnant women that were introduced in the 1920s and 1930s and were the first orally active estrogens. (wikipedia.org)
  • Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood-cells after charbroiled beef consumption. (cdc.gov)
  • Metabolism
  • During its metabolism, codeine is conjugated with glucuronic acid by the enzyme UDP-Glucuronosyltransferase-2B7 (UGT2B7) to form codeine-6-glucuronide. (wikipedia.org)
  • uptake
  • According to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop via Abcc3 transporter-mediated efflux and subsequent Oatp1a/1b-mediated liver uptake. (aacrjournals.org)
  • Enzymes
  • Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases. (wikipedia.org)
  • We further demonstrate that sorafenib-glucuronide excreted into the gut lumen can be cleaved by microbial enzymes to sorafenib which is then reabsorbed, supporting its persistence in the systemic circulation. (aacrjournals.org)
  • enzyme
  • Luteolin 7-O-glucuronosyltransferase is an enzyme that uses UDP-glucuronate and luteolin to produce UDP and luteolin 7-O-beta-D-glucuronide. (wikipedia.org)
  • Soyasapogenol B glucuronide galactosyltransferase (EC 2.4.1.272, UDP-galactose:SBMG-galactosyltransferase, UGT73P2, GmSGT2 (gene), UDP-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase. (wikipedia.org)
  • bile
  • Using transporter-deficient mouse models, we show here that sorafenib-glucuronide can be extruded from hepatocytes into the bile by Abcc2 or back into the systemic circulation by Abcc3, and that it can be taken up efficiently again into neighboring hepatocytes by Oatp1a/1b. (aacrjournals.org)
  • compound
  • This compound belongs to the class of organic compounds known as o-glucuronides. (hmdb.ca)
  • Incubation of iso-DON and iso-DOM with RLM and HLM yielded two main glucuronides for each parent compound, which were isolated and identified as iso-DON/DOM-3-GlcAc and iso-DON/DOM-8-GlcAc by NMR. (springer.com)
  • Luteolin-7-O-glucuronide is a flavone, a chemical compound. (wikipedia.org)
  • substance
  • A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. (wikipedia.org)
  • significantly
  • Unlike norbuprenorphine, but similarly to buprenorphine (and norbuprenorphine-3-glucuronide), B3G is not a substrate for P-glycoprotein, and hence may cross the blood-brain-barrier significantly. (wikipedia.org)