• insulin secretion
  • OBJECTIVE We tested the hypotheses that in nondiabetic individuals, partial inhibition of insulin secretion with the ATP-sensitive K + channel agonist (opener) diazoxide, compared with placebo, results in higher plasma glucose and higher plasma glucagon concentrations after a mixed meal and after administration of the sulfonylurea glimepiride. (diabetesjournals.org)
  • CONCLUSIONS Partial inhibition of insulin secretion results in impairment of glucose tolerance after a mixed meal and after glimepiride administration in the absence of a difference in glucagon secretion. (diabetesjournals.org)
  • However, intravenous and oral administration of diazoxide, an ATP-sensitive K + (K ATP ) channel agonist (opener), partially inhibited insulin secretion and raised postabsorptive plasma glucose concentrations in nondiabetic humans ( 3 ). (diabetesjournals.org)
  • We therefore tested the hypothesis that partial inhibition of insulin secretion with diazoxide, compared with placebo, would result in higher plasma glucose concentrations after a mixed meal and, on a separate occasion, after administration of the sulfonylurea glimepiride (with glucose infused to prevent hypoglycemia) in nondiabetic individuals. (diabetesjournals.org)
  • Metabolism
  • The first experiment that led to the discovery of Cr3+ playing a role in glucose metabolism proposed that the biologically active form of the metal existed in a protein called glucose tolerance factor, however, new evidence suggests that it is simply an artifact obtained from isolation procedures. (wikipedia.org)
  • Maternal
  • If the mother of the infant is a diabetic, and does not properly control her blood glucose levels, the hyperglycemic maternal blood can create a hyperglycemic environment in the fetus. (wikipedia.org)
  • Following birth, the hyperglycemic maternal blood is no longer accessible to the neonate resulting in a rapid drop in the newborn's blood glucose levels. (wikipedia.org)
  • levels
  • If fluid is not replaced (by mouth or intravenously), the osmotic effect of high glucose levels, combined with the loss of water, will eventually lead to dehydration. (wikipedia.org)
  • oral
  • Dr Falutz reported findings suggesting that the oral glucose tolerance test may be the most reliable screening test. (natap.org)
  • test
  • A 50-g glucose challenge test (GCT) was performed between 24 and 28 weeks' gestation. (diabetesjournals.org)
  • We determined the reliability of first-trimester ultrasonography for measuring subcutaneous and visceral adipose tissue in pregnancy and whether either is predictive of a positive glucose challenge test (GCT), which is commonly used to screen for GDM later in pregnancy. (diabetesjournals.org)
  • normal
  • Small quantities of chromium are needed for glucose utilization by insulin in normal health, but deficiency is extremely rare and has only been observed in hospital patients on long-term defined diets. (wikipedia.org)
  • high
  • The invention relates to improved enteral nutritional formulas and more particularly to formulas which provide protein, low carbohydrate, high fat, dietary fiber and micronutrients specific to the needs of glucose intolerant individuals. (google.com)
  • Although
  • Although glucose abnormalities have been associated with use of protease inhibitors (PIs), other factors may contribute to the development of DM in HIV-infected patients. (natap.org)