• acute
  • To determine the acute in vivo effects of indinavir on whole-body glucose homeostasis, glucose tolerance tests were performed on PI-naïve Wistar rats immediately after a single intravenous dose of indinavir. (diabetesjournals.org)
  • These data demonstrate that indinavir causes acute and reversible changes in whole-body glucose homeostasis in rats and support the contribution of GLUT4 inhibition to the development of insulin resistance in patients treated with PIs. (diabetesjournals.org)
  • Therefore, if the insulin resistance observed in the HIV PI-associated lipodystrophy syndrome is caused by GLUT4 inhibition, PIs should be capable of producing acute and reversible effects on whole-body glucose disposal. (diabetesjournals.org)
  • However, to date, there have been no reported studies examining acute effects (i.e., after a single dose) of any PI on glucose tolerance in PI-naive animals or humans. (diabetesjournals.org)
  • To determine the contribution of impaired GLUT4 activity to the development of the insulin resistance associated with PI therapy, we investigated the acute effects of indinavir on whole-body glucose homeostasis and peripheral insulin sensitivity in a rodent model. (diabetesjournals.org)
  • Aerobic exercise has been shown to effectively reduce lipemia in both the fasted and postprandial states, and to have both acute [ 8 ] and chronic [ 9 ] anti-inflammatory properties. (biomedcentral.com)
  • To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. (biomedsearch.com)
  • Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. (wikipedia.org)
  • sedentary
  • Thirty-nine young adults (18-40 year) with no known metabolic disease were randomized to either a control group (CON) who remained sedentary during the postprandial period or an exercise (EX) group who walked at 60 % VO 2peak to expend ≈ 5 kcal/kgbw one-hour following the HFM. (biomedcentral.com)
  • lipid
  • This organ is not only composed of lipid-laden mature adipocytes and adipocyte precursors called preadipocytes, but also comprises a stromal vascular fraction (SVF), which includes blood cells, endothelial cells and macrophages. (nature.com)
  • mechanisms
  • While our data do not support a role for GC-C and uroguanylin in the hypothalamic control of food intake, uroguanylin does appear to influence energy and glucose homeostasis potentially via mechanisms that are independent of the GC-C receptor. (diabetesjournals.org)
  • substrate
  • When released from GKRP, GK exits the nucleus due to the presence of a leucine-rich nuclear export signal sequence ( 15 , 16 ), where it can phosphorylate its substrate glucose. (diabetesjournals.org)
  • decreases
  • The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. (wikipedia.org)
  • induce
  • Signs and symptoms only occur after severe narrowing or closure impedes blood flow to different organs enough to induce symptoms. (wikipedia.org)
  • adiposity
  • We also carefully phenotyped mice lacking the GC-C receptor and found them to have normal body weight, adiposity, and glucose tolerance. (diabetesjournals.org)
  • Further, there were no differences in body weight, adiposity, or glucose tolerance between GC-C-deficient mice and their littermate controls. (diabetesjournals.org)
  • pancreatic
  • factors related to stress, socio-economic status and history have been shown to activate the stress response, which increases the production of glucose and insulin resistance, as well as inhibiting pancreatic function and thus might be of importance, although it is not fully corroborated by the scientific evidence. (wikipedia.org)
  • metabolic
  • In theory, insulin resistance should even be strengthened under harsh metabolic conditions such as pregnancy, during which the expanding fetal brain demands more glucose. (wikipedia.org)
  • Effects
  • In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. (nature.com)
  • Our data indicate that the modest effects of uroguanylin on energy and glucose homeostasis are not mediated by central GC-C receptors. (diabetesjournals.org)
  • Because of the potential importance of a cGMP-based central nervous system circuit regulating food intake and energy homeostasis, we sought to determine the effects of central nervous system administration as well as loss of function of both the receptor and uroguanylin on energy balance regulation. (diabetesjournals.org)
  • According to the researchers, eating mangoes for an extended period can increase the fruit's anti-inflammatory effects compared with irregular consumption. (superfoodsnews.com)
  • We are excited about these promising findings for mangoes, which contain many bioactive compounds, including mangiferin, an antioxidant that may contribute to the beneficial effects of mango on blood glucose. (superfoodsnews.com)
  • diabetes
  • While diabetes is typically thought of as a blood-sugar disease, diabetes may result in numerous life-threatening complications. (google.com)
  • Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
  • peripheral
  • Peripheral arteries, which supply blood to the legs, arms, and pelvis, also experience marked narrowing due to plaque rupture and clots. (wikipedia.org)
  • symptoms
  • Marked narrowing in the coronary arteries, which are responsible for bringing oxygenated blood to the heart, can produce symptoms such as the chest pain of angina and shortness of breath, sweating, nausea, dizziness or light-headedness, breathlessness or palpitations. (wikipedia.org)
  • decrease
  • A class of drugs used to decrease hypertension, mainly by interfering with the renin kidney-blood pressure control cycle. (wikipedia.org)
  • Treatment of established disease may include medications to lower cholesterol such as statins, blood pressure medication, or medications that decrease clotting, such as aspirin. (wikipedia.org)
  • hormone
  • It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. (wikipedia.org)
  • Alpha cells make and release a hormone called glucagon, which raises the level of glucose (sugar) in the blood. (wikipedia.org)
  • mice
  • The results of this study support what we learned in our recent animal model, which found that mango improved blood glucose in mice fed a high-fat diet. (superfoodsnews.com)
  • thus
  • Thus, in hepatocytes, GK is sequestered by GKRP within the nucleus in an inactive state during conditions of low glucose (elevated fructose-6-phosphate) and is released by GKRP to the cytosol in an active state in the presence of high glucose (or by fructose-1-phosphate). (diabetesjournals.org)
  • citation needed] Atherosclerosis is asymptomatic for decades because the arteries enlarge at all plaque locations, thus there is no effect on blood flow. (wikipedia.org)
  • protein
  • Trout alevins received during the five first days of exogenous feeding either a hyperglucidic (40% gelatinized starch + 20% glucose) and hypoproteic (20%) diet (VLP diet) or a high-protein (60%) glucose-free diet (HP diet, control). (biologists.org)
  • pregnancy
  • The findings from this study may help to address important questions on screening and management of high blood sugar in pregnancy. (biomedcentral.com)
  • body
  • In a recent report in which oral glucose tolerance tests and euglycemic clamps were performed on healthy volunteers taking indinavir, insulin resistance was observed as soon as 4 weeks after start of therapy ( 16 ), before the development of any discernable changes in serum lipids or body fat composition. (diabetesjournals.org)
  • Acidosis An acidic condition in body fluids, chiefly blood. (wikipedia.org)
  • The narrowing of arteries limits the flow of oxygen-rich blood to parts of the body. (wikipedia.org)
  • lower
  • Our results indicate that daily consumption of 10 g of freeze-dried mango, which is equivalent to about one-half of a fresh mango (about 100 g), may help lower blood sugar in obese individuals…We believe this research suggests that mangoes may give obese individuals a dietary option in helping them maintain or lower their blood sugar. (superfoodsnews.com)
  • Acetohexamide A pill taken to lower the level of glucose (sugar) in the blood. (wikipedia.org)