• This in turn renders the supply of oxygen in tumor vasculature insufficient, consequently leading to formation of hypoxia or anoxia regions in malignant tumors. (nature.com)
  • This in turn causes partial or complete inhibition of mitochondrial respiration, also known as hypoxia or anoxia, respectively. (biomedcentral.com)
  • 3- 5 Therefore, during severe hypoxia or anoxia, the cell initiates a cascade of events that leads to apoptotic cell death, thereby preventing the accumulation of cells with hypoxia induced mutations. (bmj.com)
  • Due to high rainfall, irrigation practices and/or poor soil drainage, waterlogging annually affects large areas of farmlands worldwide, and these effects result in anoxic (absence of O 2 ) soils and severe hypoxia or anoxia within crop roots. (biomedcentral.com)
  • To find out, Nilsson and his team examined cardiac function in the crucian carp over a period of 5 days of anoxia at 8±1°C. In a paper recently published in Science , they report that following an initial 24 h adjustment period of increased stroke volume and cardiac output, the carp's cardiac function returned to normal levels. (silverchair.com)
  • It would be of interest to investigate in more detail the biochemical and molecular bases of continued cardiac function during anoxia. (silverchair.com)
  • The pain of a myocardial infarction results from myocardial ischemia caused by anoxia. (rnpedia.com)
  • Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). (biomedcentral.com)
  • We used an in vitro model of cerebral ischemia (oxygen-glucose deprivation) to examine changes in [Cl - ] i and GABA A receptor-mediated responses in hippocampal slices from adult rats. (jneurosci.org)
  • One of the first consequences of oxygen and glucose deprivation during cerebral ischemia is membrane depolarization, the rapid depletion of cellular ATP, and the accumulation of extracellular excitatory amino acids. (jneurosci.org)
  • The accumulation of Na + and Ca 2+ during ischemia or oxygen-glucose deprivation (OGD), an in vitro model for transient global ischemia, has been investigated extensively. (jneurosci.org)
  • In contrast, if anoxia is prolonged or if adult hippocampal slices are subjected to OGD under conditions that model cerebral ischemia, in vivo , the loss of synaptic transmission may become irreversible ( Zhu and Krnjević, 1999 ). (jneurosci.org)
  • Oxygen-glucose deprivation induced an immediate rise in [Cl - ] i , which recovered within 20 min. (jneurosci.org)
  • However, oxygen-glucose deprivation caused a progressive downregulation of the K + -Cl - cotransporter (KCC2), which may have contributed to the Cl - accumulation. (jneurosci.org)
  • Here, we added diazepam early after oxygen-glucose deprivation and prevented the downregulation of KCC2 and the accumulation of [Cl - ] i . (jneurosci.org)
  • Thus, after oxygen-glucose deprivation, diazepam may decrease neuronal excitability, thereby reducing the energy demands of the neuron. (jneurosci.org)
  • A previous study reported an ethanol-tolerant C. thermocellum strain with AdhE mutations (P704L and H735R) that shifted the cofactor specificity from NADH to NADPH, which was proposed to confer ethanol resistance by altering the internal redox balance (9). (researchgate.net)
  • This issue was addressed by metabolic engineering of EcN to uncouple the glucose-mediated control circuit and the L-arabinose transport-induction loop and to block L-arabinose catabolism. (nature.com)
  • Fat loss follows as the metabolic machinery switches from using glucose to using ketones as fuel. (mightyketo.net)
  • Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
  • The intrinsic limitation of P BAD for the gene expression is known to be negated by glucose and afflicted with all-or-nothing induction in host bacteria. (nature.com)
  • 3] During ketosis, ketones not only replace glucose as the primary energy source that the body uses, but ketones may actually be preferred over glucose by some of our most vital organs: the brain, the heart, and skeletal muscle. (mightyketo.net)
  • The varieties of maize hybrids with increased tolerance to heat and drought stress and resistance to pests and diseases are serious for handling existing climatic variability and for adaptation to progressive climate change. (lupinepublishers.com)
  • Differences ¥ Increase in blood glucose level in diabetes mellitus, which is not necessarily seen in xiao-ke. (journalofchinesemedicine.com)
  • Under these conditions, HPV can increase pulmonary vascular resistance and subsequently right heart afterload and may lead, in concert with pulmonary vascular remodelling processes, to fixed pulmonary hypertension and right heart insufficiency. (ersjournals.com)
  • Peak Male contains adaptogens -- nature's most powerful anti-stress and anti-anxiety herbs -- which have been specifically formulated to reduce all types of stress and the damage they cause, as well as increase your resistance to stress. (leanfactor.com)
  • Reductions in blood sugar fluctuations are also believed to play a role through the complex interactions of glucose-insulin-ghrelin-leptin. (mightyketo.net)
  • Frequent blood glucose monitoring played a critical role in maintaining this equilibrium, with the participants encouraged to use their blood glucose meter consistently. (diabetesresearchconnection.org)
  • The HlyE production was insensitive to glucose and reached a saturated level in response to L-arabinose at 30-50 μM. (nature.com)
  • After a 12-hour fast, the normal fasting blood glucose level is 80 to 120 mg/dl. (rnpedia.com)
  • The team also incorporated the use of a continuous glucose monitoring (CGM) system, an advanced technology providing real-time glucose readings, an invaluable tool in achieving a granular level of insight into blood sugar control. (diabetesresearchconnection.org)
  • This vasodilation allows the carp to transport the glucose required for anaerobic respiration to metabolically active tissues while also enabling the removal of toxic waste products. (silverchair.com)
  • In fact, the only cardiovascular functions that seemed to have changed over 2-5 days of anoxia were the fish's peripheral vascular resistance and blood pressure in the ventral aorta, which continued to be depressed, indicating that the fish's blood vessels had dilated. (silverchair.com)
  • Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
  • Leprosy: All forms of leprosy except for cases of proven Dapsone resistance. (nih.gov)
  • Resistance of Plasmodium falciparum to chloroquine is widespread and cases of Plasmodium vivax resistance have been reported. (drugs.com)
  • The flow and mass transfer equations for oxygen as well as different metabolites such as albumin, glucose, glutamine, ammonia, and urea were solved in three different domains, i.e., free flow, hydrogel, and spheroid porous media sections. (frontiersin.org)
  • By monitoring the flow of 13 C from fully labeled glucose into metabolites, it is possible to determine the major pathways that are influenced by immortalization and transformation, including the activity of glycolysis, the oxidative and non-oxidative pentose phosphate pathways, the tricarboxylic acid cycle and pyrimidine biosynthesis. (biomedcentral.com)
  • If you have diabetes, pre-diabetes or insulin resistance, you know how difficult it can be to control blood sugar (glucose) levels. (nervedoctor.info)
  • These habitual spikes in blood glucose will eventually lead to insulin resistance, which ultimately will develop into a full blown case of diabetes-it's not a matter of if you develop diabetes …it's when you will develop diabetes. (nervedoctor.info)
  • The main cause of diabetes is insulin deficiency or insulin resistance, which result in glucose accumulation in the blood stream causing glycosuria, followed by polyuria (Gilardi et al. (eurjanat.com)
  • Using different schemes of oxygen-glucose deprivation (OGD), the conditions taking place upon cerebral ischemia, we optimized a model of mimicking ischemic conditions in organotypical hippocampal slices for the long-lasting assessment of CA1 neuronal death (at least 3 weeks). (nih.gov)
  • Spikes in your blood sugar levels (glucose) are the biggest culprit leading to chronic inflammation, which, over time, may damage your peripheral nerves and blood vessels. (nervedoctor.info)
  • 9. Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia. (nih.gov)
  • Hemolysis and Heinz body formation may be exaggerated in individuals with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, or methemoglobin reductase deficiency, or hemoglobin M. This reaction is frequently dose-related. (nih.gov)
  • We found that the introduction of activated H-Ras V12 into immortalized human bronchial epithelial cells unexpectedly increased tricarboxylic acid cycle activity as measured by the direct conversion of 13 C-glucose carbons into the anabolic substrates glutamate/glutamine, aspartate and uridine. (biomedcentral.com)
  • With regard to neuropathies, chronically elevated glucose levels can damage blood vessels that carry oxygen and nutrients to the nerves. (nervedoctor.info)
  • This can lead to anoxia-a lack of oxygen to the nerve cells and blood vessels-which can result in poor circulation and nerve damage. (nervedoctor.info)
  • For this reason, when making good food choices, it is important to choose foods that do not cause rapid spikes in blood glucose levels. (nervedoctor.info)
  • After a 12-hour fast, the average fasting blood glucose level is 80 to 120 mg/dl. (nclexnursing.com)
  • PMID- 5097498 TI - 52 factors that can affect blood glucose levels. (nih.gov)
  • Diabetes mellitus (DM) is an endocrinal disorder characterized by a sustained elevation of blood glucose level, if uncontrolled, it can cause cardiovascular, renal and hepatic complications due to its effect on microvasculature. (eurjanat.com)
  • Grains are naturally high in starches and, as a result, will elevate glucose levels after eating them. (nervedoctor.info)
  • Foods containing carbohydrates are converted into sugars during the digestive process and cause your glucose levels to increase, shortly after your meal. (nervedoctor.info)
  • These findings provide mechanistic insights into how T-ALL develops resistance to drugs targeting the TCA cycle and therapeutic strategies to overcome this resistance. (biomed.news)
  • Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs. (molcells.org)
  • This need can be met under aerobic conditions by increasing the flux of acetyl coenzyme A into the tricarboxylic acid cycle (and via anaplerotic reactions to replenish carbon used for biosynthesis) derived from glucose, amino acid and fatty acid oxidation. (biomedcentral.com)
  • 15. [Microvesicles derived from LPS-induced microglia aggravate the injury of tight junction in rat brain microvascular endothelial cells under oxygen-glucose deprivation]. (nih.gov)
  • Despite the development of metabolism-based therapy for a variety of malignancies, resistance to single-agent treatment is common due to the metabolic plasticity of cancer cells. (biomed.news)
  • Improved understanding of how malignant cells rewire metabolic pathways can guide the rational selection of combination therapy to circumvent drug resistance. (biomed.news)
  • We examined the effects of sequential immortalization and H-Ras V12 -transformation of human bronchial epithelial cells on the anabolic fate of fully-labeled 13 C-glucose-derived carbons using two-dimensional total correlated spectroscopic analysis-nuclear magnetic resonance spectroscopy (2D TOCSY-NMR). (biomedcentral.com)
  • However normal, non-immortalized human bronchial epithelial cells supplemented with growth factors were recently observed to consume glucose and secrete lactate at a similar rate as Ras V12 -transformed human bronchial epithelial cells [ 15 ]. (biomedcentral.com)