• rdna origin
  • EXUBERA (insulin human rdna origin) ® consists of blisters containing human insulin inhalation powder, which are administered using the EXUBERA (insulin human rdna origin) ® Inhaler. (rxlist.com)
  • EXUBERA (insulin human rdna origin) blisters contain human insulin produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli (K12). (rxlist.com)
  • EXUBERA (insulin human rdna origin) (insulin human [rDNA origin]) Inhalation Powder is a white to off-white powder in a unit dose blister (fill mass, see Table 1 ). (rxlist.com)
  • Each unit dose blister of EXUBERA (insulin human rdna origin) contains a 1 mg or 3 mg dose of insulin (see Table 1 ) in a homogeneous powder formulation containing sodium citrate (dihydrate), mannitol, glycine , and sodium hydroxide. (rxlist.com)
  • After an EXUBERA (insulin human rdna origin) blister is inserted into the inhaler, the patient pumps the handle of the inhaler and then presses a button, causing the blister to be pierced. (rxlist.com)
  • Under standardized in vitro test conditions, EXUBERA (insulin human rdna origin) delivers a specific emitted dose of insulin from the mouthpiece of the inhaler (see Table 1 ). (rxlist.com)
  • EXUBERA (insulin human [rdna origin]) doses should be administered immediately prior to meals (no more than 10 minutes prior to each meal). (rxlist.com)
  • EXUBERA (insulin human [rdna origin]) is intended for administration by inhalation and must only be administered using the EXUBERA (insulin human [rdna origin]) ® Inhaler. (rxlist.com)
  • Refer to the EXUBERA (insulin human [rdna origin]) Medication Guide for a description of the EXUBERA (insulin human [rdna origin]) ® Inhaler and for instructions on how to use the inhaler. (rxlist.com)
  • recombinant DNA techno
  • citation needed] Biosynthetic "human" insulin is now manufactured for widespread clinical use using genetic engineering techniques using recombinant DNA technology, which the manufacturers claim reduces the presence of many impurities, although there is no clinical evidence to substantiate this claim. (wikipedia.org)
  • Human insulin is produced by recombinant DNA technology utilizing a non- pathogenic laboratory strain of Escherichia coli . (rxlist.com)
  • fatty acids
  • Without insulin, glucose is unable to enter the cells where it will be used for this and other anabolic ("building up") purposes, such as the synthesis of glycogen, proteins, and fatty acids. (wikipedia.org)
  • absorption
  • A man injects insulin into his abdomen for quick absorption. (livestrong.com)
  • Moreover, the site of injection, volume of injection, and the condition of the tissues into which the insulin is injected can alter its rate of absorption and peak action times, and exercising the limb which has been injected immediately after injection can increase the speed of absorption. (thefreedictionary.com)
  • Through genetic engineering of the underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics. (wikipedia.org)
  • injections
  • Review of controlled trials shows that, in most patients, mean blood glucose concentrations and glycated hemoglobin percentages are either slightly lower or similar on CSII versus multiple insulin injections. (diabetesjournals.org)
  • This allowed larger amounts of active monomeric insulin to be available for postprandial (after meal) injections. (wikipedia.org)
  • therapy
  • Insulin was formerly used in a psychiatric treatment called insulin shock therapy. (wikipedia.org)
  • First line therapy against insulin hypersensitivity reactions include symptomatic therapy with antihistamines. (wikipedia.org)
  • But enthusiasm from some is mixed with uncertainty from others, who are concerned about the possible complications of pump therapy ( 22 ) or intensive insulin therapy in general ( 23 ). (diabetesjournals.org)
  • 5. Identify therapeutic problems encountered in insulin therapy. (powershow.com)
  • Other problems of insulin therapy include insulin allergy , insulin resistance , insulin rebound due to the somogyi effect , and lipodystrophies or other localized tissue changes at injection sites. (thefreedictionary.com)
  • Continuous subcutaneous sensor-augmented insulin-pump therapy (SAPT) with an insulin pump from Medtronic (Paradigm® Velo) for a period of approximately 3 months post-transplantation. (clinicaltrials.gov)
  • injection
  • We review the evidence base that justifies this increase, including effectiveness compared with modern intensified insulin injection regimens and concern about possible complications. (diabetesjournals.org)
  • Lipodystrophies are localized manifestations of disordered fat metabolism at the sites of insulin injection. (thefreedictionary.com)
  • Measures that can help prevent lipodystrophies include (1) systematic rotation of injection sites, (2) warming insulin to room temperature before injection, (3) pinching the skin when injecting the insulin so that it is deposited between fat and muscle tissue, and (4) use of human insulin. (thefreedictionary.com)
  • NPH insulins are suspensions that require shaking for reconstitution prior to injection. (wikipedia.org)
  • Clinically
  • For the determination of the intra-individual rise in HbA1c, the previously observed rise of 0.5±0.7 % (mean ± standard deviation) from baseline to 3 months in the TIP-study basal insulin treatment group will be judged to be clinically not meaningful, hence if the intra-individual rise in the SAPT-treatment group remains below that value, the rise in HbA1c will be considered to be not meaningful, clinically. (clinicaltrials.gov)
  • allergy
  • Allergy to Insulin products is rare with a prevalence of about 2%, of which most reactions are not due to the insulin itself but to preservatives added to insulin such as zinc, protamine, and meta-cresol. (wikipedia.org)
  • A suspected allergy to insulin can be confirmed by skin prick testing, patch testing and occasionally skin biopsy. (wikipedia.org)
  • pump
  • In the SAPT-NODAT study, we will employ sensor-augmented insulin-pump technology, which performs like a semi-closed loop to prevent hypoglycemic events. (clinicaltrials.gov)
  • human
  • Though purity has improved steadily since the 1920s ultimately reaching purity of 99% by the mid-1970s thanks to high-pressure liquid chromatography (HPLC) methods, minor allergic reactions still occur occasionally, although the same types of allergic reactions have also been known to occur in response to synthetic "human" insulin varieties. (wikipedia.org)
  • The host cells are then allowed to grow and reproduce normally, and due to the inserted human DNA, they produce a synthetic version of human insulin. (wikipedia.org)
  • Chemically, human insulin has the empirical formula C 257 H 383 N 65 O 77 S 6 and a molecular weight of 5808. (rxlist.com)
  • Recombinant human types may duplicate exactly the human insulin protein sequence, or may be analogues with small differences in sequence. (thefreedictionary.com)
  • levels
  • It is also used along with glucose to treat high blood potassium levels. (wikipedia.org)
  • significant amount is removed during first pass through the liver, therefore hepatic insulin levels exceed peripheral level. (powershow.com)
  • Differences
  • Differences in suitability of beef-, pork-, or fish-derived insulin for individual patients have historically been due to lower preparation purity resulting in allergic reactions to the presence of non-insulin substances. (wikipedia.org)