• binds
  • Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. (abcam.com)
  • When the GR binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. (wikipedia.org)
  • The activated GR can then regulate gene expression via one of two pathways: Transactivation The first (direct) pathway is called transactivation whereby the activated GR dimerizes, is translocated into the nucleus and binds to specific sequences of DNA called glucocorticoid response elements (GREs). (wikipedia.org)
  • corticosteroid
  • See 'General principles of dermatologic therapy and topical corticosteroid use', section on 'Side effects' and 'Major side effects of inhaled glucocorticoids', section on 'Contact hypersensitivity' . (uptodate.com)
  • modulator
  • It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity. (wikipedia.org)
  • pharmacologic
  • RESULTS: Glucocorticoids, administered in the critical care setting for planned extubation, markedly reducing the risk of reintubation and remain a rudimentary pharmacologic adjunct in laryngeal manifestations of common autoimmune and inflammatory disorders. (biomedsearch.com)
  • acute
  • This summary of a Cochrane review presents what we know from research about the effect of glucocorticoid injections (into affected joints) in people with acute gout. (cochrane.org)
  • There is presently no evidence from randomised trials to support the use of intra-articular glucocorticoid treatment in acute gout. (cochrane.org)
  • Although intra-articular glucocorticoids are a commonly used intervention in the treatment of acute gout, there is little evidence to support their safety and efficacy in this setting. (cochrane.org)
  • To evaluate the safety and efficacy of intra-articular glucocorticoids in the treatment of acute gout. (cochrane.org)
  • No trials were identified that evaluated the efficacy and safety of intra-articular glucocorticoids for acute gout. (cochrane.org)
  • Wechalekar MD, Vinik O, Schlesinger N, Buchbinder R. Intra-articular glucocorticoids for acute gout. (cochrane.org)
  • 2001) presented a 10-year-old male patient, with no prior psychiatric history, who showed significant declines in academic performance that began during a 5-week course of glucocorticoid treatment for acute asthma flare. (wikipedia.org)
  • glucose
  • Importantly, although mice lacking LXR-beta did not develop high levels of blood glucose or fatty liver when administered a glucocorticoid drug, they did show all the signs of immunosuppression. (redorbit.com)
  • Indeed, the designation glucocorticoid arose from observations that the hormones played a role in the utilization of glucose. (encyclopedia.com)
  • In an absence of food, which can be broken down to supply glucose, glucocorticoids act to increase and maintain the normal levels of glucose in the blood. (encyclopedia.com)
  • As well, glucocorticoids curb the storage of glucose in cells of the body, which leaves the sugar ready for use. (encyclopedia.com)
  • The name glucocorticoid (glucose + cortex + steroid) is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). (wikipedia.org)
  • The name "glucocorticoid" derives from early observations that these hormones were involved in glucose metabolism. (wikipedia.org)
  • secretion
  • In accordance, glucocorticoids are known to affect cognition, stress-adaptive behavior, and neuroendocrine output (e.g., suppression of oxytocin and vasopressin secretion) within minutes. (wikipedia.org)
  • In GRA, the hypersecretion of aldosterone and the accompanying hypertension are remedied when ACTH secretion is suppressed by administering glucocorticoids. (wikipedia.org)
  • Medication
  • Dementia-like symptoms have been found in some individuals who have been exposed to glucocorticoid medication, often dispensed in the form of asthma, arthritis, and anti-inflammatory steroid medications. (wikipedia.org)
  • These symptoms have been shown to improve within months to a year after discontinuing glucocorticoid medication, but residual impairments following prolonged steroid use can remain. (wikipedia.org)
  • Aside from discontinuation of glucocorticoid medication, potential treatments discussed in the research literature include:[citation needed] anti-glucocorticoids psychoactive drugs that up-regulate the GRII glucocorticoid receptor:tricyclic antidepressants: Desipramine, Imipramine, and Amitriptyline (SSRIs do not ) serotonin antagonists: Ketanserin mood stabilizers: Lithium corticotropin-releasing hormone (CRH) antagonists glutamate antagonists dehydroepiandrosterone (DHEA) small molecule brain-derived neurotrophic factor (BDNF) analogs stress reduction therapies and exercise. (wikipedia.org)
  • elicit
  • A team of researchers, led by Carolyn Cummins, at the University of Toronto, Ontario, has now shown that the protein LXR-beta is required in mice for glucocorticoid drugs to elicit many of their negative side effects. (redorbit.com)
  • In vivo evidence on whether particular SEGRAMs can elicit similar effects than classic glucocorticoid in cancer pathologies is currently lacking. (wikipedia.org)
  • Current preclinical tests show that the SEGRAMs available so far would elicit fewer side effect or at least less grave side effects than classic glucocorticoids would. (wikipedia.org)
  • hippocampus
  • Despite having a high level of receptor expression, the physiological role of glucocorticoid signaling in the developing hippocampus is not well defined. (wikipedia.org)
  • Scientific studies have mainly focused on the impact of glucocorticoids on the hippocampus because of its role in memory processes and on the prefrontal cortex for its role in attention and executive function. (wikipedia.org)
  • injections
  • An early report in the 1950s described 6700 glucocorticoid injections given to 2256 patients [ 1 ]. (uptodate.com)
  • Studies of glucocorticoid injections in other conditions that lead to joint pain suggest that this therapy may be well tolerated, relatively safe and effective in relieving pain. (cochrane.org)
  • hippocampal
  • The following will provide an introduction to hippocampal development with particular focus on the role of glucocorticoid signaling. (wikipedia.org)
  • More research is needed to understand the role of glucocorticoids in the context of human hippocampal development. (wikipedia.org)
  • Steroid dementia syndrome describes the signs and symptoms of hippocampal and prefrontal cortical dysfunction, such as deficits in memory, attention, and executive function, induced by glucocorticoids. (wikipedia.org)
  • osteoporosis
  • Long-term (=3 months) use for chronic diseases is associated with a serious complication called glucocorticoid-induced osteoporosis (GIO). (innovations-report.com)
  • Osteoporotic fractures are typically associated with postmenopausal osteoporosis, but up to one half of patients on chronic glucocorticoid therapy may experience an osteoporotic fracture," said Tjeerd van Staa, MD, PhD, Department of Pharmacoepidemiology and Pharmacotherapy, University of Utrecht, the Netherlands and Drug Safety & Epidemiology, Procter & Gamble Pharmaceuticals - the presenting author of this study. (innovations-report.com)
  • placebo
  • While we were unable to find any controlled trials that have compared intra-articular glucocorticoids to placebo or another treatment, trials of intra-articular glucocorticoids for other conditions including osteoarthritis (some of which include people who have other types of crystals in their joints) and rheumatoid arthritis have found that this treatment is effective and safe. (cochrane.org)
  • In the placebo group, the statistically significant predictors for fracture were number of existing fractures and daily glucocorticoid dose. (innovations-report.com)
  • In the BMD threshold analysis, the one-year fracture risk in postmenopausal placebo glucocorticoid users was compared to that of 2,570 postmenopausal women with low BMD not using glucocorticoids from four other Actonel trials. (innovations-report.com)