Glomerulosclerosis podocytes. Medical search. Frequent questions

Patients with focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and diabetic nephropathy (DN) and control patients were enrolled in this study. (hindawi.com)
Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of primary glomerular disease in adults. (medscape.com)
In 2008 and 2011, Reiser led ground using highly collaborative team science of international researchers and scientists to discover that the uronkinase receptor and its soluble form suPAR can trigger the glomerular kidney disease Focal Segmental Glomerulosclerosis (FSGS). (rush.edu)
Focal segmental glomerulosclerosis (FSGS) is a frequent glomerular kidney disease that is revealed by proteinuria or even nephrotic syndrome. (nephcure.org)
This histopathological lesion may be caused by a primary podocyte injury (idiopathic FSGS) but is also associated with other pathologies (secondary FSGS). (nephcure.org)
Genome-wide association studies linked single-nucleotide polymorphisms (SNPs) at the MYH9 locus to chronic kidney disease among African-Americans, particularly glomerular diseases such as HIV nephropathy and idiopathic focal and segmental glomerulosclerosis (FSGS). (johnshopkins.edu)
Focal segmental glomerulosclerosis (FSGS) is a common histologic pattern of kidney injury, often associated with progressive chronic kidney disease and overt kidney failure. (biomedcentral.com)
Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy and hypertension-associated end-stage kidney disease. (omicsdi.org)
Patients with focal segmental glomerulosclerosis (FSGS) commonly present with heavy proteinuria, hypertension, renal dysfunction, edema, or a combination. (msdmanuals.com)
Focal segmental glomerulosclerosis (FSGS) is suspected in patients with nephrotic syndrome, proteinuria, or renal dysfunction with no obvious cause, particularly patients who have disorders or use illicit drugs or medications associated with FSGS. (msdmanuals.com)

Herein, we report that genetic activation of Gα12 in podocytes leads to time-dependent increases in proteinuria and glomerulosclerosis. (medscape.com)
We tested whether Myh9 podocyte deletion predisposed mice to glomerulopathy in response to injury by doxorubicin hydrochloride (Adriamycin), and we found that Myh9 podocyte-deleted mice developed proteinuria and glomerulosclerosis, while control mice were resistant. (johnshopkins.edu)
Expression of interferon gamma (IFN-γ) via plasmid tail vein injection results in upregulation of APOL1 protein levels together with robust induction of heavy proteinuria and glomerulosclerosis in G1/G1 and G2/G2 but not G0/G0 mice. (omicsdi.org)

Podocyte-specific deletion of Klf6 expression in mice leads to mitochondrial dysfunction and apoptosis, followed by glomerulosclerosis. (jci.org)
QLα12 LacZ+/Cre+ mice showed no changes in podocyte number, apoptosis, proliferation or Rho/Src activation. (medscape.com)

Preclinical data have shown that in models of rare chronic kidney disease this activity reduces proteinuria , protects podocytes, and prevents glomerulosclerosis and mesangial cell proliferation. (medscape.com)
Histopathological diagnoses were focal segmental glomerulosclerosis (8), mesangial proliferative glomerulonephritis (4), IgM nephropathy (3), and minimal change disease (1). (nephcure.org)
Proteinuria increased with age, and by 12-14 months, many demonstrated glomerulosclerosis with ultrastructural changes, including foot process fusion and both mesangial and subendothelial deposits. (medscape.com)
Both microarrays and RNA-seq were used to characterize the gene expression profiles of the podocytes, mesangial cells and endothelial cells, providing a global dual platform cross-validating dataset. (refine.bio)
Of interest, the mesangial cells also showed significant expression of Wt1, which has generally been considered podocyte specific. (refine.bio)
Focal segmental glomerulosclerosis is scattered (segmental) mesangial sclerosis that begins in some but not all (focal) glomeruli and eventually involves all glomeruli. (msdmanuals.com)

The podocytes have long foot processes called pedicels, for which the cells are named (podo- + -cyte). (wikipedia.org)
The foot processes known as pedicels that extend from the podocytes wrap themselves around the capillaries of the glomerulus to form the filtration slits. (wikipedia.org)
A loss of the foot processes of the podocytes (i.e., podocyte effacement) is a hallmark of minimal change disease, which has therefore sometimes been called foot process disease. (wikipedia.org)
Modest increases in glomerular basement membrane thickness and albuminuria were detected with podocyte foot processes largely preserved, in the absence of podocyte GLUT1 overexpression. (elsevierpure.com)
The lipid accumulation causes distorted podocyte structure, damaged podocyte foot processes, and podocyte detachment and loss, which impairs kidney filtration resulting in proteinuria (leakage of protein in the urine) and disease progression 2-5 . (zyversa.com)
Zebrafish with knockdown generated by morpholino oligonucleotides displayed hypoplastic glomerulus structures Oxoadipic acid and abnormal podocyte foot processes, thereby mimicking the pathological changes seen in the kidneys of the SRNS individuals with mutations. (edrc2013.org)
Electron microscopy reveals diffuse effacement of podocyte foot processes in idiopathic cases but may show patchy effacement in secondary cases. (msdmanuals.com)

The glomerular podocyte is particularly sensitive to mitochondrial dysfunction, as seen in various genetic disorders manifesting as progressive glomerulosclerosis. (jci.org)
In the central nervous system, MC has been claimed as the cause of neuronal death in many neurologic disorders, while MC in podocytes and tubular death is connected with the development of progressive glomerulosclerosis. (intechopen.com)
Progression is the process by which progressive glomerulosclerosis leads to end stage kidney disease (ESKD). (umich.edu)

A diagnosis can be established from a kidney biopsy that shows focal and segmental glomerulosclerosis. (nephcure.org)

Recent evidence suggests that the factor could be released by T-cells or B-cells, podocyte cell lines can be treated with plasma from patients with nephrotic syndrome to understand the specific responses of the podocyte to the circulating factor. (wikipedia.org)

Reduction in blood pressure alone did not reduce proteinuria or prevent podocyte loss from destabilized glomeruli. (umich.edu)
Finally, a diminution of EPB41L5-dependent signaling programs appears to be a common theme of podocyte disease, and therefore offers unexpected interventional therapeutic strategies to prevent podocyte loss and kidney disease progression. (elsevierpure.com)

This approach led to the identification of FERM domain protein EPB41L5 as a highly enriched podocyte-specific FA component in vivo. (elsevierpure.com)

Podocyte Injury and Albuminuria in Mice with Podocyte-Specific Overexpression of the Ste20-Like Kinase, SLK. (ohri.ca)
Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling. (nih.gov)

Crocin Protects Podocytes Against Oxidative Stress and Inflammation Induced by High Glucose Through Inhibition of NF-κB. (viamedica.pl)
Cyclodextrin protects podocytes in diabetic kidney disease. (zyversa.com)

Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. (musc.edu)

The miR-217 inhibitor and mimics were transfected into human podocyte cells to investigate the pathological mechanism of miR-217 in this disease. (hindawi.com)
In 2002 Professor Moin Saleem at the University of Bristol made the first conditionally immortalised human podocyte cell line. (wikipedia.org)

Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis. (ohri.ca)
Rituximab prevention of recurrent focal segmental glomerulosclerosis is associated with podocyte protection via sphingomyelination Science Translational Medicine 2011 *co-correspondence author. (rush.edu)
Read more about the angiotensin II type-2-receptor and its potential role in focal segmental glomerulosclerosis in the study by Liao and Miyata et al. (portlandpress.com)
Optimal management of primary focal segmental glomerulosclerosis in adults. (nephcure.org)
Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures. (nih.gov)
Disorders in their metabolism and transport have been implicated in numerous diseases and conditions 1-3 , including Atherosclerosis, Niemann Pick Type C, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Chronic Kidney Diseases (Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease). (zyversa.com)
Mutations in the Alpha-actinin-4 gene (ACTN4) cause a rare form of familial focal segmental glomerulosclerosis in humans. (biomedcentral.com)
Development of a novel cell-based assay to diagnose recurrent focal segmental glomerulosclerosis patients. (musc.edu)
A Novel CLCN5 Mutation Associated With?Focal Segmental Glomerulosclerosis and?Podocyte Injury. (musc.edu)
Genetic deletion of Epb41l5 resulted in severe proteinuria, detachment of podocytes, and development of focal segmental glomerulosclerosis. (elsevierpure.com)
Wilcoxon Rank-Sum check, * ValueaAntiretrovirals + corticosteroids, Antiretrovirals alone, Focal segmental glomerulosclerosis, Not specified Microcysts otherwise, lymphocytic infiltrate and fibrosis in the interstitium was graded 0C4: [0? (bioskinrevive.com)
Mutations in several genes expressed in podocytes, including Cd2ap, have been associated with focal segmental glomerulosclerosis in humans. (refine.bio)
These individuals have pathologically focal segmental glomerulosclerosis, a condition that leads to end-stage renal disease with high frequency. (edrc2013.org)
HIV-Associated Nephropathy HIV-associated nephropathy is characterized by clinical findings similar to those of focal segmental glomerulosclerosis and often biopsy features of collapsing glomerulopathy (a variant of focal. (msdmanuals.com)

The cover of this issue of Clinical Science (volume 136, issue 10) features an immunofluorescent image of cathepsin L (red), F-actin (green) and DAPI (blue) in mouse podocytes treated with adriamycin and C21. (portlandpress.com)
To investigate the role of MYH9 in kidney disease, we selectively deleted Myh9 from mouse podocytes and found that mutant C57BL/6 mice did not develop renal insufficiency or proteinuria compared to control littermates, even when the mice were aged for 9 months. (johnshopkins.edu)

Urinary Podocyte Microparticles Identify Prealbuminuric Diabetic Glomerular Injury. (ohri.ca)
Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. (ohri.ca)

Podocyte injury associated with mutant alpha-actinin-4. (ohri.ca)
Other projects in the laboratory are geared to understand the cellular behavior of podocytes as well as their injury response. (rush.edu)
APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress. (nih.gov)
Taken together, these studies suggest that Gα12 activation promotes glomerular injury without podocyte depletion through a novel mechanism regulating collagen (α)IV expression, and supports the notion that glomerular damage may accrue through persistent GPCR activation in podocytes. (medscape.com)
Gα12/13 are expressed in podocytes and couple to angiotensin II, thrombin, endothelin and LPA receptors, which are important in renal injury. (medscape.com)
After initial diphtheria toxin-induced podocyte injury (over 30% loss in 4 weeks), glomeruli became destabilized, resulting in continued autonomous podocyte loss causing global podocyte depletion (ESKD) by 13 weeks. (umich.edu)
Local TNF causes NFATc1-dependent cholesterol mediated podocyte injury. (zyversa.com)
Mitochondrial biogenesis induced by the ?2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. (musc.edu)
Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. (musc.edu)
Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. (musc.edu)
Considering the unique properties of?the podocyte (highly differentiated foot-process architecture and slit membrane and the inability to regenerate), we propose a podocyte-injury model as the pathomechanism for SRNS due to biallelic mutations. (edrc2013.org)

Glomerulosclerosis is a common pathological finding that often progresses to renal failure. (medscape.com)
Glomerulosclerosis (GS) is a common pathological finding in patients with progressive chronic kidney disease (CKD) and often leads to end-stage renal disease. (medscape.com)

Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression. (ohri.ca)
Young adults and children, often associated with HIV, heroin use, igA nephropathy and maladaption of nephron loss damage to podocyte initiates to global sclerosis. (freezingblue.com)

To mimic activation of Gα12 pathways, constitutively active Gα12 (QL) was conditionally expressed in podocytes using Nphs2-Cre and LacZ/floxed QLα12 transgenic mice. (medscape.com)
Moderately severe glomerulosclerosis (GS) was established by 26 wk of age in GT1S mice, with increased glomerular type IV collagen and fibronectin. (elsevierpure.com)
To explain the surprisingly normal phenotype, we considered genetic redundancy with the paralog Myh10 in podocytes, but we found that Myh10 was not expressed in podocytes in Myh9-deficient or control mice. (johnshopkins.edu)
In summary, Myh9 podocyte deletion in C57BL/6 mice results in susceptibility to experimental doxorubicin hydrochloride glomerulopathy. (johnshopkins.edu)

Detachment of podocytes from the glomerular basement membrane precedes most glomerular diseases. (elsevierpure.com)

Discontinuing angiotensin II blockade resulted in recurrent glomerular destabilization, podocyte loss, and progression to ESKD. (umich.edu)

Genetic mutations can cause podocyte dysfunction leading to an inability of the filtration barrier to restrict urinary protein loss. (wikipedia.org)
Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. (viamedica.pl)
Disruption of the exocyst induces podocyte loss and dysfunction. (musc.edu)

CD2AP regulates the podocyte cytoskeleton and stabilizes the slit diaphragm. (wikipedia.org)
Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. (musc.edu)

Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. (wikipedia.org)
In chronic kidney diseases, cholesterol accumulates in the kidneys' filtration system (glomerular podocytes), due in part to impaired efflux (transport out of the cell) resulting from reduced expression of the cholesterol transporters ABCA1 and ABCG1 3,4 . (zyversa.com)

Thus, we systematically screened for podocyte-specific focal adhesome (FA) components, using genetic reporter models in combination with iTRAQ-based mass spectrometry. (elsevierpure.com)

Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. (umich.edu)
Angiotensin II blockade (combined enalapril and losartan) restabilized the glomeruli, and prevented continuous podocyte loss and progression to ESKD. (umich.edu)
Thus, an initiating event resulting in a critical degree of podocyte depletion can destabilize glomeruli and initiate a superimposed angiotensin II-dependent podocyte loss process that accelerates progression resulting in eventual global podocyte depletion and ESKD. (umich.edu)

This was monitored by urine mRNA analysis and by quantitating podocytes in glomeruli. (umich.edu)

Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes. (ohri.ca)

Podocyte depletion is a major mechanism driving glomerulosclerosis. (umich.edu)
Similar patterns of podocyte depletion were found in the puromycin aminonucleoside and 5/6 nephrectomy rat models of progressive end-stage disease. (umich.edu)

The protective effect of angiotensin II blockade was entirely accounted for by reduced podocyte loss. (umich.edu)

30%] Podocytes and parietal cell hypertrophy/hyperplasia were graded 0? (bioskinrevive.com)

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. (nephcure.org)

a combination of phospholipase A2 receptor antibody and corresponding antigen on the podocytes forms in the immune complex and then activates the C5b-9 complex through the relative channels, damages the podocytes, destroys the glomerular filtration barrier, and generates proteinuria [ 5 - 7 ]. (hindawi.com)
The podocytes form one layer of the filtration barrier. (wikipedia.org)
Thus, by linking extracellular matrix sensing and signaling, focal adhesion maturation, and actomyosin activation EPB41L5 ensures the mechanical stability required for podocytes at the kidney filtration barrier. (elsevierpure.com)

In order to determine mechanisms contributing to persistent podocyte loss, we used a human diphtheria toxin transgenic rat model. (umich.edu)

Basic and translational science as well as patient studies have linked a common circulating blood protein-soluble urokinase plasminogen activator receptor (suPAR)-with chronic kidney disease risk and mechanistically to be harmful for podocytes, the filtering cells of the kidney. (rush.edu)

Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype. (nih.gov)
APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. (omicsdi.org)

Podocytes make up the epithelial lining of Bowman's capsule, the third layer through which filtration of blood takes place. (wikipedia.org)
Although various viscera have epithelial layers, the name visceral epithelial cells usually refers specifically to podocytes, which are specialized epithelial cells that reside in the visceral layer of the capsule. (wikipedia.org)

Podocytes are also involved in regulation of glomerular filtration rate (GFR). (wikipedia.org)
When podocytes contract, they cause closure of filtration slits. (wikipedia.org)
Disruption of the filtration slits or destruction of the podocytes can lead to massive proteinuria, where large amounts of protein are lost from the blood. (wikipedia.org)
Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration. (elsevierpure.com)

We hypothesized that podocytes are susceptible to filtered plasma components, including hormones and growth factors that stimulate signaling pathways leading to glomerulosclerosis. (medscape.com)
Transcriptomics Reveal Altered Metabolic and Signaling Pathways in Podocytes Exposed to C16 Ceramide-Enriched Lipoproteins. (musc.edu)
The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes. (musc.edu)

Anatomy18

Organisms12

Diseases35

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes18

Disciplines and Occupations1

Health Care1

FSGS10

Proteinuria and glomerulosclerosis3

Apoptosis2

Mesangial6

Foot processes7

Progressive glomerulosclerosis3

Focal and segmental glomerulosclerosis1

Nephrotic syndrome1

Prevent podocyte loss2

Enriched podocyte-specific1

Albuminuria2

Protects podocytes2

Effacement1

Human podocyte2

Segmental14

Mouse podocytes2

Diabetic2

Injury11

Renal2

Nephropathy2

Mice4

Glomerular basement1

Recurrent1

Dysfunction3

Slit diaphragm2

Kidneys2

Genetic1

Progression3

Glomeruli1

Prevents1

Depletion2

Angiotensin1

Hypertrophy1

Risk variants1

Barrier3

Persistent1

Chronic1

APOL12

Epithelial2

Filtration4

Pathways3