• mesangial cells
  • Glomerular mesangial cells structurally support the tufts. (wikipedia.org)
  • The juxtaglomerular cells secrete renin in response to: Stimulation of the beta-1 adrenergic receptor Decrease in renal perfusion pressure (detected directly by the granular cells) Decrease in NaCl concentration at the macula densa, often due to an decrease in glomerular filtration rate Extraglomerular mesangial cells are located in the junction between the afferent and efferent arterioles, but their significance in this location is unknown. (wikipedia.org)
  • hypertension
  • We conclude that hypothalamic lesioning induces overeating and obesity and selectively in the male causes hypertension and glomerular damage as well as declines in renal function. (ahajournals.org)
  • The incidence of hypertension increases with obesity, 1 and there is also evidence that obesity is associated with glomerular damage in people and animals. (ahajournals.org)
  • 5 6 Hypertension, specifically when it leads to increases in P GC , provides a separate risk factor for the development of glomerular injury. (ahajournals.org)
  • 11 This model is an excellent one for most human obesity and has been reported to be associated with glomerular damage, proteinuria, and hypertension. (ahajournals.org)
  • Excretion
  • Ditzel J, Junker K. Abnormal glomerular filtration rate, renal plasma flow and renal protein excretion in recent and short-term diabetes. (springer.com)
  • Renal abnormalities of glucose excretion, causing glycosuria, may happen as either a result of reduced Tm for glucose or because of an abnormally wide range of nephron heterogeneity so splay of the glucose excretion curve is increased. (wikipedia.org)
  • mechanism
  • Acute or chronic DDP administration in experimental models have shown an important reduction on glomerular filtration rate but, the pathophysiological mechanism of this acute renal failure (ARF) is unclear. (springer.com)
  • A countercurrent system in the renal medulla provides the mechanism for generating a hypertonic interstitium, which allows the recovery of solute-free water from within the nephron and returning it to the venous vasculature when appropriate. (wikipedia.org)
  • micropuncture
  • Lesioned rats were followed over a 7-month period after lesioning and an equivalent period in controls and were studied by glomerular micropuncture in a terminal experiment. (ahajournals.org)
  • To examine these possibilities, micropuncture and clearance experiments were performed on nine anesthetized dogs evaluating renal and glomerular hemodynamics before and during the administration of an angiotensin converting enzyme inhibitor (SQ20,881). (ahajournals.org)
  • isolated microscopic
  • A substantially increased risk for treated ESRD attributed to primary glomerular disease was found for individuals with persistent asymptomatic isolated microscopic hematuria compared with those without the condition. (nephronpower.com)