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  • urine
  • G F R = Urine Concentration × Urine Flow Plasma Concentration {\displaystyle GFR={\frac {{\mbox{Urine Concentration}}\times {\mbox{Urine Flow}}}{\mbox{Plasma Concentration}}}} There are several different techniques used to calculate or estimate the glomerular filtration rate (GFR or eGFR). (wikipedia.org)
  • These come close to the ideal properties of Inulin (undergoing only glomerular filtration) but can be measured more practically with only a few urine or blood samples. (wikipedia.org)
  • From there, it flows into the renal tubule - the nephron - which follows a U-shaped path to the collecting ducts, finally exiting into a renal calyx as urine. (wikipedia.org)
  • Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in protein and blood in the urine. (wikipedia.org)
  • perfusion
  • N. Schor, I. Ichikawa and B.M. Brenner, Mechanism of intermittent glomerular perfusion in the rat, Clin. (springer.com)
  • The juxtaglomerular cells secrete renin in response to: Stimulation of the beta-1 adrenergic receptor Decrease in renal perfusion pressure (detected directly by the granular cells) Decrease in NaCl concentration at the macula densa, often due to an decrease in glomerular filtration rate Extraglomerular mesangial cells are located in the junction between the afferent and efferent arterioles, but their significance in this location is unknown. (wikipedia.org)
  • mechanism
  • Acute or chronic DDP administration in experimental models have shown an important reduction on glomerular filtration rate but, the pathophysiological mechanism of this acute renal failure (ARF) is unclear. (springer.com)
  • A countercurrent system in the renal medulla provides the mechanism for generating a hypertonic interstitium, which allows the recovery of solute-free water from within the nephron and returning it to the venous vasculature when appropriate. (wikipedia.org)
  • mesangial
  • D.A. Ausiello, J.I. Kreisberg, C. Roy and M.J. Karnovsky, Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin, J. Clin. (springer.com)
  • Glomerular mesangial cells structurally support the tufts. (wikipedia.org)
  • Excretion
  • Ditzel J, Junker K. Abnormal glomerular filtration rate, renal plasma flow and renal protein excretion in recent and short-term diabetes. (springer.com)
  • Renal abnormalities of glucose excretion, causing glycosuria, may happen as either a result of reduced Tm for glucose or because of an abnormally wide range of nephron heterogeneity so splay of the glucose excretion curve is increased. (wikipedia.org)
  • solute
  • The goal of this study was to investigate water and solute transport, with a focus on sodium transport (TNa) and metabolism along individual nephron segments under differing physiological and pathophysiological conditions. (duke.edu)
  • micropuncture
  • Lesioned rats were followed over a 7-month period after lesioning and an equivalent period in controls and were studied by glomerular micropuncture in a terminal experiment. (ahajournals.org)
  • To examine these possibilities, micropuncture and clearance experiments were performed on nine anesthetized dogs evaluating renal and glomerular hemodynamics before and during the administration of an angiotensin converting enzyme inhibitor (SQ20,881). (ahajournals.org)
  • eGFR
  • Foram avaliados a etiologia da LRA, o uso de drogas vasoativas, ventilação mecânica, necessidade de diálise, presença de morbidades associadas, ritmo de filtração glomerular estimado (eGFR), duração da internação e a progressão da DRC. (bjn.org.br)
  • fibrosis
  • 16 - 22 However, the mechanism by which AKI leads to progressive CDK is not fully understood, pre-clinical studies point to possible mechanisms, such as acute endothelial injury, nephron loss and the degree of tubulointerstitial fibrosis is the best predictor of ESRD. (bjn.org.br)
  • proteinuria
  • Diabetic nephropathy is characterized by a progressive accumulation of extracellular matrix components in the glomerular mesangium and tubular interstitium, which eventually leads to proteinuria and renal failure ( 2 ). (pubmedcentralcanada.ca)
  • Many of these individuals eventually develop a glomerulopathy leading to glomerular proteinuria (present in as many as 30%) and, in some, the nephrotic syndrome. (wikipedia.org)
  • rate
  • We evaluated the etiology of AKI, the use of vasoactive drugs and mechanical ventilation, the need for dialysis, the presence of comorbidities, the glomerular filtration rate (GFR), the length of stay and the progression of CKD. (bjn.org.br)
  • It is recommended that alternatives to spironolactone be considered if serum creatinine is >2.5 mg/dL (221µmol/L) in males or >2 mg/dL (176.8 µmol/L) in females, if glomerular filtration rate is below 30mL/min or with a serum potassium of >5.0 mEq/L given the potential for adverse events detailed elsewhere in this article. (wikipedia.org)
  • lumen
  • Here, a deposit is also present but it appears that the overlying glomerular epithelium degenerated and is sloughing into the lumen. (blogspot.com)
  • contributes
  • This layer contains heparan sulfate, a negatively charged glycosaminoglycan that contributes to the electrostatic barrier of the glomerular filter. (wikipedia.org)
  • normal
  • The insulin-like growth factor system exerts endocrine and parakrine effects that are required for normal growth and nephron development. (fu-berlin.de)