Glioblastoma multiforme astrocytomas glioma. Medical search. Frequent questions

Astrocytomas in the base of the brain are more common in young people and account for roughly 75% of neuroepithelial tumors. (wikipedia.org)
Astrocytomas are usually noncancerous, slow-growing tumors. (medlineplus.gov)
Also called low-grade gliomas, these are the most common brain tumors in children. (medlineplus.gov)
Brainstem gliomas are very rare tumors that occur almost only in children. (medlineplus.gov)
Astrocytomas of the spinal cord are rare tumors that arise from astrocytes in the spinal cord and occur in both adult and pediatric populations. (medscape.com)
Astrocytes are non-excitable cells in the CNS that can cause life-threatening astrocytoma tumors when they transform to cancerous cells. (mdpi.com)
The incidence of brain tumors in children is about 5 cases per 100,000 population, 75% of which are classified as gliomas ( 2 ). (frontiersin.org)
Clinical trials to date have benefited only limited subsets of patients, accentuating the fact that pediatric high-grade gliomas (HGGs) constitute an extremely heterogeneous group of highly aggressive brain tumors. (frontiersin.org)
Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
In gliomas and colorectal carcinomas, aberrant methylation was detected in 40% of the tumors, whereas in non-small cell lung carcinomas, lymphomas, and head and neck carcinomas, this alteration was found in 25% of the tumors. (aacrjournals.org)
Some brain tumors, such as glioblastoma multiforme, are malignant and may be fast-growing. (cancercenter.com)
Gliomas are primary tumors that originate in brain parenchyma. (msdmanuals.com)
Astrocytomas Astrocytomas are central nervous system tumors that develop from astrocytes. (msdmanuals.com)
General references Gliomas are primary tumors that originate in brain parenchyma. (msdmanuals.com)
Both primary and secondary glioblastomas have distinct genetic characteristics, which can change as the tumors evolve. (msdmanuals.com)
Tumors in the pons are called pontine gliomas (or diffuse intrinsic pontine gliomas, DIPG). (kidshealth.org)
Midbrain tumors may cause eye symptoms similar to pontine gliomas, along with headaches and vomiting. (kidshealth.org)
Glioblastomas (GBMs) account for almost half of all cancerous brain tumors in adults. (clevelandclinic.org)
Glioma tumors like GBM start in glial cells. (clevelandclinic.org)
Pediatric-type diffuse high-grade gliomas continue to be one of the most difficult types of brain tumors to treat in children, given their infiltrative nature and low probability of successful gross total resection. (medlink.com)
Recognizing that brain tumors contained heterogeneous cell populations, gliomas were classified based on the morphological appearance and presumed histogenesis of the predominant cell type. (medlink.com)
The most frequent tumors in these clusters are astrocytoma, medulloblastoma[6,7] and glioblastoma[8]. (familialcancerdatabase.nl)
In the Swedish Family-Cancer Database, which included 2060 childhood brain tumors, 1.3% of brain tumor patients had a parent with nervous system cancer Some studies conclude that a family history of brain tumors or cancer in general do not significantly contribute to glioma risk in adults and brain tumor risk in children[13-17]. (familialcancerdatabase.nl)
26] studied cancer risk in the first-degree relatives of Swedish astrocytoma patients and found an increased risk for astrocytomas (relative risk 2.1) but not for other primary brain tumors in these relatives. (familialcancerdatabase.nl)
The worse prognosis of advanced high grade gliomas always promotes the clinicians to evolve the new approaches to deal with these types of aggressive tumors. (world-sci.com)
The most common primary brain tumors are gliomas. (sheclick.com)
Like all brain tumors, astrocytomas are very serious and are usually described by the medical community based upon their grade. (microscopyu.com)
In children, the majority of astrocytomas that occur are classified as low-grade, but in adults most of the tumors are of the high-grade variety. (microscopyu.com)
Gliomas are the most common primary tumors of the central nervous system (CNS). (oncotarget.com)
Meningiomas are extragenital tumors, more common in older people, and their prognosis is relatively favorable( overall five-year survival is 81%, a five-year survival rate for meningosarcoma is 55%).The appearance of gliomas is somewhat more predisposed to men, to meningiomas - women. (womensecr.com)
Only 2-10% of patients were genetically predisposed to brain tumors, and only 5% of gliomas could be hereditary. (womensecr.com)
Most neuroepithelial tumors are gliomas. (womensecr.com)
Gliomas account for 60% of all primary brain tumors. (womensecr.com)
Malignant gliomas - glioblastoma multiforme and anaplastic gliomas( anaplastic astrocytoma, anaplastic oligodendroglioma and anaplastic oligoastrocytoma) are the most common infiltrative primary brain tumors. (womensecr.com)
Glioblastoma, previously known as glioblastoma multiforme, is the most aggressive among infiltrative gliomas, a group of primary tumors arising from the central nervous system (CNS). (cancernetwork.com)
1] 'Multiforme,' which refers to a heterogenous histologic appearance and proliferation of multiple cell types, was abandoned from the revised nomenclature in the 2007 World Health Organization Classification of Tumors of the Central Nervous System, and is now simply called 'glioblastoma. (cancernetwork.com)
Researchers from the University of Florida have published a study evaluating a high-fat, low-carbohydrate diet in the treatment of glioblastoma brain tumors. (medscape.com)
Preliminary data have shown that the modified diet appears to make glioblastoma tumors more sensitive to treatment with radiation and chemotherapy. (medscape.com)

20% of pediatric gliomas are high grade gliomas (HGGs) and include anaplastic astrocytoma (AA), diffuse intrinsic pontine glioma (DIPG), and glioblastoma multiforme (GBM). (frontiersin.org)
Symptoms of a pontine glioma may start suddenly and get worse very quickly. (kidshealth.org)
High-grade gliomas of the brainstem, such as "typical diffuse intrinsic pontine glioma" (as well as histologically and genetically diagnosed "diffuse midline gliomas HR K27M mutated WHO-grade IV", as long as they are located in the brainstem), account for about one third of all HGG in children and teenagers. (gpoh.de)
Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy that occurs relatively rarely in childhood and young adulthood and carries a median survival of less than one year. (esmo.org)

Rarely, astrocytomas contain astrocytoma and oligodendroglioma cells. (msdmanuals.com)
Low-grade gliomas , such as oligodendroglioma, are found in young patients, whereas high-grade ones, such as glioblastoma multiforme, occur in older patients. (womensecr.com)
Biopsy specimens included glioblastoma multiforme (n = 80), anaplastic astrocytoma (n=76), anaplastic oligodendroglioma (n = 10), diffuse astrocytoma (n = 37), fibrillary astrocytoma (n = 4), oligodendroglioma (n = 2), low-grade astrocytoma (n = 8), and unknown (n = 71). (esmo.org)

Astrocytoma is a type of brain tumor. (wikipedia.org)
Grading of the tumor sample is a method of classification that helps the doctor to determine the severity of the astrocytoma and to decide on the best treatment options. (wikipedia.org)
citation needed] Low grade astrocytoma of the midbrain (lamina tecti), sagittal T1-weighted magnetic resonance imaging after contrast medium administration: The tumor is marked with an arrow. (wikipedia.org)
A pathological specimen of a gemistocytic astrocytoma MRI scans of an astrocytoma patient, showing tumor progression over the course of seven years Of numerous grading systems in use for the classification of tumor of the central nervous system, the World Health Organization (WHO) grading system is commonly used for astrocytoma. (wikipedia.org)
Astrocytoma: Surgery to remove the tumor is the main treatment. (medlineplus.gov)
Determine the concentration of interleukin-13 PE38QQR immunotoxin that produces histologic evidence of toxicity to tumor and the corresponding toxic effects of this drug when administered via continuous intratumoral infusion prior to second resection in patients with recurrent resectable supratentorial malignant glioma. (knowcancer.com)
Tumor progression was evaluated clinically using established criteria for malignant gliomas. (ajnr.org)
With advances in adjuvant chemotherapy, patients with malignant gliomas are living longer and there is a need for more sophisticated imaging surveillance of tumor progression. (ajnr.org)
Perturbed homeostasis of the neurotransmitter glutamate is associated with astrocytoma tumor onset and progression, but the factors that govern this phenomenon are less known. (mdpi.com)
The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. (frontiersin.org)
Pediatric gliomas represent the most common brain tumor in children. (frontiersin.org)
Gliomas also can be named according to the type of glial cells involved or the location of the tumor. (childrenshospital.org)
Glioma is the most common malignant primary brain tumor that survives less than 12 months after diagnosis. (researchsquare.com)
Glioma is the most common malignant primary brain tumor that develops inside the skull. (researchsquare.com)
Collectively, these results contribute to the increasing clinical relevance of assessing tumor biological markers in gliomas. (uludag.edu.tr)
The most common type of primary brain tumor is called a glioma, which originates in the glial (supportive) tissue. (cancercenter.com)
A tumor that develops in any area of the brain stem is called a brain stem glioma . (kidshealth.org)
A tumor that develops along this pathway is called an optic pathway glioma. (kidshealth.org)
Glioblastoma multiforme (GBM) is the most common type of malignant (cancerous) brain tumor in adults. (clevelandclinic.org)
GBMs are the fastest-growing astrocytoma (tumor that forms in astrocytes). (clevelandclinic.org)
Hill et al reported that in individuals with a family history of a brain cancer or a brain tumor, risk of glioma was 1.6 and 3.0, respectively, in comparison with those without such family histories. (familialcancerdatabase.nl)
Astrocytomas are the most common variety of glioma (tumor that arises from glial cells) and may be benign or malignant. (microscopyu.com)
In this study, we investigated the mRNA expression and association between TERT and GABPA/B isoforms in tumor samples of different glioma grades. (oncotarget.com)
Glioblastoma is an aggressive primary tumor of the central nervous system. (cancernetwork.com)

Pilocytic, other low-grade, or anaplastic astrocytomas tend to develop in younger patients. (msdmanuals.com)
Anaplastic astrocytomas, in particular, can later evolve into glioblastomas (called secondary glioblastomas). (msdmanuals.com)
Forty one (75.9%) of these patients harbored anaplastic astrocytomas and 13 (24%) patients harbored World Health Organization Grade IV Glioblastoma multiforme (GBM). (world-sci.com)
In children and adolescents, the most common among HGG are are anaplastic astrocytomas (WHO grade III) and glioblastoma multiforme (WHO grade IV). (gpoh.de)
They comprise the diffuse astrocytomas and oligodendrogliomas World Health Organization (WHO) grade II, the anaplastic astrocytomas and oligondendrogliomas WHO grade III and also the most frequent one, the glioblastoma multiforme (GBM) WHO grade IV [ 1 ]. (oncotarget.com)

WHO grades I-IV have extremely different 5-year survival rates up from 95% for grades I and II gliomas to 15-35% for grade IV gliomas or even less than 1% for DIPG ( 3 ). (frontiersin.org)
DIPG, which are usually diagnosed by imaging, frequently turn out as "diffuse midline gliomas histone 3 K27M-mutated (WHO-grade III)" based on their histology and molecular biological characteristics and are, therefore, classified by the WHO as an entity of their own. (gpoh.de)

Eighteen children with newly diagnosed high-grade astrocytomas arising in the spinal cord were enrolled in the Children's Cancer Group (CCG) protocol 945. (nih.gov)
Each year, about 60 to 80 children and adolescents younger than 15 years of age are newly diagnosed with a high-grade glioma in Germany. (gpoh.de)
Tumour-treating fields (TTFields) have emerged as an additional treatment option in combination with maintenance temozolomide treatment for patients with newly diagnosed glioblastoma. (smw.ch)
Bevacizumab prolongs progression-free survival in newly diagnosed and recurrent glioblastoma, but does not impact overall survival. (smw.ch)
This review focuses on clinical developments and management of newly diagnosed glioblastoma, and includes a discussion about the incorporation of molecular features into the classification of this disease. (cancernetwork.com)
Recent advances in our biological understanding of gliomas have led to important and substantive changes in their classification, in the identification of prognostic and predictive molecular markers, and in the therapeutic management of newly diagnosed glioma. (cancernetwork.com)

Various types of high-grade gliomas (HGG) have been identified based on their localization within the central nervous system (CNS), the cell of origin and the degree of malignancy. (gpoh.de)
These gliomas can be further subgrouped based on their histological and molecular characteristics, which provide inside into their origin and degree of malignancy. (gpoh.de)
Although its cells are frequently of low-grade malignancy, this tumour is classified as a highly malignant glioma because of its distinct growth pattern. (gpoh.de)
Gliomas are intrinsic brain tumours, which are classified by the World Health Organization (WHO) into different grades of malignancy, with glioblastoma being the most frequent and most malignant subtype (WHO grade IV). (smw.ch)
The present study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas. (oncotarget.com)

Conventional chemotherapy, targeting mitotic activity, is rarely effective in treating recurrent gliomas (1-4) . (ajnr.org)
Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. (frontiersin.org)
Treatment of high-grade spinal cord astrocytoma of childhood with '8-in-1' chemotherapy and radiotherapy: a pilot study of CCG-945. (nih.gov)
Because the brain stem is an area of the brain where surgery can be difficult, brain stem gliomas are often treated with radiation therapy (high-energy X-rays that kill cancer cells) and/or chemotherapy . (kidshealth.org)
Optic pathway gliomas are usually treated with chemotherapy, although radiation also can be used. (kidshealth.org)
In secondary glioblastomas after chemotherapy, GABPB1 and GABPB1-L are expressed on a lower level than without treatment. (oncotarget.com)
Between primary and secondary glioblastomas with and without chemotherapy, TERT is elevated in the former while GABPB1 is increased in the secondary glioblastomas. (oncotarget.com)
The average life expectancy in patients with glioblastoma is about 17 weeks without treatment and 62 weeks with radiation and chemotherapy. (womensecr.com)

The other forms of brain cancers are meningiomas, medulloblastomas, chordomas and central nervous system lymphomas.Brain cancers can be fast growing (high grade), such as glioblastoma multiforme or slow growing (low grade), such as pilocytic astrocytoma. (singaporecancersociety.org.sg)

A centralized neuropathology review was used to confirm the diagnosis of high-grade astrocytoma in 13 of the 18 children: anaplastic astrocytoma (eight patients), glioblastoma multiforme (four patients), and mixed malignant glioma (one patient). (nih.gov)
In this article, the authors present a comprehensive review of the basic principles and practices underlying the causes, diagnosis, treatment, and outcomes of pediatric-type diffuse high-grade glioma. (medlink.com)
European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. (smw.ch)
Molecular characterization has allowed for further refinement of the condition's classification and is now an integral part of the diagnosis of malignant glioma. (cancernetwork.com)

Herein, we report on comparative genomic hybridization (CGH) and immunohistochemical (IHC) assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas (10 WHO grade II, 3 WHO grade III), one oligoastrocytoma (WHO grade III) and 23 high-grade astrocytomas Q WHO grade III, 20 glioblastoma multiforme). (uludag.edu.tr)
Some individual imbalances were associated with increasing numbers of chromosomal changes, that were +7q in both oligodendrogliomas and astrocytomas, and -9p, -10q, +20p, and +20q in astrocytomas. (uludag.edu.tr)
The markers p53 and MIB-1 were significantly higher expressed in astrocytomas than in oligodendrogliomas and expression levels of p53 and EGFR were inversely associated within the astrocytic group. (uludag.edu.tr)
These include astrocytomas, oligodendrogliomas, ependymomas and mixed cell type gliomas. (singaporecancersociety.org.sg)
Oligodendrogliomas (WHO grade II) are among the slowest-growing gliomas. (msdmanuals.com)
Like astrocytomas, oligodendrogliomas can evolve into more aggressive forms, such as anaplastic oligodendrogliomas (WHO grade III), which are managed accordingly. (msdmanuals.com)

In recent years, thanks to the study of genetic variants, significant information associated with the prognosis and clinical course of glioma has been acquired. (frontiersin.org)
The purpose of this study was to devise an improved method of treating high-grade gliomas of the spinal cord in children who have a dismal prognosis following conventional treatment. (nih.gov)
Overexpression of ZEB1 and YAP1 is related to poor prognosis in patients with gliomas with different IDH1 status. (cdc.gov)
MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. (cdc.gov)

Determine the efficacy of talampanel, in terms of 6-month progression-free survival, in patients with recurrent high-grade gliomas. (knowcancer.com)
The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response of recurrent malignant gliomas to thalidomide and carboplatin. (ajnr.org)
Serial MR imaging was performed in 18 consecutive patients with recurrent malignant gliomas receiving both thalidomide and carboplatin for 12-month periods. (ajnr.org)
Angiogenesis is one of the most malignant features of recurrent high-grade glioma, and the recent emergence of antiangiogenic agents offers the hope of more effective treatment. (ajnr.org)
MR imaging studies were performed in 18 consecutive patients with recurrent malignant gliomas who were enrolled in a trial to investigate treatment with thalidomide and carboplatin (9) . (ajnr.org)
Six patients (three men and three women, 27-64 years old, mean age, 46 years) undergoing high-dose carboplatin therapy without thalidomide for recurrent malignant gliomas served as a control group. (ajnr.org)
To describe the role of gamma knife radiosurgery in the management of patients with recurrent or unresectable high-grade gliomas. (world-sci.com)
During a 15-months interval, 54 patients underwent gamma knife stereotactic radiosurgery as part of multimodal treatment of their recurrent or unresectable high-grade gliomas. (world-sci.com)
Gamma Knife radiosurgery is a useful adjunctive intervention in the management of recurrent or unresectable high grade gliomas to have better local controls and increased time to progression of disease with lower complication rates. (world-sci.com)

An increased risk of developing glioma and acoustic neuroma has been found in human epidemiological studies. (spandidos-publications.com)

This review discusses the similarities and differences between the morphology of astrocytes and astrocytoma cells, and the role that dysregulation in glutamate and calcium signaling plays in the aberrant morphology of astrocytoma cells. (mdpi.com)

Brainstem gliomas: Surgery may not be possible because of the tumor's location deep in the brain. (medlineplus.gov)

Homozygous deletion of CDKN2A/B is the main feature of high grade astrocytoma. (wikipedia.org)

The examination modality of choice for diagnosing and evaluating spinal cord astrocytoma is contrast-enhanced MRI of the spine with a closed magnet. (medscape.com)
Yang and colleagues investigated the prognostic factors of spinal cord astrocytoma (SCA) and sought to establish a nomogram prognostic model for management of patients with SCA. (medscape.com)

WHO Astrocitoma Grade IV) is the most common and deadly subtype of glioma in adults. (researchsquare.com)
In adults, astrocytomas most often arise in the cerebrum. (sheclick.com)
Brain stem gliomas most often are diagnosed in young children and middle-aged adults. (sheclick.com)
Characteristics of H3 K27M-mutant gliomas in adults. (smw.ch)

The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)

2] Glioblastoma is histologically defined by neoplastic cells with astrocytic characteristics and the presence of either endothelial proliferation-often in a glomeruloid morphology-and/or necrosis, which may resemble a pseudopalisading pattern (a false fence of neoplastic cells surrounding an area of necrotic tissue). (cancernetwork.com)

Radiotherapy has been the mainstay in the treatment of diffuse gliomas for several decades. (smw.ch)

A grade IV astrocytoma is usually called a glioblastoma multiforme. (sheclick.com)
Due to its aggressive and highly proliferative course, glioblastoma is considered a grade IV astrocytoma. (cancernetwork.com)
It is often referred to as a grade IV astrocytoma, and is the most common type of brain cancer. (metvital.com)

An increased incidence of glioma in the brain and malignant schwannoma in the heart was found in the US National Toxicology Program (NTP) study on rats and mice. (spandidos-publications.com)
The incidence of glioma varies considerably based on age, sex and race. (researchsquare.com)

Glioblastoma multiforme is characterized as highly invasive and rapidly growing astrocytomas, and scientists have sought for efficient treatment against malignant gliomas for a long time. (ogu.edu.tr)

Histology reveals a low-grade astrocytoma. (medscape.com)
Histology of autopsy tissue included glioblastoma multiforme (n = 48), anaplastic astrocytoma (n = 12), diffuse astrocytoma (n = 3), and unknown (n = 13). (esmo.org)

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. (smw.ch)
IDH1-Mutation in Diffuse Gliomas in Persons Age 55 Years and Over. (smw.ch)

Many gliomas infiltrate brain tissue diffusely and irregularly. (msdmanuals.com)
Anhydrous Enol-Oxaloacetate is a molecule that has demonstrated safety and efficacy in animal models with human Glioblastoma tissue implants, in animal models of ALS, and in animal models of Alzheimer's disease. (metvital.com)

This pattern identifies among lower-grade astrocytoma patients a subtype, where the CNA genotype is correlated with an approximately one-year survival phenotype. (wikipedia.org)
Survival rates vary in glioma subtypes, but a relative five-year survival ratio of gliomas has been suggested based on population-based studies. (researchsquare.com)
Short overall survival was significantly associated with +7p and -10q in astrocytomas. (uludag.edu.tr)
In patients with multiform glioblastoma, the forecast is most unfavorable, the two-year survival rate is from 30% in patients younger than 20 years and up to 2% in patients older than 65 years. (womensecr.com)
Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model. (cdc.gov)

Secondary glioblastomas typically have mutations in the IDH1 or IDH2 genes. (msdmanuals.com)
A small fraction of familial clustering of gliomas may be contributed to germline TP53 mutations[28-31]. (familialcancerdatabase.nl)
Mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes are frequent in lower (WHO II/III) grade tumours but typically absent in classical glioblastoma. (smw.ch)
Enhanced expression of TERT in gliomas is a result of two hotspot mutations, C228T and C250T, at the promoter region. (oncotarget.com)
Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma. (cdc.gov)

Glioblastomas contain chromosomally heterogeneous cells. (msdmanuals.com)
In general, the familial clustering of gliomas may be associated with a range of congenital malformations and is a genetically heterogeneous group[2]. (familialcancerdatabase.nl)

Astrocytomas (also astrocytomata) originate from a specific kind of star-shaped glial cell in the cerebrum called an astrocyte. (wikipedia.org)

They trigger the overexpression of platelet-derived growth factor, which results in cell proliferation, glioma migration and inactivation of the TP53 gene, which normally inhibits the growth of abnormal cells. (womensecr.com)

this metabolite can modify DNA methylation of normal neural and glial progenitor cells causing them to produce neoplastic glioma cells. (msdmanuals.com)
The majority of glioblastomas are IDH wild-type and correspond to the longstanding clinical description of primary glioblastomas, which arise rapidly from non-neoplastic brain cells and progress quickly. (cancernetwork.com)

Anatomy11

Organisms6

Diseases32

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment59

Phenomena and Processes40

Disciplines and Occupations1

Information Science6

Health Care9

Tumors38

Pontine glioma4

Oligodendroglioma3

Tumor24

Anaplastic astrocytomas5

DIPG2

Newly diagnosed6

Malignancy5

Chemotherapy8

Pilocytic astrocytoma1

Diagnosis4

Oligodendrogliomas6

Prognosis4

Recurrent9

Risk of develo1

Astrocytes1

Brainstem1

High grade astrocytoma1

Spinal cord astrocytoma2

Adults4

Cancers1

Histologically1

Radiotherapy1

Grade IV3

Incidence of glioma2

Malignant gliomas1

Histology2

Diffuse gliomas2

Tissue2

Survival5

Mutations5

Heterogeneous2

Star-shaped glial1

Overexpression1

Neoplastic2