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  • proliferation
  • Insulin-like growth factor-binding protein-3 induce proliferation of hepatocellular carcinoma cells via IGF-1 that influences bFGF and PDGF autocrine/paracrine loops . (qingres.com)
  • It is further to the ongoing dysfunctionalities that cancer-associated fibroblasts contribute to the progressive support and enhancement of tumor cell growth and proliferation on the one hand and also for migratory and metastatic phenomena that in turn define the tumor biology of such lesions as the pro-neural forms of glioblastoma. (qingres.com)
  • It is indeed in such milieu that PDGF ligands and receptors operate in an overall system mechanism that enhances in particular both the growth/proliferation activities of tumor cells. (qingres.com)
  • Although it is well known that cancer epithelial cells and stromal cells interact extensively to form a critical network that sustains and regulates cancer growth, the development of cancer is generally attributed to clonal proliferation of transformed epithelial cells, resulting from accumulated genetic mutations of either somatic or adult stem cells. (pubmedcentralcanada.ca)
  • While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution, many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death (apoptosis). (wikipedia.org)
  • At the level of the cell, there is selection for increased cell proliferation and survival, such that a mutant cell that acquires one of the hallmarks of cancer (see below), will have a competitive advantage over cells that have not acquired the hallmark. (wikipedia.org)
  • Sox2
  • A) Adherent CSC cultures express the stem cell marker Sox2, while (B) the patient-matched non-CSC culture does not express stem markers and has a more differentiated morphology. (nih.gov)
  • vitro
  • In this work, we have designed a novel cationic peptide of 27 amino acids (Cypep-1), which shows efficacy against a number of cancer cell types, both in vitro and in vivo, while normal human fibroblasts were significantly less affected. (jove.com)
  • metabolism
  • Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3," Proceedings of the National Academy of Sciences of the United States of America , vol. 110, no. 21, pp. 8644-8649, 2013. (hindawi.com)
  • The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. (wikipedia.org)
  • In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed that alterations in whole-organism metabolism such as obesity are associated with heightened risks for a variety of cancers. (wikipedia.org)
  • stromal cells
  • The paracrine and autocrine functionalities and dysfunctionalities of platelet-derived growth factor (PDGF) receptor-alpha and receptor-beta constitute a predominantly mesenchymal axis with stromal cells such as fibroblasts, pericytes and smooth muscle cells. (qingres.com)
  • Stromal cells are generally considered to be derived primarily from the host's normal mesenchymal stromal cells or bone marrow. (pubmedcentralcanada.ca)
  • However, the origins of stromal cells have been quite controversial. (pubmedcentralcanada.ca)
  • A carcinoma is a complex tissue composed of multiple cell types, including epithelial cancer cells as well as stromal cells that include fibroblasts, endothelial cells, and inflammatory cells [ 1 - 4 ]. (pubmedcentralcanada.ca)
  • In this regard, cancer cells and stromal cells can symbiotically recycle and maximize the use of nutrients. (wikipedia.org)
  • Mesenchymal
  • A mesenchymal glioma stem cell profile is related to clinical outcome," Oncogenesis , vol. 3, article e91, 2014. (hindawi.com)
  • The epithelial-mesenchymal transition generates cells with properties of stem cells. (naver.com)
  • The incremental populations of PDGF receptor number attest to a dysfunction that links parent cell populations of the tumor lesion with the participation of mesenchymal stromal elements such as fibroblasts and pericytes within a further context of smooth muscle cells. (qingres.com)
  • invasion
  • Invasion is a complex process involving interactions between tumor cells with the extracellular matrix (ECM), in addition to normal cells. (spandidos-publications.com)
  • Some studies have reported that normal brain cells influence GBM invasion behavior ( 6 , 8 ). (spandidos-publications.com)
  • Confirming the metabolic flux results, immunohistochemical analysis showed an up-regulation of lactate dehydrogenase in the bevacizumab-treated tumor core as well as in single tumor cells infiltrating the brain, which may explain the increased invasion observed after bevacizumab treatment. (jove.com)
  • genetic
  • Genetic alterations in primary glioblastomas in Japan. (naver.com)
  • Essentially this theory proposes that all cells have the ability to be tumorigenic making all tumor cells equipotent with the ability to self-renew or differentiate, leading to tumor heterogeneity while others can differentiate into non-CSCs The cell's potential can be influenced by unpredicted genetic or epigenetic factors, resulting in phenotypically diverse cells in both the tumorigenic and non-tumorigenic cells that compose the tumor. (wikipedia.org)
  • Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal cells. (wikipedia.org)
  • When a cancer cell divides, both daughter cells inherit the genetic and epigenetic abnormalities of the parent cell, and may also acquire new genetic and epigenetic abnormalities in the process of cellular reproduction. (wikipedia.org)
  • cancer
  • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis," Cancer Cell , vol. 9, no. 3, pp. 157-173, 2006. (hindawi.com)
  • Despite a causative role during malignant transformation and progression in hepatocarcinogenesis, consequences of c-MYC activation for the biology of hepatic cancer stem cells (CSC) are undefined. (aacrjournals.org)
  • Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity to the original resection cavity. (rupress.org)
  • Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging. (biomedsearch.com)
  • The interactions of aberrant cell migratory mechanisms and the tumor microenvironment likely differentiate cancer from normal cells. (biomedsearch.com)
  • Compartmentalizing microfluidics can be a versatile platform to study the migratory behavior of BTSCs and other cancer stem cells. (biomedsearch.com)
  • Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. (naver.com)
  • Originally known as host defence peptides for their substantial bacteriotoxic effects, many cationic antimicrobial peptides also exhibit a potent cytotoxic activity against cancer cells. (jove.com)
  • Polyploid giant cancer cells (PGCCs) are mononucleated or multinucleated cells with multiple genome copies that can be observed in cancer but that can also play an important role in many normal physiologic and nonmalignant pathologic processes [ 10 - 12 ]. (pubmedcentralcanada.ca)
  • DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. (nih.gov)
  • The principal objective of this study was to evaluate the effects of DNMT inhibitors on the radiosensitivity of human cancer cell lines, and to elucidate the mechanisms relevant to that process. (nih.gov)
  • A549 (lung cancer) and U373MG (glioblastoma) cells were exposed to radiation with or without six DNMT inhibitors (5-azacytidine, 5-aza-2'-deoxycytidine, zebularine, hydralazine, epigallocatechin gallate, and psammaplin A) for 18 hours prior to radiation, after which cell survival was evaluated via clonogenic assays. (nih.gov)
  • CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. (wikipedia.org)
  • Cancer stem cells were first identified by John Dick in acute myeloid leukemia in the late 1990s. (wikipedia.org)
  • This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity: the cancer stem cell (CSC) and stochastic model. (wikipedia.org)
  • This model suggests that only certain subpopulations of cancer stem cells have the ability to drive the progression of cancer, meaning that there are specific (intrinsic) characteristics that can be identified and then targeted to destroy a tumor long-term without the need to battle the whole tumor. (wikipedia.org)
  • This cell model suggests these mutations could occur to any cell in the body resulting in a cancer. (wikipedia.org)
  • They examined cancer stem cell plasticity in which cancer stem cells can transition between non-cancer stem cells (Non-CSC) and CSC via in situ supporting a more Stochastic model. (wikipedia.org)
  • Cancer therapies act as a form of artificial selection, killing sensitive cancer cells, but leaving behind resistant cells. (wikipedia.org)
  • Often the tumor will regrow from those resistant cells, the patient will relapse, and the therapy that had been previously used will no longer kill the cancer cells. (wikipedia.org)
  • Thus, at the level of the cell there is selection for cancer. (wikipedia.org)
  • High amount of aerobic glycolysis (also known as the Warburg effect) distinguishes cancer cells from normal cells. (wikipedia.org)
  • Rather than oxidizing glucose for ATP production, glucose in cancer cells tends to be used for anabolic processes, such as ribose production, protein glycosylation and serine synthesis. (wikipedia.org)
  • Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. (wikipedia.org)
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • vivo
  • A recombinant lentiviral PDGF-driven mouse model allows for the facile in vivo testing of gene function in pro neural glioblastoma . (qingres.com)
  • By using a two component vector consisting of a transgene of interest and MGMT, in vivo drug selection can be utilized to select for successfully transduced cells. (wikipedia.org)
  • foci
  • A549 and U373MG cells growing in chamber slides were exposed to DNMT inhibitors for 18 hours, irradiated, and fixed at specific times for immunocytochemical analyses of nuclear γH2AX foci. (nih.gov)
  • Cells with more than five foci per nucleus were classified as positive for radiation-induced γH2AX. (nih.gov)
  • propagation
  • An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours," Journal of Neuroscience Methods , vol. 176, no. 2, pp. 192-199, 2009. (hindawi.com)
  • pathways
  • Molecular and systems biologists are tasked with the comprehension and analysis of incredibly complex networks of biochemical interactions, called pathways, that occur within a cell. (biomedcentral.com)
  • NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction pathways, regulating magnitude and duration of cell signaling cascades The overall structure of NEDD9 is represented graphically in Figure 1. (wikipedia.org)
  • benign
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • substantially
  • Despite intense investigation on the neuronal fate of NG2 cells, there is no definitive evidence that they contribute substantially to the neuronal population. (frontiersin.org)
  • epithelial cells
  • To determine the role of polyploidy in tumor development, we examined the fate of normal mullerian epithelial cells during the immortalization and transformation process by tracing the expression of SV40 large T antigen. (pubmedcentralcanada.ca)
  • brain
  • Glioblastoma (GBM) is a highly invasive and malignant brain tumor. (spandidos-publications.com)
  • This perspective article will discuss recent findings and unsolved questions related to the astrocyte and neuronal fate of NG2 cells and their role in brain pathophysiology, primarily in the rodent CNS. (frontiersin.org)
  • Collier, however, was "unable to accept this explanation", his view being that since the sixth nerve emerges straight forward from the brain stem, whereas other cranial nerves emerge obliquely or transversely, it is more liable to the mechanical effects of backward brain stem displacement by intracranial space occupying lesions. (wikipedia.org)
  • A brain tumor occurs when abnormal cells form within the brain. (wikipedia.org)
  • glial
  • Autocrine processes of stimulation and activation of epithelial and glial cells account for self-sufficiency in terms also of tumor angiogenesis. (qingres.com)
  • undergo
  • In order for a cell to become cancerous it must undergo a significant number of alterations to its DNA sequence. (wikipedia.org)
  • marker
  • The term OPCs is used when discussing their role in oligodendrocyte production, while the terms "NG2 cells" and "NG2 glia" are used when discussing their property that is not directly related to their OPC role, even though NG2, which is also expressed on vascular pericytes, is not an absolute marker for these cells. (frontiersin.org)
  • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. (naver.com)
  • morphology
  • The phase live images of cell morphology during migration are recorded over several days. (biomedsearch.com)
  • To avoid using different names to refer to the same cells in different biological contexts, the word "polydendrocytes" has been suggested as a unified name for these cells, in keeping with the names of other types of glia that are loosely associated with their morphology. (frontiersin.org)
  • spheroid
  • Low c-MYC activation increased spheroid formation in p53-deficient tumor cells, whereas p53-dependent effects were blunted in the absence of c-MYC overexpression. (aacrjournals.org)
  • expression
  • Several recent studies prospectively isolated and evaluated putative hepatic CSCs by using surrogate characteristics such as xenograft tumor growth, expression of stem cell-associated antigens (e.g. (aacrjournals.org)
  • Prolongation of γH2AX expression was observed in the cells treated with DNMT inhibitors prior to radiation as compared with those treated by radiation alone. (nih.gov)
  • The γH2AX expression of cells treated with radiation alone was compared with those treated with a combination of DNMT inhibitors and radiation. (nih.gov)
  • The expression-deficient MGMT gene could then be carried along as a selectively neutral or only slightly deleterious passenger (hitch-hiker) gene when the mutated stem cell generates an expanded clone. (wikipedia.org)
  • tumor cell
  • Homologous pairing of the PDGF ligand polypeptides contrasts with the heterologous pairing of the A-B polypeptides of the PDGF ligand in an extensive cross-talk of pathway effects and of receptor-receptor interactivity within the tumor cell membrane. (qingres.com)
  • distinct
  • Here, distinct levels of c-MYC overexpression were established by using two dose-dependent tetracycline-inducible systems in four hepatoma cell lines with different p53 mutational status. (aacrjournals.org)
  • biology
  • The Paddison lab has broad expertise in functional genomics, stem cell biology, and molecular biology, and provides a vibrant research environment for career advancement toward top-tier academic or industry positions. (genomeweb.com)
  • The endothelial cell plays a crucial role in PDGF biology in the activation and pericyte response of supplying vasculature in a manner that is reflected in such phenomena as chemotaxis and increased tumor blood supply. (qingres.com)
  • whereas
  • From a functional standpoint, PAX3c, PAX3d, and PAX3h stimulate activities such as cell growth whereas PAX3e and PAX3g inhibit these activities, and PAX3a and PAX3b show no activity or inhibit these endpoints. (wikipedia.org)
  • radiation
  • Pretreatment with psammaplin A increased the sub-G1 fraction of A549 cells, as compared to cells exposed to radiation alone. (nih.gov)
  • tumor cells
  • Orthotopic models have their limitations too, but with proper technique tumor cells of interest can be accurately engrafted into tissue that most closely mimics conditions in the human brain. (jove.com)
  • At experiment termination, several distinct endpoints can be measured, such as size and molecular characterization of the primary tumor, the presence and quantification of circulating tumor cells in the blood and bone marrow, and formation of metastasis to the lung. (jove.com)
  • Essentially this theory proposes that all cells have the ability to be tumorigenic making all tumor cells equipotent with the ability to self-renew or differentiate, leading to tumor heterogeneity while others can differentiate into non-CSCs The cell's potential can be influenced by unpredicted genetic or epigenetic factors, resulting in phenotypically diverse cells in both the tumorigenic and non-tumorigenic cells that compose the tumor. (wikipedia.org)
  • These mutations could progressively accumulate and enhance the resistance and fitness of cells that allow them to outcompete other tumor cells, better known as the somatic evolution model. (wikipedia.org)
  • The clonal evolution model, which occurs in both the CSC model and stochastic model, postulates that mutant tumor cells with a growth advantage outproliferate others. (wikipedia.org)
  • The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. (wikipedia.org)
  • This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs. (wikipedia.org)
  • progenitor
  • Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta. (nih.gov)
  • Neural stem/progenitor cell (NPC)-specific constitutive Ras activation in vivo plus p53 deficiency led to development of primarily anaplastic astrocytoma (grade III), whereas combined loss of p53 plus p16 Ink4a /p19 Arf led to development of GBM (grade IV) at 100% penetrance within 6 weeks. (aacrjournals.org)
  • Furthermore, Alcantara Llaguno and colleagues ( 7 ) have shown that inactivation of Nf1 combined with loss of other tumor suppressors ( p53 and Pten ) in neural stem/progenitor cells (NPC), but not in non-NPCs, was both necessary and sufficient to induce glioma formation, indicating critical roles for Ras activation in NPCs on gliomagenesis in vivo . (aacrjournals.org)
  • tissues
  • These cells are a hallmark of 'activated fibroblasts' that share similar properties with myofibroblasts commonly observed in injured and fibrotic tissues 6 . (jove.com)
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • gene
  • Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. (wikipedia.org)
  • cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells and hypothesized to play a role in the process of T cell costimulation, designating this gene Cas-L (Crk-associated substrate-related protein, Lymphocyte type). (wikipedia.org)
  • Therefore, canonical PRC1 complexes and PRC2 can act together to repress gene transcription and maintain this repression through cell division (i.e. the repressed state is also present in daughter cells). (wikipedia.org)
  • The expression-deficient MGMT gene could then be carried along as a selectively neutral or only slightly deleterious passenger (hitch-hiker) gene when the mutated stem cell generates an expanded clone. (wikipedia.org)
  • squamous
  • It is now widely accepted that p16INK4A as a sensitive and specific marker of squamous and glandular dysplastic cells of the cervix, and is considered as a valuable adjunctive test in diagnosis and screening. (clytojournals.com)
  • We have compared the expression pattern of p16INK4A, MCM2, MCM5 and CDC6 to assess their potential as markers of dysplastic squamous and glandular cells of the cervix.60% of LSIL and 80% of HSIL were positive for p16,MCM and cdc6 proteins in tissue samples. (clytojournals.com)
  • Patterns of expressions of transforming growth factor and epidermal growth factor receptor in squamous cell lesions of the urinary bladder. (abnova.com)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung squamous cell carcinoma (A, B) with EGFR monoclonal antibody, clone GFR/1667 (Cat # MAB14766). (abnova.com)
  • Thyroid transcription factor 1 expression is associated with outcome of patients with non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. (cancerindex.org)
  • The aim of our retrospective study was to evaluate the association of thyroid transcription factor 1 expression with outcome of a large cohort of patients with non-squamous non-small cell lung cancer treated with pemetrexed. (cancerindex.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • commonly
  • Here we use tumor cell migration and invasion as an example and describe two related assays to illustrate the commonly used, easily accessible methods to measure these processes. (jove.com)
  • While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media. (wikipedia.org)
  • differentiation
  • Therefore, beyond the differences that can create apparent heterogeneity of alterations among GSC lines, there's a sort of selective force acting on them in order to converge towards the impairment of cell development and differentiation processes. (nih.gov)
  • lesions
  • Collier, however, was "unable to accept this explanation", his view being that since the sixth nerve emerges straight forward from the brain stem, whereas other cranial nerves emerge obliquely or transversely, it is more liable to the mechanical effects of backward brain stem displacement by intracranial space occupying lesions. (wikipedia.org)
  • lung cancer
  • Pemetrexed is an antifolate cytostatic agent targeting several folate-dependent enzymatic pathways, widely used in the treatment of locally advanced or metastatic stage non-small cell lung cancer. (cancerindex.org)
  • We retrospectively analysed clinical data of 463 patients with advanced-stage non-small cell lung cancer (IIIB or IV) treated with pemetrexed-based chemotherapy. (cancerindex.org)
  • novel
  • To overcome this difficulty, we developed a novel technique to experimentally generate immortalised human mammary CAF cell lines (exp-CAFs) from human mammary fibroblasts, using a coimplantation breast tumour xenograft model. (jove.com)
  • xenograft
  • These cells were coimplanted with MCF-7 human breast carcinoma cells expressing an activated ras oncogene (MCF-7-ras cells) into a mouse xenograft. (jove.com)
  • situ
  • Transitional cell papilloma, NOS M8120/2 Transitional cell carcinoma in situ Urothelial carcinoma in situ M8120/3 Transitional cell carcinoma, NOS Urothelial carcinoma, NOS Transitional carcinoma M8121/0 Schneiderian papilloma, NOS (C30.0, C31. (wikipedia.org)
  • processes
  • Rather than oxidizing glucose for ATP production, glucose in cancer cells tends to be used for anabolic processes, such as ribose production, protein glycosylation and serine synthesis. (wikipedia.org)
  • glucose
  • The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. (wikipedia.org)
  • See Hallmarks below) Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. (wikipedia.org)
  • apoptosis
  • Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. (readbyqxmd.com)
  • However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL). (readbyqxmd.com)
  • carcinoma
  • In support of our hypothesis, it was recently shown by Chin and colleagues ( 15 ) that a kRAS variant within the let-7 target site increased the risk for non-small cell lung carcinoma among moderate smokers. (aacrjournals.org)
  • Here we describe a further usage of this pDNA vector with the human Ubiquitin C promoter to create stably transfected human hepatoma (Huh7) and human Pancreatic Carcinoma (MIA-PaCa2) cell lines, which were delivered into "immune deficient" mice and monitored longitudinally over time using a bioluminometer. (jove.com)
  • Both cell lines revealed sustained episomal long-term luciferase expression and formation of a tumour showing the pathological characteristics of hepatocellular carcinoma (HCC) and pancreatic carcinoma (PaCa), respectively. (jove.com)
  • The tumour-associated stroma is responsive to substantial paracrine signals released by neighbouring carcinoma cells. (jove.com)
  • Many laboratories, including our own, have shown that CAFs, when injected with carcinoma cells into immunodeficient mice, are capable of substantially promoting tumourigenesis 7-10 . (jove.com)
  • NEDD9-binding regions in the miR-145 locus would allow the direct binding of the NEDD9 3'UTR to the genomic region of miR-145, and some studies suggests this miR regulates NEDD9 in glioblastoma prostate cancer, and renal cell carcinoma cells. (wikipedia.org)
  • M8090/3) Basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Basal cell epithelioma Rodent ulcer Pigmented basal cell carcinoma M8091/3 Multifocal superficial basal cell carcinoma (C44. (wikipedia.org)
  • Multicentric basal cell carcinoma M8092/3 Infriltrating basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Infiltrating basal cell carcinoma, non-sclerosing Infiltrating basal cell carcinoma, sclerosing Basal cell carcinoma, morpheic Basal cell carcinoma, desmoplastic type M8093/3 Basal cell carcinoma, fibroepithelial (C44. (wikipedia.org)
  • Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
  • M8097/3 Basal cell carcinoma, nodular (C44. (wikipedia.org)
  • Basal cell carcinoma, micronodular M8098/3 Adenoid basal carcinoma (C53. (wikipedia.org)
  • Cylindrical cell carcinoma M8122/3 Transitional cell carcinoma, spindle cell Transitional cell carcinoma, sarcomatoid M8123/3 Basaloid carcinoma M8124/3 Cloacogenic carcinoma (C21.2) M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67. (wikipedia.org)
  • Papillary urothelial neoplasm of low malignant potential M8130/2 Papillary transitional cell carcinoma, non-invasive (C67. (wikipedia.org)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • Metabolic
  • Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate. (nih.gov)
  • protein
  • EGFR is a cell surface protein that binds to epidermal growth factor. (abnova.com)
  • NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction pathways, regulating magnitude and duration of cell signaling cascades The overall structure of NEDD9 is represented graphically in Figure 1. (wikipedia.org)
  • Activated mTOR stimulates protein and lipid biosynthesis and cell growth in response to sufficient nutrient and energy conditions and is often constitutively activated during tumorigenesis. (wikipedia.org)
  • abnormal
  • 2 . The method of claim 1 wherein the anti-EGFR antibody is an antibody which recognizes an EGFR epitope which is found in tumorigenic, hyperproliferative or abnormal cells and not detectable in normal cells. (google.es)
  • generate
  • The theory suggests that conventional chemotherapies kill differentiated or differentiating cells, which form the bulk of the tumor but do not generate new cells. (wikipedia.org)
  • Thus, a cell that acquires a mutation that increases its fitness will generate more daughter cells than competitor cells that lack that mutation. (wikipedia.org)
  • tumour
  • Importantly, these cells, defined as exp-CAFs, closely mimic the tumour-promoting myofibroblastic phenotype of CAFs isolated from breast carcinomas dissected from patients. (jove.com)
  • growth
  • Cells in the dominant population have a similar potential for initiating tumor growth (Fig. 4). (wikipedia.org)
  • As neoplastic cells accumulate in three-dimensional multicellular masses, local low nutrient and oxygen levels trigger the growth of new blood vessels into the neoplasm. (wikipedia.org)
  • Human
  • Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts. (nih.gov)
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • successfully
  • It is our goal to describe these methods in a highly accessible manner so that the procedures can be successfully performed in research laboratories even just with basic cell biology setup. (jove.com)
  • Methods
  • Methods to examine cell migration are very useful and important for a wide range of biomedical research such as cancer biology, immunology, vascular biology, cell biology and developmental biology. (jove.com)