• metabolism
  • Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3," Proceedings of the National Academy of Sciences of the United States of America , vol. 110, no. 21, pp. 8644-8649, 2013. (hindawi.com)
  • 2 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Molecular, Cellular, and Developmental Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. (docplayer.net)
  • The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. (wikipedia.org)
  • In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed that alterations in whole-organism metabolism such as obesity are associated with heightened risks for a variety of cancers. (wikipedia.org)
  • proliferation
  • Insulin-like growth factor-binding protein-3 induce proliferation of hepatocellular carcinoma cells via IGF-1 that influences bFGF and PDGF autocrine/paracrine loops . (qingres.com)
  • It is indeed in such milieu that PDGF ligands and receptors operate in an overall system mechanism that enhances in particular both the growth/proliferation activities of tumor cells. (qingres.com)
  • Although it is well known that cancer epithelial cells and stromal cells interact extensively to form a critical network that sustains and regulates cancer growth, the development of cancer is generally attributed to clonal proliferation of transformed epithelial cells, resulting from accumulated genetic mutations of either somatic or adult stem cells. (pubmedcentralcanada.ca)
  • While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution, many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death (apoptosis). (wikipedia.org)
  • At the level of the cell, there is selection for increased cell proliferation and survival, such that a mutant cell that acquires one of the hallmarks of cancer (see below), will have a competitive advantage over cells that have not acquired the hallmark. (wikipedia.org)
  • genes
  • Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival," Clinical Cancer Research , vol. 15, no. 21, pp. 6541-6550, 2009. (hindawi.com)
  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. (naver.com)
  • In terms of overall functionality a link is created between autocrine malignant epithelial cells and glial cells in a manner that is further compounded by fusion receptor genes and the mutational and amplification dysfunctionalities of the receptor-ligand genes. (qingres.com)
  • However, reduced or absent expression of MGMT would cause increased rates of mutation, and one or more of the mutated genes may provide the cell with a selective advantage. (wikipedia.org)
  • Moreover, the fact that Jarid2 and the Pcl proteins are thought not to be present in the same complexes means that, in mammalian cells, distinct PRC2 complexes target different genes. (wikipedia.org)
  • Maintenance of embryonic stem cells (ES) Lineage-specific genes are genes that will define the final identity of the differentiated cell. (wikipedia.org)
  • These genes are primed for expression (also known as existing in a bivalent state in embryonic stem cells but are kept in a repressed state by chromatin modifications. (wikipedia.org)
  • The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals. (wikipedia.org)
  • overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). (wikipedia.org)
  • vivo
  • In this work, we have designed a novel cationic peptide of 27 amino acids (Cypep-1), which shows efficacy against a number of cancer cell types, both in vitro and in vivo, while normal human fibroblasts were significantly less affected. (jove.com)
  • By using a two component vector consisting of a transgene of interest and MGMT, in vivo drug selection can be utilized to select for successfully transduced cells. (wikipedia.org)
  • NSCs
  • NSCs in the SGZ mainly give rise to new granular cells in the DG which are thought to be important for spatial learning and memory. (dkfz.de)
  • growth
  • Several recent studies prospectively isolated and evaluated putative hepatic CSCs by using surrogate characteristics such as xenograft tumor growth, expression of stem cell-associated antigens (e.g. (aacrjournals.org)
  • The paracrine and autocrine functionalities and dysfunctionalities of platelet-derived growth factor (PDGF) receptor-alpha and receptor-beta constitute a predominantly mesenchymal axis with stromal cells such as fibroblasts, pericytes and smooth muscle cells. (qingres.com)
  • Traditionally, PGCCs were considered to be senescent and not able to divide, since multiple mechanisms exist in animal cells to limit polyploid cell growth [ 13 , 14 ]. (pubmedcentralcanada.ca)
  • Targeting DRP1 using RNA interference or pharmacologic inhibition induced BTIC apoptosis and inhibited tumor growth.Downstream, DRP1 activity regulated the essential metabolic stress sensor, AMP-activated protein kinase (AMPK), and targeting AMPK rescued the effects of DRP1 disruption.DRP1 activation correlated with poor prognosis in glioblastoma, suggesting that mitochondrial dynamics may represent a therapeutic target for BTICs. (nih.gov)
  • Using a pharmacologic activator of AMPK, we found that AMPK activation decreased BTIC growth and induced caspase activation (Supplementary Fig. 4b, c), concordant with studies in glioma cell lines41, phenocopying DRP1 targeting. (nih.gov)
  • The clonal evolution model, which occurs in both the CSC model and stochastic model, postulates that mutant tumor cells with a growth advantage outproliferate others. (wikipedia.org)
  • Cells in the dominant population have a similar potential for initiating tumor growth (Fig. 4). (wikipedia.org)
  • From a functional standpoint, PAX3c, PAX3d, and PAX3h stimulate activities such as cell growth whereas PAX3e and PAX3g inhibit these activities, and PAX3a and PAX3b show no activity or inhibit these endpoints. (wikipedia.org)
  • Activated mTOR stimulates protein and lipid biosynthesis and cell growth in response to sufficient nutrient and energy conditions and is often constitutively activated during tumorigenesis. (wikipedia.org)
  • survival
  • AMP-activated protein kinase (AMPK) is a central cellular sensor of energy stress, suggesting a potentially critical role in determining the survival of cells under metabolic stress. (nih.gov)
  • On a clinical level, this translates into a prolonged survival of glioblastoma patients with a methylated MGMT promoter. (wikipedia.org)
  • Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. (wikipedia.org)
  • Mesenchymal
  • A mesenchymal glioma stem cell profile is related to clinical outcome," Oncogenesis , vol. 3, article e91, 2014. (hindawi.com)
  • The epithelial-mesenchymal transition generates cells with properties of stem cells. (naver.com)
  • The incremental populations of PDGF receptor number attest to a dysfunction that links parent cell populations of the tumor lesion with the participation of mesenchymal stromal elements such as fibroblasts and pericytes within a further context of smooth muscle cells. (qingres.com)
  • biology
  • The Paddison lab has broad expertise in functional genomics, stem cell biology, and molecular biology, and provides a vibrant research environment for career advancement toward top-tier academic or industry positions. (genomeweb.com)
  • Despite a causative role during malignant transformation and progression in hepatocarcinogenesis, consequences of c-MYC activation for the biology of hepatic cancer stem cells (CSC) are undefined. (aacrjournals.org)
  • The endothelial cell plays a crucial role in PDGF biology in the activation and pericyte response of supplying vasculature in a manner that is reflected in such phenomena as chemotaxis and increased tumor blood supply. (qingres.com)
  • Regulation
  • Confirming the metabolic flux results, immunohistochemical analysis showed an up-regulation of lactate dehydrogenase in the bevacizumab-treated tumor core as well as in single tumor cells infiltrating the brain, which may explain the increased invasion observed after bevacizumab treatment. (jove.com)
  • phenotype
  • Together, our results confirm the role of c-MYC as a master regulator during hepatocarcinogenesis and establish a new gatekeeper role for p53 in repressing c-MYC-induced CSC phenotype in liver cancer cells. (aacrjournals.org)
  • propagation
  • An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours," Journal of Neuroscience Methods , vol. 176, no. 2, pp. 192-199, 2009. (hindawi.com)
  • pathways
  • NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction pathways, regulating magnitude and duration of cell signaling cascades The overall structure of NEDD9 is represented graphically in Figure 1. (wikipedia.org)
  • tumor cell
  • Homologous pairing of the PDGF ligand polypeptides contrasts with the heterologous pairing of the A-B polypeptides of the PDGF ligand in an extensive cross-talk of pathway effects and of receptor-receptor interactivity within the tumor cell membrane. (qingres.com)
  • BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggesting that BTICs increase mitochondrial fission. (nih.gov)
  • benign
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • epithelial cells
  • To determine the role of polyploidy in tumor development, we examined the fate of normal mullerian epithelial cells during the immortalization and transformation process by tracing the expression of SV40 large T antigen. (pubmedcentralcanada.ca)
  • lesions
  • Collier, however, was "unable to accept this explanation", his view being that since the sixth nerve emerges straight forward from the brain stem, whereas other cranial nerves emerge obliquely or transversely, it is more liable to the mechanical effects of backward brain stem displacement by intracranial space occupying lesions. (wikipedia.org)
  • Cancerous
  • In order for a cell to become cancerous it must undergo a significant number of alterations to its DNA sequence. (wikipedia.org)
  • spheroid
  • Low c-MYC activation increased spheroid formation in p53-deficient tumor cells, whereas p53-dependent effects were blunted in the absence of c-MYC overexpression. (aacrjournals.org)
  • mutations
  • Strikingly, these cells can also initiate gliomagenesis after acquiring the same oncogenic mutations which were found in human brain tumor patients. (dkfz.de)
  • This cell model suggests these mutations could occur to any cell in the body resulting in a cancer. (wikipedia.org)