• motility
  • Class I genes code for structural proteins that effect changes in epidermal cell shape and motility, including zipper , coracle , canoe and myospheroid . (sdbonline.org)
  • migrate
  • These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule. (stanford.edu)
  • suggests
  • These early crest cells are thought to be multipotent, and only later acquire their fates from their migratory environments, but a growing body of evidence suggests that many crest cells may be specified much earlier. (biologists.org)
  • signals
  • It remains undetermined whether the survival of enteric neurons depends on extracellular survival signals in vivo and, if so, whether the absence of such factors results in the activation of conserved molecular and morphological death pathways. (biologists.org)
  • Motor nerves are nerves that convey signals from the central nervous system to muscles and internal organs. (neurohacker.com)
  • Thus, the same signals that induce neural crest cells may also specify their future migration patterns and fates within the embryo. (biologists.org)
  • progenitor
  • We decided to opt for single-cell approaches so as to address the contribution of an individual progenitor to the spatial development and function of the ENS at both the cellular and molecular level. (biologists.com)
  • mutant embryos
  • Transcription of these targets is abolished in leading edge epidermal cells in hep (DJNKK), bsk (DJNK) and Jra (DJun) mutant embryos, and expanded in embryos overexpressing either activated c-Jun or wild-type DJun. (sdbonline.org)
  • development
  • It is now known that these cell types are essential in the maintenance of the neuronal network, in neuronal migration during development and in the generation of myelin. (scholarpedia.org)
  • Early in the evolution of CNS, and during development, such cells were devoid of any plasmalemmal extensions. (scholarpedia.org)
  • These include mechanisms activated during normal development and systems for detecting and responding to foreign or unwanted genetic activity. (stanford.edu)
  • The novel protein encoded by raw is required for restriction of DJNK signaling to leading edge epidermal cells as well as for proper development of the amnioserosa. (sdbonline.org)
  • apoptosis
  • Enteric neuron death induced by GFR α 1 inactivation is not associated with the activation of common cell death executors, caspase-3 or -7, and lacks the morphological hallmarks of apoptosis, such as chromatin compaction and mitochondrial pathology. (biologists.org)
  • TUNEL labeling of dying cells in mutants revealed a transient period of apoptosis in crest cells prior to and during their migration. (biologists.org)
  • fates
  • Molecular mechanisms that control the differentiation of many of these derivatives have been studied extensively, but less is known about the early events that induce neural crest cells and specify their fates. (biologists.org)
  • dorsal
  • In an effort to distinguish between these structural and instructive models and to understand better the role of Raw in dorsal closure, epidermal morphology and signaling was examined Epidermal cell elongation, a hallmark of dorsal closure, is thought to be driven by the movement of a myosin motor with a filamentous actin (F-actin) substrate in leading edge cells. (sdbonline.org)
  • The fact that F-actin accumulates normally in leading edge epidermal cells and that these cells can elongate in animals harboring either hypomorphic or amorphic raw alleles indicates that dorsal closure initiates properly in raw mutants. (sdbonline.org)
  • Mosaic
  • Mosaic analysis, using cell transplantation, demonstrated that neural crest defects in low are cell autonomous and secondarily cause disruptions in surrounding mesoderm. (biologists.org)
  • several
  • The ENS is layered in close apposition to contractile sheets of smooth muscle cell syncytia, thereby complicating several experimental approaches to a large extent. (biologists.com)
  • control
  • It also executes and transmits orders arising from the CNS to all other organs and systems, including motor control. (neurohacker.com)
  • Associated with the plasmalemma (but also with other intracellular elements) are transmembrane macromolecules that control the functionality of nerve cells (voltage and ligand activated ionic channels, ionic pumps, non-gated 'leakage' channels) and the machinery that keeps the cells alive by continuously taking up and replacing the molecular modules that constitute the cell's functional matrix. (scholarpedia.org)
  • roles
  • Much of the current effort in the lab is directed toward a molecular understanding of the RNAi machinery and its roles in the cell. (stanford.edu)
  • developmental
  • Developmental transitions, environmental shifts, and pathogenic invasions lend a dynamic character to both the genome and its activity pattern.We study a variety of natural mechanisms that are utilized by cells adapting to genetic change. (stanford.edu)
  • mechanisms
  • our categorizations of a specific system as using intrinsic or extrinsic/stochastic mechanisms below reflect either the biased use of one mechanism over the other or that our understanding of one mechanism is more complete than our understanding of the other in that system. (springer.com)
  • In reviewing findings from each system, we first describe the established relationships between cell lineage or birth timing and wiring specificity, and then summarize potential mechanisms at the molecular and cellular levels underlying such regulation. (springer.com)
  • Our lab studies the mechanisms by which cells and organisms respond to genetic change. (stanford.edu)
  • functions
  • One of our goals is to use genetic approaches in zebrafish to discover new genes with essential functions in the glial cells that form the myelin sheath, which allows for rapid axonal conduction in vertebrates. (stanford.edu)
  • cellular
  • Indication, Collection, and Laboratory Processing of Cytologic Samples -- The Cellular and Acellular Components of the Urinary Sediment -- The Cytologic Makeup of the Urinary Sediment According to the Collection Technique -- Cytologic Manifestations of Benign Disorders Affecting Cells of the Lower Urinary Tract -- Tumors and Related Conditions of the Bladder and Lower Urinary Tract -- Urine-Based Assays Complementing Cytologic Examination in the Detection of Urothelial Neoplasm. (stanford.edu)
  • biology
  • Laboratory methods in cell biology : biochemistry and cell culture. (stanford.edu)
  • Cell biology spans among the widest diversity of methods in the biological sciences. (stanford.edu)
  • This new volume of Methods in Cell Biology covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as transfection, cell enrichment and magnetic batch separation. (stanford.edu)
  • Covers the most important laboratory methods in cell biology Chapters written by experts in their fields. (stanford.edu)
  • Laboratory methods in cell biology : imaging. (stanford.edu)
  • different
  • Simply put - It is a very challenging system for various different reasons. (biologists.com)
  • The membranous system bounds and defines different intracellular compartments and includes the outer cell membrane (the plasmalemma) that encompasses the global compartment defining cellularity itself. (scholarpedia.org)
  • lines
  • It helps one to read the lines of communication that are built into the system for its proper functioning. (biologists.com)
  • DNA and RNA are extracted from the selected cell lines and cDNA is generated. (jove.com)
  • allows
  • The anatomical variation of these neurons is large, but the general morphology and their electrical and ligand dependant responsiveness allows these cells to be classed as neurons (coined in 1891 by Wilhelm von Waldeyer). (scholarpedia.org)
  • questions
  • From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way! (stanford.edu)
  • At the root of these studies are questions of how a cell can distinguish 'self' versus 'nonself' and 'wanted' versus 'unwanted' gene expression. (stanford.edu)
  • activation
  • The naturally occurring fusion of the transcriptional activation domain of E2A with PBX1 creates an oncoprotein implicated in human pre-B-cell leukemias. (sdbonline.org)