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Alveolar Bone LossAlveolar ProcessPeriodontitisBacteroidaceae InfectionsTooth CervixMaxillary DiseasesPeriodontal DiseasesBone and BonesBone ResorptionPeriodontiumPorphyromonas gingivalisPeriodontal LigamentMandibleRadiography, BitewingPhotography, DentalGingivaBone RemodelingAggregatibacter actinomycetemcomitansBone DensityPeriodontal PocketChronic PeriodontitisActinobacillus InfectionsTooth SocketMaxillaMacrophages, AlveolarAlveoloplastyDisease Models, AnimalRANK LigandLigationRats, WistarRandom AllocationBone RegenerationPulmonary AlveoliTooth MovementOsteonectinOsteoclastsOsteoporosisTooth EruptionMolarDental CementumBone Diseases, MetabolicBone DevelopmentFusobacterium nucleatumX-Ray MicrotomographyBone MatrixAdhesins, BacterialHemagglutininsBone MarrowOsteogenesisAlveolar Bone GraftingBone TransplantationToothBacteroidesBone DiseasesBone Marrow CellsBone NeoplasmsTooth ExtractionOsteoblastsRadiography, DentalPeriodontal Attachment LossGingival Crevicular FluidTooth RootTime FactorsMandibular DiseasesDental ImplantsTooth MobilityPulmonary Alveolar Proteinosis
PorphyromonasPeriodontitisExtent of alveolar bone lossBacteriaCementumSubcutaneous chamber modelInflammationInfectionSignificantlyHuman gingival fibroblastsGingivaMurineTeethResorptionGingival fibroblastsNucleatumAntibodiesAntibodyClinicalLipopolysaccharideRadiographic examinationDestructionTissueConcentrationProteinConclusionsInhibitorRgpACytokinesPathologicBacterialGingipainGingivitisSevereOral bone lossEruptionOrganismSurvivalRegeneration
Porphyromonas29
Periodontitis21
  • This response likely contributes to the inflammatory nature of periodontitis and is involved in tissue and bone destruction. (wikipedia.org)
  • Periodontitis is a serious and progressive disease that effects the tissues and the alveolar bone that support the teeth. (colgate.com)
  • These data demonstrate a previously unrecognized role for IL-33 in exacerbating bone loss in a RANKL-dependent manner in the context of bacterial infection and suggest that this pathway may be amenable to manipulation as a novel therapeutic target in periodontitis. (gla.ac.uk)
  • The alveolar bone loss induced by oral mixed infection was evaluated by micro-CT using the experimental periodontitis model. (huji.ac.il)
  • Conclusions: While vaccination produced specific antibodies and suppressed the inflammatory response, it failed to prevent or reduce the progression of experimental periodontitis induced by mixed infection with P. gingivalis and F. nucleatum. (huji.ac.il)
  • In periodontitis, however, the development of periodontal pockets as a result of breakdown of the bone and soft-tissues supporting the teeth, creates a new subgingival niche that promotes growth of bacterial species suited to the environment. (biomedcentral.com)
  • These results suggest that endothelin plays an important role in P. gingivalis-mediated periodontitis. (elsevierpure.com)
  • Secondly, P. gingivalis-induced periodontitis was utilized to investigate necroptosis related-periodontopathogensis. (engreen.com.cn)
  • Positive staining of phosphorylated MLKL in mice periodontitis biopsies was detected to a higher degree, while larger amount of alveolar bone loss was observed in MLKL (-) group comparing to those in the MLKL (+) group. (engreen.com.cn)
  • These findings may suggest that P. gingivalis play essential roles in necroptosis process during periodontitis, and our research may shed light on the further work on the related periodontopathogenesis investigation. (engreen.com.cn)
  • B cell-deficient mice were protected from the alveolar bone loss normally induced in the model of periodontitis. (gla.ac.uk)
  • Periodontitis includes various degenerative and inflammatory states of the tissue surrounding the tooth, e.g., gingival, periodontal ligaments, cementum, and alveolar bone. (encyclopedia.pub)
  • Chronic periodontitis (PD), which is the world's commonest inflammatory disease often resulting in destruction of alveolar bone and tooth loss, has been suggested as an environmental determinant for the occurrence and severity of RA [ 7 - 9 ]. (biomedcentral.com)
  • Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. (lookformedical.com)
  • Periodontal and bacteriological examinations after treatment revealed regression of the localized periodontitis with bone regeneration. (biomedcentral.com)
  • Asymptomatic patients with localized severe periodontitis may clear a screening test before orthodontic treatment but develop acute symptoms with bone resorption during orthodontic treatment. (biomedcentral.com)
  • Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. (biomedcentral.com)
  • It was shown, that in patients with severe periodontitis, there was a significant reduction in serum albumin concentration and an increase in loss of attachment [ 5 ] . (encyclopedia.pub)
  • RIBEIRO, R.A. Disodium chlodronate prevents bone resorption in experimental periodontitis in rats. (edu.br)
  • HAYNES, D.R. Mechanisms and control of pathologic bone loss in periodontitis. (edu.br)
  • ROCHA, F.A. Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. (edu.br)
Extent of alveolar bone loss2
  • It was also found that the extent of alveolar bone loss was significantly greater among subjects with ACS. (sciencedaily.com)
  • 6]. The extent of plaque, scales, inflammation and bleeding of gingival, depth of periodontal pockets, and the extent of alveolar bone loss have also been examined in such studies [7]. (bvsalud.org)
Bacteria8
  • P. gingivalis invades gingival epithelial cells in high numbers, in which case both bacteria and epithelial cells survive for extended periods of time. (wikipedia.org)
  • The elimination of these bacteria with scaling and root planing can promote bone healing and initiate an increase in radiographic bone density. (ui.ac.id)
  • Animals immunized against either bacteria following a mixed infection with P. gingivalis and F. nucleatum, showed decreased TNFα (but not IL-1β) levels as compared with non-immunized animals. (huji.ac.il)
  • Some of the microbiome communities are comprised of pathogenic bacteria that cause tooth decay, gum inflammation, and tooth loss. (hansendentistryapex.com)
  • The amount of oral bacteria was two times higher in the ACS group for the combination of the bacteria streptococci spp, P. gingivalis, T. forsythia and T. denticola. (sciencedaily.com)
  • This chronic inflammatory disease results from the response to bacteria in dental biofilm and may remain confined to the gingival tissues with minimal tissue alterations or this disease may progress to extreme periodontal destruction with the loss of attachment and alveolar bone. (bvsalud.org)
  • The inflammation is primarily localized to the gum but penetrates deeper if left untreated, creating pockets that host anaerobic bacteria which can then lead to further erosion of the tooth attachment and eventually to tooth loss. (encyclopedia.pub)
  • This method is used to eliminate or inhibit gingival bacteria flora, decrease inflammation, and help to discontinue bone desorption. (encyclopedia.pub)
Cementum3
Subcutaneous chamber model2
  • The cytokine response to mixed infection with P. gingivalis and F. nucleatum was evaluated using the subcutaneous chamber model. (huji.ac.il)
  • Firstly, C57BL/6 mice were injected with P. gingivalis in the subcutaneous chamber model. (engreen.com.cn)
Inflammation6
  • 5] Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. (edu.pl)
  • Rheumatoid arthritis (RA), a complex chronic inflammatory disease with a worldwide prevalence of 0.5-1.0 % [ 1 ], is characterized by production of anti-citrullinated protein/peptide antibodies (ACPA) in the majority of patients and persistent inflammation in the synovial tissue of the joints leading to destruction of cartilage and bone [ 2 - 4 ]. (biomedcentral.com)
  • Inflammation of gum tissue ( GINGIVA ) without loss of connective tissue. (lookformedical.com)
  • Inflammation and loss of connective tissues supporting or surrounding the teeth. (lookformedical.com)
  • Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. (lookformedical.com)
  • COCHRAN, D.L. Inflammation and bone loss in periodontal disease. (edu.br)
Infection11
  • P. gingivalis infection has been linked to Alzheimer's disease and rheumatoid arthritis. (wikipedia.org)
  • Conversely, P. gingivalis infection-induced alveolar bone loss was attenuated in mice lacking ST2. (gla.ac.uk)
  • However, the vaccination did not change the level of mixed infection-induced alveolar bone loss when compared with non-immunized animals. (huji.ac.il)
  • These findings suggest that MAbs against 40-kDa OMP may be useful for the development of passive immunotherapy and for assessing treatment for periodontal diseases caused by P. gingivalis infection. (tmu.edu.tw)
  • Work in this area provides experimental evidence that P. gingivalis is a potential risk factor for atherosclerosis, and that this infection-elicited acceleration can be prevented through immunization. (ufl.edu)
  • Furthermore, collaborative studies have begun to explore P. gingivalis interactions with adipocytes, as well as integrative studies to investigate aspects of P. gingivalis / HIV co-infection. (ufl.edu)
  • Moreover, P. gingivalis infection has been shown to induce the production of ET-1 along with other inflammatory cytokines. (elsevierpure.com)
  • Periodontal disease is a chronic bacterial infection that affects the gingiva and bone that supports the teeth. (bvsalud.org)
  • Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. (jax.org)
  • Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. (jax.org)
  • These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. (jax.org)
Significantly2
  • The MAbs reacted with r40-kDa OMP, the outer membrane fraction, vesicles, and P. gingivalis cell extracts, and significantly inhibited the hemagglutinating activities of the polymeric r40-kDa OMP as well as of P. gingivalis vesicles. (tmu.edu.tw)
  • Anti- P. gingivalis antibody concentrations were significantly increased in RA patients compared with controls, and were detectable years before onset of symptoms of RA, supporting an aetiological role for P. gingivalis in the development of RA. (biomedcentral.com)
Human gingival fibroblasts1
  • It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in the presence of antibiotics. (wikipedia.org)
Gingiva2
Murine3
  • To investigate cell-free protein synthesis (CFPS) as a platform to produce vaccinable targets suitable for efficacy testing in a P. gingivalis-induced murine oral bone loss model. (nih.gov)
  • Alveolar bone level, serum antibody, and lymphocyte responses were assessed in the murine model. (gla.ac.uk)
  • Interplay between P. gingivalis, F. nucleatum and A. actinomycetemcomitans in murine alveolar bone loss, arthritis onset and progression. (mdbioproducts.com)
Teeth7
  • It usually manifests as a worsening of gingivitis and then, if untreated, with loosening and loss of teeth. (merckmanuals.com)
  • Left to run amok, it will destroy gum tissue and the alveolar bone that supports your teeth. (hansendentistryapex.com)
  • The microenvironment of the oral cavity may change according to the age of the patient, eruption or loss of teeth, or active other conditions (eg, caries, periodontal disease). (medscape.com)
  • This includes loss of alveolar bone, apical migration of junctional and pocket epithelium and eventual pathological exfoliation of periodontally compromised teeth [9,10]. (oatext.com)
  • Periodontal diseases are inflammatory diseases affecting the periodontium, causing progressive loss of the bone around the teeth. (bvsalud.org)
  • If left untreated, it can result in loose teeth and eventually teeth loss. (bvsalud.org)
  • Orthodontic treatment involves movement of teeth by compression and resorption of the alveolar bone using orthodontic forces. (biomedcentral.com)
Resorption4
  • An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption. (lookformedical.com)
  • PD and PNXPD groups demonstrated greater alveolar bone resorption due to a higher activity of the osteoclasts compared to the osteoblasts evidenced by the increase of the resorption marker, and decrease of the formation marker as well as histomorphometric results. (perioiap.org)
  • In groups with PD, melatonin protected the alveolar bone resorption. (perioiap.org)
  • Therefore, these results demonstrate that melatonin is efficient in controlling both alveolar bone resorption and TNF-α in rats (PD and PNX), demonstrating its local and systemic importance. (perioiap.org)
Gingival fibroblasts1
  • Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: Clinical implications for alveolar bone loss in denture wearers. (tohoku.ac.jp)
Nucleatum2
  • Materials and Methods: Mice were immunized against either P. gingivalis or F. nucleatum. (huji.ac.il)
  • A model multi-species sub-gingival community containing Fusobacterium nucleatum, Streptococcus constellatus , Parvimonas micra with wild type or isogenic mutants of P. gingivalis was then created and growth and proteolytic activity in serum assessed as above. (biomedcentral.com)
Antibodies5
  • High levels of specific antibodies can be detected in patients harboring P. gingivalis. (wikipedia.org)
  • They have the ability to cleave subclass 1 and 3 IgG antibodies as well as proinflammatory cytokines such as IL-1β, IL-2, IL-6, TNF-α and IL-8 in regions of high P. gingivalis concentration, impairing host immune response function. (wikipedia.org)
  • In the present study, in order to clarify the pathological role of 40-kDa OMP and develop passive immunotherapy, we examined the inhibitory effect of monoclonal antibodies (MAbs) against r40-kDa OMP on the hemagglutinating activity of P. gingivalis vesicles. (tmu.edu.tw)
  • The aim of this study was to investigate whether anti- P. gingivalis antibodies pre-date symptom onset and ACPA production. (biomedcentral.com)
  • Antibodies against P. gingivalis virulence factor arginine gingipainB (RgpB), and a citrullinated peptide (CPP3) derived from the P. gingivalis peptidylarginine deiminase enzyme, were analysed by ELISA. (biomedcentral.com)
Antibody3
  • Serum levels of protein-specific antibody were measured by ELISA, and oral bone levels were defined by morphometrics. (nih.gov)
  • Furthermore, an affinity-purified antibody against r40-kDa OMP inhibited the hemagglutinating activity of P. gingivalis vesicles. (tmu.edu.tw)
  • We have shown that ACPA precede RA onset by years, and that anti- P. gingivalis antibody levels are elevated in RA patients. (biomedcentral.com)
Clinical3
  • A total of 40 subjects gave informed consent, and underwent clinical examination, radiographic examination for bone density, and laboratory examination for the load of Pg and Td using RT-PCR. (ui.ac.id)
  • Clinical attachment loss corresponded to pocket probing depths. (uni-frankfurt.de)
  • Alveolar bone response to light-force tipping and bodily movement in maxillary incisor advancement: A prospective randomized clinical trial. (vcu.edu)
Lipopolysaccharide1
  • Stimulation of HGECs with P. gingivalis or P. gingivalis lipopolysaccharide increased the expression of ET-1 and ETA suggesting the activation of the endothelin signaling pathway. (elsevierpure.com)
Radiographic examination1
Destruction1
  • Targeting the RANKL pathway by osteoprotegerin administration abrogated periodontal bone destruction in P. gingivalis-infected, IL-33-treated mice. (gla.ac.uk)
Tissue3
  • Tissue may be rapidly destroyed, risking tooth loss. (merckmanuals.com)
  • High pressure oxygen teraphy (HBOT), teraphy with breathing using 100% oxygen in high pressure chamber (more than 1 ATA), can accelerate alveolar bone healing as part of health tissue regeneration Purpose: To prove the effects of high pressure oxygen teraphy in the increasing of alveolar bone osteocytes of rat with DM induced by P.g. (hangtuah.ac.id)
  • By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
Concentration1
Protein6
  • Recombinantly generated P. gingivalis minor fimbriae protein (Mfa1), RgpA gingipain hemagglutinin domain 1 (HA1), and RgpA gingipain hemagglutinin domain 2 (HA2) were combined in equivalent doses in adjuvants and injected intramuscularly to immunize mice. (nih.gov)
  • Recombinantly generated P. gingivalis proteins possessed high fidelity to predicted size and elicited protein-specific IgG following immunization. (nih.gov)
  • We previously succeeded in gene cloning the 40-kDa outer membrane protein (OMP) from P. gingivalis 381. (tmu.edu.tw)
  • In the multi-species consortium, growth was facilitated by the wild-type and Rgp-expressing strains of P. gingivalis, suggesting that Rgp is involved in delivery of nutrients to the whole community through degradation of complex protein substrates in serum. (biomedcentral.com)
  • Therapeutic effects of anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor treatment in psoriasis and arthritis. (mdbioproducts.com)
  • Dec. 23, 2021 Blocking function of a blood-clotting protein, called fibrin, prevented bone loss from periodontal (gum) disease in mice, according to new research. (sciencedaily.com)
Conclusions1
  • In conclusions, Scaling and root planing decrease the amount of Pg and Td and increase the radiographic bone density. (ui.ac.id)
Inhibitor1
  • The inhibition of the endothelin receptor-mediated signaling pathway with the dual receptor inhibitor, bosentan, partially ameliorated alveolar bone loss and immune cell infiltration. (elsevierpure.com)
RgpA1
  • The P. gingivalis genes encoding RgpA, Kgp, and hemagglutinin A (HagA) were strongly expressed after incubation with T. denticola. (wikipedia.org)
Cytokines1
  • CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. (jax.org)
Pathologic1
Bacterial2
  • The hemagglutinin adhesion domain-containing proteins act to increase adhesive capacities of P. gingivalis with other bacterial species. (wikipedia.org)
  • Adherence of P. gingivalis strains to serum-coated surfaces was studied with confocal microscopy and 2D-gel electrophoresis of bacterial supernatants used to investigate extracellular proteins. (biomedcentral.com)
Gingipain2
  • Arg-gingipain (Rgp) and lys-gingipain (Kgp) are endopeptidase enzymes secreted by P. gingivalis. (wikipedia.org)
  • Whereas they are constitutively expressed by P. gingivalis in nutrient broth, gingipain expression in the model periodontal pocket environment (serum) appeared to be orchestrated through signaling to P. gingivalis from other members of the community, a phenomenon which then promoted growth of the whole community. (biomedcentral.com)
Gingivitis1
  • While the more severe forms of periodontal disease associated with alveolar bone loss are less frequent, gingivitis is widespread at all ages and is the most common form of periodontal disease. (encyclopedia.pub)
Severe2
  • Currently, the lack of robust tools to identify the individuals with a high degree of risk for tooth loss means that even people who may not develop severe disease undergo intensive treatment, placing a significant burden on healthcare budgets in the developed world. (biomedcentral.com)
  • The extent of bone loss was more severe in the ACS group than in the non-ACS group. (sciencedaily.com)
Oral bone loss3
  • Although prior immunization approaches targeting P. gingivalis have reported variable success in limiting facets of disease such as oral bone loss, it remains that a vaccine for this disease may be attainable. (nih.gov)
  • Importantly, immunization with the vaccine cocktail protected from P. gingivalis elicited oral bone loss. (nih.gov)
  • oral bone loss. (nih.gov)
Eruption1
Organism1
  • P. gingivalis can also degrade transferrin within host cells which provides the organism with an abundant iron source needed to perform multiple cellular functions. (wikipedia.org)
Survival1
  • Arg-gingipains have been found to play a key role in the collection of nutrients for P. gingivalis survival. (wikipedia.org)
Regeneration1