Germ cell ovarian sex cord stromal sertoli cell tumor. Medical search. Frequent questions

The 5-year survival rate is 96% if the tumor is confined to the ovary and 63% if extension occurs beyond the ovaries. (medscape.com)
Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin. (medscape.com)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
An ovarian cyst is an abnormal growth of tissue that forms on the surface of the ovary and includes fluid. (cancer.net)
Table 13-1 THE 2020 WHO CLASSIFICATION OF GERM CELL TUMORS OF THE OVARY Teratomas, Mature and Immature Mature teratoma Immature teratoma Primitive Germ Cell Tumors Dysgerminoma Yolk sac tumor Embryonal carcinoma Nongestational choriocarcinoma Mixed germ. (arppress.org)
Women with ovarian cancer who are able to keep one ovary can have a baby after treatment. (uchealth.org)
In this review, we highlighted some of the main gene networks and regulatory mechanisms involved in the plasticity of sex-determining pathways that help to establish a functional ovary that can nurture the follicles to generate a good ovarian reserve, both in quantity and quality. (lidsen.com)
Polycystic Ovary Syndrome (PCOS) and Premature Ovarian Insufficiency (POI), were selected and briefly discussed in this review. (lidsen.com)
The most common human ovarian pathologies that cause infertility are Polycystic Ovary Syndrome (PCOS) and Premature Ovarian Insufficiency (POI), and both pathologies have been briefly discussed at the end of the review. (lidsen.com)
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)
Krukenberg tumor , also known as carcinoma mucocellulare , refers to the "signet ring" subtype of metastatic tumor to the ovary . (radiopaedia.org)
The stomach followed by colon are the two most common primary tumors to result in ovarian metastases , pursued by the breast, lung, and contralateral ovary. (radiopaedia.org)
The tumors represent 5-10% of all ovarian tumors and up to 50% of all metastatic tumors to the ovary. (radiopaedia.org)
Krukenberg tumors are metastatic tumors to the ovary that contain well-defined histological characteristics (mucin-secreting "signet ring" cells) and usually originate in the gastrointestinal tract 4 . (radiopaedia.org)
There are a variety of metastatic carcinomas to the ovary that can mimic primary ovarian tumors 4 . (radiopaedia.org)
With sex cord-stromal ovarian cancer , Ovarian refers to " ovary ", of which women have two that sit along either side of the uterus . (osmosis.org)

The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
Ovarian cancer describes cancer in women that begins in the different cells of the ovaries (they produce eggs), fallopian tubes or peritoneum, which determines the type of ovarian cancer. (uchealth.org)
Recent research in women with ovarian cancer shows that cancer actually starts in the fallopian tubes and spreads to the surface of the ovaries and beyond. (uchealth.org)
No. A hysterectomy does not remove your ovaries, so you may still be at risk for ovarian cancer. (uchealth.org)
Cancerous tumors from several organ systems, such as gastrointestinal and female genital tract, could spread to the ovaries [2]. (symptoma.com)
Lymphatic spread of tumor is faster and more common from the stomach to the ovaries than from the colon while the vascular spread is higher from the colon than from the stomach [2]. (symptoma.com)
Krukenberg tumors are associated with bilateral, asymmetrical enlargement of the ovaries without peritoneal adhesions and deposits while metastases from other tumors are embedded within the ovarian capsule or in the peritoneum [1]. (symptoma.com)
The exact mechanism of primary tumor metastasize to the ovaries is unclear. (radiopaedia.org)

in other instances, the granulosa cells remain productive, with prolonged secretion of estrogen. (medscape.com)
Follicle cysts are lined with an inner layer of granulosa cells and an outer layer of theca interna cells. (medscape.com)
follicle-like spaces (right) are also apparent, which are typical of juvenile granulosa cell tumor. (arppress.org)
ADULT GRANULOSA CELL TUMOR A: Adult granulosa cell tumor with extensive he. (arppress.org)
ADULT GRANULOSA CELL TUMOR Figure 12-10 ADULT GRANULOSA CELL TUMOR A: Adult granulosa cell tumor with extensive hemorrhage. (arppress.org)
C: An adult granulosa cell tumor that recurred in the retroperitoneum as a large solid mass. (arppress.org)
Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
Bjorkholm E, Silfversward C. Granulosa- and theca-cell tumors. (cancercentrum.se)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
Each follicle is made up of an oocyte, which is an immature egg, surrounded by two types of cells - theca cells and granulosa cells. (osmosis.org)
Granulosa and theca cells work together to support follicle development. (osmosis.org)
Luteinizing hormone stimulates theca cells to generate androgens and follicle stimulating hormone stimulates granulosa cells to convert those androgens to estradiol using the enzyme aromatase. (osmosis.org)
The first main type of sex-cord stromal tumor is a granulosa-theca cell tumor. (osmosis.org)
Some of these tumors are granulosa-theca cell tumors and Sertoli-Leydig cell tumors. (osmosis.org)
Granulosa-theca cell tumors produce excess estradiol, which can cause very specific hormone-associated symptoms like uterine bleeding , breast tenderness, and early puberty in young girls. (osmosis.org)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
The estimated incidence of Krukenberg tumor is at approximately 0.16/100000 per year. (radiopaedia.org)
Features will favor towards a Krukenberg tumor if a concurrent gastric or colic mural lesion is seen. (radiopaedia.org)
The great majority of Krukenberg tumors are signet ring cell carcinomas arising in the stomach. (radiopaedia.org)
Therefore, Krukenberg tumors can occasionally show low or high signal intensity on T2-weighted images 5 . (radiopaedia.org)
Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)

The main neoplasms in the differential diagnosis of ovarian dysgerminoma are lymphoma/leukemia, yolk sac tumor , embryonal carcinoma , and Sertoli cell tumor. (medscape.com)
When present, embryonal cell carcinoma exhibits more nuclear hyperchromasia and nuclear pleomorphism, amphophilic cytoplasm, high mitotic index, and necrosis than ovarian dysgerminomas. (medscape.com)
The cells of embryonal carcinoma express CD30 and cytokeratin (strong, diffuse), whereas those of dysgerminoma do not. (medscape.com)
Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
CLEAR CELL CARCINOMA Figure 6-1 CLEAR CELL CARCINOMA An ovarian endometriotic cyst containing a mural nodule (A) or several nodules (B) is a classic appearance. (arppress.org)
Some tumors are almost entirely solid in appearance (C), while occasional tumors demonstrate focal carcinoma (mural nodule in cyst. (arppress.org)
MIXED ENDOMETRIOID AND CLEAR CELL CARCINOMA Figure 6-17 MIXED ENDOMETRIOID AND CLEAR CELL CARCINOMA The clear cell component (bottom) is histologically distinct from the endometrioid component (top). (arppress.org)
Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
CT appearances can be indistinguishable from primary ovarian carcinoma 2 . (radiopaedia.org)
Differentiation between primary and metastatic ovarian carcinoma is of great importance with respect to treatment and prognosis but may be very difficult based on imaging findings solely. (radiopaedia.org)

An endometrioid tumor exhibiting squamous differentiation. (nih.gov)

We don't use CT scans to biopsy an ovarian tumor, but we can use it to help biopsy a suspected metastasis in a procedure called a CT-guided needle biopsy. (uchealth.org)
Ovarian metastasis is not a rare condition and occurs secondary to malignancies originating from the stomach, colon , breast, endometrium, fallopian tubes , or cervix. (symptoma.com)
Ovarian metastasis accounts for up to 30% of all ovarian malignancies. (symptoma.com)
The discovery of a unique doorway that allows tumor cells into the blood stream opens new opportunities for the development of anti-metastasis therapeutics, said Dr. John Condeelis. (regenerativemedicine.net)
The site where these three cells come in direct and stable contact called a tumor microenvironment of metastasis, or TMEM is where tumor cells enter blood vessels. (regenerativemedicine.net)

In fact, dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years. (medscape.com)
Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
It is often difficult to differentiate from other ovarian neoplasms 1,4 . (radiopaedia.org)

These tumors mostly occur in women, although the disease also occurs in pseudohermaphrodites and patients with gonadal dysgenesis (see Complications). (medscape.com)
We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)
Second, networks of genes and hormones regulate the advancement of sex determination and gonad differentiation, known as the gonadal sex phase. (lidsen.com)
Serum AMH measurements are useful, together with testosterone determination, in the diagnosis of patients with ambiguous genitalia: both are low in patients with gonadal dysgenesis, including ovotesticular disorders of sex development, testosterone is low but AMH is in the normal male range or higher in patients with disorders of androgen synthesis, and both hormones are normal or high in patients with androgen insensitivity. (biomedcentral.com)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)

The effect is temporary but can last long enough to allow cancer cells to enter the blood stream escaping the primary tumor and traveling to distant metastatic sites. (regenerativemedicine.net)

This gives rise to the possibility of repairing some defects of testicular niche cells which may cause male infertility. (wikipedia.org)
Although germ cell tumors arise from primordial ovarian and testicular germ cells, the pathogenesis of the ovarian germ cell tumors is unknown. (medscape.com)
Epidemiological risk factors for TC are components of the testicular dysgenesis syndrome, which encompasses cryptorchidism, hypospadias, decreased spermatogenesis and impaired fertility [ 11-13 ] or disorders/differences of sex development [ 14 ]. (uroweb.org)
Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)
[1] Complications may include ovarian torsion , testicular torsion , or hydrops fetalis . (mdwiki.org)
Treatment of tailbone, testicular, and ovarian teratomas is generally by surgery. (mdwiki.org)

Percentages of malignant germ cell tumors. (medscape.com)
They further advised that because NUT protein appears to play a role in normal germ cell maturation, it may influence intestinal or hepatoid differentiation within malignant germ cell tumors. (medscape.com)

Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)

Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)
Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)

Incidence and occurrence of second primary tumors. (cancercentrum.se)

The occluding junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. (wikipedia.org)
Sertoli cells control the entry and exit of nutrients, hormones, and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site. (wikipedia.org)
A study that investigated nuclear protein in the testis (NUT) expression in ovarian germ cell tumors found that most malignant ovarian germ celll tumors express NUT protein, albeit focally. (medscape.com)
The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)

And these are the most common malignant stromal tumors and they're associated with middle-aged women. (osmosis.org)

Conversely, germ cell tumors (GCTs) are rare, comprising approximately 20% of all ovarian tumors, both benign and malignant. (medscape.com)
Approximately 3-5% of ovarian GCTs are malignant. (medscape.com)
To date, no racial predilection exists for ovarian germ cell tumors (GCTs). (medscape.com)
Most malignant post-pubertal GCTs originate from germ cell neoplasia " in situ " (GCNIS). (uroweb.org)

Pregnancy does not alter the prognosis of most ovarian malignancies, but complications such as torsion and rupture may increase the incidence of spontaneous abortion or preterm delivery. (medscape.com)

A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
Simple ovarian cysts are not cancerous. (cancer.net)

Yolk sac tumors may exhibit a solid pattern, simulating dysgerminoma, but other classic architectural patterns of yolk sac tumor (ie, reticular, microcystic, glandular, or Schiller-Duvall bodies) are also invariably present. (medscape.com)

NUT protein immunoreactivity in ovarian germ cell tumours. (medscape.com)
At diagnosis, 1-2% are bilateral and 90-95% of cases are germ cell tumours (GCT) [ 6 ]. (uroweb.org)

Sertoli cell proliferation and differentiation is mainly activated by FGF9, with which they also form a feedforward loop. (wikipedia.org)
Sertoli cells are also responsible for establishing and maintaining the spermatogonial stem cell niche, which ensures the renewal of stem cells and the differentiation of spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of spermatozoa in a process known as spermiation. (wikipedia.org)
Lines of differentiation distinguish germ cell tumors. (medscape.com)
[ 1 ] Primitive, unipotential germ cells are the precursors to ovarian dysgerminomas, whereas pleuripotential germ cells diverge along several lines of differentiation. (medscape.com)
An error during these developmental steps in females may lead to defective gonads, affecting the differentiation and/or function of the gonads and the development, differentiation, and maturity of the germ cells. (lidsen.com)

Though doctors are not certain of the cause of these tumors, they are generally attributed to changes in the body's homeostasis. (knowcancer.com)
The exact cause of these tumors is not known, but there are believed to be hereditary links. (knowcancer.com)

thyroid-stimulating hormone, and hCG are all known to affect Sertoli cell development and male reproductive health. (wikipedia.org)
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. (medscape.com)
Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. (medscape.com)
If the results of your pelvic exam or other tests suggest that you have ovarian cancer, you will meet with a gynecologic oncologist, who is specially trained in treating cancers of the female reproductive system. (uchealth.org)
While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
When managing such tumors, the physician must consider both potential fetal effects, as well as the potential loss of the patient's future reproductive capacity as a result of any chosen cancer therapy. (biomedcentral.com)

A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)

Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis (the production of sperm) as a structural component of the seminiferous tubules. (wikipedia.org)
Sertoli cells are specifically located in the convolutions of the seminiferous tubules, since this is the only place in the testes where spermatozoa are produced. (wikipedia.org)
Therefore, once spermatogenesis has begun, no more Sertoli cells are created, and their population within the seminiferous tubules is finite. (wikipedia.org)
Translocation of cells from the basal lamina to the lumen of the seminiferous tubules occurs by conformational changes in the lateral margins of the Sertoli cells. (wikipedia.org)
Varicoceles can lead to infertility by raising local temperature, which damages the Sertoli cells of the seminiferous tubules . (osmosis.org)

Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)
Instead, if a clinical suggestion of ovarian cancer is present, the patient should undergo laparoscopic evaluation or laparotomy, based on the presentation, for diagnosis and staging. (medscape.com)
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. (nih.gov)
This might affect the ovarian reserve and lead to the diagnosis of infertility later in life. (lidsen.com)
Diagnosis depends on imaging studies and can only be confirmed with a histopathological examination of the ovarian tissue specimen. (symptoma.com)
Ten (62.5%) of the ovarian cancer cases were diagnosed by ultrasonography during a prenatal checkup or at the time of initial pregnancy diagnosis. (biomedcentral.com)
Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)

See Ovarian Cancer and Borderline Ovarian Cancer for more information on these topics. (medscape.com)
Newer markers for ovarian cancer are on the horizon. (medscape.com)
In women desiring future fertility who have stage IA low-risk ovarian cancer, conservative surgical therapy is appropriate, provided that close follow-up can be maintained. (medscape.com)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Early ovarian cancer causes minimal, nonspecific, or no symptoms. (medscape.com)
Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. (medscape.com)
The US Preventive Services Task Force (USPSTF) recommends against screening (with serum CA125 level or transvaginal ultrasonography) for ovarian cancer in the general population. (medscape.com)
Routine imaging is not required in all patients in whom ovarian cancer is highly suggested. (medscape.com)
This is the first page of Cancer.Net's Guide to Ovarian, Fallopian Tube, and Peritoneal Cancer. (cancer.net)
In this guide, this group of cancers is referred to as "ovarian/fallopian tube cancer" because peritoneal cancer is relatively rare. (cancer.net)
When the term "ovarian cancer" is used, it includes both fallopian tube and peritoneal cancers because it may be unclear where the cancer started. (cancer.net)
These types of cancer begin when healthy cells in these areas change and grow out of control, forming a mass called a tumor. (cancer.net)
Just as with ovarian cancer, some peritoneal cancers may begin in the fallopian tubes and spread from the end of the fallopian tube into the peritoneal cavity. (cancer.net)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
Can I have a baby with ovarian cancer? (uchealth.org)
Does a hysterectomy cure ovarian cancer? (uchealth.org)
Can my doctor tell if I have ovarian cancer through a pelvic exam? (uchealth.org)
A pelvic exam is an important part of detecting ovarian cancer, but it alone is not definitive. (uchealth.org)
If there is reason to suspect you have ovarian cancer based on your symptoms and/or physical exam, your doctor will order some tests to check further. (uchealth.org)
For ovarian cancer, the biopsy is most commonly done by removing the tumor during surgery. (uchealth.org)
In rare cases, a suspected ovarian cancer may be biopsied during a laparoscopy procedure or with a needle placed directly into the tumor through the skin of the abdomen. (uchealth.org)
If you have been diagnosed with an epithelial ovarian cancer, we will recommend that you get genetic counseling to help you decide if you should be tested for a mutation in the BRCA1 or BRCA2 gene. (uchealth.org)
Might be done to determine whether ovarian cancer has metastasized to the lungs. (uchealth.org)
Helps us see if ovarian cancer has spread. (uchealth.org)
MRI scans are not used often to look for ovarian cancer, but they are particularly helpful to examine the brain and spinal cord where cancer could spread. (uchealth.org)
So a sex cord-stromal ovarian cancer is a type of tumor that develops from either ovarian follicle cells or connective tissue cells . (osmosis.org)
Sex cord-stromal ovarian cancer is a type of tumor that develops from either ovarian follicle cells, or connective tissue cells . (osmosis.org)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Tumors or cancer of the SKIN. (lookformedical.com)
Researchers have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body. (regenerativemedicine.net)
The second stimulant activates the dendritic cells, which then instruct T cells, the immune system's soldiers, to kill cancer cells and spare non-cancer cells. (regenerativemedicine.net)
This immune army learns to recognize features of the tumor cells so it can seek them out and destroy them throughout the body, essentially turning the tumor into a cancer vaccine factory. (regenerativemedicine.net)
The in situ vaccine is also being tested in the lab in liver and ovarian cancer. (regenerativemedicine.net)
Using real-time, high-resolution imaging, scientists have identified how a doorway in the blood vessel wall allows cancer cells to spread from breast tumors to other parts of the body. (regenerativemedicine.net)
The Einstein-Montefiore researchers previously found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell s ability to invade. (regenerativemedicine.net)
The discovery was made using intravital high-resolution two-photon microscopy to image primary breast cancer tumors in mice and human xenografts (human breast cancer tissue grafted into mice). (regenerativemedicine.net)

Arise from sex cord cells (e.g. (amboss.com)
Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)

The most commonly occurring GCT is the dysgerminoma, which accounts for approximately 2% of all ovarian cancers . (medscape.com)
Although most ovarian cancers occur during the menopausal and perimenopausal years (ie, 50-59 y), dysgerminomas tend to occur frequently in the pediatric population. (medscape.com)
Based on this updated knowledge, when discussing contraception to avoid future pregnancy, some doctors recommend removal of the fallopian tubes, rather than tying or banding the tubes, in order to lower the risk of ovarian/fallopian tube cancers. (cancer.net)
Some ovarian cancers are linked to mutations in these or other genes. (uchealth.org)
Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C. Intrauterine factors and risk of nonepithelial ovarian cancers. (cancercentrum.se)
Tumors or cancers of the KIDNEY. (lookformedical.com)

Twaalhoven 1999,Houck 2000, Tempfer 2007, Brun 2008 Accuracy for malignancy of epithelial OvTu 90-94% Accuracy for borderline tumors approx. (symptoma.com)

One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)

Typically, germ cells are encapsulated at birth within the primordial follicle. (medscape.com)

Sertoli-Leydig cell tumors can secrete excess testosterone , which can cause women to have more masculine features like hirsutism , which is increased hair growth. (osmosis.org)

Clinical manifestations are due to the primary tumor as well as due to the metastases. (symptoma.com)
A majority of patients with ovarian metastases may be asymptomatic . (symptoma.com)
Lower limb deep vein thrombosis and paraneoplastic syndromes are some of the other manifestations in individuals with ovarian metastases. (symptoma.com)

patients often present with ovarian torsion. (medscape.com)
Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)

Hypertrophy of the ovarian tissue may result in endocrine manifestations such as virilization [6]. (symptoma.com)
The term sex cord refers to an embryonic structures that develop into ovarian follicles and stromal cells are the connective tissue of any organ. (osmosis.org)
If any of those cells starts to divide uncontrollably, it can either form a benign tumor which means that it doesn't invade nearby tissue or spread to other parts of the body , or it can be a malignant tumor which means that it can invade nearby tissue and spread to other parts of the body . (osmosis.org)
Under the microscope, these tumors classically develop little fluid pockets scattered throughout the tissue that are called Call-Exner bodies. (osmosis.org)
A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
adenomatoid t. a small benign t. of the male epididymis and female genital tract , consisting of fibrous tissue or smooth muscle enclosing anastomosing glandlike spaces containing acid mucopolysaccharide lined by flattened cells that have ultra-structural characteristics of mesothelial cells. (en-academic.com)
brown t. a mass of fibrous tissue containing hemosiderin-pigmented macrophages and multinucleated giant cells, replacing and expanding part of a bone in primary hyperparathyroidism . (en-academic.com)
neoplastic cells are frequently palisaded at the periphery of the small groups, and the latter have a tendency to infiltrate surrounding tissue . (en-academic.com)
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)

The tumors result from either failure of a dominant mature follicle to rupture or failure of an immature follicle to undergo the normal process of atresia. (medscape.com)
Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)

An ovarian dysgerminoma consists of primitive, undifferentiated germ cells. (medscape.com)
Sertoli cell tumors may be mistaken for dysgerminoma when tubules are indistinct and/or solid, especially if they are poorly fixed. (medscape.com)
Although these tumors are thought to be hormonally inert, at least one case of precocious puberty occurring in association with ovarian dysgerminoma has been reported. (medscape.com)
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. (medscape.com)

Large-cell lymphomas typically occur bilaterally. (medscape.com)
Paragangliomas tumors (sometimes referred to as glomus, as glomus cells are the place of origin) are a typically benign abnormal cell growth. (knowcancer.com)
[5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)

Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)

Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)

Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
[18] There also may be a cultural difference, with fetiform teratoma being reported more often in ovarian teratomas (by gynecologists) and fetus in fetu being reported more often in retroperitoneal teratomas (by general surgeons). (mdwiki.org)

[4] [9] Most ovarian teratomas are mature. (mdwiki.org)
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)

In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. (lidsen.com)
It is an essential structural component of mammalian cell membranes. (absoluteastronomy.com)

a painless, slowly growing, mixed radiolucent-radiopaque lesion characterized histologically by cords of polyhedral epithelial cells, deposits of amyloid , and spherical calcifications. (en-academic.com)

A tumor can be cancerous or benign. (cancer.net)
A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)

In mouse, only epiblast cells can be directly converted into cultured pluripotent embryonic stem cells, capable of forming all adult cell types. (bioone.org)

A benign tumor means the tumor can grow but will not spread. (cancer.net)
Compared with benign tumor cells, malignant tumor cells have key features like not having a clearly defined border or like having slightly less organized nuclei. (osmosis.org)

It has been suggested that Sertoli cells may derive from the fetal mesonephros. (wikipedia.org)
AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. (biomedcentral.com)

Extraovarian tumor spread of dysgerminomas often involves the retroperitoneal and pelvic lymph nodes. (medscape.com)
Evaluation after induction showed very good tumour response with three remaining localisations: two abdominal and one pelvic . (symptoma.com)

Signet ring cells scatter in the ovarian stroma with abundant collagen formation or marked edema. (radiopaedia.org)

In general they originate in the chromaffin cells. (knowcancer.com)

Anatomy8

Organisms1

Diseases19

Chemicals and Drugs2

Phenomena and Processes1

Ovary27

Ovaries10

Granulosa19

Krukenberg6

Carcinoma12

Endometrioid1

Metastasis5

Neoplasms4

Gonadal5

Metastatic1

Testicular6

Malignant germ2

Cystic1

Mucinous3

Primary tumors1

Testis5

Common malignant1

GCTs4

Malignancies1

Cysts3

Yolk sac t1

Tumours2

Differentiation5

Cause of these tumors2

Reproductive6

Neoplasm2

Seminiferous tubules5

Diagnosis7

Cancer37

Arise2

Cancers6

Borderline tumors1

Serous2

Primordial1

Leydig1

Metastases3

Present with ovarian2

Tissue9

Immature2

Dysgerminoma4

Typically3

Cervix1

Necrosis1

Teratoma3

Teratomas2

Mammalian2

Epithelial cells1

Cancerous2

Embryonic1

Benign tumor2

Fetal2

Pelvic2

Stroma1

Originate1