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  • therapies
  • Interest about novel stem cell-based therapies has exponentially been increasing over the past years, not only in the scientific community but also within the society. (mdpi.com)
  • This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. (indigo.ca)
  • Biologic therapies derived from such cells-through tissue regeneration and repair as well as through the targeted delivery of genetic material-are expected to be effective in the treatment of a wide range of medical conditions. (nih.gov)
  • Stem cell therapies have been showing incredible progress. (euvolution.com)
  • Embryonic cell lines and autologous embryonic stem cells generated through somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for future therapies. (wikipedia.org)
  • Current research focuses on differentiating ES into a variety of cell types for eventual use as cell replacement therapies (CRTs). (wikipedia.org)
  • Cell-based therapies hold great promise to restore the lost nerve tissue and function for CNS disorders. (jove.com)
  • However, cell therapies based on CNS-derived neural stem cells have encountered supply restriction and difficulty to use in the clinical setting due to their limited expansion ability in culture and failing plasticity after extensive passaging 1-3 . (jove.com)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression. (wikipedia.org)
  • differentiate
  • Adipose and skin derived neurospheres are able to grow well and to differentiate into glial/neuron cells without any chromosomal imbalance in both scaffolds. (mdpi.com)
  • In summary, we have demonstrated that neurospheres isolated from skin and adipose tissues are able to differentiate in glial/neuron-like cells, without any chromosomal imbalance in two scaffold types, useful for tissue engineering application: hyaluronan based membrane and fibrin-glue meshes. (mdpi.com)
  • Mesenchymal stem cells are adherent stromal cells able to self-renew and differentiate into a wide variety of cells and tissues. (mdpi.com)
  • Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. (wikipedia.org)
  • Potency: the capacity to differentiate into specialized cell types. (wikipedia.org)
  • Totipotent (a.k.a. omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. (wikipedia.org)
  • Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells, i.e. cells derived from any of the three germ layers. (wikipedia.org)
  • Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
  • Embryonic stem cells of the inner cell mass are pluripotent, that is, they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. (wikipedia.org)
  • Additionally, under defined conditions, embryonic stem cells are capable of propagating themselves indefinitely in an undifferentiated state and have the capacity when provided with the appropriate signals to differentiate, presumably via the formation of precursor cells, to almost all mature cell phenotypes. (wikipedia.org)
  • According to a 2002 article in PNAS, "Human embryonic stem cells have the potential to differentiate into various cell types, and, thus, may be useful as a source of cells for transplantation or tissue engineering. (wikipedia.org)
  • After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
  • They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
  • Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • organ
  • We are at the beginning of a new era in medicine, with multiple applications for stem cell therapy, not only as a monotherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. (mdpi.com)
  • However, the main obstacle in transplantation is the rejection of tissues or organ by the receiver, due to the three main immunological barriers: the human leukocyte antigen (HLA), the ABO blood group, and minor antigens. (hindawi.com)
  • The bone marrow, a well-studied organ, has multiple niches with distinct roles for supporting stem cell functions. (bioportfolio.com)
  • The first tissue-engineered organ transplantation was still based on a donor trachea. (biomedcentral.com)
  • When selecting new biomaterials for trachea bioengineering, researchers should evaluate a wide range of biological properties of candidate material including toxicity, toxigenicity, biocompatibility, biodegradability, durability, cell adhesion characteristics, and ability to mimic the function of a native organ as much as possible. (biomedcentral.com)
  • It can be induced by modifying the growth medium when stem cells are cultured in vitro or transplanting them to an organ of the body different from the one they were originally isolated from. (wikipedia.org)
  • The first attempt, an unsuccessful one, at gene therapy (as well as the first case of medical transfer of foreign genes into humans not counting organ transplantation) was performed by Martin Cline on 10 July 1980. (wikipedia.org)
  • For example, the results have included the near-eradication of polio and the development of organ transplantation, and have benefited both humans and animals. (wikipedia.org)
  • spinal
  • Its beneficial influence is important for regeneration after trauma, for example, in spinal cord injury or Huntington's and Parkinson's diseases. (umdnj.edu)
  • blindness and spinal cord injuries. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Similar techniques are also being explored for nerve repair in the spinal cord but nerve regeneration in the central nervous system poses a greater challenge because its axons do not regenerate appreciably in their native environment. (wikipedia.org)
  • pluripotency
  • iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. (wikipedia.org)
  • 2007 Nov;73:1106-10) and "very small embryonic like" - "VSEL" stem cells, and display pluripotency in vitro. (wikipedia.org)
  • graft-versus-
  • Sometimes, an upside of graft-versus-host disease is that the newly transplanted cells recognize the body's cancer cells as different or foreign, and actually work to fight them. (kidshealth.org)
  • Blood products are treated with radiation in the blood bank to inactivate or prevent T-cells from causing graft-versus-host disease in the recipient. (childrensnational.org)
  • vitro
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • and transplantation of in vitro grown organs and tissues (tissue engineering). (wikipedia.org)
  • They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
  • These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. (wikipedia.org)
  • endogenous
  • In another study, upon exposure to cyclosporine A, an immunosuppressant, there was enhanced recovery of cortical injury following stroke secondary to endogenous stem cell activity and migration [ 2 ]. (mdpi.com)
  • organs
  • Tissues or organs derived from hPS cells could be the best solution to cure many different human diseases, especially those who do not respond to standard medication or drugs, such as neurodegenerative diseases, heart failure, or diabetes. (hindawi.com)
  • However, the availability of donor tissues and organs is constantly limited, which presents a serious bottleneck for widespread transplantation surgery. (biomedcentral.com)
  • allogenic stem
  • As one may expect, the use of allogenic stem cells may predispose an individual to various immunologic complications upon treatment, giving rise to the significant limitation of graft rejection with this method of treatment. (mdpi.com)
  • neurons
  • Our experiments will help to define groups of microRNAs that are regulated during neurogenesis and how they work to control production of neurons or non-neuronal cells in the nervous system. (umdnj.edu)
  • Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons and oligodendrocytes within the brain. (wikipedia.org)
  • Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (wikipedia.org)
  • Multipotency or multidifferentiative potential, which is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single-cell type. (wikipedia.org)
  • Fetal
  • Although precedents exist for the clinical use of human stem cells, there is considerable reluctance to proceed with clinical trials involving human stem cells derived from embryonic and fetal sources. (nih.gov)
  • Similar to ESCs, these iPSCs had unlimited self-renewal and were pluripotent, contributing to lineages from all three germ layers in the context of embryoid bodies, teratomas, and fetal chimeras. (wikipedia.org)
  • undergo
  • For instance, a child who is about to undergo cancer treatment will have his or her own stem cells removed (harvested) and frozen for later use. (kidshealth.org)
  • clinical
  • This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential. (mdpi.com)
  • Efforts to analyze and assess the safety of using human stem cells in the clinical setting are vitally important to this endeavor. (nih.gov)
  • A diversity of opinion exists among researchers about the feasibility of initiating pilot clinical studies using human stem cells. (nih.gov)
  • Clinical studies involving the transplantation of blood-restoring, or hematopoietic, stem cells have been under way for a number of years. (nih.gov)
  • Moreover, clinical trials are being conducted to assess the safety and efficacy of using hematopoietic stem cell transplantation to treat various autoimmune conditions including multiple sclerosis, lupus, and rheumatoid arthritis. (nih.gov)
  • The purpose of pedigree evaluation and/or genetic testing is to establish whether the human stem cells in question are suitable for use in the context of a particular clinical situation. (nih.gov)
  • Advances in perinatal stem cells research: a precious cell source for clinical applications. (bioportfolio.com)
  • When direct suturing of the two stumps of a severed nerve cannot be accomplished without tension, the standard clinical treatment for peripheral nerve injuries is autologous nerve grafting. (wikipedia.org)
  • Spinal
  • 2 Spinal Cord Society NZ Inc. Who: Aim: Started by Noela & Keith Vallis & people with spinal cord injury (SCI), their families and care-givers in To support research into treatment of SCI and achieve a Cure - Neurological repair and, or regeneration. (docplayer.net)
  • 3 SCSNZ & Regenerative Medicine Spinal cord injury is an extremely complex issue. (docplayer.net)
  • Ethical approval from HDEC Spinal cord injury trials take a long time and measuring benefit is multimodal. (docplayer.net)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • blindness and spinal cord injuries. (wikipedia.org)
  • Similar techniques are also being explored for nerve repair in the spinal cord but nerve regeneration in the central nervous system poses a greater challenge because its axons do not regenerate appreciably in their native environment. (wikipedia.org)
  • malignant
  • These include autoimmune disease such as aplastic anaemia, inherited blood diseases such as sickle cell disease, or malignant diseases of blood system. (pavlu.co.uk)
  • generate
  • A variety of nontumorigenic stem cells display the ability to generate multiple cell types. (wikipedia.org)
  • Scientific interest in adult stem cells is centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (wikipedia.org)
  • Multipotency or multidifferentiative potential, which is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single-cell type. (wikipedia.org)
  • Embryonic stem cells of the inner cell mass are pluripotent, that is, they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. (wikipedia.org)
  • These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (wikipedia.org)
  • retinal pigment epitheli
  • One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
  • On September 12, 2014, surgeons at the Institute of Biomedical Research and Innovation Hospital in Kobe, Japan, transplanted a 1.3 by 3.0 millimeter sheet of retinal pigment epithelium cells, which were differentiated from iPS cells through Directed differentiation, into an eye of an elderly woman, who suffers from age-related macular degeneration. (wikipedia.org)
  • patients
  • In patients with disseminated germ cell tumor, because of the incomplete penetration of the chemotherapeutic agent to the testes, orchiectomy must be performed sooner or later. (medscape.com)
  • As of 2014 these approaches involve removing cells from patients, editing a chromosome and returning the transformed cells to patients. (wikipedia.org)
  • patient's own cells
  • In 2012, Professor Paolo Macchiarini and his team improved upon the 2008 implant by transplanting a laboratory-made trachea seeded with the patient's own cells. (wikipedia.org)
  • Muscular Dystrophy
  • Currently stem cell therapy is being looked into readily because it appears to be a possible cure for muscular dystrophy. (docplayer.net)
  • Stem cells have been used to treat diseases in the past, but the use of these various cells to treat muscular dystrophy is being heavily researched. (docplayer.net)
  • There is more than just one type of stem cell, so these various types are being researched to determine which cell has the greatest effect on muscular dystrophy. (docplayer.net)
  • Stem Cell Therapy in Muscular Dystrophy: Methods of Injection Early assessment with stem cells used mice to test the effectiveness of different injection methods. (docplayer.net)
  • Genetic
  • 2 Stem-cell therapy treatment for genetic disorders has large potential as a long term solution. (docplayer.net)
  • Bone marrow has been used to treat cancer for quite some time, but the use of stem cells in genetic diseases is being continuously researched. (docplayer.net)
  • Following early advances in genetic engineering of bacteria, cells, and small animals, scientists started considering how to apply it to medicine. (wikipedia.org)
  • endothelial
  • 10. The method of claim 9, wherein said endothelialization causes a confluent layer of cells to form on the surface of said hybrid carotid bypass graft when said hybrid carotid bypass graft is placed into said endothelial cell-containing environment. (patentsencyclopedia.com)
  • Procedure
  • citation needed] This procedure was referred to sensationally and somewhat inaccurately in the media as a "three parent baby", though mtDNA is not the primary human genome and has little effect on an organism's individual characteristics beyond powering their cells. (wikipedia.org)