• genome
  • and re-inserting into said genome the deleted sequences within the defective genome wherein said sequences have a homology of at least 60% to the natural sequence of the virus, wherein said sequences code for an RNA-dependent RNA polymerase and at least one structural or non-structural protein, and wherein a fragment of said DNA is capable of being transcribed into RNA and assembled to a virion. (patentsencyclopedia.com)
  • The genome of Rabies virus, Borna disease virus and Ebola virus code for the P phosphoprotein and VP35 that can block the antiviral response induced by IFN [ 8 , 9 , 10 ]. (intechopen.com)
  • cytoplasm
  • Replication occurs within the cytoplasm, and virions mature by budding through the plasma membrane, where virus-encoded surface glycoproteins E2 and E1 are assimilated. (wikipedia.org)
  • After virus attachment and entry into the cell, gene expression and replication takes place within the cytoplasm. (wikipedia.org)
  • dengue fever
  • The o'nyong'nyong virus (ONNV) was first isolated by researchers at the Uganda Virus Research Institute in Entebbe, Uganda, during a large outbreak of a disease in 1959 that resembled dengue fever. (wikipedia.org)
  • mRNA
  • Taken together, these data confirmed our hypothesis that RNA viruses, such as SinV, do in fact interface with the cellular mRNA decay machinery. (pubmedcentralcanada.ca)
  • Though not used by the ICTV, Baltimore classification, which groups viruses together based on how they produce mRNA, is used in conjunction with the ICTV's work in modern virus classification. (wikipedia.org)
  • bovine
  • 83. The infective clone according to claim 80, wherein said full-length cDNA is flanked at the 3' end by a poly(A) tail, the ribozyme of the hepatitis delta virus (HDV), and the termination and polyadenylation sequences of bovine growth hormone (BGH). (patentsencyclopedia.com)
  • The infected cell polypeptide 0 (ICP0) from Bovine herpes virus can interact with IRF3 and induce its proteasome-dependent degradation [ 12 ]. (intechopen.com)
  • infects
  • SFV infects cells by cell surface receptor binding, uptake via receptor-mediated endocytosis, and low pH-triggered fusion of the virus membrane with that of the endosome. (rupress.org)
  • viral
  • Upon exposure of the virus to the acidity of the endosome, E1 dissociates from E2 to form an E1 homotrimer, which is necessary for the fusion step to drive the cellular and viral membranes together. (wikipedia.org)
  • Within the acute phase, two stages have been identified: a viral stage during the first five to seven days, during which viremia occurs, followed by a convalescent stage lasting approximately ten days, during which symptoms improve and the virus cannot be detected in the blood. (wikipedia.org)
  • cellular
  • The mechanisms utilized by viruses to protect their transcripts from the cellular RNA decay machinery, as well as the biological relevance of this protection, are largely unknown. (pubmedcentralcanada.ca)
  • There are certain cellular components which are manipulated by viruses to evade the innate immune response. (intechopen.com)
  • In contrast, the human herpes simplex virus 8 encodes different analogs of IRF with negative dominant activity, allowing it to interfere with the activity of cellular IRFs [ 11 ]. (intechopen.com)
  • sequences
  • Since there are no recognized alignment programs that can adequately accommodate very divergent sequences, a method has been devised to construct and analyse a substantially improved 3′UTR alignment between these highly divergent viruses, based on the concept that deletions and/or insertions, in addition to substitutions, are important drivers of 3′UTR evolution. (microbiologyresearch.org)
  • wherein
  • 50. The method of claim 49, wherein the polynucleotide is a recombinant adenovirus or a recombinant adeno-associated virus. (patentsencyclopedia.com)
  • 53. The method of claim 52, wherein the polynucleotide is a recombinant adenovirus or a recombinant adeno-associated virus. (patentsencyclopedia.com)
  • 3. The method of claim 1, wherein the cell-penetrating peptide is a human immunodeficiency virus (HIV) trans-activator of transcription (TAT) cell-penetrating peptide. (freepatentsonline.com)
  • 81. The infective clone according to claim 80, wherein said coronavirus is an isolate of the porcine transmissible gastroenteritis virus (TGEV). (patentsencyclopedia.com)
  • protein
  • The srf-3 mutant emphasizes the relationship between the role of cholesterol in membrane fusion and virus exit, and most significantly, identifies a novel spike protein region involved in the virus cholesterol requirement. (rupress.org)
  • vectors
  • It is the only virus whose primary vectors are anopheline mosquitoes (Anopheles funestus and Anopheles gambiae)[citation needed]. (wikipedia.org)
  • complex
  • The present review will highlight the different complex mechanisms associated with the host immune evasion by the viruses with special reference to the Classical Swine Fever Virus. (intechopen.com)
  • hosts
  • Viruses have coevolved with their hosts and thus have limited pathogenicity in any immunocompromised natural host. (intechopen.com)
  • During the period of coexistence with their hosts, viruses have learned how to manipulate host immune control mechanism. (intechopen.com)
  • fever
  • Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. (wikipedia.org)
  • temperature
  • Mutations in nsP2 that produce noncytopathic viruses or a temperature sensitive phenotypes cluster at the P2/P3 interface region. (wikipedia.org)
  • cells
  • This recognition leads to the expression of cytokines, chemokines and co-stimulatory molecules that eliminate pathogens like viruses for the activation of antigen presenting cells and for the activation of specific adaptive response [ 4 ]. (intechopen.com)
  • group
  • A study of this taxon suggests that this group of viruses had a marine origin - specifically the Southern Ocean - and that they have subsequently spread to both the Old and New World. (wikipedia.org)
  • structure
  • The structure of the Semliki Forest virus revealed a structure that is similar to that of flaviviral glycoprotein E, with three structural domains in the same primary sequence arrangement. (wikipedia.org)