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  • characteristic
  • One characteristic of bacillary dysentery is blood in stool, which is the result of invasion of the mucosa by the pathogen. (wikipedia.org)
  • HLA-B27 AAU has characteristic clinical features including male preponderance, unilateral alternating acute onset, a non-granulomatous appearance, and frequent recurrences, whereas HLA-B27 negative AAU has an equivalent male to female onset, bilateral chronic course, and more frequent granulomatous appearance. (wikipedia.org)
  • receptors
  • MHC interacts with TCR and its co-receptors to optimize binding conditions for the TCR-antigen interaction, in terms of antigen binding affinity and specificity, and signal transduction effectiveness. (wikipedia.org)
  • presence
  • Recently, I wanted to see if I could impute the presence of the HLA-B27 antigen using my raw 23andMe DNA data. (csl.name)
  • So the idea is to statistically compare your genome with others whose HLA-B27 presence or absence is known, and then infer the probability that you have it or not. (csl.name)
  • So the probability is a whooping 88.8% for the complete absence of HLA-B27 in this case (but 11.2% for the presence of at least one copy). (csl.name)
  • type
  • Any cell displaying that person's HLA type belongs to that person and, therefore, is not an invader. (wikipedia.org)
  • known
  • Because you can't use a service 23andMe to find out if you have HLA-B27: There is no known SNP algorithm that can accurately tell you if you have it (although rs4349859 comes close, but 23andMe doesn't sequence it). (csl.name)
  • specific
  • When a foreign pathogen enters the body, specific cells called antigen-presenting cells (APCs) engulf the pathogen through a process called phagocytosis. (wikipedia.org)
  • complement
  • Among the alternatives to traditional typing by the complement‐dependent cytotoxicity assay, flow cytometric HLAB27 screening is most widely used in general diagnostic laboratories, as it is simple, rapid, and cost effective. (currentprotocols.com)
  • class
  • HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. (wikipedia.org)
  • test
  • Although I used a very small reference data set, I managed to get a rough result that happened to coincide with a blood test. (csl.name)
  • And, it did match up with the result of the blood test, which was fun, but could just as well have been pure luck. (csl.name)
  • A blood test will always be more accurate than imputation, but is time consuming and costs money. (csl.name)
  • If a doctor could quickly see that the probability of HLA-B27 is low, and depending on the context, it may not be necessary to order a blood test at all. (csl.name)
  • protein
  • The image off to the side shows a piece of a poisonous bacterial protein (SEI peptide) bound within the binding cleft portion of the HLA-DR1 molecule. (wikipedia.org)
  • people
  • HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community. (wikipedia.org)
  • tools
  • The doctor can then, based on a permission scheme, run imputation for things like HLA-B27 as one of many tools when diagnosing. (csl.name)
  • inflammation
  • Traditional lipid testing measures the amount of LDL cholesterol (LDL-C) present in the blood, but it does not evaluate the number of particles of LDL (LDL-P). Some studies have shown that increased numbers of small, dense LDL particles (sdLDL) are associated with inflammation and are more likely to cause atherosclerosis than fewer light, fluffy LDL particles. (labtestsonline.org)
  • The level of acute phase reactants such as C-reactive protein (CRP) and fibrinogen increases in the blood in response to inflammation. (labtestsonline.org)
  • It is most commonly associated with HLA-B27, which has important features: HLA-B27 AAU can be associated with ocular inflammation alone or in association with systemic disease. (wikipedia.org)
  • Antibodies
  • These additional tests may help identify abnormalities such as the presence of sperm antibodies, abnormal hormone levels ( testosterone , FSH , LH , prolactin ), excessive number of white blood cells, and genetic tests for conditions that may affect fertility, such as Klinefelter syndrome , cystic fibrosis , or other chromosomal abnormality. (labtestsonline.org)
  • These particular antigens stimulate the multiplication of T-helper cells (also called CD4 positive T cells), which in turn stimulate antibody-producing B-cells to produce antibodies to that specific antigen. (wikipedia.org)
  • characteristic
  • HLA-B27 AAU has characteristic clinical features including male preponderance, unilateral alternating acute onset, a non-granulomatous appearance, and frequent recurrences, whereas HLA-B27 negative AAU has an equivalent male to female onset, bilateral chronic course, and more frequent granulomatous appearance. (wikipedia.org)
  • One characteristic of bacillary dysentery is blood in stool, which is the result of invasion of the mucosa by the pathogen. (wikipedia.org)
  • known
  • when present in the blood, conjugated bilirubin can become chemically bound to albumin, forming delta-bilirubin (also known as biliprotein). (labtestsonline.org)
  • class
  • HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. (wikipedia.org)
  • specific
  • When a foreign pathogen enters the body, specific cells called antigen-presenting cells (APCs) engulf the pathogen through a process called phagocytosis. (wikipedia.org)
  • cells
  • The test actually measures the rate of fall (sedimentation) of erythrocytes (red blood cells) in a sample of blood that has been placed into a tall, thin, vertical tube. (labtestsonline.org)
  • When a sample of blood is placed in a tube, the red blood cells normally settle out relatively slowly, leaving little clear plasma. (labtestsonline.org)
  • Self-antigens are suppressed by regulatory T cells. (wikipedia.org)
  • They are then displayed by the antigen-presenting cells to CD4+ helper T cells, which then produce a variety of effects to eliminate the pathogen. (wikipedia.org)
  • Upon binding, T cells should in principle tolerate the auto-antigen, but activate when exposed to the allo-antigen. (wikipedia.org)
  • bound
  • The image off to the side shows a piece of a poisonous bacterial protein (SEI peptide) bound within the binding cleft portion of the HLA-DR1 molecule. (wikipedia.org)
  • potential
  • Methotrexate is eliminated from the body by the kidneys, so any condition that decreases kidney function or interferes with drug clearance has the potential to increase blood concentrations. (labtestsonline.org)
  • study
  • As the study of HLA genetics has evolved and expanded, the nomenclature has been continually altered, posing challenges for those attempting to follow the science. (uptodate.com)
  • HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community. (wikipedia.org)
  • conditions
  • Acidosis and alkalosis describe the abnormal conditions that result from an imbalance in the pH of the blood caused by an excess of acid or alkali (base). (labtestsonline.org)
  • MHC interacts with TCR and its co-receptors to optimize binding conditions for the TCR-antigen interaction, in terms of antigen binding affinity and specificity, and signal transduction effectiveness. (wikipedia.org)
  • rate
  • Raising and lowering the respiratory rate alters the amount of CO 2 that is breathed out, and this can affect blood pH within minutes. (labtestsonline.org)