• genes
  • Many of the associations identified for reactions affecting the liver and skin involve human leukocyte antigen (HLA) genes and for reactions relating to the drugs abacavir and carbamazepine, HLA genotyping is now in routine use prior to drug prescription. (biomedcentral.com)
  • Progress on non-HLA genes affecting adverse drug reactions has been less, but some important associations, such as those of SLCO1B1 and statin myopathy, KCNE1 and drug-induced QT prolongation and NAT2 and isoniazid-induced liver injury, are considered. (biomedcentral.com)
  • analysis
  • Lander, S. CHROMOSOME 6 UPD Maternal UPD6 Case 1 HLA analysis of the family of a renal transplant patient forex optimizer 4 the Netherlands revealed that the only demonstrable HLA antigens shown in the propositus were from the maternal haplotype (HLA-A11,-B46,-CW1,-DR14,-DQ1) (van den Berg-Loonen et al. (retzepti.ru)
  • specific
  • In 1989, a curious phenomenon was described: HIV-specific T-cell responses to the viral envelope and core proteins could be detected in antibody-positive and antigen-negative sexual partners of known HIV-positive men . (lww.com)
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • Cell Lines
  • 3) adopt individual cell lines for experiments in which knowledge of HLA molecule expression is relevant. (biomedcentral.com)
  • Since genome-based typing does not guarantee actual surface protein expression, further characterization of relevant cell lines should be entertained to verify surface expression in experiments requiring correct antigen presentation. (biomedcentral.com)
  • Although antiquated and partial information about the HLA phenotype of some of the NCI-60 cell lines is available through the American Type Culture Collection (ATCC), Rockville, MD, no high-resolution information obtained by definitive sequence-based typing (SBT) has ever been published. (biomedcentral.com)