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  • bioinformatics
  • In addition to Levesque, the team that developed the Genomics Data Warehouse includes Jianxin "Jason" Wang, PhD, a bioinformatics computational scientist, and Mohammad Zia, PhD, a bioinformatics programmer, both part of the Center for Computational Research, UB's supercomputing center. (buffalo.edu)
  • As part of the agreement, Erasmus MC is also allowing Complete Genomics to use its bioinformatics training center for customer training purposes. (nbcnews.com)
  • We decided to focus our research efforts with Complete Genomics on diseases where the current technology has not been able to identify the genetic variants responsible," said Professor Dr. Peter J. van der Spek, head of bioinformatics at Erasmus MC. (nbcnews.com)
  • bioengineering oncogenomics, oncodiagnostics, oncoprognosis, oncovirology mobile and repeating genetic elements and their evolution molecular immunology biopolymer structure and molecular dynamics the design of new biologically active compounds genetic enzymology signal transfer at molecular and cellular level plant genomics genomic and proteomic bioinformatics The development of fundamental principles of new molecular and cellular technologies and bionanotechnologies. (wikipedia.org)
  • The head of bioinformatics, Dr. Peter J. van der Spek, claimed that Complete Genomics' complete human genome sequencing service will allow us to study genetic variations at a higher resolution and greater sensitivity than has been previously possible. (wikipedia.org)
  • Comparative
  • Here, we have performed comparative genomic hybridizations (CGH) with different coral species to an Acropora palmata microarray platform containing 13,546 cDNA clones in order to identify potentially rapidly evolving genes and to determine the suitability of existing microarray platforms for use in gene expression studies (via heterologous hybridization). (biomedcentral.com)
  • Genomic comparative studies have found large numbers of highly conserved noncoding elements (HCNEs) spanning these and other loci. (uib.no)
  • Alamouti SM, Haridas S, Feau N, Robertson G, Bohlmann J, Breuil C. Comparative genomics of the pine pathogens and beetle symbionts in the genus Grosmannia . (springer.com)
  • Paleontology, evolutionary developmental biology, comparative genomics and genomic phylostratigraphy contribute most of the evidence for macroevolution's patterns and processes[citation needed]. (wikipedia.org)
  • accelerate
  • These results indicate that analysis of naturally existing genomic diversity complements traditional genetics approaches to accelerate genotype-phenotype analysis. (biomedcentral.com)
  • Testing existing variants can reduce the amount of time and resources spent on constructing isogenic strains, so we hypothesized that using naturally occurring genomic diversity can accelerate gene function discovery. (biomedcentral.com)
  • UB built the tool to accelerate genomics-based research, but the technology can be used to solve big data problems in any field, from drug discovery to materials development and supply chain management. (buffalo.edu)
  • The University at Buffalo's Institute for Healthcare Informatics will play a key role in the new state-funded genome research center - part of a statewide public-private partnership designed to accelerate advances in genomic medicine into clinical care. (buffalo.edu)
  • populations
  • BayesRS is a novel approach to share information across populations for genomic predictions. (biomedcentral.com)
  • Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest, but the naturally existing genomic and phenotypic diversity of microbial populations has rarely been exploited. (biomedcentral.com)
  • Genomic diversity of existing microbial populations can be used to infer the consequences of polymorphisms by evaluating phenotypic differences between naturally occurring variants, if 1) the naturally occurring variants harbor the genetic variation of interest and 2) other known genetic determinants of the phenotypic difference can be accounted for. (biomedcentral.com)
  • While current genomic screens are done with entire populations of cells, focusing in on a single stem cell will help determine specific signaling activity associated with varying degrees of stem cell differentiation and limit background due to heterogeneous populations. (wikipedia.org)
  • 2016
  • In 2016 Katie Jacobs Stanton became the CMO of Color Genomics and Jill Hagenkord became the Chief Medical Officer. (wikipedia.org)
  • In 2016, Color Genomics and University of Washington released a publicly available database of variants in 27 breast cancer genes based on samples from women who were over 70 years old and had never had breast cancer to serve as a scientific control in efforts to understand variants of uncertain significance. (wikipedia.org)
  • genomes
  • We have termed these regions genomic regulatory blocks (GRBs), and show that they underlie the phenomenon of conserved synteny through all sequenced vertebrate genomes. (uib.no)
  • These results led us to apply information theoretical methods to examine the extent to which information content differed between the genomes of bacterial chromosomes, plasmids, phages and GIs, and whether such differences could be related to distinct genomic properties of bacterial chromosomes and mobile genomic elements. (biomedcentral.com)
  • Stem cell genomics analyzes the genomes of stem cells. (wikipedia.org)
  • UB's
  • Through the Buffalo Institute for Genomics and Data Analytics (BIG), UB's supercomputing experts have developed a tool that enables researchers and companies to sift through, query and analyze enormous amounts of digital information. (buffalo.edu)
  • The technology, called the Genomics Data Warehouse, stores and queries vast quantities of data efficiently - a challenging computational task, says project manager Adrian Levesque, MBA, a senior programmer/analyst with UB's Center for Computational Research. (buffalo.edu)
  • Healthcare informatics is just one component of UB's contribution to the Buffalo genomic research center, funded with $48 million recently approved by Empire State Development. (buffalo.edu)
  • evolutionary
  • To illustrate the covered topics and to demonstrate the potential of landscape genomics, we provide empirical examples addressing a variety of research question, i.e., the investigation of evolutionary processes driving population differentiation, the landscape genomics of range expanding species, and landscape genomic patterns in organisms of special interest, including species inhabiting aquatic and terrestrial environments. (springer.com)
  • Harnessing the power of RADseq for ecological and evolutionary genomics. (springer.com)
  • chromatin
  • Here we used histone modification and chromatin-associated protein ChIP-Seq data sets in mouse embryonic stem (ES) cells as well as genomic features to identify functional enhancer regions. (biomedcentral.com)
  • research
  • Landscape genomics is a rapidly advancing research field that combines population genomics, landscape ecology, and spatial analytical techniques to explicitly quantify the effects of environmental heterogeneity on neutral and adaptive genetic variation and underlying processes. (springer.com)
  • Landscape genomics has tremendous potential for addressing fundamental and applied research questions in various research fields, including ecology, evolution, and conservation biology. (springer.com)
  • We conclude by outlining remaining challenges and future research avenues in landscape genomics. (springer.com)
  • We want Buffalo and Western New York to be the international center for genomic research and lead the way in revolutionizing the diagnosis and treatment of serious diseases. (buffalo.edu)
  • Erasmus MC and Complete Genomics are also collaborating in several other research areas, which have not yet been disclosed. (nbcnews.com)
  • Irish life sciences company, Genomics Medicine Ireland Ltd. today announced a new research collaboration with leading Dublin hospitals St. Vincent's University Hospital / University College Dublin Clinical Research Centre and Tallaght Hospital which aims to identify genetic markers that can help diagnose, predict disease severity and identify personalised treatments for people with Inflammatory Bowel Disease (IBD). (stvincents.ie)
  • TBI research draws on four main areas of discourse: clinical genomics, genomic medicine, pharmacogenomics, and genetic epidemiology. (wikipedia.org)
  • General topics that appear in recent conferences include: (1) personal genomics and genomic infrastructure, (2) drug and gene research for adverse events, interactions and repurposing of drugs, (3) biomarkers and phenotype representation, (4) sequencing, science and systems medicine, (5) computational and analytical methodologies for TBI, and (6) application of bridging genetic research and clinical practice. (wikipedia.org)
  • It is spearheaded by the MMRC and in collaboration with the Broad Institute and the Translational Genomics Research Institute (TGen). (wikipedia.org)
  • According to its mission statement, the National Institute of Genomic Medicine contributes to the health care of Mexican society through research projects. (wikipedia.org)
  • Its objective is not only to improve preventive medical care in the country, but also to expand knowledge of genomic medicine through research in oncogenomics, nutrigenomics, and autoimmune disease genomics, and more. (wikipedia.org)
  • Venter founded Celera Genomics, The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). (wikipedia.org)
  • clinical
  • The institute aims to drive innovation and job creation in New York State by advancing genomic medicine, a field that uses information on an individual's genetic make-up to improve his or her clinical care. (buffalo.edu)
  • gene
  • This approach, known as HLS-CATCH, allows users to apply long-range genomics to their gene or genomic region of interest, characterizing and phasing not only single nucleotide variants but also large structural variants including deletions, inversions, and translocations. (sagescience.com)
  • analysis
  • Circulating tumor DNA (ctDNA) analysis is a robust noninvasive method to detect and monitor genomic alterations in blood in real time. (aacrjournals.org)
  • Genomic data from the core can be transferred seamlessly to the genomic data warehouse, where the data can be stored for subsequent analysis. (buffalo.edu)
  • The technology gives researchers access to a wide range of genomics analysis tools for applying their data, and facilitates collaboration by providing investigators with the ability to grant secure access to data to collaborators. (buffalo.edu)
  • The Genomic HyperBrowser is a web-based system for statistical analysis of genomic annotation data. (wikipedia.org)
  • The primary focus of the system is on statistical inference on relations between genomic tracks, though simpler descriptive statistics and analysis of individual tracks is also supported. (wikipedia.org)
  • molecular
  • Dr. Rose is co-founder, Director and CEO of Transplant Genomics, a molecular diagnostic services company commercializing tests to improve outcomes for organ transplant recipients by enabling personalized immunosuppression. (wikipedia.org)
  • data
  • What we've created through the Genomics Data Warehouse is a simple method of managing a vast amount of information. (buffalo.edu)
  • The new Genomics Data Warehouse furthers this mission by facilitating solutions to big data problems in genomics. (buffalo.edu)
  • Queries are welcome from users working in genomics and other fields that feature big data problems. (buffalo.edu)
  • The company planned to profit from their work by creating genomic data to which users could subscribe for a fee. (wikipedia.org)
  • medicine
  • Peter Winkelstein, MD, MBA, says UB will have opportunities to train experts for high-demand jobs in genomic medicine both locally and nationwide. (buffalo.edu)
  • It is generally accepted that genomic medicine will lead to tremendous health benefits, including better treatments and prevention," he notes. (buffalo.edu)
  • The National Institute of Genomic Medicine (INMEGEN for its name in Spanish, Instituto Nacional de Medicina Genómica) is one of Mexico's twelve national institutes under the Secretariat of Health. (wikipedia.org)
  • INMEGEN is dedicated to the development of genomic medicine for the Mexican population. (wikipedia.org)
  • The National Institute of Genomic Medicine (Spanish Instituto Nacional de Medicina Genómica (INMEGEN)) is the eleventh National Institute of Health founded in Mexico. (wikipedia.org)
  • The National Institute of Genomic Medicine is located in Mexico City, on Anillo Periferico in the south of the city, next to the Instituto Federal Electoral. (wikipedia.org)
  • The National Institute of Genomic Medicine centers its attention on two main objectives, development of preventive medicine and the design of medical treatments tailored to a person's genetic makeup. (wikipedia.org)
  • cancer
  • Next-generation Sequencing (NGS) of cancer tissues is increasingly being carried out to identify somatic genomic alterations that may guide physicians to make therapeutic decisions. (aacrjournals.org)
  • markers
  • Genomic binding also correlated with markers of transcribed genes such as histone modifications H3K4me3 and H3K36me3, even outside of annotated transcribed loci, implying NFI in the control of the deposition of these modifications. (biomedcentral.com)
  • include
  • The approach described here provides a general setup for inclusion of location specific priors: the approach could be used to include biological information in genomic predictions. (biomedcentral.com)
  • physicians
  • Test are not delivered directly to the consumer, and must be ordered through a physician-either a family physician, specialist, or via the independent physicians that can be contacted through the Color Genomics website. (wikipedia.org)
  • approaches
  • However, the unique combination of different scientific disciplines and analytical approaches also constitute a challenge to most researchers wishing to apply landscape genomics. (springer.com)
  • Institute
  • He is on the Jenner Board, the Gray Institute Board.He is on the advisory Board for the McGill Genomics Institute and the Montreal Neurological Institute and chairs the advisory board for the Oak Foundation and the Robertson Foundation. (wikipedia.org)
  • In September 2012 the Beijing Genomics Institute purchased Complete Genomics for $117M. (wikipedia.org)
  • human
  • A project to compile a differential disease regulome used the Genomic HyperBrowser in mapping transcription factors against all human diseases. (wikipedia.org)
  • study
  • Also, study of genomics and evolution. (unam.mx)
  • The study of stem cell genomics has wide reaching implications in the study of stem cell biology and possible therapeutic usages of stem cells. (wikipedia.org)