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Liver NeoplasmsLiver Neoplasms, ExperimentalCarcinogensCarcinoma, HepatocellularRats, Inbred F344Liver DiseasesLiverLiver TransplantationLiver CirrhosisMicrosomes, LiverLiver RegenerationFatty LiverPancreatic NeoplasmsNeoplasmsMolecular Sequence DataLiver Function TestsBase SequenceMitochondria, LiverGenomic InstabilityDrug-Induced Liver InjuryNeoplasms, Cystic, Mucinous, and SerousComparative Genomic HybridizationGenomicsGenomic LibraryLiver ExtractsLiver CirculationSkin NeoplasmsSequence Analysis, DNANeoplasms, Multiple PrimaryLiver Failure, AcuteLiver AbscessGenomic IslandsLiver Diseases, AlcoholicDNA, NeoplasmKidney NeoplasmsAmino Acid SequenceGenomeCloning, MolecularHepatectomyNeoplasms, Second PrimaryRNA, MessengerDNAImmunohistochemistryPolymerase Chain ReactionHepatocytesChromosome MappingPhylogenyThyroid NeoplasmsNucleic Acid HybridizationLung NeoplasmsAdenocarcinoma, MucinousMyeloproliferative DisordersMutationGenome, HumanLiver Cirrhosis, ExperimentalGenomic ImprintingNeoplasms, ExperimentalLiver Cirrhosis, AlcoholicCystadenomaOvarian NeoplasmsGene Expression ProfilingNeoplasms, Plasma CellGenome, BacterialParotid NeoplasmsNeoplasm ProteinsLiver, ArtificialOligonucleotide Array Sequence AnalysisLiver GlycogenTime FactorsNeoplasms, Connective and Soft TissueAppendiceal NeoplasmsGastrointestinal NeoplasmsAlanine TransaminaseCystadenoma, MucinousEndocrine Gland NeoplasmsRats, Inbred StrainsExonsEnd Stage Liver DiseaseColorectal NeoplasmsPhenotypeEye NeoplasmsBile Duct NeoplasmsCarcinoma, Pancreatic DuctalNeoplasm StagingAdenomaNeoplasms, Vascular TissueNeoplasms, Radiation-InducedRetrospective StudiesNose NeoplasmsTumor Markers, BiologicalTranscription, GeneticLymphomaSalivary Gland NeoplasmsColonic NeoplasmsEvolution, MolecularBlotting, SouthernAdenocarcinoma, PapillaryChromosome AberrationsCarcinoma, PapillaryNeoplasms, Glandular and Epithelial
Pancreatic NeoplasmsAdenocarcinomaMalignant neoplasm characterizedTumorsEpithelialBenignMyeloproliferative neoplasmGastrointestinalHeterogeneityPathology2016MucinousCancerProteomicMutationsCarcinomaFollicularPancreasHistologicChronicLymphomasMucosaGenesTumor suppressorLesionNodulesVascularSoft tissueOriginateDistinctivePrimaryUrinaryMiceFeaturesProstateBoneCancersCategoryOral
Pancreatic Neoplasms4
  • T his is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. (coek.info)
  • Although understanding of the molecular features underlying pancreatic neoplasms is still in its infancy, a strong emphasis on the relevance of these findings for the practicing surgical pathologist is provided. (coek.info)
  • INTRODUCTION Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States.1 There have been significant advances in our understanding of the genetics of pancreatic neoplasms in the past 2 decades, as well as an explosion of information over the past 3 years, largely because of the availability of whole genome and exome sequencing technologies. (coek.info)
  • This article provides a state-of-the-art review of the molecular genetics of pancreatic neoplasms with a strong emphasis on the relevance of these findings for the practicing surgical pathologist. (coek.info)
Adenocarcinoma2
  • PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
Malignant neoplasm characterized2
  • An angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces. (medscape.com)
  • A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures. (nih.gov)
Tumors5
  • Nasir A, Ahmed MK, Saller JJ, Henderson-Jackson EB, Malafa MP, Yeatman TJ, Coppola D. p21 Protein Outperforms Clinico-pathological Criteria in Predicting Liver Metastases in Pancreatic Endocrine Tumors. (moffitt.org)
  • Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)
  • Xpa −/− mice showed a significant elevation in liver tumors. (aacrjournals.org)
  • Uncommon liver tumors: Case report and literature review. (nih.gov)
  • My work on liquid biopsies has involved blood based protein signatures for pancreatic cancer, and single-cell morphometric, proteomic and genomic characterization of circulating tumor cells, in comparison to solid tumors. (lu.se)
Epithelial4
  • Pathologists should be aware of the diagnostic criteria for GNET in order to avoid misdiagnosis due to confusion with other non-epithelial gastrointestinal neoplasms. (bvsalud.org)
  • Epithelial Protein Lost in Neoplasm α is a novel cytoskeleton-associated tumor suppressor whose expression inversely correlates with cell growth, motility, invasion and cancer mortality. (biomedcentral.com)
  • Epithelial neoplasms (new, abnormal tissue growth) of the appendix are rare, but without an effective way to study them, the opportunities to develop new treatments have also been rare. (ucsd.edu)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Benign3
  • Postoperative evaluation of FTC revealed preoperative FNA was classified as benign follicular lesion (category II), atypia or follicular lesion of undetermined significance (AUS/FLUS, category III), follicular neoplasm or suspicious for follicular neoplasm (FN/SFN, category IV), or suspicious for malignancy (SM, category V) according to the Bethesda System [ 9 , 15 ]. (sch.ac.kr)
  • oxidation modification of the genetic material may also participate in the progression of benign to malignant neoplasms. (bvsalud.org)
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of fine-needle aspiration (FNA) biopsy. (medscape.com)
Myeloproliferative neoplasm2
  • 1. A referral to p. 57 has been added to the table title, to refer the reader to the Myeloproliferative neoplasm, unclassifiable section, to which this table relates. (who.int)
  • The diagnosis of myeloproliferative neoplasm (MPN), The diagnosis of myeloproliferative neoplasm (MPN), unclassifiable, requires that either all 3 criteria are met. (who.int)
Gastrointestinal3
  • Malignant gastrointestinal neuroectodermal tumour (GNET) is an extremely rare neoplasm first described by Zambrano in 2003 as clear cell sarcoma like tumor of the gastrointestinal tract. (bvsalud.org)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • The senescence cascade and the cell-cycle checkpoints that dictate the progression and maintenance of senescence are important in all types of gastrointestinal cancers, including pancreatic, liver, gastric, colon, and esophageal cancers. (elsevierpure.com)
Heterogeneity1
  • PL and LM showed limited heterogeneity in the genomic landscape, while the LM tumor microenvironment displayed lower levels of immune activation and infiltration than PL, which might contribute to developing precise immunotherapy strategies for patients with NSCLC with LM. (bmj.com)
Pathology2
  • Dr. Dolores López-Terrada and the members of the Division of Genomic Medicine are dedicated to provide Molecular and Genomic Pathology, state-of-the-art diagnostic services for children and their families. (texaschildrens.org)
  • Pathology of intraductal papillary mucinous neoplasms. (nih.gov)
20161
  • We report 3 cases of M. orygis -associated TB in wild animals from among 85 unexplained deaths screened as part of disease investigations during February 2016-March 2020, which also revealed cases of suppurative bronchopneumonia (n = 32), TB caused by M. tuberculosis or M. bovis (n = 29), verminous pneumonia (n = 9), fungal granulomas (n = 6), and neoplasms (n = 6). (cdc.gov)
Mucinous1
  • The majority of neoplasms have mucinous histology, a characteristic that makes them difficult to assess under a microscope and to culture. (ucsd.edu)
Cancer12
  • Malignant neoplasms of the small bowel are among the rarest types of cancer, accounting for 4% of all GI cancers. (medscape.com)
  • Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). (bmj.com)
  • These changes have been predicted by cancer epidemiologists for many years, but even they are surprised by the speed at which these changes are occurring, e.g., the emergence of cancer of the breast, colon and prostate in several countries in which these neoplasms were hardly known only 20 to 30 years ago. (who.int)
  • 6XUYLYDO RI FDQFHU SDWLHQWV Survival data allow the calculation of the prevalence of organ-specific neoplasms in a given country and provide a basis for national cancer control strategies to be pursued in collaboration with the WHO programme on cancer control. (who.int)
  • Defining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data. (ucsf.edu)
  • Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
  • As quoted in our article about the traditional Japanese tattoo In order to translate our genomic efforts to diagnostic applications, we have developed approaches for detection of mutated DNA in the circulation of cancer patients. (autohaus-alpbachtal.at)
  • We've learned that appendiceal cancer has a distinctive genomic landscape and is surprisingly full of immune cells," said senior author Andrew Lowy, MD , chief of the Division of Surgical Oncology at Moores Cancer Center and a professor of surgery at UC San Diego School of Medicine. (ucsd.edu)
  • Lowy and colleagues developed an organotypic slice culture of living appendiceal cancer cells. (ucsd.edu)
  • Modulation and response of the immune system are of interest in cancer treatment due to the success of immunotherapy in the treatment of various neoplasms. (spandidos-publications.com)
  • Today's topic is the Genomic Prostate Score (GPS) and its potential to help men decide what to do if they have been diagnosed with a clinically localized prostate cancer . (medscape.com)
  • Cite this: Predicting Prostate Cancer Outcomes With Genomic Testing - Medscape - Nov 22, 2017. (medscape.com)
Proteomic1
  • His research interests are focused on determining genomic, transcriptomic and proteomic biomarkers with the potential to provide meaningful prognostic information and insight about responsiveness to treatment. (moffitt.org)
Mutations2
  • Genomic landscapes profiling revealed similar somatic mutations, tumor mutational burden, and neoantigen number between PL and LM. (bmj.com)
  • Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
Carcinoma1
  • According to the World Health Organization (WHO), these neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. (medscape.com)
Follicular2
  • We aimed to study the diagnostic performance of shear wave elastography (SWE) to differentiate follicular neoplasm (FN) from NH in follicular lesions of thyroid nodules. (sch.ac.kr)
  • Some investigators believe that this condition is distinct from other follicular cell neoplasms. (medscape.com)
Pancreas2
  • No significant differences were found in the survival from tumours largely refractive to therapy, e.g., carcinomas of the pancreas, lung and liver. (who.int)
  • Yilmaz & Deshpande occasionally, they are cystic and thus can mimic primary cystic neoplasms of the pancreas. (coek.info)
Histologic2
  • The diagnosis mandates that the lesion must have proven histologic differences from the primary neoplasm (carcinomas, lymphomas). (medscape.com)
  • The term fibroma is inappropriate because the neoplasm exhibits defined histologic features that differ from those of fibromas and may express malignant behavior. (medscape.com)
Chronic1
  • DQFHUV DVVRFLDWHG ZLWK FKURQLF LQIHFWLRQV IARC epidemiologists have estimated that in developing countries up to 20% of all human neoplasms develop in association with chronic infectious conditions. (who.int)
Lymphomas1
  • Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
Mucosa1
  • These are termed xenobiotic-metabolizing enzymes (XMEs) found especially in the liver but also in the mucosa of the upper aerodigestive tract, and several are polymorphic and strongly influence individual biological responses to carcinogens. (bvsalud.org)
Genes2
  • We find some very striking similarities, including recurring genomic rearrangements, alterations of the regulation of specific growth-promoting genes, population-genetic features that affect the fitness trajectories of growth rate variants in evolving populations, and physiological and metabolic similarities derived from the conservation of the basic plan of growth and cell multiplication among all eukaryotes. (nih.gov)
  • Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. (cancerindex.org)
Tumor suppressor1
  • This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
Lesion1
  • A Hürthle cell neoplasm is defined generally as an encapsulated thyroid lesion comprising at least 75% Hürthle cells. (medscape.com)
Nodules1
  • Postmortem examination revealed nonuniform, multifocal, coalescing pale-yellow nodules embedded in the parenchyma of the lungs with caseated yellowish-white material and enlarged liver and mesenteric lymph nodes with surface nodules. (cdc.gov)
Vascular1
Soft tissue1
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
Originate1
  • Prostatic stromal sarcoma is a rare malignant neoplasm that is believed to originate from specialized stromal prostatic cells. (medscape.com)
Distinctive1
  • [ 1 ] The current World Health Organization (WHO) (also known as l'Organisation Mondiale de la Sante [OMS]) classification includes this tumor as a distinctive spindle cell neoplasm. (medscape.com)
Primary1
  • Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification. (nih.gov)
Urinary1
  • median, 33 years) and involved the soft tissues of the neck (3), shoulder (1), buttock (2), orbit (1), tongue/parapharyngeal space (1), urinary bladder (1), and falciform ligament/liver (1). (bvsalud.org)
Mice1
  • Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)
Features1
  • The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder. (nih.gov)
Prostate1
  • most of these were presented as a few isolated case reports and without distinction from other spindle cell neoplasms of the prostate. (medscape.com)
Bone1
  • They then metastasize via the lymphatics or portal circulation to the liver, lung, bone, brain, and other distant sites. (medscape.com)
Cancers1
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
Category1
  • The Medical College of Wisconsin designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™ . (mcw.edu)
Oral2
  • In February 2006, a live, oral, human-bovine reassortant rotavirus vaccine (RotaTeq® [RV5]) was licensed as a 3-dose series for use among U.S. infants for the prevention of rotavirus gastroenteritis, and the Advisory Committee on Immunization Practices (ACIP) recommended routine use of RV5 among U.S. infants (CDC. (cdc.gov)
  • In April 2008, a live, oral, human attenuated rotavirus vaccine (Rotarix® [RV1]) was licensed as a 2-dose series for use among U.S. infants, and in June 2008, ACIP updated its rotavirus vaccine recommendations to include use of RV1. (cdc.gov)