• To aid map-based cloning and future genome sequencing projects, we constructed a BAC-based physical map of the short arm of wheat chromosome 1A (1AS). (inrae.fr)
  • Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). (wikipedia.org)
  • Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. (nature.com)
  • The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
  • We sequenced and constructed the complete genome of an environmental strain CR1 of P. aeruginosa and performed the comparative genomic analysis. (frontiersin.org)
  • We identified eight new regions of genomic plasticity and a plasmid pCR1 with a VirB/D4 complex followed by trimeric auto-transporter that can induce virulence phenotype in the genome of strain CR1. (frontiersin.org)
  • Xq28 appears to be an unstable region of the human genome and genomic rearrangements are recognised as major causes of two single gene defects, haemophilia A and incontinentia pigmenti, which map within Xq28. (bmj.com)
  • Bread wheat (Triticum aestivum L.) has a large, complex and highly repetitive genome which is challenging to assemble into high quality pseudo-chromosomes. (usda.gov)
  • As part of the international effort to sequence the hexaploid bread wheat genome by the international wheat genome sequencing consortium (IWGSC) we are focused on assembling a reference sequence for chromosome 7B. (usda.gov)
  • Researchers create reference human genome sequences to help detect genomic variants in each sequenced human genome. (genome.gov)
  • The human pangenome is a more comprehensive framework that aims to account for genomic variation across human populations, thereby reducing biases that can come with the use of a single reference human genome sequence. (genome.gov)
  • One copy of the human genome contains about 3 billion nucleotides, which are distributed among 23 chromosomes. (genome.gov)
  • Most genomic variants have no influence on the functioning of a person's genome, but a small subset of variants do have an impact. (genome.gov)
  • The substantially large bread wheat genome, organized into highly similar three sub-genomes, renders genomic research challenging. (biomedcentral.com)
  • The construction of BAC-based physical maps of individual chromosomes reduces the complexity of this allohexaploid genome, enables elucidation of gene space and evolutionary relationships, provides tools for map-based cloning, and serves as a framework for reference sequencing efforts. (biomedcentral.com)
  • Here, we provide a chromosome-specific view into the organization and evolution of the D genome of bread wheat, in comparison to one of its ancestors, revealing recent genome rearrangements. (biomedcentral.com)
  • Despite the advent of next-generation sequencing technologies, the above mentioned attributes of the wheat genome have rendered the assembly of genomic sequences extremely difficult. (biomedcentral.com)
  • In the absence of a finished quality genome sequence, insights into wheat genome structure and function have been accumulating through survey sequencing of individual chromosomes or chromosome-specific Bacterial Artificial Chromosome (BAC) libraries. (biomedcentral.com)
  • The simplified and known genetic background of captive mouse populations such as the Collaborative Cross, BXD recombinant inbred strain panel, the Diversity Outbred population, and collections of diverse inbred strains render them uniquely powerful resources for studying the mechanisms of short-term genome evolution and genomic inheritance. (jax.org)
  • Despite their fundamental significance for chromosome transmission and genome stability, little is known about the levels and patterns of genetic diversity across centromeres and the PAR, or the biological impacts of this variation. (jax.org)
  • In order to enrich the genomic tools already available in this species and provide further insight on the complexity of its genome, we sequenced a large number of rainbow trout BAC-end sequences (BES) and characterized their contents. (biomedcentral.com)
  • Furthermore, comparative genomics through BES can be used for identifying positional candidate genes from QTL mapping studies, aid in future assembly of a reference genome sequence and elucidating sequence content and complexity in the rainbow trout genome. (biomedcentral.com)
  • Commenting on the research efforts of Dr. Stelly, Dr. Jonathan Wendel of Iowa State University lauded his history of accomplishments: "His training was in classical plant cytogenetics, but over the years he has expanded into many different aspects of plant genomics, including comparative mapping, the development of new tools for germplasm characterization, the creation and genomic evaluation of chromosome substitution lines, and genome sequencing. (cottoninc.com)
  • These community building efforts include research projects in chromosome substitution lines, SNP markers, and genome sequencing to name a few. (cottoninc.com)
  • Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome. (jcvi.org)
  • The sequence-tagged connector (STC) strategy proposes to generate sequence tags densely scattered (every 3.3 kilobases) across the human genome by arraying 450,000 bacterial artificial chromosomes (BACs) with randomly cleaved inserts, sequencing both ends of each, and preparing a restriction enzyme fingerprint of each. (jcvi.org)
  • By reiterating this "sequence-then-map by computer analysis against the STC database" strategy, a minimum tiling path of clones can be sequenced at a rate that is primarily limited by the sequencing throughput of individual genome centers. (jcvi.org)
  • Because the STC resource permits the easy integration of genetic, physical, gene, and sequence maps for chromosomes, it will be a powerful tool for the initial analysis of the human genome and other complex genomes. (jcvi.org)
  • With the advent of advanced technologies, such as gene sequencing and chromosome mapping, scientists are now able to delve deeper into understanding the human genome. (drfournier.com)
  • Eleven markers located on chromosomes 1A, 2B, 5A, 5D, 7B, and 7D by the genome-wide association studies analysis showed significant associations with at least two resistance-associated traits in two of the environments. (unboundmedicine.com)
  • With the ďm to facilitate high-throughput genome profiling and genetic and physical mapping within the Festuca-Inlium, gomplex, we have developed a Diversity Arrays Technology (DArT) array for five important species: Festuca pratensis, Festuca arundinacea, Festuca glaucescens, Inlium perenne and Lolium multiflorum. (cas.cz)
  • Lastly, we use ceX-QTL to map loci that influence fitness genome-wide confirming previously reported causal variants and uncovering new fitness loci. (escholarship.org)
  • Therefore, we generated genome-wide methylation and transcriptome maps of size-selected, growing oocytes to capture the onset and progression of methylation. (biomedcentral.com)
  • 11 SNPs exceeded genome-wide significance with the strongest association with rs12913832 SNP on chromosome 15, mapping to HERC2 gene (p=6.94x10-14). (cdc.gov)
  • Evolutionary superscaffolding and chromosome anchoring to improve Anopheles genome assemblies. (cdc.gov)
  • A detailed mapping of the chromosome abnormality using whole genome array based comparative genomic hybridization (CGH) of the patient DNA revealed a duplication 16q12.1-q22.1 corresponding to gain of 19.8 Mb of DNA without any detectable loss of genetic material on chromosome 11. (lu.se)
  • PCR amplifications sequence is the yidY gene, which is also found in the chromo- yielded products from genomic DNA extracted from the sero- some of other S. enterica serotypes (7,8). (cdc.gov)
  • The ADAMTS13 gene is mapped to chromosome 9q34 by genomic sequence analysis. (iowaodes.com)
  • A total of 3,671 sequence contigs and scaffolds were mapped to deletion bins on wheat chromosome 7B providing a foundation for developing high-resolution integrated physical map for this chromosome. (usda.gov)
  • The successful completion of the reference chromosome sequence is highly dependent on the integration of genetic and physical maps. (usda.gov)
  • Chinese spring deletion lines, a total of 3,671 sequence contigs and scaffolds (~7.8 % of chromosome 7B physical length) were mapped into nine deletion bins. (usda.gov)
  • Our method of genotyping deletions on chromosome 7B relied on a model-based clustering algorithm (Mclust) to accurately predict the presence or absence of a given genomic sequence in a deletion line. (usda.gov)
  • Validation of the bin mapping results suggested a high accuracy of the assignment of 7B sequence contigs and scaffolds to the 7B deletion bins. (usda.gov)
  • The high-quality physical map constructed in this study paves the way for the assembly of a reference sequence, from which breeding efforts will greatly benefit. (biomedcentral.com)
  • The PAR is a region of conserved sequence identity between the X and Y chromosomes over which the meiotic program of pairing, synapsis, and recombination unfolds to ensure correct sex chromosome segregation. (jax.org)
  • Five quantitative trait loci (QTLs) on chromosomes 1A, 2B, 7B, and 7D overlapped or were in close proximity to previously reported QTLs based on the consensus and physical maps using the reference sequence of bread wheat (IWGSC RefSeq v1.0). (unboundmedicine.com)
  • Comparison of sequence data with the porcine BAC fingerprint map show that the cluster of genes resides in a 300 kb region. (biomedcentral.com)
  • Homo sapiens chromosome X multiple clones map p11.23, complete sequence. (lu.se)
  • Using a gene microarray containing ∼40 K NCBI UniGene EST clusters, PCR marker screening and BAC end sequences, we arranged 160 physical contigs (97 Mb or 35.3% of the chromosome arm) in a virtual order based on synteny with Brachypodium, rice and sorghum. (inrae.fr)
  • BAC end sequences and information from microarray hybridisation was used to anchor 3.8 Mbp of Illumina sequences from flow-sorted chromosome 1AS to BAC contigs. (inrae.fr)
  • CGH has been widely applied to detect gains and losses of DNA sequences on specific chromosomes in the study of solid tumours, 1 but has not been extensively used to study unbalanced constitutional karyotypes. (bmj.com)
  • a) PCR-based amplification of randomly selected bin mapped sequences (b) comparison with previously mapped ESTs and (c) comparison with a 7B genetic map developed in the present study. (usda.gov)
  • e. disassemble genomic DNA sequences into small segments. (quizlet.com)
  • The STC resource, containing end sequences, fingerprints, and arrayed BACs, creates a map where the interrelationships of the individual BAC clones are resolved through their STCs as overlapping BAC clones are sequenced. (jcvi.org)
  • As a postdoctoral trainee at the University of Washington, I used computational approaches to mine large-scale genomic datasets to identify and catalog signatures of one specific subclass of recombination - gene conversion - within structurally complex and repetitive genomic regions. (jax.org)
  • It also illustrates the power of the STC strategy for creating minimum tiling paths of BAC clones for large-scale genomic sequencing. (jcvi.org)
  • Avoiding the costs associated with such approaches, comparative genomic analysis of gene order conservation (synteny) to predict scaffold neighbours (adjacencies) offers a potentially useful complementary method for improving draft assemblies. (cdc.gov)
  • The majority of deletions are concentrated in a single genomic segment corresponding to only 2 kb of the transcript. (nih.gov)
  • We have used comparative genomic hybridisation to analyse 19 constitutional chromosome abnormalities detected by G band analysis, including seven deletions, five supernumerary marker chromosomes, two interstitial duplications, and five chromosomes presenting with abnormal terminal banding patterns. (bmj.com)
  • Deletions of part or all of chromosome 9 are commonly found in bladder cancer. (medlineplus.gov)
  • Only 61 (0.06%) of the markers displayed identifiable non-Mendelian transmission and neither of the two males typed were assigned a heterozygous state for any of the 178 single nucleotide polymorphisms (SNPs) mapping to the X chromosome. (diabetesjournals.org)
  • A genetic map (also called a linkage map) shows the relative location of genetic markers (reflecting sites of genomic variants) on a chromosome. (genome.gov)
  • A genetic map is based on the concept of genetic linkage: the closer two markers are to each other on a chromosome, the greater the probability that they will be inherited together. (genome.gov)
  • By studying inheritance patterns, the relative order and location of genetic markers along a chromosome can be established. (genome.gov)
  • It helps us to appreciate how genetic markers along the chromosome may be inherited together. (genome.gov)
  • The present study reports the identification of significant single nucleotide polymorphism (SNP) markers associated with super soft trait using single marker trait association and composite interval mapping (CIM) to determine sources of genetic variation for kernel texture conferring the super soft trait. (usda.gov)
  • Efforts are in progress to narrow down the genomic regions harboring major QTLs controlling super soft kernel texture to identify closely associated markers with the trait using fine mapping approach. (usda.gov)
  • A genetic linkage map was constructed with 1425 markers, which assembled to 21 linkage groups. (usda.gov)
  • Of the 1425 markers, 372 were mapped on 21 linkage groups involving 14 chromosomes with 3.0 LOD scores. (usda.gov)
  • In order to improve cultivated wheat, genes and traits of agricultural importance need to be positioned accurately on chromosomes and closely linked markers identified to allow rapid selection in breeding programs. (usda.gov)
  • In this study a method of accurately placing thousands of markers onto chromosome intervals was evaluated. (usda.gov)
  • Using the IMpRH 7000rad and IMNpRH2 12000rad radiation hybrid panels, these 5 genes mapped between microsatellite markers SWR67 and SW2067 . (biomedcentral.com)
  • We assigned DArT markers to individuď chromosome regions of F. pratensis using a series of single chromosome substitution and recombinant lines of E pratensis in Z. multiflorum. (cas.cz)
  • Moreover, we enriched the existing genetic map of F. pratensis by over 200 DArT markers and existing genetic map of Z. multiflorum by over 500 DAIT markers. (cas.cz)
  • The main part deals with examples of modern FISH-applications, highlighting unique possibilities of the approach, like the possibility to study individual cells and even individual chromosomes. (frontiersin.org)
  • Dr. Jonathan Wendel of Iowa State University commented on Dr. Josh Udall and lauded his leadership: "He has been a global leader in the development of genomic resources for cotton. (cottoninc.com)
  • A very small subset of genomic variants contributes to human health and disease. (genome.gov)
  • that person's set of genomic variants accounts for the ~0.4% difference. (genome.gov)
  • The differences among human genomes are called genomic variants. (genome.gov)
  • A person's set of genomic variants is part of what makes them unique. (genome.gov)
  • What are the different types of genomic variants? (genome.gov)
  • There are multiple types of genomic variants. (genome.gov)
  • The smallest genomic variants are single-nucleotide variants (SNVs). (genome.gov)
  • Expression quantitative trait loci (eQTLs), genetic variants associated with gene expression levels, are identified in eQTL mapping studies. (escholarship.org)
  • Different variants of FISH can be used to retrieve information on genomes from (almost) base pair to whole genomic level, as besides only second and third generation sequencing approaches can do. (frontiersin.org)
  • Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat. (tamu.edu)
  • Our study highlights the importance of genomic variants affecting homoeolog expression dosage in shaping agronomic phenotypes and points at their potential utility for improving yield in polyploid crops. (tamu.edu)
  • Comparative genomic hybridisation (CGH) is one of several molecular approaches that can be applied to ascertain the origin of extra chromosomal material. (bmj.com)
  • Chromosomal identification of marker chromosomes and extra bands on chromosomes through molecular techniques is always of clinical interest. (bmj.com)
  • We performed a molecular cytogenetic investigation of the scleractinian coral Acropora solitaryensis, which is dominant in the temperate region of Japan (30-35°N). Molecular cytogenetic analysis, using fluorescence in situ hybridization (FISH), was carried out for karyotyping and gene mapping. (bioone.org)
  • Here especially highlighted variations of FISH are molecular combing, chromosome orientation-FISH (CO-FISH), telomere-FISH, parental origin determination FISH (POD-FISH), FISH to resolve the nuclear architecture, multicolor-FISH (mFISH) approaches, among other applied in chromoanagenesis studies, Comet-FISH, and CRISPR-mediated FISH-applications. (frontiersin.org)
  • Other research themes are molecular and genomic ecology, e.g. immune gene evolution, telomere ecology and sex chromosome evolution in birds. (lu.se)
  • Our improved Anopheles reference assemblies highlight the utility of applying comparative genomics approaches to improve community genomic resources. (cdc.gov)
  • Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • Although the structural chromosome abnormalities in these cases were too small to identify the origin of the extra genomic material based on banding pattern, none of the abnormalities described by these authors can be considered to be subtle or cryptic. (bmj.com)
  • We present here the clinical findings and a fine mapping of the associated structural chromosome abnormalities. (lu.se)
  • Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (ox.ac.uk)
  • In particular, G band analysis usually does not show the chromosomal origin of small marker chromosomes or of a small amount of extra material detected on otherwise normal chromosomes. (bmj.com)
  • The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 9. (medlineplus.gov)
  • 9q22.3 microdeletion is a chromosomal change in which a small piece of the long (q) arm of chromosome 9 is deleted in each cell. (medlineplus.gov)
  • Centromeres provide chromosomal points of attachment to the cellular segregation machinery, linking chromosomes to the proteins that pull them to the cell poles during both somatic and germline cell divisions. (jax.org)
  • Two of the introns in HB5 are not found in other genes of this family, suggesting an evolutionary split between MKPs displaying specificity toward different MAP kinases. (ox.ac.uk)
  • With the broad goal of elevating the profile of wild mice in biomedical research, my group is pursuing population genomic investigations in wild mice to understand the natural evolutionary forces that shape variation in wild mouse populations. (jax.org)
  • Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
  • The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
  • My research aims to understand the causes and consequences of variation in the mechanisms that govern DNA inheritance: chromosome segregation, recombination, and de novo mutation. (jax.org)
  • Chromosome level ordering of the scaffolds was achieved by anchoring the assemblies either to a genetic map for Fv (ref. 7 ), or an optical map for Fol ( Supplementary Information A and Supplementary Table 2 ). (nature.com)
  • For subsets of the assemblies, we integrated these with additional supporting data to confirm and complement the synteny-based adjacencies: 6 with physical mapping data that anchor scaffolds to chromosome locations, 13 with paired-end RNA sequencing (RNAseq) data, and 3 with new assemblies based on re-scaffolding or long-read data. (cdc.gov)
  • Our combined analyses produced 20 new superscaffolded assemblies with improved contiguities: 7 for which assignments of non-anchored scaffolds to chromosome arms span more than 75% of the assemblies, and a further 7 with chromosome anchoring including an 88% anchored Anopheles arabiensis assembly and, respectively, 73% and 84% anchored assemblies with comprehensively updated cytogenetic photomaps for Anopheles funestus and Anopheles stephensi. (cdc.gov)
  • The translocation involved in this condition, written as t(9;22), fuses part of the ABL1 gene from chromosome 9 with part of the BCR gene from chromosome 22, creating an abnormal fusion gene called BCR-ABL1 . (medlineplus.gov)
  • The abnormal chromosome 22, containing a piece of chromosome 9 and the fusion gene, is commonly called the Philadelphia chromosome. (medlineplus.gov)
  • An abnormal karyotype was identified involving the long arm of chromosome 11. (lu.se)
  • To identify the disease locus we carried out a genomewide linkage search using an early access version of the GeneChip Mapping 10K Xba Array. (diabetesjournals.org)
  • The numerous microsatellites will facilitate integration of the linkage and physical maps and serve as valuable resource for fine mapping QTL and positional cloning of genes affecting aquaculture production traits. (biomedcentral.com)
  • These loci, corresponding to seven genomic regions based on linkage disequilibrium decay distance, explained 9.3 to 26.0% of the total phenotypic variation. (unboundmedicine.com)
  • The researchers have previously used microsatellite analysis of cervical cancer cell lines and primary tumors to localize a tumor suppressor gene to a 300kb interval of chromosome 11q13. (uclahealth.org)
  • Many cases of NMIBC tumors have a chromosome 9 deletion, which typically occurs early in tumor formation. (medlineplus.gov)
  • Genomic amplification of FLT3 has been reported in solid tumors including colorectal cancer, breast cancer, and gastric cancer [ 9 ]. (hindawi.com)
  • Childhood tumors can provide a good model for studying genetic questions because they have acquired fewer mutations than adult tumors, so there is less background noise muddling the genomic picture. (mskcc.org)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Constitutional chromosome studies involving conventional GTG band cytogenetic analysis, however, often show unbalanced karyotypes which cannot be fully defined because the extra material is too small to have a recognisable banding pattern. (bmj.com)
  • Others have applied CGH to the study of constitutional chromosome abnormalities detected postnatally. (bmj.com)
  • Characterisation of breakpoints in patients with apparently balanced constitutional chromosome rearrangements and phenotypic abnormalities has proved an invaluable strategy for identifying disease causing genes, especially those on the X chromosome. (bmj.com)
  • Although some reference genomes are available for this clade, few are at the chromosome level, inhibiting high-resolution genomic studies. (biorxiv.org)
  • Here, we assemble genomes from three members of the genus, the tiger ( Panthera tigris ), the snow leopard ( Panthera uncia ), and the African leopard ( Panthera pardus pardus ), at chromosome or near-chromosome level. (biorxiv.org)
  • A Physical Map of the Short Arm of Wheat Chromosome 1A. (inrae.fr)
  • This is a pre-requistied to complete sequencing of this chromosomes and identifying the important genes that can be used to improve modern wheat cultivars. (usda.gov)
  • In this study, we constructed the first comprehensive physical map of wheat chromosome arm 5DS, thereby exploring its gene space organization and evolution. (biomedcentral.com)
  • Here, we use diverse wheat accessions to map expression quantitative trait loci (eQTL) and evaluate their effects on the population-scale variation in homoeolog expression dosage. (tamu.edu)
  • 2014) Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array. (usda.gov)
  • To investigate the possibility that a novel candidate gene for XLMR was disrupted at the X chromosome translocation breakpoint, we mapped the breakpoint using fluorescence in situ hybridisation (FISH). (bmj.com)
  • Intriguingly, we found that the X chromosome breakpoint in the daughter could not be defined by a single breakpoint spanning genomic clone and further analysis showed a 650 kb submicroscopic duplication between DXS7067 and DXS7060 on either side of the X chromosome translocation breakpoint. (bmj.com)
  • A rearrangement (translocation) of genetic material between chromosomes 9 and 22 causes a type of cancer of blood-forming cells called chronic myeloid leukemia. (medlineplus.gov)
  • Here, genomic prediction models revealed different genetic architectures for the morphological traits. (nih.gov)
  • These data provide the base for very good estimates of Darwinian fitness, as well as for QTL mapping, selection and microevolution studies of behavioural (e.g. spring arrival) and morphological traits. (lu.se)
  • The application of genomic prediction models that take into account the effects of all individual loci may greatly enhance the elucidation of the genetic architecture of quantitative traits in plants. (nih.gov)
  • Combining biological and phenotypic data with genomic information can be used to increase our basic knowledge of the regulation of biological functions, and ultimately used in applied research to improve the environmental and genetic management of aquaculture production systems with focus on complex traits such as meat and carcass quality, stress tolerance or resistance to specific pathogens. (biomedcentral.com)
  • Mapping Switchgrass Traits with Common Gardens The combination of field data and genetic information has allowed researchers to associate climate adaptations with switchgrass biology. (doe.gov)
  • The resonrces developed in this project will facilitate development of genetic maps in Festuca and I'olium, the anďysis of genomic constitution in Festuca x Lolium hybrids, as well as marker-assisted selection for multiple traits. (cas.cz)
  • Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. (escholarship.org)
  • Quantitative trait loci (QTL) for age of puberty, nipple number and ovulation rate have been identified in Meishan crosses on pig chromosome 10q (SSC10) near the telomere, which is homologous to human chromosome 10p15 and contains an aldo-keto reductase (AKR) gene cluster with at least six family members. (biomedcentral.com)
  • We developed a new method, C. elegans eXtreme Quantitative Trait Locus (ceX-QTL) mapping, that overcomes this obstacle via bulk selection on millions of unique recombinant individuals. (escholarship.org)
  • From the assembly of 25,918 high information content (HICF) fingerprints from a 1AS-specific BAC library, 715 physical contigs were produced that cover almost 99% of the estimated size of the chromosome arm. (inrae.fr)
  • The physical map of 5DS was comprised of 164 contigs, of which 45 were organized into 21 supercontigs, covering 176 Mb with an N50 value of 2,173 kb. (biomedcentral.com)
  • Ordering of 80 contigs along the deletion bins of chromosome arm 5DS revealed small-scale breaks in syntenic blocks. (biomedcentral.com)
  • Comparative genomic hybridisation (CGH) is a dual fluorescence in situ hybridisation protocol capable of detecting global gains and losses of genomic regions by competitive DNA hybridisation. (bmj.com)
  • 5 clones) that constitute ~95 % of the cumulative length of the map. (biomedcentral.com)
  • Screening the porcine CHORI-242 BAC library with a full-length AKR1C4 cDNA identified 7 positive clones and sample sequencing of 5 BAC clones revealed 5 distinct AKR1C genes ( AKR1CL2 and AKR1C1 through 4 ), which mapped to 126-128 cM on SSC10. (biomedcentral.com)
  • 3- 6 Phenotypic abnormalities seen in cases with apparently balanced chromosome rearrangements have usually been explained by the disruption of a gene at the breakpoint causing the loss of gene function. (bmj.com)
  • 12- 17 However, there is still further allelic heterogeneity within this region as there are additional XLMR families published that map to Xq28 with a significant lod score but do not have abnormalities in any of these genes. (bmj.com)
  • The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins among other functions. (wikipedia.org)
  • FLT3 (FMS-related tyrosine kinase 3) located on chromosome 13q12.2 encodes a receptor tyrosine kinase (RTK) that activates the Ras and PI3 kinase pathway leading to the increased proliferation and inhibition of apoptosis in hemopoietic progenitor cells [ 7 ]. (hindawi.com)
  • These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
  • Integrating genomic prediction and association mapping enabled the assignment of many plausible candidate genes explaining the observed variation. (nih.gov)
  • This genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases. (genome.gov)
  • Genomic variation reflects the differences in a person's DNA compared to other peoples' DNA. (genome.gov)
  • SNVs are the most common type of genomic variation. (genome.gov)
  • In a new study, an international research team found that this genetic colour variation that is shared between several species arose through changes in a specific genomic region at least five million years ago. (lu.se)
  • In the new study published in Nature Ecology and Evolution, a research team mapped the extensive and striking colour variation among the females of the bluetail damselfly (Ischnura elegans). (lu.se)
  • By sequencing the DNA of the three colour forms of the bluetail damselfly and comparing it to the two colour forms in its closely related tropical relative Ischnura senegalensis , the researchers were able to demonstrate that this genetic colour variation in females arose at least five million years ago - through several different mutations in a specific genetic region on the damselfly's thirteenth chromosome. (lu.se)
  • One of the QTL regions is located on the long arm of pig chromosome 10 (SSC10q) near the telomere, which is homologous to human chromosome 10p15 [ 5 , 6 ]. (biomedcentral.com)
  • In the human, an aldo-keto reductase (AKR) gene family (AKR1C) has been identified near the telomere on chromosome 10p15 that contains at least six aldo-keto reductase family 1, member C genes [ 11 ]. (biomedcentral.com)
  • By analyzing the parental origin of chromosomes showing aneuploidy and comparing with the phenotype in HMs, we are identifying genomic regions likely to habour/not harbour imprinted genes relevant for early differentiation. (au.dk)
  • Replication studies in the mother and daughter showed a skewed X inactivation pattern in lymphocytes, with the normal X chromosome preferentially inactivated. (bmj.com)
  • FISH mapping of the rRNA gene was carried out with a probe generated by PCR amplification using rRNA gene primers. (bioone.org)
  • Double minute chromosomes (dmins) are a form of gene amplification presenting as small spherical paired chromatin bodies. (hindawi.com)
  • Genomic amplification of FLT3 has not been reported in hematological disease. (hindawi.com)
  • The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
  • Double minute chromosomes (dmins) are cytogenetic indicators of extrachromosomal gene amplification which usually act as small spherical paired chromatin particles [ 1 ]. (hindawi.com)
  • Des isolats suspects de Staphylococcus ont d'abord été identifiés par l'analyse biochimique classique, puis les souches confirmées par amplification en chaîne par polymérase (29 isolats de S. aureus et 17 isolats de S. saprophyticus) ont été analysées pour déterminer leur sensibilité aux différents antimicrobiens. (who.int)
  • So, genetic map tells us the location of each gene on the chromosome. (genome.gov)
  • Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum , converting a non-pathogenic strain into a pathogen. (nature.com)
  • We have identified Salmonella genomic island I (SGI1) in an serotype Paratyphi B strain of biovar Java isolated from a trop- isolate of Salmonella enterica serotype Paratyphi B. This antibi- otic-resistance gene cluster, which confers multidrug resis- ical fish in Singapore (13). (cdc.gov)
  • Thus, these PCR mapping results indicated that the sero- which confers resistance to streptomycin and spectinomycin, type Paratyphi B strain contains the entire antibiotic-resistance gene cluster of serotype Typhimurium DT 104. (cdc.gov)
  • We are also actively involved in the development of new strain and genomic resources derived from wild-caught animals. (jax.org)
  • Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum . (nature.com)
  • Ethics of genomic passports: should the genetically resistant be exempted from lockdowns and quarantines? (bmj.com)
  • This assembly phenomenon of the human chromosome 6 gives researchers an opportunity to investigate the origin of the ENC on chromosome 6. (wikipedia.org)
  • Composite interval mapping (CIM) was conducted and ten QTLs were identified including four major QTLs controlling SKCS HI harboring three genomic regions located on 1B, 4B and 5A chromosomes. (usda.gov)
  • Comparison of genetic and synteny-based physical maps indicated that ∼50% of all genetic recombination is confined to 14% of the physical length of the chromosome arm in the distal region. (inrae.fr)
  • The 1AS physical map provides a framework for future genetic mapping projects as well as the basis for complete sequencing of chromosome arm 1AS. (inrae.fr)
  • c. align genetic maps based on recombination frequencies to physical maps of chromosomes. (quizlet.com)
  • People normally have two copies of this chromosome. (wikipedia.org)
  • Two copies of chromosome 9, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
  • Cells containing two copies of each chromosome are called "diploid. (genome.gov)
  • The bin mapping results were validated using three different approaches, viz. (usda.gov)
  • We focused on SNPs within or near TACR1/LOC105374811 (chromosome 2) and CTNNA3/DNAJC12 (chromosome 10). (cdc.gov)
  • Research shows that several genes that control cell growth and division are located on chromosome 9. (medlineplus.gov)
  • As of February 1999, we had deposited, together with The Institute for Genomic Research (TIGR), into GenBank 314,000 STCs ( approximately 135 megabases), or 4.5% of human genomic DNA. (jcvi.org)
  • He suggested to introduce the term chromosomics being equal to cytogenomics to bring the three-dimensional morphologically of chromosomes into the focus of research, as this is essential for gene regulation. (frontiersin.org)
  • However, when complex hybridization scenarios might explain a species' history, or when events are recent enough that coalescent methods cannot be used, haplotype-level information such as is provided by contiguous, chromosome-level assemblies can greatly improve our understanding of these events. (biorxiv.org)
  • CONCLUSIONS: Experimental data from probe mapping, RNAseq, or long-read technologies, where available, all contribute to successful upgrading of draft assemblies. (cdc.gov)
  • Although HPVs (Human Papilloma Viruses) play an important role in tumor development, detailed studies have shown that viral infection is not sufficient and additional risk factors, including genomic alterations, are involved. (uclahealth.org)
  • Chromosome 11q13 genomic mapping studies have also identified PACS-1 (phosphofurin acidic cluster sorter protein-1) gene as an oncogene. (uclahealth.org)
  • Under this generic term, all chromosome-related studies should be summarized to introduce novel ideas and concepts in biology and medicine, thus having an integrative effect on the field. (frontiersin.org)
  • The mapping of these chromosomes provides valuable insights into the human genome's layout and functionality. (drfournier.com)