Genomes outbreak coronavirus. Medical search. Frequent questions

Get rapid access to Wuhan coronavirus (2019-nCoV) sequence data from the current outbreak as it becomes available. (nih.gov)
Coronavirus Wuhan (2019-nCoV). (nih.gov)
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by coronavirus, 2019-nCoV. (pasteur.fr)
On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the outbreak. (pasteur.fr)
On January 9, 2020, the Chinese health authorities and the World Health Organization (WHO) announced the discovery of a novel coronavirus, known as 2019-nCoV (isolated on January 7), which was confirmed as the agent responsible for the pneumonia cases (see the Institut Pasteur's fact sheet on the "2019-nCoV coronavirus" - page in French ). (pasteur.fr)
there is not much diversity in the viruses analyzed, which suggests that coronavirus 2019-nCoV did not need to mutate in order to adapt and spread," continues Vincent Enouf. (pasteur.fr)
The National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur in Paris is one of WHO's reference laboratories for coronavirus 2019-nCoV. (pasteur.fr)
Preliminary investigations conducted by the Chinese authorities have found no clear evidence of human-to-human transmission of the novel #coronavirus (2019-nCoV) identified in #Wuhan , #China . (breitbart.com)
WHO begins using the phrase "2019 Novel Coronavirus" or "2019-nCoV" to refer to disease causing the outbreak in Wuhan, China. (cdc.gov)
CDC publishes information about the 2019 Novel Coronavirus (2019-nCoV) outbreak caused by the SARS CoV-2 virus on its website. (cdc.gov)
Interpretion of my coronavirus 2019-nCov, Wuhan, China BLAST tree? (stackexchange.com)

CoV-2) genomes sequenced from case-patients during outbreak in the church, Australia, 2020. (cdc.gov)
On March 12 the U.S. Court of Appeals for the Federal Circuit announced that it will proceed with arguments scheduled for the April 2020 sitting, with some modifications responsive to public health guidance concerning minimizing the spread of the coronavirus. (ipo.org)
In early January 2020, the specific virus was isolated and later identified as a novel coronavirus by sequencing ( 3 ). (spandidos-publications.com)
By January 12, 2020, four other genomes have been uploaded to the viral sequence database curated by the Global Initiative on Sharing All In uenza Data (GISAID). (cdc.gov)
A novel coronavirus that emerged in late 2019 has rapidly become a global pandemic , affecting more than 1 million people worldwide as of April 11, 2020. (cdc.gov)
Since the publication of the first sequence at the beginning of 2020, viral genome sequencing has become a powerful tool to study the SARS-CoV-2 genome 1 , 4 . (medrxiv.org)
On 31 December 2019, a cluster of acute respiratory illness was reported from China and later confirmed as novel coronavirus on 7 January 2020 (1). (who.int)
Consequent to its spread, Dr Tedros Ghebreyesus, Director General of the World Health Organization (WHO), declared the outbreak a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 (3). (who.int)
A sharp decline in the incidence of norovirus outbreaks was observed in early 2020 owing to COVID-19-related measures, including limiting travel, physical distancing, mask-wearing, handwashing, and surface disinfection. (medscape.com)

The result was that weeks before the WHO declared the outbreak a global public health emergency and months before COVID-19 was formally designated a pandemic, virologists around the world were already studying the protein spikes on the virus and designing vaccines, which were developed much more quickly, and turned out to be much more effective, than even the most optimistic had predicted. (buecher.de)
The team, co-led by researchers at the University of Arizona and the University of Adelaide, used computational methods to uncover genetic traces of adaptation to coronaviruses, the family of viruses responsible for three major outbreaks in the last 20 years, including the ongoing COVID-19 pandemic. (arizona.edu)
We found the 42 VIPs are primarily active in the lungs - the tissue most affected by coronaviruses - and confirmed that they interact directly with the virus underlying the current pandemic," said the paper's first author Yassine Souilmi of the University of Adelaide's School of Biological Sciences. (arizona.edu)
Recently, severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS‑CoV‑2)‑causing CoV disease 2019 (COVID‑19) emerged in China and has become a global pandemic. (spandidos-publications.com)
The World Health Organization (WHO) is under fire from the United States president and lawmakers, after its unfailing defense of the Chinese Communist Party's handling of the coronavirus pandemic that may have slowed the global response and cost lives. (breitbart.com)
The WHO has backed China throughout the coronavirus pandemic, from promoting false Chinese statements to helping it deflect blame as the virus spread from Wuhan, China, to the rest of the world, infecting more than 1.6 million worldwide. (breitbart.com)
Bedford, a computational biologist at Fred Hutchinson Cancer Research Center, became well-known in the Seattle area early in the pandemic for detecting the coronavirus outbreak locally. (seattletimes.com)
Since the pandemic started, however, he's been focusing on understanding the virus' transmission, using genome sequence data to help epidemiologists track local outbreaks, as well as global spread. (seattletimes.com)
Cases of mink-to-human coronavirus transmission took place on mink farms early in the pandemic , Live Science previously reported . (livescience.com)
However, multiple issues related to its origin, its transfer time in humans, evolutionary patterns, and underlying forces that derived the SARS-CoV-2 outbreak and pandemic remain unclear. (benthamscience.com)
SARS-CoV-2 ORF7a protein deletions (del) have been reported since the initial coronavirus disease 2019 (COVID-19) pandemic period. (news-medical.net)
The day that Dr Sikhulile Moyo ruefully calls "Omicron Day" started like any normal day, or as normal as one can be for a medical virologist in the middle of a global coronavirus pandemic. (azureedge.net)
[ 1 ] Prior to the coronavirus disease 2019 (COVID-19) pandemic, an estimated 179 million cases of acute gastroenteritis occurred every year in the United States. (medscape.com)

The sequencing run was completed by early evening on the Tuesday, and the scientists used data analysis to obtain the sequence of the whole genome in two of the first three confirmed cases in France. (pasteur.fr)
Whole-genome sequencing can detect microevolution within Mycobacterium tuberculosis strains. (blogspot.com)
Whole-genome sequencing can delineate outbreaks of tuberculosis and allows inference about direction of transmission between cases. (blogspot.com)
Whole-Genome Sequencing of SARS-CoV-2 from Quarantine Hotel Outbreak. (cdc.gov)
This project aims to carry out whole genome sequencing of SARS-CoV-2 from coronavirus-positive patients across the UK. (ed.ac.uk)
Delta outbreaks occurred in Australia from June 2021 to February 2022, and whole-genome sequencing (WGS) of the causative Delta variant showed ORF7a truncation due to the presence of a 17-nucleotide (nt) frameshift-inducing deletion. (news-medical.net)

The virus was sequenced at the Institut Pasteur's Mutualized Platform for Microbiology (P2M), which performs genome sequencing on bacterial, viral, fungal and parasite strains received by National Reference Centers and World Health Organization Collaborating Centers for the purpose of infectious disease surveillance. (pasteur.fr)
In December 2019, an outbreak of apparently viral pneumonia of unknown etiology emerged in the city of Wuhan, in the Chinese province of Hubei. (pasteur.fr)
That same Friday evening, scientists launched the process of sequencing the viral genome based on the samples. (pasteur.fr)
COVID-19-compatible symptoms, and symptomatic HCP sequencing demonstrated that SARS-CoV-2 viral genomes were sent home per MDH and CDC guidance. (cdc.gov)
India has announced an ambitious 1000-genome sequencing project to better understand the viral and host genomics of the COVID-19 outbreak. (nature.com)
the National Institute of Virology, Pune, and Gujarat Biotechnology Research Centre, Gandhinagar are sequencing the viral genome. (nature.com)
Besides, the Central Drug Research Institute (CDRI), Lucknow and IICB, Kolkata are also gearing up to sequence the viral genome. (nature.com)
IGIB director and clinician scientist Anurag Agrawal, who is overseeing a molecular and digital surveillance project around the genome sequences from India, says it would be extremely useful to know the viral loads and numbers of symptomatic versus asymptomatic cases. (nature.com)
While the interests of this year's 33 "investigators" range from brain electricity in mental health disorders to cures for cancer, Bedford, Matsen and Veesler are focusing on viral outbreaks, including SARS-CoV-2, the virus that causes COVID-19. (seattletimes.com)
SARS-CoV-2 has spread with the evolution of its viral genome since its emergence in late 2019. (medrxiv.org)
By developing greater insights into the ancient viral foes, we gain understanding of how genomes of different human populations adapted to the viruses that have been recently recognized as a significant driver of human evolution. (phys.org)
Genetic changes in the viral genome may have enabled the virus to adapt to humans. (bvsalud.org)

most scientists believe the virus spilled into human populations through natural zoonosis (transfer directly from an infected non-human animal), similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. (wikipedia.org)
For example, the emergence of Nipah virus in Perak, Malaysia, and the 2002 outbreak of SARS-CoV-1 in Guangdong province, China, were natural zoonosis traced back to wildlife origin. (wikipedia.org)
Differences between bat coronaviruses and SARS‑CoV‑2 suggest that humans may have been infected via an intermediate host. (wikipedia.org)
The team synthetized both human and SARS-CoV-2 proteins, without using living cells, and showed that these interacted directly and specifically pointed to the conserved nature of the mechanism coronaviruses use to invade cells. (arizona.edu)
Collectively, all the associated diseases caused by SARS-CoV-2 are termed Coronavirus Disease of 2019 (COVID-19). (spandidos-publications.com)
As an accurate profile of the virus is urgently required, the present article screened the available literature on SARS-CoV-2 and other members of the coronavirus family to perform a literature review. (spandidos-publications.com)
The first SARS-CoV-2 genome data became available mid-January, and a few days later, "it became clear to me what sort of situation we were in," he said. (seattletimes.com)
During the past two decades, three high pathogenic coronaviruses have been identified as the causal agents of large-scale disease outbreaks-SARS-CoV-1, MERS-CoV and SARS-CoV-2-that have claimed tens of thousands of human lives. (mdpi.com)
As a successful example, the identification of bat HKU2-related coronavirus led us to quickly set up diagnosis and control measures against swine disease outbreak caused by SARS-CoV, which shared 95% genome identity to HKU2-CoV. (mdpi.com)
A team of researchers from the National Library of Medicine (NLM), part of the National Institutes of Health, identified genomic features of SARS-CoV-2, the virus that causes COVID-19, and other high-fatality coronaviruses that distinguish them from other members of the coronavirus family. (nih.gov)
Using integrated comparative genomics and machine learning techniques, the researchers compared the genome of the SARS-CoV-2 virus against the genomes of other members of the coronavirus family and identified protein features that are unique to SARS-CoV-2 and two other coronavirus strains with high fatality rates, SARS-CoV and MERS-CoV. (nih.gov)
In this report from Klompas and colleagues, the evaluation of a nosocomial outbreak of 52 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among 14 patients and 38 staff members in an academic medical center with well-established infection prevention and control program in place is described. (shea-online.org)
SARS (Severe Acute Respiratory Syndrome Coronavirus or SARS-CoV-1) outbreak. (cdc.gov)
PhD students Alex Morgan and Áine O'Toole are working on projects that are providing insight into the effectiveness of different social distancing measures, and characterising the different lineages of SARS-CoV-2 present in UK coronavirus patients. (ed.ac.uk)
A Danish hospital outbreak of SARS-CoV-2. (openaire.eu)
In this paper we report on genome sequencing of 154 SARS-CoV-2 samples between June and July 2021 (Summer outbreak) in the Bailiwick of Jersey, a UK channel island. (medrxiv.org)
The median age of SARS-CoV-2 positive individuals was higher during winter than the summer outbreak, and the contact tracing program showed that younger individuals stayed positive for longer. (medrxiv.org)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China and caused coronavirus disease of 2019 (COVID-19) 1 , 2 . (medrxiv.org)
The first SARS-CoV-2 genome sequence confirmed the virus as part of the betacoronavirus genus, belonging to the Coronaviridae family, consisting of single-strand positive-sense RNA 1 , 3 . (medrxiv.org)
SARS-CoV-2 genome variation study enables a comprehensive understanding of virus transmission, rate of mutations, track evolution, development of vaccines, and treatment 5 . (medrxiv.org)
SARS-CoV-2 has a genome of 29,903 nucleotides, with 5'-cap structure and 3' poly(A) tail 9 , 10 . (medrxiv.org)
This virus is the same member of the coronavirus family that caused the severe acute respiratory syndrome (SARS-CoV) reported in China 2003, and Middle East respiratory syndrome (MERS-CoV) reported in Saudi Arabia in 2012. (who.int)
The 2002-2004 outbreak of SARS , caused by severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), infected over 8,000 people from 30 countries and territories, and resulted in at least 774 deaths worldwide. (wikipedia.org)
In late December 2019, SARS-CoV-2 , a strain of coronavirus closely related to the one that caused SARS, was discovered in Wuhan , Hubei , China. (wikipedia.org)
In link with earlier coronaviruses, the SARS-CoV-2 was noticed with a more contagious nature, and it quickly spread throughout the world. (benthamscience.com)
Although the acute respiratory syndromes causing SARS-Coronaviruses are not new to humanity, the recent SARS-CoV-2 based epidemic has spread to almost every part of the world and claimed a large number of human lives without any discrimination of race, gender, and color. (benthamscience.com)
KAUST researchers work to understand the SARS-CoV-2 genome to identify opportunities for treatment and vaccine development. (edu.sa)
Researchers across disciplines are coming together at KAUST to tackle this pressing global challenge by working to understand the coronavirus (SARS-CoV-2) to help protect our communities. (edu.sa)
The emergence of SARS-CoV-2 in January, with its genome sequenced and made available in December 2019, provided an opportunity for Alam to use KMAP in conjunction with the computational resources and other systems developed by the CBRC to begin investigating the genetic structure of the virus in detail. (edu.sa)
We are using the University's supercomputer [and] specially designed software to not only compare and analyze coronaviruses but also to scan billions of environmental samples for traces of SARS-CoV-2," Alam said. (edu.sa)
In a recent study posted to the medRxiv * preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7a Δ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7a Δ17del deletion (Delta-ORF7a intact ) and/or the SARS-CoV-2 lineage (A.2.2). (news-medical.net)
Each genome in the dataset was searched for ORF7a del by aligning each sequence against the Wuhan Hu-1 reference SARS-CoV-2 genome. (news-medical.net)
A . Sample dates of all chosen samples relative to the index case of the Australian Delta outbreak (16 June 2021), and all variants in the sample genomes relative to the SARS-CoV-2 reference genome (created in part using snipit ( https://github.com/aineniamh/snipit ). (news-medical.net)
Amino acids 1-44 are identical to the SARS-CoV-2 reference genome in all samples and are not presented. (news-medical.net)
This includes severe acute respiratory syndrome coronavirus SARS-Cov, first identified in 2002 and the middle east respiratory syndrome corona virus MERS Co-V first identified in 2012. (dentalreach.today)
In the study, the researchers used data from the 1000 Genomes Project, which is the largest public catalog of common human genetic variation, and looked at the changes in the human genes coding for SARS-CoV-2 interacting proteins. (phys.org)
In an in vitro study done in 2004 during the last SARS outbreak, experimental compounds that release NO increased the survival rate of nucleus-containing mammalian cells infected with SARS-CoV. (mightynatural.com)
The SARS CoV, which caused the 2003/2004 outbreak, shares most of its genome with SARS CoV-2, the virus responsible for COVID-19. (mightynatural.com)
[ 7 ] SARS-CoV belongs to the lineage B betacoronavirus and was responsible for the 2002-2003 severe acute respiratory syndrome (SARS) outbreaks, which first highlighted the potentially high pathogenicity of human coronaviruses. (medscape.com)
syndrome coronavirus 2 (SARS-CoV-2) was first To meet the national capacity for WGS, which is about reported in the Central Visayas region, Philippines, 750 samples weekly, 2 the Epidemiology Bureau further in January 2021. (who.int)

Figure 1 shows the relationship of the Wuhan virus to selected coronaviruses. (nih.gov)
Phylogenetic tree showing the relationship of Wuhan-Hu-1 (circled in red) to selected coronaviruses. (nih.gov)
Central to many is a misplaced suspicion about the proximity of the outbreak to a virology institute that studies coronaviruses, the Wuhan Institute of Virology (WIV). (wikipedia.org)
Most of the patients had been to a food market in Wuhan, the city that's still the epicenter of the outbreak. (vox.com)
These reports show the outbreak started weeks or months sooner than China let on, and the virus was already spreading among people - and beyond the food market in Wuhan - in early January. (vox.com)
A study published on January 24 in The Lancet showed that in the first days China acknowledge the outbreak , by January 2, more than a third of patients had no connection with the Wuhan food market, including the outbreak's index (or first) case. (vox.com)
1] The epidemics of coronavirus disease 2019 started from Wuhan, China, in December 2019 and have become a major challenging health problem not only for China but for other countries also around the world. (dentalreach.today)

Hi Tiana, we make genomic sequences available for the coronavirus. (nih.gov)
We measured pairwise nucleotide differences within hosts and between hosts in household outbreaks and estimated the rate of change in DNA sequences. (blogspot.com)
The estimated rate of change in DNA sequences was 0·5 single nucleotide polymorphisms (SNPs) per genome per year (95% CI 0·3-0·7) in longitudinal isolates from 30 individuals and 25 families. (blogspot.com)
April 2003 - CDC labs sequences entire genome of SARS coronavirus. (cdc.gov)
Wonderful Choga, 31, a bioinformatician from Zimbabwe, kept an eye on the computer as the USB-connected MinION outputted genome sequences, his usual cup of coffee at the ready. (azureedge.net)
Shortly after, Dr Moyo uploaded the new genetic data to GISAID, a popular open-access database that labs around the world use to rapidly share genome sequences. (azureedge.net)
The sequencing of the human genome revealed that at least 1% of the human genome consists of endogenous retroviral sequences, representing past encounters with retroviruses during the course of human evolution. (msdmanuals.com)

Laboratory (MDH-PHL) and multiple commercial laborato- serial testing at two SNFs experiencing COVID-19 outbreaks. (cdc.gov)

Real-time genomic sequencing enabled rapid confirmation tracking the outbreak to a recently returned traveler and linked 2 cases of infection in travelers at the same facility. (cdc.gov)
In this work, we set out to identify genomic features unique to those coronaviruses that cause severe disease in humans," said Dr. Eugene Koonin, an NIH Distinguished Investigator in the intramural research program of NLM's National Center for Biotechnology Information, and the lead author of the study. (nih.gov)
Advances in technology now make it possible to analyze host genomic factors while an outbreak is underway. (cdc.gov)
Following the outbreak, the full COVID 19 genomic sequence was released in public databases. (dentalreach.today)
Computational scientists on the team applied evolutionary analysis to the human genomic dataset to discover evidence that the ancestors of East Asian people experienced an epidemic of a coronavirus-induced disease similar to COVID-19," Professor Alexandrov said. (phys.org)
For instance, as a first step in understanding the genomic code we have learnt that the human genome is made of 3.2 billion nucleotide bases (of which there are four types: A, C, T, G). It is thought that over 30,000 genes are encoded by this sequence. (ubc.ca)
Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)

The new strain of coronavirus that has killed hundreds of people in China and caused a travel lockdown of some 56 million people has been classified as a "zoonosis" because of the way it spreads from animals to humans. (wuwf.org)

On December 31, when China first announced the outbreak of a mysterious pneumonia , officials there emphasized a few things. (vox.com)

Based on these subtle genetic differences, the team determined that some of the hamsters likely caught the coronavirus in November 2021, before being imported to Hong Kong from the Netherlands. (livescience.com)
Kamal Niaz, Muhammad Farrukh Nisar , " Coronavirus Disease-19 (COVID-19): A Perspective of New Scenario ", Bentham Science Publishers (2021). (benthamscience.com)
Objectives: This series describes 13 EVD patients and 276 patients with suspected EVD treated during a Zaire Ebolavirus outbreak in Guinea in 2021. (bvsalud.org)
Data were reviewed from all patients with suspected or confirmed EVD hospitalised in these two ETCs during the outbreak (14 February 2021 - 19 June 2021). (bvsalud.org)
Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
Philippine Genome Central Visayas Regional Unit between 12 February and Center, unpublished data, 2021). (who.int)

In addition to already established risk loci, our data identify and replicate two genome-wide significant loci at 17q21.31 and 19q13.33 associated with severe COVID-19 with respiratory failure. (cdc.gov)
On 16 November 2002, [11] an outbreak of severe acute respiratory syndrome (SARS) began in China's Guangdong province, bordering Hong Kong. (wikipedia.org)
This rate is patterns, gene sequencing, immuno- Centre for Disease Prevention and higher than that of severe acute respira- genicity and the animal-human and hu- Control (ECDC) and the National In- tory syndrome coronavirus (SARS), man-human interfaces. (who.int)

When Bedford joined The Hutch in 2013, he was working on influenza research and flu evolution, eventually helping launch Nextstrain, an open-source project that analyzes pathogen genome data. (seattletimes.com)
Human genetic factors have also been investigated in avian and swine influenza outbreaks, for example in studies of family clustering of H5N1 and pediatric morbidity following H1N1 infection. (cdc.gov)
Initially, the cause of the outbreak was unknown, and some media outlets reported that an influenza virus was a potential culprit. (wikipedia.org)
All GK glade genomes (predominantly comprising Delta genomes) were downloaded from the GISAID (global initiative on sharing all influenza) database. (news-medical.net)
In the same time it is unlikely to undergo gene reshuffling typical of influenza, since coronaviruses have single RNA genome. (stackexchange.com)

Researchers are hoping that three principal actions of NO may help fight covid: dilating the pulmonary arteries and increasing blood flow through the lungs, dilating the airways and increasing oxygen delivery to the lungs and blood, and directly killing and inhibiting the growth and spread of the coronavirus in the lungs. (mightynatural.com)

Finding these features in animal coronavirus isolates could predict the jump to humans and the severity of disease caused by such isolates. (nih.gov)
A Bioinformatic Pipeline for Improved Genome Analysis and Clustering of Isolates during Outbreaks of Legionnaires' Disease. (cdc.gov)

Scientists from WIV had previously collected SARS-related coronaviruses from bats in the wild, and allegations that they also performed undisclosed risky work on such viruses are central to some versions of the idea. (wikipedia.org)
Scientists in Korea and China have completed full genome sequencing of coronaviruses from the current outbreak. (continuitycentral.com)
Scientists report that in the past, such outbreaks have wiped out entire colonies of prairie dogs and the black-footed ferrets that depended on them for food. (sciencedaily.com)
The profusion of information that keeps emerging about the growing COVID-19 outbreak presents challenges for reporters and the scientists they talk to when researching their stories. (scientificamerican.com)
While keeping track of the outbreak, we've become aware of how hard this vigilance is for even the most energetic and well-motivated scientists and journalists, given the firehose of available information from both traditional sources (public health authorities, journals) and new ones (preprints, blogs). (scientificamerican.com)
These 3 Seattle scientists study the coronavirus. (seattletimes.com)
Three Seattle scientists who have been studying the coronavirus have been selected among hundreds for national biomedical funding that offers millions of dollars toward their research, positioning them for possible scientific breakthroughs down the road. (seattletimes.com)
This research could be a crucial step in helping scientists develop approaches to predict, by genome analysis alone, the severity of future coronavirus disease outbreaks and detect animal coronaviruses that have the potential to infect humans. (nih.gov)
CDC scientists confirm the first outbreak of monkeypox in the Western Hemisphere. (cdc.gov)
The HGP was an initiative started in the early 1990's that has involved the efforts of hundreds of scientists to generate high-quality reference sequence for the 3 billion base pairs of nucleotide sequence that make up the human genome. (ubc.ca)
By reading the sequence of the human genome, scientists hope to gain an understanding of the underlying code that determines how a complex biological system, such as a human cell, acts and reacts. (ubc.ca)
The HGP started at a meeting of scientists during which the value of knowing the genome sequence of an organism was recognized. (ubc.ca)
Nonetheless, scientists at genome centres took up the challenge. (ubc.ca)
Two large groups of scientists published the first analyses of this human genome sequence in the February 2001 issues of the journals Nature [1] and Science [2]. (ubc.ca)
With genome sequence in-hand scientists are now more effectively able to study gene function and explore new areas of research such as how human variation contributes to different diseases worldwide. (ubc.ca)
Scientists today are discovering that the more we learn about the human genome, the more that there is to explore. (ubc.ca)
Yet we have also discovered that over 50% of the human genome is repetitive sequence that does not code for any proteins and the function of this large portion of "junk" DNA is still puzzling scientists. (ubc.ca)

Union co-founders David Engelthaler, Paul Keim, and Michael Worobey are sequencing samples of coronavirus from COVID-19 patients to examine where each strain originated from, and how it transmits from person to person. (azbigmedia.com)

Upasana Ray Banerjee, a virologist at the CSIR-Indian Institute of Chemical Biology (IICB) whose team recently analysed the genome sequence from a COVID-19 patient from Gujarat, agrees. (nature.com)

Research priorities in the current outbreak include devising rapidly deployable diagnostic tests, better understanding transmission, developing and testing antiviral drugs, and ultimately, developing a protective vaccine. (cdc.gov)

Starting from 12 June 2015, Disease Outbreak News concerning MERS-CoV in the Republic of Korea will be published on a bi-weekly basis (on Tuesdays and Fridays). (continuitycentral.com)
So far, the number of confirmed cases and associated deaths by the coronavirus disease outbreak has surpassed overall cases and deaths from the SARS epidemic. (who.int)
Following the announcement of disease outbreak by international or local authorities, dentists can play a significant role in disrupting the transmission chain, thereby reducing the incidence of the disease by simply postponing all non-emergency dental care for all patients. (dentalreach.today)

Research into the natural reservoir of the virus that caused the 2002 SARS outbreak has resulted in the discovery of many SARS-like coronaviruses circulating in bats, most found in horseshoe bats. (wikipedia.org)
Thus, it is highly likely that future SARS-like coronavirus outbreaks will originate from bats. (mdpi.com)
In addition, it is increasingly important to understand why bats can maintain coronaviruses long-term without showing clinical symptoms of diseases. (mdpi.com)
In this regard, global efforts on the discovery and active surveillance of bat coronaviruses, and on understanding of the relationship between bats and coronaviruses are urgently needed. (mdpi.com)
These features are found in all three high-fatality coronaviruses and their closest relatives that infect animals, such as bats, but not in four other human coronaviruses that cause non-fatal disease. (nih.gov)
Sources have indicated that the COVID-19 shares 88-96% of its genome with coronavirus originating in bats, but there is possibly an intermediate host, as was the case with SARS and MERS-CoV (6,7). (who.int)
In the case of the new coronavirus, researchers believe that the virus may have originated with horseshoe bats in China and then could have possibly spread to other animals - which people then ate. (wuwf.org)

Sharing the complete genome sequence, promising the vaccines a global public product, and cooperating with developing countries in vaccine production. (cgtn.com)

However, Arizona does have one major transmission chain from the other cases examined, and researchers have determined the outbreak was present in the state in early March. (azbigmedia.com)
Some of the plague-impacted prairie-dog colonies were occupied by ferrets, but researchers do not know yet how many ferrets have died from the outbreak. (sciencedaily.com)
Studying the genomes of modern humans from 26 worldwide populations, researchers discovered the genetic "footprint" of an ancient coronavirus outbreak. (arizona.edu)
In a paper published in Current Biology, researchers analyzed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks. (arizona.edu)
The researchers found signs of adaptation in 42 different human genes encoding VIPs, suggesting the ancestors of modern East Asians were first exposed to coronaviruses over 20,000 years ago. (arizona.edu)
Studying the "tracks" left by ancient viruses can help researchers better understand how the genomes of different human populations adapted to viruses that have emerged as important drivers of human evolution. (arizona.edu)
An in-depth analysis of the genome sequence of coronavirus circulating in Norfolk, UK by researchers at the Quadram Institute and University of East Anglia has mapped the spread of the virus, identified hidden outbreaks and provided insights into the effectiveness of interventions to stop. (quadram.ac.uk)
In the present retrospective study, researchers investigated the persistence of ORF7a Δ17del for months, unlike other mutations in ORF7a that have been detected worldwide in Delta genomes. (news-medical.net)

Most large Chinese cities have laboratories that study coronaviruses, and virus outbreaks typically begin in rural areas, but are first noticed in large cities. (wikipedia.org)
A total of eight people from the CNR and two from the P2M sequencing platform have been working on the virus this week and will continue to monitor the outbreak in France. (pasteur.fr)
With the 1000-genome project, about 10 more facilities across the country will be pulled in to sequence the virus. (nature.com)
Microscopic view of a coronavirus particle showing surface proteins that play key roles in the interaction between the virus and the host cell. (arizona.edu)
We did not find the ancient virus directly - instead we found signatures of the natural selection that it imposed on human genomes at the time of an ancient epidemic. (arizona.edu)
We investigate the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus genomes, and community-based PCR data. (cdc.gov)
The full genomes of all human coronaviruses were aligned to identify regions (red) that might code for lethal differences in the virus that causes COVID-19 as well as SARS and MERS. (nih.gov)
In particular, the insertions in the spike protein are predicted, from protein structure analysis, to facilitate the recognition of the coronavirus receptors on human cells and the subsequent penetration of the virus into those cells. (nih.gov)
Hamsters can be infected with the coronavirus in laboratory settings and are often used in research, but prior to the Hong Kong outbreak, there wasn't evidence of the rodents passing the virus to humans, Nature reported . (livescience.com)
I've been working on a lineage typing tool called pangolin (phylogenetic assignment of named global outbreak lineages) that will allow any research group to type their virus genome. (ed.ac.uk)
Hospitals and research centres across the UK can input their data and check if there are outbreaks in hospitals or if the infections are separate introductions of the virus. (ed.ac.uk)
The genome data provides insight into how the virus is moving within the community, and helps inform decisions on the most effective control measures to limit virus spread. (ed.ac.uk)
Amid soaring Covid-19 cases in China, the Union Health Ministry recently warned about a possible coronavirus fourth wave after mid-January adding that the next 40 days will be crucial as the country may witness an uptick in cases, owing to a virus wave in China and the festive season. (mydosti.com)
The 5' terminus genome encodes nonstructural proteins (nsps) that are involved in the process of the virus infection cycle. (medrxiv.org)
To enhance response activities and prioritization of resources, WHO/EMRO has conducted an analysis of the risk of introduction of the virus into its countries, as well as their capacity to manage a COVID-19 outbreak. (who.int)
Month by month, CDC consistently provided a strong return on the American people's investment, acting swiftly and decisively to control outbreaks like SARS, Monkeypox, and West Nile Virus while carrying out sound, science-based programs to reduce illness and death from conditions like heart disease and obesity. (cdc.gov)
October 2002 - CDC staff investigates outbreaks of Norwalk virus, which sicken thousands on cruise ships. (cdc.gov)
His laboratory produced the virus genome analysis of the Middle East Respiratory Syndrome Coronavirus (MERS CoV) outbreaks working with the Department of Health in Saudi Arabia, showing that the transmission pattern of the virus was consistent with multiple transfer events from an animal reservoir and contributing to the identification of camels as the animal reservoir. (imperial.ac.uk)
His laboratory contributed to the international Ebola virus genome analysis to help the WHO control the outbreak and to show the factors influencing virus transmission. (imperial.ac.uk)
One of these five patients had Lassa virus disease and a coronavirus disease 2019 (COVID-19) co-infection. (bvsalud.org)
This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)
A collection of the most up-to-date and cleared information on the ongoing Zika virus outbreak. (cdc.gov)

Sequencing the genome of pathogens is crucial for the development of specific diagnostic tests and the identification of potential treatment options," explains Sylvie van der Werf, Director of the National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur. (pasteur.fr)
Modern human genomes contain evolutionary information tracing back hundreds of thousands of years, including physiological and immunological adaptions that have enabled humans to survive new threats, including viruses. (arizona.edu)
In addition to the VIPs, which are located on the surface of a host cell and used by coronaviruses to enter the cell, the viruses interact with many other cellular proteins once inside. (arizona.edu)
Coronaviruses are the largest of all RNA viruses, with positive-sense single-stranded RNA genomes of 26-32 kb. (medscape.com)
Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)

Other independent studies have shown that mutations in VIP genes may mediate coronavirus susceptibility and also the severity of COVID-19 symptoms. (arizona.edu)
In the decade following the SARS outbreak in 2003, several human candidate gene studies of infection susceptibility and severity were conducted. (cdc.gov)

It had taken over a year to do it in 2002 during the first SARS outbreak. (cgtn.com)
The outbreak was first identified in Foshan , Guangdong , China , in November 2002. (wikipedia.org)

Between 8 and 12 June 2015, the National IHR Focal Point of the Republic of Korea notified WHO of 62 additional confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), including 6 deaths. (continuitycentral.com)
By studying other SARS and Middle East respiratory syndrome coronaviruses, it is hypothesized that patients with COVID‑19 may lack sufficient antiviral T‑cell responses, which consequently present with innate immune response disorders. (spandidos-publications.com)
Vero cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV). (medscape.com)
The complete CDC guidance can be found on the CDC website ( Interim Infection Prevention and Control Recommendations for Hospitalized Patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV ). (medscape.com)
ABSTRACT A literature review of publically available information was undertaken to summarize current understanding and gaps in knowledge about Middle East respiratory syndrome coronavirus (MERS-CoV), including its origin, transmission, effective control measures and management. (who.int)
Consequently, stitute for Clinical Excellence (NICE) estimated at 15%, and is strongly age- a myriad of literature has been pro- databases on 19 April 2015 for "Middle and sex-dependent ( 3 ).To date, 26 duced, much of it providing evidence East respiratory syndrome coronavirus" countries on four continents ( 2,4 ) have to answer questions about the origin, [MESH] OR "MERS-CoV" [keyword] been affected. (who.int)
Middle East respiratory syndrome (MERS) is a respiratory disease caused by a newly recognized coronavirus (MERS-CoV). (medscape.com)

The modern human genome contains evolutionary information tracing back tens of thousands of years, like studying the rings of a tree gives us insight into the conditions it experienced as it grew," Professor Alexandrov said. (phys.org)

The complete string of nucleotide letters that make up the DNA sequence in our cells is often referred to as our genome. (ubc.ca)

We aimed to estimate the genetic diversity of related M tuberculosis strains in the UK Midlands and to investigate how this measurement might be used to investigate community outbreaks. (blogspot.com)
Diagnosis of Lassa fever has also advanced from basic serological tests to more sophisticated methods such as quantitative real time polymerase chain reaction (qRT-PCR) and sequencing, which are particularly useful for identifying outbreak strains. (bvsalud.org)

Syndrome Coronavirus (MERS-CoV). (cdc.gov)
Human genome-wide association studies (GWAS) were proposed as a way to investigate the " super-spreader" phenomenon observed in the SARS and MERS outbreaks. (cdc.gov)
A large MERS outbreak occurred in the Republic of South Korea linked to a traveler from the Arabian Peninsula in 2015. (medscape.com)
Orient (MERS-CoV), notamment sur son origine, la transmission, les mesures de lutte efficaces et la prise en charge. (who.int)
Because of an ongoing 2015 outbreak of MERS in South Korean healthcare facilities, the CDC has also recently advised clinicians to ask patients with serious respiratory problems whether they have recently been in a healthcare facility in South Korea to screen for MERS-CoV. (medscape.com)

Our global outbreak response system depends on the full participation of all actors at all levels of government," Steven Hoffman , director of the Global Strategy Lab and a professor of global health at York University, summed up. (vox.com)
I am declaring a public health emergency of international concern over the global outbreak of #2019nCoV , not because of what is happening in #China , but because of what is happening in other countries. (breitbart.com)
Through WHO's global outbreak alert and response network or GOARN 13 experts have been deployed to support the government with case management, epidemiology, infection prevention and control, laboratory support and information management. (bvs.br)

But nearly everywhere Chu turned, officials repeatedly rejected the idea, interviews and emails show, even as weeks crawled by and outbreaks emerged in countries outside China, where the infection began. (boston.com)
Suspecting that this might be another potential case of animal-to-human transmission, Hong Kong health officials began screening animals at the pet shop for evidence of coronavirus infection. (livescience.com)
Breathing in through the nose delivers NO directly into the lungs, where it helps fight coronavirus infection by blocking the replication of the coronavirus in the lungs . (mightynatural.com)

A new study co-authored by a University of Arizona researcher has discovered a coronavirus epidemic broke out in the East Asia region more than 20,000 years ago, with traces of the outbreak evident in the genetic makeup of people from that area. (arizona.edu)

As the situation evolves, many details regarding the epidemiological profile of Coronavirus Disease 2019 (COVID-19) have yet to be elucidated. (who.int)

Human-to-human transmission among close contacts has occurred, including in health care workers, although large nosocomial outbreaks have been avoided so far. (who.int)

When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop the spread. (cdc.gov)

He's long been analyzing outbreaks and developing surveillance networks, such as the Seattle Flu Study, an effort led by the Brotman Baty Institute for Precision Medicine, UW Medicine, "The Hutch" and Seattle Children's. (seattletimes.com)
While it is almost impossible to predict or prevent the next coronavirus outbreak, we believe that active surveillance is the best we can do at the present time to provide early warnings and, in turn, minimize the impact of such future outbreaks. (mdpi.com)
Results from blood donation screening during outbreaks can add to what is known about Zika through routine clinical and surveillance data and improve targeting of public health prevention and response efforts. (cdc.gov)

Rapid access to sequence data from public databases such as GenBank plays a vital role in helping countries develop specific diagnostic kits for disease outbreaks like this one. (nih.gov)
Campylobacter , and Escherichia coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends. (cdc.gov)

The Centre has also directed states to ramp up genome sequencing of positive Covid cases for early detection of new variants. (mydosti.com)

CDC dedicates new Emergency Operations Center that allows for a more efficient response to infectious disease outbreaks and other public health emergencies. (cdc.gov)

But this study of the evolution of the human genome has revealed another large coronavirus epidemic broke out thousands of years earlier. (arizona.edu)
The results revealed that the ancestors of East Asian people experienced an epidemic of a coronavirus-induced disease similar to COVID-19. (arizona.edu)

[2] The World Health Organization (WHO) was notified of the outbreak in February 2003, and issued a global alert in March 2003. (wikipedia.org)
[3] The major part of the outbreak lasted about 8 months, and the World Health Organization declared SARS contained on 5 July 2003. (wikipedia.org)
[15] The People's Republic of China notified the World Health Organization (WHO) about this outbreak on 11 February 2003, reporting 305 cases including 105 health-care workers and five deaths. (wikipedia.org)

According to the CDC , as of January 11, Chinese health authorities say they've identified more than 40 human infections as part of this outbreak that was first reported on December 31. (nih.gov)
India's Council for Scientific and Industrial Research (CSIR), which undertook a mega 1008-human genome sequencing project last year, has been leading the sequencing efforts in India. (nature.com)
Taiwan's vice president told the Financial Times that Taiwanese health authorities warned the WHO that the coronavirus could be transmitted from human-to-human in late December, but that the WHO ignored them and did not accept that finding until more than 20 days later. (breitbart.com)
The identified features correspond with the high fatality rate of these coronaviruses, as well as their ability to move from animal to human hosts. (nih.gov)
This made me wonder of what we know about the coronavirus evolution, particularly where it comes to evading human immune defenses: it is not mutating as fast as HIV - indeed, the genomes responsible for outbreaks in various countries are almost identical . (stackexchange.com)
What is the Human Genome Project? (ubc.ca)
The completion of the human genome project (HGP) is an example of newsworthy science that has the potential to have major effects on our society today. (ubc.ca)
This DNA sequence contained in a genome contains the complete code that determines which genes and proteins will be present in human cells. (ubc.ca)
Insights from deciphering the human genome have potential to be applied to a better understanding of human health and could help to develop better treatments for disease. (ubc.ca)
Officially, funding for the project began in the 1990 with the goal of sequencing the human genome by 2005. (ubc.ca)
Ten years after the official beginning of the HGP, the first working draft of the human genome was announced. (ubc.ca)
The race to publish human genome sequence information was fuelled by competition between research from the publicly funded HGP and the privately owned company, Celera Genomics. (ubc.ca)
This first working draft of the human genome sequence was hailed with much excitement and fanfare as the "completion of the human genome" in the media. (ubc.ca)
What have we learned from the Human Genome Project? (ubc.ca)

Knowledge of a genome unlocks the secrets of what DNA is making which proteins. (ubc.ca)

If a coronavirus outbreak occurs in China, there is a high likelihood it will occur near a large city, and therefore near a laboratory studying coronaviruses. (wikipedia.org)

India has so far witnessed three surges of Covid-19, including the deadly second wave driven by the Delta variant of the coronavirus which majorly attacked the lungs and led to oxygen deficiencies in an infected person. (mydosti.com)

Subsequently, genomes were discarded if they were not assigned to Delta, were duplicates, did not cover the entire ORF7a gene, and/or the collection dates were not mentioned. (news-medical.net)

Nearly six weeks after China announced the coronavirus outbreak , there's still a surprising amount we don't know about this newly discovered disease. (vox.com)
Since the outbreak of COVID-19, China has made many firsts in research and development of vaccines. (cgtn.com)
To date, the outbreak has spread to most provinces in China and 25 other countries within a relatively short period. (who.int)
WHO has categorized the risk of the COVID-19 outbreak globally as high, including the Eastern Mediterranean Region, because of the direct and indirect international travel from to and from China. (who.int)
Thousands of civets in captivity were butchered and electrocuted and smothered and drowned in this first, panicked blind reaction in China to the SARS outbreak. (wuwf.org)

Anatomy7

Organisms46

Diseases41

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes70

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture5

Information Science12

Health Care21

Geographicals5

2019-nCoV11

20209

Pandemic13

Whole genome6

Viral12

SARS-CoV40

Wuhan7

Sequences7

Experiencing COVID-191

Genomic7

Strain of coronavirus1

Pneumonia1

20216

Severe3

Influenza5

Spread of the coronavirus1

Isolates2

Scientists17

Samples of coronavirus1

Analysed the genome sequence1

Current outbreak1

Disease outbreak3

Bats7

Complete genome1

Researchers8

Virus22

Viruses6

Severity2

20022

Respiratory syndrome7

Evolutionary information trac1

Nucleotide1

Strains2

MERS5

Global outbreak3

Infection3

Genetic1

Epidemiological1

Nosocomial1

Epidemiologists1

Surveillance3

Sequence data2

Centre1

Infectious disease1

Epidemic2

World Health Organ3

Human14

Proteins1

Laboratory1

Lungs1

Subsequently1

China5