• nucleotide
  • Some microbial pa thogens use nucleotide repeats in their genome to stochastically vary phenotypic traits and thereby evade host defense. (ethz.ch)
  • M. tuberculosis lacks a mismatch repair system, and this renders nucleotide repeats particularly unstable. (ethz.ch)
  • Results We found that proteins of M. tuberculosis are encoded by using codons in a context-dependent manner that prevents the emergence of nucleotide repeats. (ethz.ch)
  • The isochore theory was the first to identify the nonuniformity of nucleotide composition within vertebrate genomes and predict that the genome of "warm-blooded" vertebrates such as mammals and birds are mosaic of isochores (Bernardi et al. (wikipedia.org)
  • entire genome
  • We have taken a sample of (XDR) TB from a Kwazulu-Natal patient and sequenced the entire genome of the strain of TB,' said Carl Montague, the health portfolio manager of Lifelab which funds the National Genomics Platform. (medindia.net)
  • Results: Cross-matching of literature and in silico-derived data, in conjunction with the prioritization scheme and biological rationale, allowed for selection of 189 putative vaccine candidates from the entire genome. (www.gov.uk)
  • A genome wide association study (GWAS), by contrast, can scan nearly the entire genome for variants associated with a phenotype, free from limiting hypotheses of biological plausibility. (beds.ac.uk)
  • coli
  • Although operon structure has been well studied at the biochemical level in microorganisms such as Escherichia coli , genome-wide operon organization in pathogenic organisms, such as M. tuberculosis , remains largely unknown. (biomedcentral.com)
  • The most widely studied variants of PHGDH are from the E. coli and M. tuberculosis genomes. (wikipedia.org)
  • The subunits from the E. coli PHGDH have three distinct domains, whereas those from M. tuberculosis have four. (wikipedia.org)
  • In 2011, Pallen led a crowdsourced analysis of the genome of the outbreak strain from the 2011 German E. coli O104:H4 outbreak, which had been genome-sequenced on the Ion Torrent platform by the BGI. (wikipedia.org)
  • Around the same time, he also led a project in which an isolate from the 2011 German E. coli O104:H4 outbreak was genome-sequenced on three new benchtop sequencing platforms, benchmarking these new platforms. (wikipedia.org)
  • While the E. coli genome is roughly 4.6Mb in length, in comparison the Human genome is much larger with a size of approximately 3.2Gb. (wikipedia.org)
  • resistance
  • Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. (ox.ac.uk)
  • The Xpert MTB/RIF is a cartridge based nucleic acid amplification test, automated diagnostic test that can identify Mycobacterium tuberculosis (MTB) DNA and resistance to rifampicin (RIF) by nucleic acid amplification test (NAAT). (wikipedia.org)
  • pulmonary
  • There is reason to expect strong genetic influences on the risk of developing active pulmonary tuberculosis (TB) among latently infected individuals. (beds.ac.uk)
  • Hospital infection control practice reflects the working assumption that extra pulmonary tuberculosis is not considered infectious. (duhnnae.com)
  • We have re-consideration our infection control practices in our hospital in the light of this case to account for the potential of tuberculosis transmission in settings other than just pulmonary disease. (duhnnae.com)
  • waxy
  • First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. (wikipedia.org)
  • genomic
  • Genetic changes may lead to both increases or decreases of genomic complexity due to adaptive genome streamlining and purifying selection. (wikipedia.org)
  • clones
  • Eukaryotic genomes evolve over time through many mechanisms including sexual reproduction which introduces much greater genetic diversity to the offspring than the prokaryotic process of replication in which the offspring are theoretically genetic clones of the parental cell. (wikipedia.org)
  • Comparative
  • Since the first sequenced genomes became available in the late 1970s, scientists have been using comparative genomics to study the differences and similarities between various genomes. (wikipedia.org)
  • organization
  • The genome organization of warm-blooded vertebrates is a mosaic of mostly GC-rich isochores. (wikipedia.org)
  • Genome organization of cold-blooded vertebrates is characterized by low GC content levels and lower compositional heterogeneity than warm-blooded vertebrates. (wikipedia.org)
  • composition
  • The isochore theory purported that the genome of "warm-blooded" vertebrates (mammals and birds) are mosaics of long isochoric regions of alternating GC-poor and GC-rich composition, as opposed to the genome of "cold-blooded" vertebrates (fishes and amphibians) that were supposed to lack GC-rich isochores. (wikipedia.org)
  • Spread
  • Our study results show that routine testing for TB and preventive isoniazid therapy works well at the community level in people with HIV disease in curbing the spread of TB and lowering the number who die," says Chaisson, a professor at the Johns Hopkins University School of Medicine and founding director of its Center for Tuberculosis Research. (medindia.net)
  • A misconception is that M. tuberculosis can be spread by shaking hands, making contact with toilet seats, sharing food or drink, sharing toothbrushes, or kissing. (wikipedia.org)