• genomic
  • Mutational bias can influence the whole genome and drives the change in genomic GC composition. (pubmedcentralcanada.ca)
  • This large genomic size makes dinoflagellates unlikely to be selected for complete genome sequencing. (pubmedcentralcanada.ca)
  • The interpretation of sequence polymorphism data, such as the data produced in large amounts from genome-wide association studies, is largely based on the concept of a gene as a stand-alone, separate genomic entity with discrete start and end, as defined by the current genomic annotations. (biomedcentral.com)
  • However, surveys aimed at an unbiased cataloguing of the transcripts produced by human and other genomes, such as [ 1 - 7 ], challenge the notion of a gene as a separate, discrete genomic unit. (biomedcentral.com)
  • In the past 10 years research in my laboratory has focused on generation of genomic tools to enable analysis of genome function and facilitate detection of naturally occurring variation in livestock affecting a variety of functions with impact on food animal production. (usda.gov)
  • Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression. (wikipedia.org)
  • phylogenetic
  • It should be valuable in phylogenetic studies of large protein families. (biomedcentral.com)
  • Sicheritz-Ponten and Andersson [ 4 ] automated phylogenetic analysis of microbial genomes in a tool called pyphy . (biomedcentral.com)
  • The draft genome is useful for advancing our understanding of the host-parasite interaction, the biology of the mite and its phylogenetic relationship to other Acari. (biomedcentral.com)
  • We present SeaView version 4, a multiplatform program designed to facilitate multiple alignment and phylogenetic tree building from molecular sequence data through the use of a graphical user interface. (wordpress.com)
  • SeaView version 4 combines all the functions of the widely used programs SeaView (in its previous versions) and Phylo_win, and expands them by adding network access to sequence databases, alignment with arbitrary algorithm, maximum-likelihood tree building with PhyML, and display, printing, and copy-to-clipboard of rooted or unrooted, binary or multifurcating phylogenetic trees. (wordpress.com)
  • colinearity
  • The two genomes exhibit extensive colinearity, and the rate of divergence appears to be higher in the chromosomal arms than in the centers. (plos.org)
  • Comparative analysis performed at the DNA sequence level has demonstrated that colinearity between the grass genomes is retained at the molecular level (microcolinearity) in most cases. (jove.com)
  • human
  • Incyte is one of several companies hoping to make money on its maps of the human genome - the collection of all human genetic material. (wired.com)
  • They are both competing with and using information from the public efforts, including the Human Genome Project, a collegial undertaking by scientists around the world that has as its aim making the data public to everyone for free. (wired.com)
  • The Human Genome Project looks at DNA. (wired.com)
  • The idea behind having a map of the human genome is to better understand disease. (wired.com)
  • The nonprofit institute was one of the founding organizations in the Human Genome Project, but has since hooked up with Connecticut-based Perkin-Elmer Corp. to try to get work done faster. (wired.com)
  • Following the results of such surveys of transcriptional output of human and other genomes [ 1 - 7 ], the concept of a gene has expanded in several directions. (biomedcentral.com)
  • Human CNTNAP4 genome location and CNTNAP4 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • According to antibody-based profiling and transcriptomics analysis, ASRGL1 protein is present in all analysed human tissues, with highest expression in female tissues such as the uterine cervix and fallopian tube, and in male tissues ASRGL1 is highest expressed in the testis. (wikipedia.org)
  • LTB4R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Receptors, Leukotriene B4 at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • RFX2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. (wikipedia.org)
  • analysis
  • However, detailed analysis has also revealed a number of exceptions to microcolinearity, which have given insight into mechanisms that are involved in grass-genome evolution. (jove.com)
  • Analysis of such tumor clones allows for the identification of integration sites of individual proviruses in the host genome. (aacrjournals.org)
  • membrane proteins
  • TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane. (wikipedia.org)
  • G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). (wikipedia.org)
  • regulatory
  • In addition, we have begun studies of an emerging class of regulatory molecules encoded by the genome called micro- RNAs, short and specific RNA sequences that appear to have the capacity to act as key regulators of growth, development, and tissue homeostasis. (usda.gov)
  • Proviruses that integrate in the vicinity of a gene can influence its expression through potent viral regulatory sequences. (aacrjournals.org)
  • The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. (wikipedia.org)
  • similarity
  • Here, we describe EPIC1 to EPIC4, a new family of P. infestans secreted proteins with similarity to cystatin-like protease inhibitor domains. (plantphysiol.org)
  • bacterial
  • Using these, for each gene in a bacterial genome the users of pyphy can then determine e.g. whether it features nearest neighbors only from the archaeal kingdom. (biomedcentral.com)
  • We played significant roles in development of genome maps of cattle, swine, and sheep, and in development of resources such as Bacterial and Yeast Artificial Chromosome libraries, Expressed Sequence Tag databases, and full-length protein- coding mRNA sequences. (usda.gov)
  • draft
  • To explore the basis for this striking conservation of structure and function, we have sequenced the C. briggsae genome to a high-quality draft stage and compared it to the finished C. elegans sequence. (plos.org)
  • With the bovine draft genome sequence in hand, and development of databases of DNA sequence variation across the genome, we can now turn our attention to leveraging the investment in genome sequence to improve our understanding of the impact and interplay of the genome and the production environment. (usda.gov)
  • Transcript
  • Sequence polymorphism 1 would affect an annotated exon of locus A that occurs in the annotated transcript RNA-1 and in unannotated transcripts (RNA-4 and RNA-5, cyan) and not in RNA-2. (biomedcentral.com)
  • Alternatively spliced transcript variants encoding the same protein have been observed for this gene. (wikipedia.org)
  • subunits
  • The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. (wikipedia.org)
  • The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. (wikipedia.org)
  • physiological function
  • The protein has a physiological function in regulation of water transport mainly in apocrine glands in the axilla, vulva, eyelid and ear canal, serous cells of the submandibular salivary gland, serous cells of the submucosal glands of the bronchi, and accessory lacrimal glands as well as cutaneous eccrine glands. (wikipedia.org)
  • ligand
  • Homer1a, acts as a natural dominant negative form that blocks interaction between long-forms and their ligand proteins by competing with the EVH1 binding site on the ligand proteins. (wikipedia.org)
  • Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). (wikipedia.org)
  • extracellular
  • During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. (wikipedia.org)
  • In each protein, about 85% of its 1600-amino-acid length is extracellular. (wikipedia.org)
  • LRP6 is regulated by extracellular proteins in the Dickkopf (Dkk) family (like DKK1), sclerostin, R-spondins and members of the cysteine-knot-type protein family. (wikipedia.org)
  • experimentally
  • Alteration of the gene structure and/or expression leading to cellular transformation and tumor growth can be experimentally achieved by insertion of the retroviral genome into the host DNA. (aacrjournals.org)
  • chromosome
  • They have the same chromosome number and genome sizes, and they occupy the same ecological niche. (plos.org)
  • Pubmed ID: 12096816 The genomes of grasses are very different in terms of size, ploidy level and chromosome number. (jove.com)
  • tissues
  • This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. (wikipedia.org)
  • family
  • For each protein family, three different phylogeny reconstruction methods are used, and a consensus is calculated. (biomedcentral.com)
  • Through searches of the genome of the sea anemone Nematostella vectensis Stephenson, one catalase gene and six SOD family members were identified, including three copper/zinc-containing SODs (CuZnSODs), two manganese-containing SODs (MnSODs) and one copper chaperone of SOD (CCS). (biologists.org)
  • repetitive
  • The difference in size between the C. briggsae (estimated at approximately 104 Mbp) and C. elegans (100.3 Mbp) genomes is almost entirely due to repetitive sequence, which accounts for 22.4% of the C. briggsae genome in contrast to 16.5% of the C. elegans genome. (plos.org)
  • different
  • It is likely that the profile of expressed transcripts is different in each tissue [ 9 ], and the effect of a nucleotide change could thus differ depending on the repertoire of transcripts expressed by the locus in each cell. (biomedcentral.com)
  • The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. (wikipedia.org)
  • These alleles encode slightly different versions of a protein, which cause different phenotypical traits. (wikipedia.org)
  • Through its tetrameric structure, long forms of Homer (such as Homer1b and Homer1c) are proposed to cross link different proteins. (wikipedia.org)