Genome mitochondrial gene rearrangement. Medical search. Frequent questions

We sequenced the complete mt genome of W. compar and conducted phylogenetic analyses using concatenated coding sequences of 12 protein-coding genes (PCGs) by maximum likelihood and Bayesian inference. (nature.com)
Recent molecular analyses of mt genome sequences have provided selectable hypotheses for the phylogenetic relationships of nematodes based on 18S rRNA. (nature.com)
The method is straightforward even if only (i) distantly related mitochondrial genomes or (ii) mitochondrial barcode sequences are available as starting-reference sequences or seeds, respectively. (scienceopen.com)
A relatively obvious approach to phylogenetic analysis of whole genomes is to extract as many genes as possible from the genome sequences, create a multiple sequence alignment from each of the genes and to concatenate all alignments. (biomedcentral.com)
Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
Summary: Comparative genomics remains a pivotal strategy to study the evolution of gene organization, and this primacy is reinforced by the growing number of full genome sequences available in public repositories. (omictools.com)
To develop molecular identification tools for Hydroides, the entire mitochondrial genomes of eight Hydroides species were sequenced by next-generation sequencing and the resultant reference sequences were used to design new taxon-specific COI primers. (edu.au)
We assembled a complete mitogenome of the intertidal spider Desis jiaxiangi and performed comparative mitochondrial analyses of data set comprising of Desis jiaxiangi and other 45 previously published spider mitogenome sequences, including that of Argyroneta aquatica . (biomedcentral.com)
The mitochondrial sequences are highly informative phylogenetic markers, but have been mostly neglected due to technical difficulties. (biomedcentral.com)
In addition, using sequences of three mitochondrial genes, the phylogenetic relationships between every sample with a known karyotype were determined, which revealed significant nucleotide divergence among the karyomorphs. (scielo.br)
Partial mitochondrial16S rRNA gene sequences from the infected flies matched sequences derived from black fly larvae cytotaxonomically identified as Simulium tribulatum . (cdc.gov)
We observed a distinction in the repeat lengths of the circumsporozoite protein (CSP) gene sequences between P. brasilianum and P. malariae. (cdc.gov)
The genome sequences were assembled from Illumina HiSeq and PacBio sequencing data and verified with the optical mapping data. (cdc.gov)
We studied chromosome structure in complete genome sequences from 167 Bordetella species isolates, as well as 469 B. pertussis isolates, to gain a generalized understanding of rearrangement patterns among these related pathogens. (cdc.gov)

Mitochondrial DNA (mtDNA) is DNA that is located in mitochondria. (dadamo.com)
These subcellular organelles contain a genome that differs from the nuclear genome and is referred to as mitochondrial DNA (mtDNA). (biomedcentral.com)
These essential subcellular organelles contain mitochondrial DNA (mtDNA), which is an extrachromosomal genetic element. (biomedcentral.com)
In view to find putative mitochondrial genes in alternative reading frames on both coding and "presupposed" non-coding strands, numerous complete mtDNA genomes have been analyzed. (biomedcentral.com)
A rapid diagnostic 'mulitplex' one-step polymerase chain reaction protocol (RD-PCR) was developed using cytochrome oxidase subunit 1 (COX1) mitochondrial DNA (mtDNA) to discriminate between S. haematobium and S. bovis. (imperial.ac.uk)
Alternatively, diagnosis may be established by muscle biopsy with histochemistry and mitochondrial DNA (mtDNA) analysis for major rearrangements. (medscape.com)
In addition, mitochondrial DNA (mtDNA) encodes 2 ribosomal RNA genes and 22 transfer RNA (tRNA) genes necessary for the intramitochondrial synthesis of these 13 polypeptides. (medscape.com)
Located within the mitochondrial matrix, and lacking the efficient repair mechanisms available to nuclear DNA, mtDNA has a relatively high rate of mutation. (medscape.com)
This genetic material is known as mitochondrial DNA or mtDNA. (medlineplus.gov)
Kearns Sayre Syndrome (OMIM #530000) occurs as a result of large-scale single deletions (or rearrangements) of mitochondrial DNA (mtDNA), which are usually not inherited but occur spontaneously, probably at the germ-cell level or very early in embryonic development. (medscape.com)
The proposed mechanism is based on the knowledge that transcription of mtDNA is polycistronic, which means that all genes encoded on the heavy and light strands are transcribed as 2 large precursor RNA strands. (medscape.com)

Mutations of mitochondrial DNA can lead to a number of illnesses including exercise intolerance and Kearns-Sayre syndrome (KSS), which causes a person to lose full function of their heart, eye, and muscle movements. (dadamo.com)
A compound heterozygous mutation of the alkaline phosphatase ALPL gene causes hypophosphatasia in a Han Chinese language household Hypophosphatasia (HPP) is a uncommon hereditary systemic illness that's characterised by faulty bone and/or dental mineralization, and is brought on by mutations within the alkaline phosphatase gene (ALPL). (sourui-koza.com)
As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes. (medlineplus.gov)
Mutations in at least three mitochondrial genes can cause cytochrome c oxidase deficiency, which is a condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver. (medlineplus.gov)
We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)

After a long period of evolution, the genetic composition of mt in most metazoans is now present consistently, suggesting that mt genes are important for maintaining the basic functions of mt 9 . (nature.com)
Researchers from The Hospital for Sick Children (SickKids) have uncovered new genes and genetic changes associated with autism spectrum disorder (ASD) in the largest autism whole genome sequencing analysis to date, providing better understanding into the 'genomic architecture' that underlies this disorder. (medicalxpress.com)
The team found 134 genes linked with ASD and discovered a range of genetic changes , most notably gene copy number variations (CNVs), likely to be associated with autism, including ASD-associated rare variants in about 14 percent of participants with autism. (medicalxpress.com)
We validated the algorithm's predictions by characterizing 646 genetic system variants, encoded in plasmids and genomes, expressed in six gram-positive and gram-negative bacterial hosts. (omictools.com)
Moreover, this strengthens evidence for mitochondrial genes coded according to an overlapping genetic code. (biomedcentral.com)
4] LI Z B,CHENG T Y,XU X L,et al.Genetic variation in mitochondrial genes of the tick Haemaphysalis flava collected from wild hedgehogs in China[J]. Experimental and Applied Acarology ,2017,71(2):131-137. (chvm.net)
17] YI J N,JIN Y C,LIU J H,et al.Genetic variation in three mitochondrial genes among cattle tick Rhipicephalus microplus originating from four provinces of China[J]. Tropical Biomedicine, 2019,36(1):1-7. (chvm.net)
The mitochondrial genome encodes the genetic information for the 13 polypeptide subunits essential for the process of oxidative phosphorylation. (medscape.com)
For the future direction, we need the in-depth genome sequence information and analysis for most of the mammals, including human to fully understand genome variation of economic traits, genetic susceptibility to diseases, and pharmacogenomics of drug response. (springer.com)
Changes in mitochondrial DNA are among the best-studied genetic factors associated with age-related hearing loss. (medlineplus.gov)
Some of the genetic changes alter single DNA building blocks (nucleotides), whereas others rearrange larger segments of mitochondrial DNA. (medlineplus.gov)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)

This study reports, for the first time, the complete W. compar mt genome sequence obtained from Chinese porcupines. (nature.com)
The approach overcomes the limitations of traditional strategies for obtaining mitochondrial genomes for species with little or no mitochondrial sequence information at hand and represents a fast and highly efficient in silico alternative to laborious conventional strategies relying on initial long-range PCR. (scienceopen.com)
Phylogenetic methods which do not rely on multiple sequence alignments are important tools in inferring trees directly from completely sequenced genomes. (biomedcentral.com)
Difficulties with this approach may arise if orthologous genes cannot be identified with certainty or if the combined sequence length is still too small to give well-resolved trees. (biomedcentral.com)
Stephen W. Scherer, Genomic Architecture of Autism From Comprehensive Whole-Genome Sequence Annotation, Cell (2022). (medicalxpress.com)
We now describe the complete re-annotation and re-analysis of the C. jejuni NCTC11168 genome using current database information, novel tools and annotation techniques not used during the original annotation.ResultsRe-annotation was carried out using sequence database searches such as FASTA, along with programs such as TMHMM for additional support. (omictools.com)
This hypothesis could be tested by purifying the gau gene product and determining its sequence. (biomedcentral.com)
LI Z B.Study on ITS sequence and the entire mitochondrial genome sequence of Haemaphysalis flava and Haemaphysalis longicornis [D].Changsha:Hunan Agricultural University,2018. (chvm.net)
Moreover, based on the mt genome DNA sequence data, we also reconstructed its phylogenetic relationships and made inferences about its biogeographic history based on a relaxed molecular clock analysis. (unam.mx)
Background: Sequence variability in the hepatitis C virus (HCV) genome has led to the development and classification of six genotypes and a number of subtypes. (upf.edu)
A nested PCR based on the sequence of the cytochrome oxidase subunit 1 gene of the parasite was developed and used to screen Simulium black flies collected from southern California for O. lupi DNA. (cdc.gov)
Furthermore, P. brasilianum had 4864 (82.1%) genes that share 80% or higher sequence similarity with 4970 (75.5%) P. malariae genes. (cdc.gov)

The mitogenome of M. sexmaculata is a circular molecule of 16,663 bp with 75.00% AT content, containing 13 protein-coding genes (PCGs), 22 tRNAs, 2 rRNAs, and one non-coding control region. (scienceopen.com)
About 2000 completely sequenced mitochondrial genomes are available from the NCBI RefSeq data base together with manually curated annotations of their protein-coding genes, rRNAs, and tRNAs. (scienceopen.com)
The mitogenome is 16,401 bp in length and consisted of 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a control region. (pensoft.net)

Molecular tools, especially cytochrome c oxidase subunit I (COI) barcoding that have proven useful for species delimitation and discovery in eukaryotes, have not been widely used in Hydroides due to the high amplification failure rate of the COI gene. (edu.au)
Combined data of three gene markers (18S, ITS, cytochrome b) and morphological data were used to resolve the taxonomic status of another widely distributed species, Hydroides brachyacantha. (edu.au)
We demonstrate that the expression of plastid coding genes is strongly functionally dependent among conifer species. (biomedcentral.com)
Here we generated and characterized the mitochondrial (mt) genome of 14 specimens of the S. talpa species-group and evaluated its species limits with the cox1 barcoding locus. (unam.mx)
Surprisingly, Pirata subpiraticus , Hypochilus thorelli , and Argyroneta aquatica each had a higher Ka/Ks value in the 13 PCGs dataset among 46 taxa with complete mitogenomes, and these three species also showed positive selection signal in the nd6 gene. (biomedcentral.com)
Comparative analysis of the mitogenomes in the FOSC revealed ongoing mitochondrial recombination within, but not between phylogenetic species. (biomedcentral.com)
The genome of F. oxysporum resembles the genome of heterothallic species, both mating types can be found in populations, the mating type genes are expressed and introns are correctly spliced from the transcript [ 7 ]. (biomedcentral.com)
As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
The chromosomes consist of 98.4% nucleotide sites that are identical to the P. malariae genome, the closest evolutionarily related species hypothesized to be the same species as P. brasilianum, with 41,125 non-synonymous SNPs (0.0722% of genome) identified between the two genomes. (cdc.gov)
240 copies of IS481, IS elements appear less numerous in other species and yield less chromosome structural diversity through rearrangement. (cdc.gov)
Therefore, while it appears that rearrangement occurs less frequently in other species than in B. pertussis, these clinically relevant respiratory pathogens likely experience similar mutation of gene order. (cdc.gov)
The chromosome of B. pertussis has previously been shown to exhibit considerable structural rearrangement, but insufficient data have prevented comparable investigation in related species. (cdc.gov)

All the 22 typical animal tRNA genes are found in M. sexmaculata mitogenome, and most of the tRNAs could be folded into the classic cloverleaf secondary structure. (scienceopen.com)
Understanding the forces that drive the evolution of the mitochondrial genome (mitogenome) provides crucial information, as this evolution is affected by a range of factors that in turn influence the information content of the genome. (biomedcentral.com)

Conclusions: Comparing genomes with unequal content, but without duplicated markers, we give a linear time algorithm to compute the genomic distance considering substitutions and double-cut-and-join (DCJ) operations. (uni-bielefeld.de)
This model provides a parsimonious genomic distance to handle genomes free of duplicated markers, that is in practice a lower bound to the real genomic distances. (uni-bielefeld.de)
Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. Genomic distance under gene substitutions. (uni-bielefeld.de)
Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
Consequently, little is known about how gene expression changes in response to genomic rearrangements in plastids. (biomedcentral.com)

Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)
Analyses of mitochondrial genomes of Hydroides showed a substantial rearrangement in gene order and numerous rarely reported large intergenic regions when compared with genomes of other known polychaetes. (edu.au)
Our selection analyses detected a positive selection signal in the nd4 gene of the aquatic branch comprising both Desis jiaxiangi and Argyroneta aquatica . (biomedcentral.com)
Also, the analyses indicate that chromosomal rearrangements occurred independently within the distinct lineages of S . marmoratus complex, which resulted in the appearance of distinct karyotypic variants in a non-linear fashion related to diploid numbers and in the appearance of similar non-homologous chromosomes. (scielo.br)

T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)
Two genes encoding putative internalin proteins were chosen for further study. (omictools.com)
This putative gene has been named gau for g ene a ntisense u biquitous in mtDNAs. (biomedcentral.com)

The First Five Mitochondrial Genomes for the Family Nidulariaceae Reveal Novel Gene Rearrangements, Intron Dynamics, and Phylogeny of Agaricales . (bvsalud.org)
Here, we extend the recently described Genome BLAST Distance Phylogeny (GBDP) strategy to compute phylogenetic trees from all completely sequenced plastid genomes currently available and from a selection of mitochondrial genomes representing the major eukaryotic lineages. (biomedcentral.com)

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans CRISPR genome modifying has revolutionized genetics in quite a few organisms. (agresearchforum.com)
Dr. Brett Trost, lead author of the paper and a Research Associate in the Genetics & Genome Biology program at SickKids, notes the use of WGS allowed researchers to uncover variant types that would not have otherwise been detectable. (medicalxpress.com)
Further information on the laboratory's involvement in mitochondrial genetics research is available on the Oxford research page of the NHS Rare Mitochondrial Disorders Service website . (ouh.nhs.uk)
De novo sequencing,assembly and analysis of salivary gland transcriptome of Haemaphysalis flava and identification of sialoprotein genes[J]. Infection,Genetics and Evolution ,2015,32(1):135-142. (chvm.net)
Matthias Fischer combines subjects such as RNA-Seq, Computational biology, Human genetics and Human genome with his study of Gene expression profiling. (research.com)

MITOS: improved de novo metazoan mitochondrial genome annotation. (scienceopen.com)

While whole genomes have been published for P. knowlesi, P. cynomolgi, P. simium, and P. inui, no complete genome for P. brasilianum has been available. (cdc.gov)

Nowadays, an increasing number of completely sequenced genomes are available and a growing field of phylogenetic research deals with the question of how to infer reliable phylogenies from this large amount of data to overcome the limitations of single-gene phylogenies. (biomedcentral.com)

Surprising to the team was that the "polygenic score"-an estimation of the likelihood of an individual having autism, calculated by aggregating the effects of thousands of common variants throughout the genome -was not higher among multiplex families. (medicalxpress.com)
During this period, tremendous success has been achieved in the fields of decoding of human genome, technological advancement of new era of human genome applications, toward personalized genomes and discovery of rare variants, leveraging genome sequencing to impact on cancer researches and mammalian evolution and population structure. (springer.com)

16S and 12S), which are essential for various mitochondrial functions [ 9 ]. (biomedcentral.com)
This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)

A positionally conserved ORF has been found on the complementary strand of the cox1 genes of both eukaryotic mitochondria (protist, plant, fungal and animal) and alpha-proteobacteria. (biomedcentral.com)
This search has led to the observation of an unknown, positionally conserved open reading frame (ORF) on the complementary strand of eukaryotic cox1 genes. (biomedcentral.com)

However many proteins found in the mitochondria are encoded by nuclear DNA: some, if not most, are thought to have been originally part of the mitochondrial DNA but have since been transferred to the nucleus during evolution. (dadamo.com)
The existence of separate mitochondrial DNA suggests that, at one point, mitochondria were separate entities from their current host cells. (dadamo.com)
The applicants identified peptides antagonizing such rearrangements and found that they differentially affect MLL binding of EndoG, which operates in mitochondria in unstressed cells. (uni-ulm.de)

His Tumor progression research integrates issues from Apoptosis, Mitochondrion, Mitochondrial ROS and Downregulation and upregulation. (research.com)
As of April 2020, there were records for 88,254 complete mitogenomes for animals in the NCBI database ( https://www.ncbi.nlm.nih.gov/nuccore/?term=mitochondrion+complete+genome ). (biomedcentral.com)

The leading genome research centers and scientists have publicly recognized that these are the core enabling goals for the next decade genomics research. (springer.com)
The National Human Genome Research Institute (NHGRI) has echoed this need through its vision for genomics research (Collins et al. (springer.com)

To improve our understanding of this important human pathogen, the C. jejuni NCTC11168 genome was sequenced and published in 2000. (omictools.com)
The completion of the first human genome drafts (Yamey 2000 ) was just a start of the modern DNA sequencing era which resulted in further invention, improved development toward new advanced strategies of high-throughput DNA sequencing, so called the " high-throughput next generation sequencing " (HT-NGS). (springer.com)

Our results indicate that, at this taxonomic level, plastid genomes are much more valuable for inferring phylogenies than are mitochondrial genomes, and that distances based on breakpoints are of little use. (biomedcentral.com)
Our understanding of plastid transcriptomes is limited to a few model plants whose plastid genomes (plastomes) have a highly conserved gene order. (biomedcentral.com)
Our data provide the first line of evidence that plastomic rearrangements not only complicate the plastomic architecture but also drive the dynamics of plastid transcriptomes in conifers. (biomedcentral.com)
Most plastid genes are presumably transcribed as polycistronic mRNAs which then undergo various post-transcriptional modifications [ 3 ]. (biomedcentral.com)
Plastid genomes (plastomes) of land plants are highly conserved in their gene content and order. (biomedcentral.com)
We have long been puzzled by these findings because it is then unclear whether plastomic rearrangements affect plastid gene transcription. (biomedcentral.com)
We also compared plastid gene expression levels among conifers and demonstrated a strong association between gene expression and plastomic rearrangements. (biomedcentral.com)

With the ongoing developments of high throughput sequencing machines and advancement of modern bioinformatics tools at unprecedented pace, the target goal of sequencing individual genomes of living organism at a cost of $1,000 each is seemed to be realistically feasible in the near future. (springer.com)
Neuroblastoma, Cancer research, Gene expression profiling, Bioinformatics and Survival analysis are his primary areas of study. (research.com)
The scientist's investigation covers issues in Neuroblastoma, Cancer research, Internal medicine, Gene and Bioinformatics. (research.com)
Matthias Fischer has researched Bioinformatics in several fields, including Microarray, DNA microarray, Cancer and Gene expression profiling. (research.com)

The mt genome accumulates mutation rates at a faster rate than the nuclear genome and is characterised by fast evolution, maternal inheritance, and a simple structure. (nature.com)
METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)

Despite a disparity in gene content, all mtDNAs encode at least two components of the mitochondrial electron transport chain, including cytochrome c oxidase I (Cox1). (biomedcentral.com)
Typical triploblastic animal mtDNAs contain genes that encode the large and small subunit ribosomal RNAs, 22 transfer RNAs (tRNAs), and 13 proteins that are all components of the oxidative phosphorylation process: ATPase subunits 6 and 8 (ATP6 and 8), cytochrome b (Cyt b), cytochrome c oxidase subunits 1-3 (Cox1-3) and NADH dehydrogenase subunits 1-6 and 4L (ND1-6 and 4L). (biomedcentral.com)
En este trabajo se caracteriza el genoma mitocondrial de 14 ejemplares del grupo de especies S. talpa y se evalúan sus límites de especie utilizando el marcador mitocondrial cox1 . (unam.mx)

Induction of secondary leukemias by chemotherapy-based cancer treatment represents a serious side effect that frequently involves endonuclease G (EndoG)-mediated chromosomal rearrangements at the mixed-lineage leukemia ( MLL) gene. (uni-ulm.de)
The following chromosomal conditions are associated with changes in the structure or number of copies of mitochondrial dna. (medlineplus.gov)
This review emphasizes the potential of analysing chromosomal rearrangements as a means to rapidly define candidate disease loci for further investigation. (neurotransmitter.net)

The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)

DCJ path formulation for genome transformations which include insertions, deletions, and duplications. (uni-bielefeld.de)
[ 5 ] The deletions vary in size and location on the mitochondrial genome in different individuals, although a common deletion of 4.9kB is present in at least a third of patients with Kearns-Sayre syndrome. (medscape.com)
How can a heterogeneous group of mitochondrial deletions lead to a similar phenotype? (medscape.com)

The complete mt genome is 14,373 bp in size and comprises 36 genes, including 12 protein-coding, two rRNA and 22 tRNA genes. (nature.com)

The genome is 31.4Mb in size and comprises 14 chromosomes, the mitochondrial genome, the apicoplast genome, and 29 unplaced contigs. (cdc.gov)

Whooping cough (pertussis), primarily caused by Bordetella pertussis, has resurged in the United States, and circulating strains exhibit considerable chromosome structural fluidity in the form of rearrangement and deletion. (cdc.gov)

CONCLUSIONS: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated. (neurotransmitter.net)

The remaining genes provide instructions for making molecules called transfer RNA (tRNA) and ribosomal RNA (rRNA), which are chemical cousins of DNA. (medlineplus.gov)

This study aimed to determine the complete mitochondrial (mt) genome of W. compar and reconstruct its phylogenetic relationship with other nematodes. (nature.com)
We sequenced the complete mitochondrial genome of Menochilus sexmaculata (Fabricius, 1781) and compared it with that of other insects. (scienceopen.com)
We present an in silico approach for the reconstruction of complete mitochondrial genomes of non-model organisms directly from next-generation sequencing (NGS) data-mitochondrial baiting and iterative mapping (MITObim). (scienceopen.com)
Please complete a mitochondrial pre-referral form to accompany samples (see referral forms ). (ouh.nhs.uk)
In the present study, the complete mitochondrial genome of P. flavomaculatus was sequenced and analyzed. (pensoft.net)
The first complete genome of the simian malaria parasite Plasmodium brasilianum. (cdc.gov)

3] SHAO R,AOKI Y,MITANI H,et al.The mitochondrial genomes of soft ticks have an arrangement of genes that has remained unchanged for over 400 million years[J]. Insect Molecular Biology ,2004,13(3):219-224. (chvm.net)
Finally, the integration of both molecular cytogenetic and phylogenetic approaches allowed the determination of specific chromosomes possibly involved in rearrangements and a better understanding about the evolutionary processes involved in the differentiation of Synbranchus genus. (scielo.br)

In these models, a deletion and a subsequent insertion that occur at the same position of the genome count for two sorting steps. (uni-bielefeld.de)
A deletion and an insertion that occur at the same position of the genome can be modeled as a substitution, counting for a single sorting step. (uni-bielefeld.de)
Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection. (omictools.com)
A deletion anywhere in the mitochondrial genome may affect transcription or translation of genes that were not affected by the deletion. (medscape.com)

Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. (medlineplus.gov)

The work should be of interest to colleagues in the fields of evolutionary biology, chromatin biology and genome biology. (elifesciences.org)

The fact that mitochondrial DNA is maternally inherited enables researchers to trace uterine lineage far back in time. (dadamo.com)
The role of the maternally inherited mitochondrial DNA was also examined in the study and found to account for two percent of autism. (medicalxpress.com)

His Regulation of gene expression research focuses on Chromatin immunoprecipitation and how it relates to N-Myc, Signal transduction and Binding protein. (research.com)
His Cancer research research incorporates elements of Chromatin, Binding protein, Regulation of gene expression and N-Myc. (research.com)

The mitochondrial genome is a 16569 base-pair closed circular loop of double-stranded DNA found in multiple copies within the mitochondrial matrix. (medscape.com)
These data were further used to predict all possible rearrangements between IS element copies present in Bordetella genomes, revealing that only a subset is observed among circulating strains. (cdc.gov)

In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)

Despite this growth, bioinformatic tools available to visualize and compare genomes and to infer evolutionary events remain restricted to two or three genomes at a time, thus limiting the breadth and the nature of the question that can be investigated. (omictools.com)

The obstacles hindering the usage of the mitogenomes are resolved by using next generation sequencing and selective genome assemblers, such as GRAbB. (biomedcentral.com)

Using a network reconstruction algorithm, we predict that known chloroplast gene expression regulators are differentially involved across those developmental stages. (biomedcentral.com)

These variant types include complex rearrangements of DNA, as well as tandem repeat expansions, a finding supported by recent SickKids research on the link between autism and DNA segments that are repeated many times. (medicalxpress.com)

Furthermore, length and, hence, information content of individual genes is limited, sometimes causing a lack of resolution in the inferred trees. (biomedcentral.com)
The mitochondrial gene content is highly variable across eukaryotes. (biomedcentral.com)
The number of mitochondrial protein genes is believed to vary from 3 to 67, while the tRNA gene content varies from 0 to 27 [ 2 ]. (biomedcentral.com)

Anatomy15

Organisms17

Diseases26

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes99

Disciplines and Occupations4

Information Science4

Health Care2

Sequences14

MtDNA11

Mutations6

Genetic13

Sequence12

Protein-codin3

Species12

Mitogenome2

Genomic5

Analyses4

Putative3

Phylogeny2

Genetics5

Annotation1

Whole genomes1

Completely sequenced1

Variants2

Various mitochondrial2

Eukaryotic2

Mitochondria3

Mitochondrion2

Genomics2

20002

Plastid7

Bioinformatics4

Mutation2

Cox13

Chromosomal3

Proteins1

Deletions3

TRNA genes1

Size and comprises1

Chromosome1

Conclusions1

Ribosomal1

Complete6

Molecular2

Deletion4

Oxidative phosphorylation1

Biology1

Maternally inherited2

Chromatin2

Copies2

Susceptibility1

Evolutionary1

Mitogenomes1

Reconstruction1

Tandem1

Content3