• ORF1 encodes a nonstructural protein (NS1) that is involved in viral genome replication. (wikipedia.org)
  • In Canine minute virus NP1 has been shown to be essential for an early step in viral replication and is also required for the read through of an internal polyadenylation site that is essential for expression of the capsid proteins. (wikipedia.org)
  • The genome encodes proteins involved in DNA replication and repair, RNA synthesis and modification, translation proteins, and capsid proteins. (virology.ws)
  • The expression of these proteins and replication of the viral genome all takes place in the cytoplasm of the host cells . (genetherapynet.com)
  • AAV is a nonhuman pathogen of the Parvoviridae family possessing a single-stranded DNA genome (4.7 kb) with two open reading frames, rep (for replication) and cap (encodes capsid proteins), flanked by two symmetric inverted terminal repeats. (molvis.org)
  • In their replication cycle, viruses must generate a protective shell (or capsid) to ferry their genome between hosts. (gla.ac.uk)
  • In many cases structural proteins are also involved in replication and integration of the viral genome. (gla.ac.uk)
  • The largest, ORF-1, codes for the nonstructural proteins responsible for viral replication. (medscape.com)
  • Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution. (expasy.org)
  • Enhanced replication of rubella virus (RuV) and replicons by de novo synthesized viral structural proteins has been previously described. (cdc.gov)
  • It is not clear whether the CP in the virus particles, i.e., the exogenous CP, modulate viral genome replication. (cdc.gov)
  • In this study, we found that exogenous RuV CP also enhanced viral genome replication, either when used to package replicons or when mixed with RNA during transfection. (cdc.gov)
  • These results suggest that the exogenous RuV CP increases efficiency of early viral genome replication by modulating the stage(s) prior to and/or at the initiation of negative-strand RNA synthesis, possibly through a general mechanism such as protecting viral RNA. (cdc.gov)
  • Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
  • Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
  • In this study, we investigated the presence of DuCV in northern Vietnam, and furthermore, conducted molecular characterization of identified DuCV strains based on the complete genome. (researchsquare.com)
  • 5665\5646\AAG13641.1\Vesicular exanthema of swine virus\Vesicular exanthema of swine virus stain A48, complete genome. (or.jp)
  • 7776\2106\AAC13889.2\Vesicular exanthema of swine virus\Vesicular exanthema of swine virus stain A48, complete genome. (or.jp)
  • 8105\333\AAC13890.1\Vesicular exanthema of swine virus\Vesicular exanthema of swine virus stain A48, complete genome. (or.jp)
  • Complete genome sequence of an Israeli isolate of Xanthomonas hortorum pv. (tau.ac.il)
  • LOCUS X86557 7555 bp RNA linear VRL 18-APR-2005 DEFINITION Lordsdale virus complete genome. (cdc.gov)
  • 140 (8), 1345-1356 (1995) PUBMED 7661689 REFERENCE 2 AUTHORS Dingle,K.E., Lambden,P.R., Caul,E.O. and Clarke,I.N. TITLE Human enteric Caliciviridae: the complete genome sequence and expression of virus-like particles from a genetic group II small round structured virus JOURNAL J. Gen. Virol. (cdc.gov)
  • We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. (cdc.gov)
  • Trees were constructed from alignment of complete genome sequences by using best-fit models and visualised using FigTree (Figure2). (qscience.com)
  • Genotyping of ASFV isolates by partial sequencing of the B646L gene that encodes the major capsid protein p72 has identified 22 genotypes ( 6 ). (cdc.gov)
  • Our discovery marks a breakthrough in the development of antiviral drugs as it does not target specific viral proteins that can rapidly mutate, causing the development of drug resistance - something that remains unresolved by current antiviral drugs against herpes and other viruses. (news-medical.net)
  • Many large viruses, including tailed dsDNA bacteriophages and herpesviruses, assemble their capsids via formation of precursors, called procapsids or proheads. (rcsb.org)
  • While BsV was isolated from fresh water, the finding of abundant related genome sequences in oceanic datasets suggests that they are part of the largest group of giant viruses in the seas. (virology.ws)
  • Of particular interest are the chimeric viruses that may be formed with alphaviral envelopes and retroviral capsids. (genetherapynet.com)
  • Two other families of giant viruses have been found in Chile and Australia, with genomes occasionally more complex than that of bacteria. (zmescience.com)
  • Our huge virus doesn't have a well developed capsid (protein shell), like most smaller viruses do. (zmescience.com)
  • Be they SARS-CoV-2, HIV, or phages that infect bacteria, all viruses comprise at least two components: their genetic material-DNA or RNA-and a protective shell called a capsid. (acs.org)
  • The fact that many viruses generate their capsids from only one or two protein species makes them all the more remarkable. (gla.ac.uk)
  • Viruses attain this level of economy by assembling their capsids in a highly symmetrical manner making these structures not only scientifically interesting but also beautiful. (gla.ac.uk)
  • This group applies the techniques of electron-cryomicroscopy and image analysis to the study of viruses and viral proteins. (gla.ac.uk)
  • with unique features: they are the only viruses that have diploid genome, i.e., two identical molecules of RNA. (futurelearn.com)
  • REFERENCE 1 (bases 1 to 7555) AUTHORS Liu,B.L., Clarke,I.N., Caul,E.O. and Lambden,P.R. TITLE Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses JOURNAL Arch. (cdc.gov)
  • In Nature the genome of viruses are protected by protein capsids. (lu.se)
  • In spherical viruses capsid proteins forms icosahedral shel s with hundreds of subunits. (lu.se)
  • The shel s of many viruses are made up by only a single type of subunit and can often form from a solution of purified protein subunits (they self-assemble). (lu.se)
  • In gene therapy viruses are used to deliver genes into cel s by swapping out the virus genome with human DNA. (lu.se)
  • Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)
  • Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
  • Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)
  • the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)
  • More to the inside, there is an icosahedral capsid, shaped like a truncated cone. (futurelearn.com)
  • Its icosahedral capsid is correspondingly small (26 nm diameter) and simple (four different proteins). (asmblog.org)
  • We found that gp21 and the herpesvirus proteases have similarity with proteins forming the tubes of phage tails and bacterial type VI secretion systems, suggesting their common evolutionary origin. (rcsb.org)
  • In the present study, we reconstructed large phage genomes from freshwater lakes known to contain bacteria that oxidize methane. (nature.com)
  • Future work is needed to determine whether phage-associated PmoC has similar functions to additional copies of PmoC encoded in bacterial genomes, thus contributing to growth on methane. (nature.com)
  • The recently reported phage genomes range up to 735 kb in length and encode a diversity of genes involved in transcription and translation, as well as genes that may augment host metabolism 2 . (nature.com)
  • An infecting phage genome needs protection to cross that compartment intact. (asmblog.org)
  • The cystovirus Pseudomonas phage phi6 has an envelope that harbors five viral membrane proteins and phospholipids derived from the cytoplasmic membrane of its Gram-negative host. (biomedcentral.com)
  • Early studies on nonsense mutants of phage phi6 suggested that the major envelope protein P9 and the non-structural protein P12 are the only proteins needed for phi6 virion envelopment [ 23 ]. (biomedcentral.com)
  • All bocaparvoviruses encode a novel protein called NP1 that is not present in parvoviruses from other genera. (wikipedia.org)
  • It encodes 1227 predicted open reading frames, of which 27% encode proteins that match known eukaryotic sequences, while over half are not recognizable. (virology.ws)
  • As BsV does not encode enzymes involved in this process, the virus must use host tRNAs in the process of protein synthesis. (virology.ws)
  • Of manually curated genomes, 22 (18 are complete), ranging from 159 kilobase (kb) to 527 kb in length, were found to encode the pmoC gene, an enzymatically critical subunit of the particulate methane monooxygenase, the predominant methane oxidation catalyst in nature. (nature.com)
  • All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). (genome.jp)
  • The L1 and L2 genes encode the major and minor capsid proteins. (clinicalpathologyassociates.com)
  • Protein sequences were clustered by the pairwise sequence similarity using CLANS. (biomedcentral.com)
  • WGS, whole-genome sequences (10 segments). (cdc.gov)
  • There are ample mobile genetic elements present, including self splicing proteins (called inteins) and sequences known as ribozymes that can splice themselves out of an RNA. (virology.ws)
  • The deduced amino acid sequences of the outer capsid protein, VP7, of serotype G1 rotavirus clinical isolates collected over a 6 year period (1990-1995) in Melbourne, Australia, were examined. (microbiologyresearch.org)
  • Phylogenetic analysis characterized the sequences into two discrete clusters representing two of the four global lineages of human G1 VP7 proteins. (microbiologyresearch.org)
  • Cell receptors recognize certain sequences of the envelope proteins. (futurelearn.com)
  • The GMO MVA-HBV is a modified vaccinia virus Ankara vector (MVA) encoding a fusion of sequences derived from two hepatitis B virus (HBV) protein antigens. (biosafety.be)
  • The sequencing of the human genome revealed that at least 1% of the human genome consists of endogenous retroviral sequences, representing past encounters with retroviruses during the course of human evolution. (msdmanuals.com)
  • The RSV capsid enclosing the viral genome materials is assembled from 1500 copies of the 237-residue RSV capsid protein CA. In vitro, tubular assembly can be obtained with the CA with similar underlying structural properties as the authentic RSV capsid. (dtic.mil)
  • As reviewed in 2017, jumbo bacteriophages have diverse genome sizes (ranging from 208 to 497 kb) as well as diverse virion morphology and complex virion structure ( Yuan and Gao, 2017 ). (frontiersin.org)
  • The L1 and L2 proteins form icosahedral capsids for progeny virion generation. (genome.jp)
  • Schematic of a T7 virion before and after ejection of the internal core proteins to extend its tail. (asmblog.org)
  • In brief, each T7 virion carries tail extension proteins as an internal core that is precisely positioned adjacent to the tail portal. (asmblog.org)
  • Its genome travels between hosts in a rather complicated virion containing 18 different proteins. (asmblog.org)
  • Upon adsorption, these proteins exit the capsid in a specific sequence ahead of the DNA to form a tube. (asmblog.org)
  • The nOPV2 candidate strains include different combinations of 5 distinct modified regions of the Sabin-2 genome, including changes to the RNA sequence in the 5' untranslated region of polio genome (5' UTR), the capsid protein coding region (P1), the non-structural protein 2C, and the polymerase 3D. (biosafety.be)
  • The rest of the modifications aim to stabilize the genetic sequence against reversion in either the 5' UTR or capsid regions. (biosafety.be)
  • An examination of the nucleic acid sequence alignment of 48 full-length rubella virus genomes revealed that the 5' terminus of the genome is more conserved than the commonly used detection windows for rubella virus RNA located in the E1 protein coding region, suggesting that the 5' terminus could be a target for improving detection of all rubella virus genotypes. (cdc.gov)
  • A genome sequence of 189,344 bp encoding 166 open reading frames (ORFs) was obtained. (cdc.gov)
  • The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. (news-medical.net)
  • The virus consists of a thin protein shell, a capsid, and inside it lies its genome, the genes. (news-medical.net)
  • A similar expansion of genes encoding an antagonist of a host innate immune protein has been observed in the genome of vaccinia virus (discussed on TWiV #198 ). (virology.ws)
  • Endogenous retroviral insertions - Ancient retroviruses inserted inactivated viral genes into genomes . (rationalwiki.org)
  • Some genes no longer code for a protein due to a mutation or error. (rationalwiki.org)
  • Augmentation of bacterial energy generation by auxiliary metabolic genes has been reported for phages with smaller genomes. (nature.com)
  • Alphaviral envelope pseudotypes of retroviruses or lentiviruses are able to integrate the genes that they carry into the expansive range of potential host cells that are recognized and infected by the alphaviral envelope proteins E2 and E1. (genetherapynet.com)
  • ORF-2 contains genes encoding the capsid. (medscape.com)
  • Genes associated with energy conversion pathways were significantly downregulated while those encoding for ribosomal proteins were dramatically upregulated in response to the consumption of SFN. (bvsalud.org)
  • These two terms describe two different ways that viral nucleic acids and proteins are arranged in virus particles. (virology.ws)
  • Thus virus particles are dynamic entities, molecular machines evolved to provide a robust protective shell for the genome and capable of undergoing dramatic conformational changes upon infection of a host cell and in response to specific environmental stimuli. (gla.ac.uk)
  • The RNA is surrounded by a double icosahedral protein capsid, the viral particles measures 60-80 nm in diameter and is not enveloped [ 7 ]. (biomedcentral.com)
  • Virus particles and purified capsids have found many applications in nanotechnology, biotechnology and medicine. (lu.se)
  • We demonstrated that CP does not affect the translation efficiency from genomic (gRNA) or subgenomic RNA (sgRNA), the intracellular distribution of the non-structural proteins (NSP), or sgRNA synthesis. (cdc.gov)
  • These results show that the assay based on the new detection window near the 5' terminus of the genome can improve the detection of rubella virus for the purpose of molecular surveillance and case confirmation, with the added benefit of improved efficiency due to multiplexing. (bvsalud.org)
  • The immense majority of virus need the cell to be active and multiplying, so that the enzymes and components that form new nucleic acids and proteins are available. (futurelearn.com)
  • Their proteomes are highly unstudied, with over 200 putative proteins with no known homologs. (frontiersin.org)
  • The production of 27 of these putative proteins was confirmed by mass spectrometry analysis. (frontiersin.org)
  • The BsV genome is a 1,385,869 base pair linear double-stranded DNA. (virology.ws)
  • The genome of rotavirus consists of 11 segments of double stranded linear molecules of RNA which are 18,555 nucleoside base pair in total. (biomedcentral.com)
  • HPV is the etiological agent responsible for more than 99% of all cervical cancers.1, 2, 3 HPV is a common sexually transmitted DNA virus comprised of more than 100 genotypes.1 The HPV viral genome is a double-stranded circular DNA approximately 7900 base pairs in length. (clinicalpathologyassociates.com)
  • Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelope. (lu.se)
  • Retroviruses use reverse transcription to create a double-stranded DNA copy (a provirus) of their RNA genome, which is inserted into the genome of their host cell. (msdmanuals.com)
  • These proteins play important roles in terms of determining host range and tropism and in delivering the RNA genome into the cytoplasm of the host's cells. (medscape.com)
  • After this, the plasma membrane fuses with the viral envelope, the capsid releases the RNA into the cytoplasm, which is always accompanied by the reverse transcriptase, represented by a star. (futurelearn.com)
  • At a certain time, due to little known circumstances, it uses the cell mechanisms to form molecules of complementary RNA that travel to the cytoplasm to be translated into the proteins of the envelope, the capsid, and the others that we have spoken about. (futurelearn.com)
  • Together gene products 16 (gp16) and 17 (gp17) actively translocate approximately the first kbp of the T7 genome across the periplasm and into the cytoplasm. (asmblog.org)
  • During genome delivery they work in concert to ratchet approximately the first kbp of the genome into the cytoplasm, then put on the brakes. (asmblog.org)
  • In it, they described how retroviral-like proteins found in the human genome form virus-like capsids that carry nucleic acids. (genengnews.com)
  • The immune system responds to antigens by producing cells that directly attack the pathogen, or by producing special proteins called antibodies . (khanacademy.org)
  • One way to find out is by testing your blood for the presence of antibodies against the viral nucleocapsid protein, which can only be encountered during natural infection. (virology.ws)
  • Antibodies directed towards the region 11-30 of the VP4 capsid enhance infection of peripheral blood cells with CVB4 in vitro. (qscience.com)
  • Fluorescent immunohistochemistry with CD206, myeloperoxidase (MPO), and RV capsid (RVC) antibodies demonstrated that RuV localized to neutrophils but not macrophages. (cdc.gov)
  • The rest of the genome is then pulled in by transcribing RNA polymerase. (asmblog.org)
  • These structural proteins encapsulate the virus. (getjar.com)
  • These structural proteins may also be required to facilitate entry to and exit from the host cell, as well as packaging the genome and the necessary functional proteins. (gla.ac.uk)
  • ORFs for the structural and non-structural proteins are located on both DNA strands. (expasy.org)
  • An international collaboration between the UCL School of Pharmacy, the Lund Protein Production Platform (LP3) and ESS, through its DEMAX platform, have performed biophysical and structural studies of three non-structural proteins from the novel coronavirus, SARS CoV-2, the causative agent of COVID-19. (lu.se)
  • This gene encodes a highly phosphorylated nonstructural protein (NP1). (wikipedia.org)
  • Host susceptibility depends on the presence of specific cellular membrane receptor proteins that bind different enteroviral types along taxonomic lines. (medscape.com)
  • Underneath the membrane lies the viral capsid - the proteins enclosing the viral genetic material. (getjar.com)
  • In Chapter 7, we carry out coarse-grained simulations to examine the HIV maturation pathways and the role of genome and membrane on the formation of conical shells. (escholarship.org)
  • More interestingly, we find that any asymmetry developed in the growing lattice due to interaction with the membrane or genome, or due to the shape of initial immature lattice creates conical capsids, as opposed to cylindrical shells. (escholarship.org)
  • This added-on conduit extends T7's basic 23 nm long tail to 40-55 nm, long enough to easily bridge the periplasm and penetrate the cell membrane (CM). These ejected proteins do more than just extend the tail. (asmblog.org)
  • Others are components of the protein-rich internal membrane that lines the inside of the protein capsid. (asmblog.org)
  • This restructuring is carried out by the abundant proteins within the membrane. (asmblog.org)
  • Our results demonstrate that the phi6 major envelope protein P9 can trigger formation of cytoplasmic membrane structures in E. coli in the absence of any other viral protein. (biomedcentral.com)
  • The bilayer is composed of phospholipids and is typically embedded with membrane proteins. (biomedcentral.com)
  • There is growing evidence that phages with unusually large genomes are common across various microbiomes, but little is known about their genetic inventories or potential ecosystem impacts. (nature.com)
  • Further, 80 proteins in our genomes, he explained, are derived from mobile genetic elements. (genengnews.com)
  • Aera's strategy is to harness these proteins, and structures, to move the cargo of genetic medicines: RNAi, antisense RNA, mRNA, or a genetic editing payload, for example. (genengnews.com)
  • But the company believes that it is the only company working on these proteins to deliver genetic medicines. (genengnews.com)
  • Because, Akinc noted, the company is founded around the discovery of human proteins that package genetic cargo. (genengnews.com)
  • AIM-2: To examine the evolutionary dynamics and genetic diversity of EVs at the full genome level from children with IA and T1D, and to quantify the extent of intra-host evolution of EVs within an infection and the kinetics of intra-host virus evolution between infections. (qscience.com)
  • Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)
  • This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)
  • The replicated RNA strand is held within a nucleocapsid formed from 12-kDa protein blocks. (getjar.com)
  • TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. (virology.ws)
  • There are 148 copies of a gene encoding a protein that might be involved in antagonizing host defenses. (virology.ws)
  • The authors believe that one copy of this gene was duplicated repeatedly as more of the encoded protein was needed to replicate in host cells. (virology.ws)
  • Furthermore, the use of whole alphaviruses for gene therapy is of limited efficacy both because several internal alphaviral proteins are involved in the induction of apoptosis upon infection and also because the alphaviral capsid mediates only the transient introduction of mRNA into host cells. (genetherapynet.com)
  • In this project we wil rebuild one of these amazing protein assemblies, spherical virus capsids, to function as nanoscale chemical reactors and containers for gene delivery of proteins into human cel s. (lu.se)
  • A capsid composed of 60 subunits is formed from 4 proteins-VP1 to VP4. (medscape.com)
  • Virus capsids, filaments, flagel a, and other large protein complexes that are central to many biological processes are generated by protein self-assembly, whereby protein subunits spontaneously organize to form functional complexes. (lu.se)
  • Product name Anti-norovirus capsid protein VP1 antibody Description Rabbit polyclonal to norovirus VP1 capsid protein Host species Rabbit Specificity Species reactivity: Norovirus Hu / Texas / TCH04-577 / 2004 / US Species reactivity Reacts with: Other species Immunogen A synthetic peptide corresponding to the capsid protein of norovirus VP1 (N terminal). (chicken-genome.org)
  • This pressure is capable of powering ejection of the entire viral genome. (lu.se)
  • This study evaluated the minimum requirements for the formation of phi6-specific vesicles and the possibility to localize P9-tagged heterologous proteins into such structures in Escherichia coli . (biomedcentral.com)
  • dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins. (expasy.org)
  • The initial conformational changes 'decap' the unique vertex and some of its neighboring vertices, thus opening the interior of the capsid to the aqueous environment. (asmblog.org)
  • Our analytical results show that the free energy of confinement of genome into a conical capsid is less than that for a cylindrical one when the genome does not interact with the capsid as in in vivo experiments. (escholarship.org)
  • We recently discovered a high internal DNA pressure of tens of atmospheres in HSV-1 capsids, resulting from tight genome confinement and repulsive DNA-DNA interactions. (lu.se)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • Additional sequencing of the entire poliovirus genome at the CDC polio laboratory confirmed that this strain was a VDPV, with 2.3% divergence in the VP1 region from the parent Sabin type 1 strain. (cdc.gov)
  • A phenomenon that has recently come to light via metagenomic studies is the prominence of phages with genomes that are much larger than the average size of ~55 kilobases (kb) predicted based on current genome databases 2 . (nature.com)
  • Phages with very large genomes were recently reported from a man-made lake that covers a deposit of methane-generating tailings from an oil sands mine in Canada 2 . (nature.com)
  • Virulent or obligate lytic phages infect and quickly kill their bacterial host cell, whereas temperate or lysogenic phages may either stably integrate into their host's genome or enter into the lytic life cycle. (asm.org)
  • The capsid is non-enveloped, and composed of 60 copies of up to six types of capsid proteins (called VP1 through to VP6) which share a common C-terminal region. (wikipedia.org)
  • pol, that encodes the enzymes such as reverse transcriptase, and env, which encodes the envelope proteins. (futurelearn.com)
  • One aspect of virology that is confusing to students is the concepts of capsids and nucleocapsids. (virology.ws)
  • But these proteins aren't building a piece of cellular machinery. (acs.org)
  • The ssDNA is converted into dsDNA by cellular proteins. (expasy.org)
  • The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos. (bvsalud.org)
  • EvoRator2: predicting site-specific amino acid substitutions based on protein structural information using deep learning Journal of Molecular Biology: 435(14):168155. (tau.ac.il)
  • Two of the EVs from IA+ cases had an N to S amino acid (AA) substitution within the 2C protein, which became dominant after 10 days passage in the islets. (qscience.com)
  • AAV2 containing cDNA encoding enhanced green fluorescent protein (GFP), under the control of a chicken β-actin promoter, was delivered by intravitreal injection to adult mice in conjunction with enzymes including collagenase, hyaluronan lyase, heparinase III, or chondroitin ABC lyase. (molvis.org)
  • In this project we wil use molecular engineering to custom- make virus capsids and going beyond the confines of Natures natural variety. (lu.se)