QTLsGenesHuman MoleculaChromosomesImprinted geneGenomicsAgronomic traitsMappingChromatin interactionRisk lociPhenotypesHeritabilityResistanceTheoretical and Applied GeneticsNature GeneticsQuality traitsDetectionAnalysesPopulationsEQTLMendelianLinkagePrincipal ComponenDifferent traitsAnalysisAdditiveAmerican JournalVariantsFunctionalPhenotypicGene expressionMicrosatelliteIdentificationMolecularNeurobiologyQualitativeGeneticallyMicrobiologyMiceVariationStudiesExpressionAssociationCrop varietiesLaboratoryMethylationImprovementComplexAgriculturalAutismLeafResearchStudy
QTLs11
- Splicing quantitative trait loci (abbreviated sQTLs or splicing QTLs) are quantitative trait loci that regulate alternative splicing of pre-mRNA. (wikipedia.org)
- Linkage studies have identified several quantitative trait loci (QTLs) for RD. The QTL on chromosome 6p21.3 has been independently replicated by several groups and spans a 16.4-Mb (13.8 cM) interval from D6S109 to D6S291. (nih.gov)
- A total of 39 QTLs for growth habit-related traits was detected on 10 chromosomes explaining 4.55-27.74% of the phenotypic variance, in which 6 QTLs were for lateral branch angle, 8 QTLs were for extent radius, 7 QTLs were for the index of plant type, 11 QTLs were for main stem height, and 7 QTLs were for lateral branch length. (frontiersin.org)
- Identification of quantitative trait loci (QTLs) underlying RL is essential to breed drought-tolerant wheat cultivars. (usda.gov)
- A mapping population of 154 recombinant inbred lines was developed from the cross between Jagger and JagMut1095 (a mutant of Jagger) to identify QTLs for the RL trait. (usda.gov)
- Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). (biomedcentral.com)
- Four loci including additive quantitative trait loci (QTLs) and epistatic interactions explained together 70% of the variance of pvr23 breakdown frequency. (datadryad.org)
- Three of the four QTLs controlling pvr23 breakdown frequency were also involved in quantitative resistance, strongly suggesting that QTLs controlling quantitative resistance have a pleiotropic effect on the durability of the major resistance gene. (datadryad.org)
- In addition, he is also using genetic populations derived from multiple parental lines to identify QTLs for various trait of interest in sorghum. (clemson.edu)
- This effectively elevates heritability and greatly improves prospects for mapping quantitative trait loci (QTLs). (nervenet.org)
- Statistically valid linkage between such genomic regions and measurements of quantitative traits are called quantitative trait loci (QTLs). (medscape.com)
Genes14
- We performed QTL analysis and identified five genes controlling the rolled leaf trait on different chromosomes. (usda.gov)
- The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve the durability of resistant cultivar, as recently observed in different pathosystems. (datadryad.org)
- This graph shows the probability that a certain area on a chromosome (displayed below the graph) contains genes related to the trait being studied. (concord.org)
- Jackson Lab researchers mentor students in the latest genetics research techniques, including Quantitative Trait Loci (QTL) analysis, a statistical process used to pinpoint the location of unknown genes. (concord.org)
- New methods of mapping offer a promising route to the identification of genetic markers for the genes of complex traits and provide a foundation for molecular enhanced breeding of maize. (cropscience.org.au)
- Positively significant h2 for different traits indicated that the average direction of dominance was positive and hence the characters were controlled by dominance genes. (slideshare.net)
- The proportion of dominant to recessive gene exhibited an excess of dominant genes controlling most of the traits. (slideshare.net)
- My current research focus is on the identification of phenotype-by-genotype trait associations and transferring useful genes through marker-assisted background selection approach for crop improvement. (clemson.edu)
- We are using various types of genetic populations derived from multi-parental lines to identify novel genes/markers associated with desirable phenotypic traits. (clemson.edu)
- Molecularly tagged genes and quantitative trait loci in cucumber with recommendations for QTL nomenclature. (msu.edu)
- These are traits that are complex, continuous and regulated by a group of genes interacting with each other and the environment. (jax.org)
- Phenotype selection for detecting variable genes: a survey of cardiovascular quantitative traits and TNF locus polymorphism. (cdc.gov)
- As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
- We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. (lu.se)
Human Molecula1
Chromosomes1
- Genetic correlations between loci on different chromosomes can be high and can generate false positive linkage. (nervenet.org)
Imprinted gene1
- An intriguing study surveying the transcriptome of murine brain tissues revealed over 1300 imprinted gene loci (approximately 10-fold more than previously reported) by RNA-sequencing from F1 hybrids resulting from reciprocal crosses. (wikipedia.org)
Genomics5
- Advanced backcrosses (ABs) and introgression lines (ILs) of eggplant ( Solanum melongena ) can speed up genetics and genomics studies and breeding in this crop. (frontiersin.org)
- GENIQUEST stands for Genomics Inquiry through Quantitative Trait Loci Exploration with SAIL Technology. (concord.org)
- He has over 12 years of experience in plant genetics, breeding and genomics. (clemson.edu)
- Emma Davenport's research focuses on integrating functional genomics and clinical data in order to understand how genetics contributes to the patient-to-patient heterogeneity in treatment response. (sanger.ac.uk)
- A public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation. (sanger.ac.uk)
Agronomic traits2
- He defined the ideotype as plants that have comprehensive agronomic traits known to influence photosynthesis, growth habit, and grain yield (in cereals). (frontiersin.org)
- For the majority of the 20th Century, pedigree breeding, combined with an extensive multi-environment testing program that was designed to measure the phenotypic performance of new genotypes across a large sample of the target population of environments, was the core breeding strategy that underpinned the successful genetic improvement of grain yield and other agronomic traits (Duvick et al. (cropscience.org.au)
Mapping16
- Plant area index ( PAI ) estimated from below‐canopy hemispherical images, as well as a suite of thirteen traits assessed by manual destructive harvests, were measured in a Setaria recombinant inbred line mapping population segregating for aboveground productivity and architecture. (osti.gov)
- Precise mapping of quantitative trait loci for resistance to southern leaf blight, caused by Cochliobolus heterostrophus race O, and flowering time using advanced intercross maize lines. (ncsu.edu)
- Construction of High-Density Genetic Map and Mapping Quantitative Trait Loci for Growth Habit-Related Traits of Peanut (Arachis hypogaea L. (frontiersin.org)
- We used the interval mapping method to conduct a quantitative trait locus (QTL) analysis of grape weight and soluble solid content of the mapping population. (geneticsmr.com)
- Various parametric approaches in the statistical literature have been proposed to study the quantitative-trait-loci (QTL) mapping of the growth curves as multivariate outcomes. (bepress.com)
- Genetically mapping these traits in elite breeding populations is difficult. (cropscience.org.au)
- Therefore, considerable interest has emerged in the use of alternative methods for the mapping of quantitative traits. (cropscience.org.au)
- Genetic association mapping methods have been the subject of great interest in human genetics. (cropscience.org.au)
- We will discuss the utility of these approaches for mapping complex traits and issues for consideration in their application to breeding. (cropscience.org.au)
- To understand the nature of the elite genetics reference population of a long-term breeding program, and how it differs from some of the more conventional reference populations used in genetics and trait mapping, it is important to understand the history of the breeding process that has given rise to the elite germplasm of today. (cropscience.org.au)
- Quantitative trait locus (QTL) mapping locates and estimates the effect of genetic loci that regulate quantitative traits. (jax.org)
- The main aim is to identify gene expression signatures for predicting disease severity and treatment response as well as using expression quantitative trait locus (eQTL) mapping to understand the role of regulatory DNA in patient heterogeneity. (sanger.ac.uk)
- We provide two-locus correlograms that can be used to detect and correct for non-syntenic association and to reduce error rates in QTL mapping studies that exploit RI strains. (nervenet.org)
- They offer compelling advantages for mapping complex genetic traits, particularly those that have low heritabilities. (nervenet.org)
- LE ROY, I. Quantitative Trait Loci (QTL) Mapping. (bvsalud.org)
- Newly developed genome resources advance Nasonia for genetic research, accelerate mapping and cloning of quantitative trait loci, and will ultimately provide tools and knowledge for further increasing the utility of parasitoids as pest insect-control agents. (lu.se)
Chromatin interaction1
- Fig. 2: Long-range chromatin interaction of the rs708727- PM20D1 locus. (nature.com)
Risk loci1
- In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains difficult to establish. (nature.com)
Phenotypes1
- Linkage was assessed by using five quantitative phenotypes, including a composite measure of reading performance and four component phenotypes. (nih.gov)
Heritability1
- Combining ability and heritability of quantitative and qualitative traits in sunflower lines, using line × tester fashion. (slideshare.net)
Resistance8
- Four common SLB resistance quantitative trait loci (QTL) were identified in all environments, two in bin 3.04 and one each in bins 1.10 and 8.02/3. (ncsu.edu)
- Analysis of quantitative trait loci for resistance to southern leaf blight in juvenile maize. (ncsu.edu)
- Unlike major gene resistance, partial resistance expressed as an increased latent period appears to be a stable trait expressed over a wide range of temperature and tight conditions, although higher temperatures tended to increase the differences among genotypes. (ncsu.edu)
- Plant growth habit is an important and complex agronomic trait and is associated with yield, disease resistance, and mechanized harvesting in peanuts. (frontiersin.org)
- Using the pepper (Capsicum annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we aimed at identifying plant genetic factors directly affecting the frequency of virus adaptation to the major resistance gene pvr23 and at comparing them with genetic factors affecting quantitative resistance. (datadryad.org)
- The resistance breakdown frequency was a highly heritable trait (h²=0.87). (datadryad.org)
- Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana. (mpg.de)
- Quantitative trait loci (QTL) for resistance to white rot (Sclerotinia sclerotiorum) attacks of terminal buds. (slideshare.net)
Theoretical and Applied Genetics1
- Theoretical and Applied Genetics, 105(6), pp.985-993. (slideshare.net)
Nature Genetics1
- Nature Genetics, 50(6):857-864, 2018. (harvard.edu)
Quality traits1
- Reproduction of hens selected for chosen egg quality traits vs. changes of some microsatellite allele frequencies. (wpsa.com)
Detection1
- The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. (cambridge.org)
Analyses2
- QTL and transcriptomic analyses implicate cuticle transcription factor SHINE as a source of natural variation for epidermal traits in cucumber fruit. (msu.edu)
- Quantitative trait loci analyses (log of the odds=15) indicated association of the genetic factor within a few centiMorgan of the best evidence for Ahl [Johnson et al. (cdc.gov)
Populations2
- In regions of the world such as Central Asia, East Africa, or Latin America where traditional physical anthropology has believed that intermixture of races has created mixed-race populations, genetics has invariably shown the hybridity of these populations. (blogspot.com)
- Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. (lu.se)
EQTL2
- We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedish origin, each represented by two independently derived primary lines to provide biological replication. (nih.gov)
- We map expression quantitative trait locus (eQTL) in cohorts of patients and use eQTL interactions to understand how the environment can modulate these regulatory effects. (sanger.ac.uk)
Mendelian3
- They begin by breeding and studying the dragons to confirm the basic Mendelian genetics they have learned in the classroom. (concord.org)
- Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
- whether Mendelian or quantitative. (nervenet.org)
Linkage1
- A new high-density genetic linkage map was constructed by using specific locus amplified fragment sequencing technology. (frontiersin.org)
Principal Componen1
- The effect on paraquat-treated mice with 5 mg/kg and principal component analysis of iron showed suggestive quantitative trait loci on chromosome 5. (cdc.gov)
Different traits1
- These results show that the average size of the quantitative trait loci effect was 1.6 phenotypic standard deviations for different traits and families. (cambridge.org)
Analysis11
- Marker-trait associations were assessed by using QTDT (a general test of association for quantitative traits) and the family-based association test (FBAT), and haplotype analysis was performed by using FBAT and the GeneHunter Transmission/Disequilibrium Test TDT. (nih.gov)
- The quantitative trait locus (QTL) analysis of the growth habit-related traits was conducted based on phenotyping data from seven environments. (frontiersin.org)
- An example of a plot used in Quantitative Trait Loci (QTL) analysis. (concord.org)
- Databases and computer-based analysis techniques have changed the face of much of biology research, especially genetics. (concord.org)
- This explosion has turned databases such as the Jackson Laboratory's Mouse Genome Database into critical research tools and has paved the way for statistical methods such as Quantitative Trait Loci (QTL) analysis. (concord.org)
- Genetic analysis for quantitative traits in sunflower (Helianthus annuus L.). Crop Improvement, 27(1), pp.82-87. (slideshare.net)
- Comparative genetic analysis of quantitative traits in sunflower (Helianthus annuus L.) 1. (slideshare.net)
- We combine genomic analysis with clinical data to understand how genetics contributes to the variation between patients in their disease severity and response to treatments. (sanger.ac.uk)
- Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)
- Systems genetics and systems biology analysis of paraquat neurotoxicity in BXD recombinant inbred mice. (cdc.gov)
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)
Additive2
- A quantitative genetic model relates the genotypic value of an individual to the alleles at the loci that contribute to the variation in a population in terms of additive, dominance, and epistatic effects. (slideshare.net)
- Results of the study showed that all observed traits showed the importance of both additive and dominance gene effects. (hindawi.com)
American Journal1
- American Journal of Human Genetics. (wikipedia.org)
Variants2
Functional1
- In this article, we view the growth curves as functional quantitative traits and propose some semiparametric models to relax the strong parametric assumptions which may not be always practical in reality. (bepress.com)
Phenotypic1
- Nine phenotypic fleece traits were recorded at 4 and 11 months of age. (cambridge.org)
Gene expression1
- The top 10 BMD loci with SNPs showing strong cis-effects on gene expression in HObs (P = 6 x 10(-10) - 7 x 10(-16)) were selected for further validation using a staged design in two cohorts of Caucasian male subjects. (nih.gov)
Microsatellite1
- The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)
Identification1
- In the current project, he is focusing on the identification of phenotype-by-genotype trait associations for above- and below-ground traits for the development of superior sorghum hybrids using molecular genetic approaches. (clemson.edu)
Molecular4
- 2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
- Here we consider that today's foundation for molecular breeding is the reference population of elite genetics to which we intend to apply the molecular technologies. (cropscience.org.au)
- The trait improvement is the key for improving existing crop varieties and also for developing new superior varieties using molecular genetic approaches. (clemson.edu)
- Molecular Genetics. (rochester.edu)
Neurobiology1
Qualitative2
- Methods We examined the association of autism traits with NF1, NS, CS and CFC, comparing affected probands with unaffected sibling controls and subjects with idiopathic ASDs using the qualitative Social Communication Questionnaire (SCQ) and the quantitative Social Responsiveness Scale (SRS). (bmj.com)
- Results Each of the four major RASopathies showed evidence for increased qualitative and quantitative autism traits compared with sibling controls. (bmj.com)
Genetically2
- The steady-state abundance of an RNA species in an organ is, in part, genetically controlled and can be considered a quantitative genetic trait. (biomedcentral.com)
- Most of the traits of importance to the breeder are genetically complex and quantitative in nature. (cropscience.org.au)
Mice2
- These famous mice are the reason students are here, studying genetics. (concord.org)
- Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
Variation1
- We integrate genetic information with our transcriptomic profiles to understand the role of genetics in the variation that we observe. (sanger.ac.uk)
Studies1
- However certain studies have individuals underwent clinical examination reported that the trait aposthia with normal by a qualified physician. (who.int)
Expression1
- We find that PM20D1 is a methylation and expression quantitative trait locus coupled to an AD-risk associated haplotype, which displays enhancer-like characteristics and contacts the PM20D1 promoter via a haplotype-dependent, CCCTC-binding-factor-mediated chromatin loop. (nature.com)
Association1
- Although the literature offers conflicting evidence for association of NF1 and autism, there has been no systematic evaluation of autism traits in the RASopathies as a class to support a role for germline Ras/MAPK activation in ASDs. (bmj.com)
Crop varieties1
- Gaining a deeper understanding of the rolled leaf trait may help design crop varieties with greater resilience to drought stress. (usda.gov)
Laboratory1
- When you think of a "genetics researcher," you might imagine a scientist in a lab coat working with chemicals, tubes, and other laboratory apparatus. (concord.org)
Methylation1
- Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. (nature.com)
Improvement1
- Dr. Kumar's research largely focused on the trait improvement for the development of new germplasm and varieties in cereal crops using marker-assisted backcross breeding. (clemson.edu)
Complex1
- Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)
Agricultural1
Autism2
- Conclusions Higher prevalence and severity of autism traits in RASopathies compared to unaffected siblings suggests that dysregulation of Ras/MAPK signalling during development may be implicated in ASD risk. (bmj.com)
- Evidence for sex bias and potential sibling correlation suggests that autism traits in the RASopathies share characteristics with autism traits in the general population and clinical ASD population and can shed light on idiopathic ASDs. (bmj.com)
Leaf1
- Leaf rolling is a morphological trait that may protect plants under drought-stressed conditions. (usda.gov)
Research2
- Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
- The project brings cutting-edge genetics research techniques to high school students. (concord.org)
Study3
- This study reports the results obtained in the search of chromosomal regions affecting fleece traits in a population of Angora goats in the Argentinean Patagonia. (cambridge.org)
- The genetic study of certain quantitative traits in growth curves as a function of time has recently been of major scientific interest to explore the developmental evolution processes of biological subjects. (bepress.com)
- We and 3 with more than 1 aposthia male: fam- think that the person with aposthia trait is a ily DG-01 had 4 living cases, family DG-02 suitable model to study the importance and had 2 living and 1 dead case and family DG- genetics of the prepuce. (who.int)