• HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. (wikipedia.org)
  • DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease DRB1*1201:DRB3*01/03: colorectal cancer HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes. (wikipedia.org)
  • Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
  • The HLA genotype of the patient (DRB1*01/DRB1*11, DQB1*0301/DQB1*0501) has been previously reported as a predisposing factor to PPH. (ersjournals.com)
  • This study aimed to determine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in an Iranian population (North East of Iran). (ac.ir)
  • The frequency of HLA -DRB1 *16 was 0.7% in the healthy subjects, however frequency of HLA -DRB1 *16 in patients with recurrent aphthous stomatitis (RAS) was 42.36%, and this difference was statistically significant (P=0.03). (ac.ir)
  • HLA typing showed the haplotype A23 851 A28 03 DRB1 * B3. (pediatriconcall.com)
  • HLA typing showed the haplotype A23 851 A28 03 DRB1 * B3 and the screening for other autoimmune disorders was negative. (pediatriconcall.com)
  • Manufacture of chimeric antigen receptor (CAR)-T cells usually involves the use of viral delivery systems to achieve high transgene expression. (cartherics.com)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
  • Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
  • Using these molecules, we will solve the crystal structure to elucidate the molecular conformation that drives the anti-Sm T cell response, and generate HLA-DR15 tetramers to determine the frequency, phenotype of anti-Sm specific T cells as well as obtain clonally expanded paired Valpha and Vbeta T cell receptor (TCR) sequences from SLE patients with active disease. (lupusresearch.org)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • Approaching the response issue from the other direction, Dr. Melero discussed invigorating T cell function using an agonist of the costimulatory receptor CD137, particularly in combination with other immunotherapies, such as ICB or adoptive T cell transfer. (acir.org)
  • A few studies have been conducted regarding the relationship between HLA alleles and the incidence of recurrent aphthous stomatitis in different human populations especially in the Iranian population (15). (ac.ir)
  • In the case of ankylosing spondylitis (AS), the risk is primarily associated with HLA-B27, with smaller effects from other HLA alleles. (the-rheumatologist.org)
  • For example, segmented filamentous bacteria (SFB) have a unique ability to drive T helper 17 (Th17) cell accumulation in the small intestine's lamina propria through SFB-derived antigens presented by dendritic cells ( 22 - 24 ). (frontiersin.org)
  • Artificial antigen-presenting cells (aAPCs) can be designed exogenously to mimic immune cells, such as dendritic cells, and administered to patients, allowing greater control over T cell differentiation. (bvsalud.org)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • An external trigger (eg, cigarette smoking, infection, or trauma) that triggers an autoimmune reaction, leading to synovial hypertrophy and chronic joint inflammation along with the potential for extra-articular manifestations, is theorized to occur in genetically susceptible individuals. (medscape.com)
  • In genetically susceptible individuals, this antigenic stimulation may ultimately result in the expression of overt rheumatoid arthritis (RA) via molecular mimicry, a process whereby foreign peptides, similar in structure to endogenous peptides, may cause antibodies or T-lymphocytes to cross-react with both foreign and endogenous peptides and thereby break immunological tolerance. (cambridge.org)
  • Celiac disease is an autoimmune enteropathy induced by gluten intake in genetically susceptible individuals. (pediatriconcall.com)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • What about testing for HLA (human leukocyte antigens) matching, in order to choose an embryo that might be a donor match for another child or family member? (americanbar.org)
  • Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
  • The first curative allogeneic SCT to a thalassemia patient from a human leukocyte antigen (HLA) identical sibling donor was reported in 1982. (healthwire.co)
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
  • This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR against the cognate tumor antigen and an NK self-recognizing inhibitory CAR that transferred a 'don't kill me' signal to NK cells upon engagement with their TROG + siblings. (nature.com)
  • This system prevented trogocytic antigen-mediated fratricide, while sparing activating CAR signaling against the tumor antigen, and resulted in enhanced CAR-NK cell activity. (nature.com)
  • Identification of a tumor-specific allo-HLA-restricted ?dTCR. (umassmed.edu)
  • TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. (umassmed.edu)
  • Dr. Sharma's main takeaway was that analysis of tumor samples before and after treatment should enable rational guidance for therapeutic decisions. (acir.org)
  • The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
  • It is not clear which factors are responsible for variation in clinical picture of APECED, but human leukocyte antigen (HLA) genotype may be important. (ersjournals.com)
  • The human leukocyte antigen (HLA) genotype may be important, since it was observed that autoimmune conditions in the APECED cohort showed HLA associations that were similar to those found in nonā€APECED patients with respective autoimmune disorders 4 . (ersjournals.com)
  • Sm specific T cells play an important role in class switching anti-Sm autoantibodies and participate as disease effectors, and anti-Sm autoreactivity is strongly associated with the human leukocyte antigen (HLA)-DR15. (lupusresearch.org)
  • The key to the research are human leukocyte antigens, or HLAs, which are markers found in most cells in the body. (ecancer.org)
  • Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. (edu.au)
  • They enrolled more than 2,000 infants with a known genetic susceptibility to type 1 diabetes (in the gene for human leukocyte antigen, or HLA) and a close relative with the disease. (blogspot.com)
  • Major histocompatibility complex (MHC) class I and II molecules which are called human leukocyte antigens (HLA), play an important role in the immune response (16). (ac.ir)
  • Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. (umassmed.edu)
  • Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. (umassmed.edu)
  • null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. (umassmed.edu)
  • cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. (umassmed.edu)
  • Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. (umassmed.edu)
  • Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease. (umassmed.edu)
  • Dr. Silverman, notes, "The discovery that every one of us has three to 10 times more microbial cells than human cells in our body lit the fuse for me, as well as for other investigators. (the-rheumatologist.org)
  • Researchers know human leukocyte antigen (HLA) molecules affect susceptibility to disease in general, and immunological disease in particular. (the-rheumatologist.org)
  • Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
  • The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
  • An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
  • Some gut bacteria species can induce autoimmunity in genetically predisposed animal models ( 6 , 7 ). (frontiersin.org)
  • Here, we propose to determine the molecular mechanism for anti-Sm autoimmunity, potentially leading to a novel way to develop Sm antigen specific regulatory T cells (Tregs) to treat patients with SLE. (lupusresearch.org)
  • Now, we propose a novel method, using the latest technologies, to determine the structure/function relationship between HLA-DR15 and anti-Sm autoimmunity in SLE, and generate Sm antigen specific Tregs. (lupusresearch.org)
  • Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. (springer.com)
  • We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
  • Amino-acid exchange scans clearly indicated the cross-reactive potential of HLA-A*02:01/ADRB3 295 - and HLA-A*02:01/CHM1 319 -TCR transgenic T cells. (oncotarget.com)
  • Amino-acid exchange scans alone predict TCR cross-reactivity with little specificity and thus require additional assessment of potentially cross-reactive HLA-A*02:01 binding candidates. (oncotarget.com)
  • The RAS etiology is less described, despite the overall agreement about the role of autoimmune reaction to oral mucosa or cross-reactive antigens. (ac.ir)
  • The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. (edu.au)
  • Dr. Silverman says research findings related to identical twins are puzzling. (the-rheumatologist.org)
  • Moreover, we showed that antigen specific Tregs are of much greater potency than polyclonal expanded Tregs, suppress autoimmune disease in an antigen specific manner, and, importantly, block the expansion of antigen specific T follicular helper cells, the key T cell subset for the development of autoantibodies. (lupusresearch.org)
  • Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)
  • Because the HLA-DPB1 gene is involved in the immune system, changes in it might be related to the autoimmune response and inflammation in the respiratory tract and kidneys characteristic of GPA. (medlineplus.gov)
  • Regarding the autoimmune etiology in RAS, it can be noted that predisposition to disease can be examined genetically (15). (ac.ir)
  • Celiac disease (CD) is an autoimmune enteropathy induced by ingestion of gluten in genetically predisposed subjects. (pediatriconcall.com)
  • In Aim 1, we will define the dominant pathogenic Sm T cell epitopes by immunizing HLA-DR15 transgenic mice with overlapping peptides encompassing all nine Sm proteins, and determine if these epitopes are naturally presented by peptide elution MALDI-TOF mass spectrometry experiments. (lupusresearch.org)
  • After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
  • TCR transgenic T cells demonstrated HLA-A*02:01/ADRB3 295 mediated ES recognition and killing in ELISpot and xCELLigence assays. (oncotarget.com)
  • HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. (umassmed.edu)
  • Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. (umassmed.edu)
  • The focus of Dr. Baker's research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. (cuanschutz.edu)
  • Dr. Benninger's research focuses on understanding the mechanisms underlying pancreatic islet function and decline in type1 and type2 diabetes. (cuanschutz.edu)
  • Complimentary to these studies, Dr Benninger's lab is also developing ultrasound-based imaging diagnostics for non-invasively detecting islet decline in pre-symptomatic diabetes and as a platform for image-guided drug delivery. (cuanschutz.edu)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. (edu.au)
  • Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
  • In Aim 2, we will generate HLA-DR15 recombinant molecules covalently linked to the dominant Sm T cell epitopes. (lupusresearch.org)
  • These molecules of cell surface play a critical role in antigen processing and T cell activity. (ac.ir)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • The AIRE protein is a transcriptional regulator expressed mainly in the thymus and plays a central role in the development and maintenance of immunological tolerance by promoting the ectopic expression of peripheral tissue-restricted antigens in medullary epithelial cells of the thymus 2 . (ersjournals.com)
  • In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. (cambridge.org)
  • In contrast to organ/tissue transplant associated GvHD, the incidence of TA-GvHD is increased with HLA matching (first-degree or close relatives). (wikipedia.org)
  • In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)
  • and 4) an increased frequency of HLA class II antigens DR3 12 and DQ7 11 have been reported among PPH patients, further suggesting that immune deregulation plays a role in the pathogenesis of the disorder. (ersjournals.com)
  • RA affects ~1% of the population worldwide ( 2 ), and its pathogenesis may be linked to genetic and environmental factors ( 3 , 4 ). (frontiersin.org)
  • The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
  • But Dr. Ooi and his lab colleagues believe that they can make more effective regulatory T cells that protect specific cells. (lupusresearch.org)
  • One of the immune cells' main targets is a portion of the cell nucleus referred to as the Smith antigen. (lupusresearch.org)
  • Regulatory T cells that recognize the Smith antigen might be able to shut down these harmful immune cells. (lupusresearch.org)
  • Their work will identify which parts of the Smith antigen that immune cells respond to. (lupusresearch.org)
  • Once they know that, they will be able to genetically engineer regulatory T cells to protect cells carrying the Smith antigen in mice. (lupusresearch.org)
  • Dr. Ooi's project aims to genetically engineer regulatory T cells that are better at shielding the body's cells from immune system attack. (lupusresearch.org)
  • This work will define the Sm T cell epitopes in the most clinically relevant HLA II in SLE, provide information including HLA II-epitope molecular structure and phenotype of Sm specific T cells, and push towards an antigen-specific therapeutic option for SLE. (lupusresearch.org)
  • Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. (edu.au)
  • A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
  • Some studies suggested that, in infants who are genetically susceptible, early exposure to complex foreign proteins, like those in cow's milk, may increase the risk for an immune system reaction to beta cells and development of type 1 diabetes. (blogspot.com)
  • We identified HLA-A*02:01/peptide-restricted T cells directed against ADRB3 295 . (oncotarget.com)
  • These proteins are involved in heart muscle contraction, natural killer and antigen presenting cells, and the major histocompatibility complex. (medrxiv.org)
  • In tumors, antigen-specific functional ICOS + CD4 + cells were increased, and both ICOS + CD4 + and CD8 + T cells were increased in the blood of patients. (acir.org)
  • HLA polymorphism can directly affect the bonding capacity of antigens and thus affect antigen-specific T-cell response (17). (ac.ir)
  • Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. (umassmed.edu)
  • A particular variant of the HLA-DPB1 gene called HLA-DPB1*0401 has been found more frequently in people with GPA, especially those with ANCAs, than in people without the condition. (medlineplus.gov)
  • Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
  • Their work, "Lupus Nephritis Is Linked to Disease-Activity Associated Expansions and Immunity to a Gut Commensal," appears in the Feb. 19, 2019, online edition of the Annals of Rheumatic Diseases . (the-rheumatologist.org)
  • Design, Setting, and Participants: Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. (bvsalud.org)
  • Some studies have linked intake of a GF diet to reduced obesity and T2D and suggested a role in reducing leptin- and insulin-resistance and increasing beta-cell volume. (mdpi.com)
  • Fig. 2: Impact of antigen-induced self-engagement on CAR-NK effector cell phenotype and function. (nature.com)
  • A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. (cdc.gov)
  • The first US Food and Drug Administration-approved immunotherapy for type 1 diabetes, the anti-CD3 antibody teplizumab, delays symptomatic type 1 diabetes onset by 2-3 years [ 4 ], opening the door for the future clinical application of antigen-specific approaches with potentially superior immunoregulatory properties [ 5 ]. (springer.com)
  • Fig. 4: A lower level of CAR-mediated TROG-antigen expression was associated with improved clinical response to CAR-NK cell-based immunotherapy. (nature.com)
  • Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. (umassmed.edu)
  • Though only present in 30-40% of SLE patients, compared to less specific autoantibody targets, Sm represents the best opportunity for antigen-specific immune regulation in SLE. (lupusresearch.org)
  • After more than 15 years of effort, this study puts to rest the controversy regarding the potential role of cow's milk formula in the development of type 1 diabetes," says Dr. Dorothy Becker at the University of Pittsburgh School of Medicine, who led the study in the United States. (blogspot.com)
  • Dr. Aturk's research is focused on immune checkpoint inhibitor-induced type 1 diabetes. (cuanschutz.edu)
  • A goal of Dr. Akturk's lab is to identify risk factors to develop diabetes and develop screening algorithms to prevent morbidity and mortality related to diabetic ketoacidosis and understand PD-1 pathway in possible prevention of the development of childhood onset type 1 diabetes. (cuanschutz.edu)
  • Dr. Alonso's primary academic interest is redesigning the system in which care is provided to children and adolescents with type 1 diabetes. (cuanschutz.edu)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). (medlineplus.gov)
  • Each HLA gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. (medlineplus.gov)
  • The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
  • However, the relationship between HLA-class I (HLA-A, -B and -C) and HLA-class II (DR, -DQ - DP) with oral disorder has not yet been investigated extensively (16). (ac.ir)
  • Nanovaccines can improve antigen presentation, targeted delivery, stimulation of the body's innate immune system, and a strong T-cell response without putting people at risk. (researchgate.net)
  • In addition to testing, we have the technology to genetically engineer gametes and embryos, giving rise to the possibility of a child having three (or possibly more) genetic parents. (americanbar.org)
  • The research team examined the HLAs of 179 non-small cell lung cancer patients and found a strong link between the genetic makeup of the HLAs and whether the person was likely to develop side effects from immunotherapy. (ecancer.org)
  • Study lead Dr Afaf Abed said this discovery would benefit all non-small cell lung cancer patients, regardless of whether they were genetically predisposed to adverse reactions to immunotherapy or not. (ecancer.org)
  • Dr. Silverman says they learned that lupus patients have reduced gut micro-biome diversity than healthy controls and varying levels of dysbiosis. (the-rheumatologist.org)
  • Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
  • Therefore, the relative abundance of different bacterial lineages may lead to changes in the host immune profile and drive inflammatory responses contributing to RA. (frontiersin.org)
  • Host genetic variation partially drives the immune and biochemical responses to COVID-19 that lead to risk of mortality. (medrxiv.org)
  • Fig. 3: Impact of TROG-antigen acquisition on CAR-NK cell phenotype and function in vivo. (nature.com)
  • Having a particular version of the HLA-DPB1 gene is the strongest genetic risk factor for developing this condition, although several other genes, some of which have not been identified, may be involved. (medlineplus.gov)
  • Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)
  • CD is associated with HLA-DR3, and such an association has been demonstrated in Graves' disease and Hashimoto's thyroiditis as well. (pediatriconcall.com)