Genetically resistance mice knockout. Medical search. Frequent questions

They found that 1,084 genes in 129 strain mice have insertions, deletions, or single-nucleotide mutations that cause them to diverge in sequence from Black 6 mice. (the-scientist.com)
The BAC mediated homologous recombination technique is based upon the Red/GET recombination, in which the bacteriophage recombination genes are genetically engineered in E. coli to efficiently manipulate the BAC containing gene of interest with ease in short period of time. (hsp-info.de)
A). buy lipitor 40 mg cheap Genes in "human tumor VS.Fig 3 Open in a disunite window Common differentially expressed genes in PDX mice and their interacting panaceas. (ika.ie)
Among the genes mostly altered in individual cancer, irrespective of tumor type, are tumor proteins 53 ((null mice (21), where TP53 is normally suppressed by MDM2, had been crossed with mice having the piggyBac (PB) transposon program (15), made up of the PB DNA transposon ATP2-S1 (ATP2) and a constitutively portrayed PB transposase Rabbit Polyclonal to PLCG1 in the locus (RosaPB) (15). (thetechnoant.info)
In addition they support the usage of transposon-based mutagenesis as a robust device for the id of novel level of resistance genes and systems in genetically improved mouse versions, and constitute the initial in vivo level of resistance display screen for TP53-MDM2 inhibition. (thetechnoant.info)
In some instances, the insertional landscaping exhibited hereditary specificities in keeping with particular tumor signs (Fig. S3 was among the top-five CIS genes inside our medulloblastoma GSK 525762A examples (Fig. S3disruption in mouse versions network marketing leads to medulloblastoma advancement (39). (thetechnoant.info)
Humans share many genes with mice. (wikipedia.org)
Much like a Tweet gone viral, plasmids replicate independently of chromosomes and often contain genes that benefit the host for survival, such as antibiotic resistance. (zymoresearch.de)
The surrogate mice fathered healthy offspring who carried the genes of the donor mice. (thebeefsite.com)

Knockout and other transgenic mice are traditionally made by genetically modifying embryonic stem cells (ESCs) in a dish and then inserting them into a recipient mouse embryo. (the-scientist.com)
Embryonic stem cells are isolated from a mouse blastocyst (a very young embryo ) and grown in vitro . (wikipedia.org)
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. (chinaagrisci.com)

In the present study, we characterized the phenotype of HSD17B13-knockout (HSD17B13KO) mice deficient in Hsd17b13. (richardvigilantebooks.com)
To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers. (nature.com)
Using Nod-deficient mice, several in vivo studies have demonstrated a role for Nod1 and Nod2 in host defense against pathogens such as Helicobacter pylori, Listeria monocytogenes, Staphylococcus aureus, and Legionella pneumophila [ 7 - 10 ]. (hindawi.com)
NOD1, NOD2, and RIP2 genetically deficient mice (NOD1 −/− , NOD2 −/− , and RIP2 −/− ) were kindly gifted by Dr. Richard Flavell (Yale University) and maintained in the animal facility of the University of São Paulo (FMRP/USP). (hindawi.com)
Wild-type and deficient mice were maintained at UFMG and used at 6-8 weeks of age. (hindawi.com)
Histamine signalling through H1 and H2 receptors increases the susceptibility of mice to infection with lethal strains of Plasmodium berghei and mice genetically deficient in the histidine decarboxylase gene - and thus lacking histamine - are highly resistant to severe malaria whether infected by mosquito bites or via injection of infected erythrocytes. (drugdiscoveryopinion.com)
Compared with wild type mice, mice deficient in the H3 receptor showed an accelerated onset of cerebral malaria, increased brain pathology and more pronounced loss of blood brain barrier integrity associated with earlier death. (drugdiscoveryopinion.com)

In the study, reported in the Proceedings of the National Academy of Sciences (PNAS) , the researchers, developed a novel mouse model in which they blocked the expression in the brain of both insulin receptors and the closely-related insulin-like growth factor (IGF1) receptors to two regions critical for learning, memory, and mood. (neurosciencenews.com)
The researchers targeted their double knockouts in the hippocampus and the central amygdala, two areas of the brain known to plays roles in impaired cognition and metabolic control. (neurosciencenews.com)
In one experiment, researchers placed the insulin and IGF1 receptor-impaired mice in a maze to study if they could recognize newly introduced stimuli. (neurosciencenews.com)
Instead of exploring this new object-a measure researchers use to determine if a subject recognizes novelty-the mouse continued through the maze as though nothing had changed. (neurosciencenews.com)
The researchers will next study the differences in risk and disease progression when these knockout mice are bred with mice genetically prone to developing Alzheimer's. (neurosciencenews.com)
Since 129 strain mice are difficult to breed, researchers typically transfer their ESCs into the embryos of Black 6 mice and then repeatedly backcross the animals with Black 6 mates while selecting for their 129 strain-derived transgene, slowly eliminating 129 strain DNA surrounding the transgene through recombination. (the-scientist.com)
When researchers compare their modified mice to control Black 6 mice, they may observe phenotypic differences that result from passenger mutations in 129 mouse DNA, rather than from changes to their actual gene of interest, according to the Ghent team. (the-scientist.com)
However, in 2011, researchers at Genentech showed that many Casp1 knockout mice also harbored a mutated Casp11 gene from 129 strain mice. (the-scientist.com)
The researchers showed that the passenger mutation to Casp11 was partly responsible for the animals' resistance to shock. (the-scientist.com)
Researchers can genetically modify Black 6 mice using Black 6 ESCs, or they can use CRISPR/Cas to make knockout mice in just about any background. (the-scientist.com)
The Ghent researchers looked through the sequences for differences between Black 6 mice and the 129 strains that would affect protein production. (the-scientist.com)
Notably, researchers speculated that neither lean mice nor genetically engineered mice (mice known as "beta(3)-AR knock-out mice") appeared to react to the lipolytic effects of AOD 9604 [vi]. (asianage.com)
A knockout mouse , or knock-out mouse , is a genetically modified mouse ( Mus musculus ) in which researchers have inactivated, or " knocked out ", an existing gene by replacing it or disrupting it with an artificial piece of DNA . (wikipedia.org)
By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function. (wikipedia.org)
Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better understand how a similar gene may cause or contribute to disease in humans. (wikipedia.org)
Researchers Richard Palmiter and Ralph Brinster generated mice expressing thymidine kinase from herpes simplex virus by injecting recombinant plasmid DNA into fertilized mouse embryos. (zymoresearch.de)
The researchers used CRISPR-Cas9 to produce mice, pigs, goats and cattle that lacked a gene called NANOS2 which is specific to male fertility. (thebeefsite.com)
Researchers have identified 420 proteins in skeletal muscle that are all affected by endurance, sprint and resistance exercise. (sciencenews.dk)
The researchers then created knockout mice that genetically lack the ability to make C18ORF25 and examined how this affected them. (sciencenews.dk)
The researchers also reintroduced the protein into the mice that could not produce it themselves, and this restored normal muscle function. (sciencenews.dk)

Since these two receptors can partially compensate for one another, what we did that was critical was this combined insulin and IGF receptor knockout. (neurosciencenews.com)
They saw that the mice had impaired expression of a neurotransmitter receptor known as glutamate receptor 1, or GluA1. (neurosciencenews.com)
A study recently published in the journal PLoS ONE has now investigated the role of the H3 receptor in the inflammatory response in the brain during P. berghei infection in mice. (drugdiscoveryopinion.com)
In wild type mice, both the H1 receptor antagonist, levocetirizine, and the H2 receptor antagonist, cimetidine, were found to be effective in reducing clinical symptoms and mortality caused by cerebral malaria. (drugdiscoveryopinion.com)
The beneficial role of the H3 receptor in controlling histamine levels and limiting disease was demonstrated by the higher effectiveness of cimetidine and, to a lesser extent, levocetirizine in wild type compared with H3 receptor knockout mice. (drugdiscoveryopinion.com)
Growth hormone (GH) plays important roles in maintaining metabolic equilibrium via GH receptor (GHR), illustrated previously by our GHR tissue specific knockout mouse models in either the liver (LKO) or adipose tissue (AKO). (tus.ac.jp)
To distinguish dopamine displacement from receptor internalization, we used wild-type and arrestin3 (arr3) knockout mice, which are incapable of internalizing D2 receptors. (grantome.com)
Current research projects focus on the altered immune homeostasis observed in mice that cannot secrete antibodies as a result of a mutation in the polymeric Ig receptor. (viin.org.au)

Pol III-related leukodystrophy was recently identified as a genetically inherited neurodegenerative disease. (einsteinmed.edu)

Passenger mutations affect experiments using transgenic animals models called congenic mice, whose modified genetic material comes from a different genetic background than the rest of their genome. (the-scientist.com)
Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century. (chinaagrisci.com)

It may be useful in dissecting the genetic and cellular mechanisms of treatment resistance and developing more effective therapies. (nih.gov)
This study highlights the gene regulatory mechanisms underlying the female-specific mode of meiotic initiation in mice. (bvsalud.org)
The outcomes highlighted the importance of the gene of interest as a therapeutic target to investigate genetically unstable ovarian cancers to further elucidate its mechanisms of action. (medicalxpress.com)

To determine the physiological roles of K(ATP) channels directly, we have generated two kinds of genetically engineered mice: mice expressing a dominant-negative form of Kir6.2 specifically in the pancreatic beta-cells (Kir6.2G132S Tg mice) and mice lacking Kir6.2 (Kir6.2 knockout mice). (diabetesjournals.org)
Thus, Kir6.2G132S Tg mice and Kir6.2 knockout mice provide a model of type 2 diabetes and clarify the various roles of K(ATP) channels in endocrine pancreatic function. (diabetesjournals.org)
Furthermore, pancreatic organoids from wild-type and KrasG12D mice were used to evaluate the effect of lysosomal dysfunction on PDAC development. (bvsalud.org)
Furthermore, the number of proliferating Ki-67+ cells increased significantly in pancreatic organoids derived from Galc knockout KrasG12D mice. (bvsalud.org)
Likewise, deletion in mice PDAC tumors (mutant and hemizygous deletion in mice with pancreatic appearance of turned on KRAS led to IPMN that advanced to PDAC [49,82]. (morainetownshipdems.org)

Our analysis suggests that the identified mutation in SPG33 family will most likely result in a loss of function of the protein due to the misfolding of C-terminal FYVE finger domain therefore a knockout mouse will be an appropriate model system to study this disease. (hsp-info.de)
To achieve this goal, we have generated a high quality polyclonal antibody against mouse ZFYVE27 (214-344 amino acids) fused with GST protein using rabbit as a host. (hsp-info.de)
A comprehensive expression analysis of ZFYVE27 in the total protein extract isolated from various tissues of mouse revealed a high level of expression primarily in the HSP affected tissues such as the brain, cerebellum and spinal cord. (hsp-info.de)
Purpose: The aim of this study was to determine whether the brain uptake of [ 18 F]Mefway is influenced by the action of P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) in rodents. (elsevierpure.com)
For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. (wikipedia.org)
Another approach is to target the CD44 protein, which helps cancer cells to grow out of control and develop resistance to standard treatments. (animalresearch.info)
Further, the calcium metabolism of the muscles was impaired when the mice could not produce the protein," says Erik A. Richter. (sciencenews.dk)

However, when the knockout mice become obese with age, they develop fasting hyperglycemia and glucose intolerance, while neither fasting hyperglycemia nor glucose intolerance is evident in the aged knockout mice without obesity, suggesting that both the genetic defect in glucose-induced insulin secretion and the acquired insulin resistance due to environmental factors are necessary to develop diabetes in Kir6.2 knockout mice. (diabetesjournals.org)
Mice with a whole body knockout of Maf1 are resistant to diet-induced obesity and have increased healthspan. (einsteinmed.edu)
Obesity resistance in these mice is associated with increased energy expenditure and metabolic inefficiency. (einsteinmed.edu)
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer , obesity , heart disease , diabetes , arthritis , substance abuse , anxiety , aging and Parkinson's disease . (wikipedia.org)

To produce the loss of function mouse model for ZFYVE27, we employed a novel Bacterial Artificial Chromosome (BAC) mediated homologous recombination method to generate the knockout construct in C57BL/6 background. (hsp-info.de)
Firstly, we identified two BAC genomic clones (RPCIB731C16470Q2 and RPCIB731A01447Q2) from the mouse genomic DNA library RPCI-23, which is derived from the C57BL/6 mouse strain containing full genomic sequence of Zfyve27 and 50 kb flanking sequence from either end of the gene. (hsp-info.de)
Nevertheless, each one of these research was performed in strains of mice (C57BL/6 and CBA/Ca) that are genetically vunerable to advancement of TE and finally develop intensifying and eventually fatal TE without immunosuppressive treatment (2, 35, 36). (jamha.org)
However, reduced production of TNF- α was detected in bone-marrow-derived macrophages (BMDM) from NOD1, NOD2, and Rip2 KO mice compared to C57BL/6. (hindawi.com)
The wild-type strain C57BL/6 mice were purchased from the Federal University of Minas Gerais (UFMG, Belo Horizonte, Brazil). (hindawi.com)

19-25 TMPRSS2 knock-out mice have no phenotype in the absence of infection, 26 indicating that inhibiting TMPRSS2 function might not be associated with substantial unwanted side effects. (rsc.org)

As opposed to prone strains genetically, genetically resistant strains (e.g. (jamha.org)

Methods: To model genetic alterations in the core signaling pathways of human glioblastoma, we induced conditional Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. (nih.gov)
Results: G1/S-defective, Rb knockout astrocytes gained unlimited self-renewal and multi-lineage differentiation capacity, in both the presence and absence of Kras and Pten mutations. (nih.gov)

Lymphocytes and IFN-gamma exert a selection pressure on tumor cells which are genetically unstable and rapidly mutating. (wikipedia.org)

FLICKR, STEFANO Passenger mutations-unwanted alterations that accompany intentional genetic modifications-can confound experiments using certain types of transgenic mice. (the-scientist.com)
The new tool "empowers the scientific community to look a little closer" at the transgenic mice they are using, said Soren Warming , a senior scientist at Genentech who was not involved in the study. (the-scientist.com)
There are now ways to make transgenic mice that are less risky. (the-scientist.com)
But a substantial quantity of biology research has been built on traditionally constructed transgenic mice, and many labs continue to use them. (the-scientist.com)

AOD 9604 was speculated to exhibit a potentially significant fat-burning impact when given to obese mice and beta(3)-AR knock-out mice for an extended period in a research published in 2001. (asianage.com)
After 14 days of presentation, the compound AOD 9604 was suggested to lower both the weight and the amount of body fat in the obese mice. (asianage.com)
It was determined that the alleged capacity of AOD 9604 to raise the synthesis of beta-3 adrenergic receptors (also known as ADRB3 in obese mice) may have been responsible for this finding. (asianage.com)

Mutation of the RB-binding site of STRA8 in female mice delays meiotic entry, which consequently delays progression of meiotic prophase and leads to precocious depletion of the oocyte pool. (bvsalud.org)

We therefore used a multifaceted strategy, combining optogenetics and conditional gene disruption to selectively stimulate dopaminergic terminals while recording postsynaptic currents from medium spiny neurons (MSNs) in either the ventral or dorsal striatum of control or conditional knock-out mice lacking VGLUT2 specifically in dopamine neurons. (jneurosci.org)

The goal of this study was to determine the selectivity of dLop for ABCB1 in human tissues using three human cell lines that over-express ABCB1, ABCC1, or ABCG2 as well as in vivo using three strains of mice that were selectively knocked out for the gene that encodes ABCB1, ABCC1, or ABCG2. (grantome.com)

During this period of Darwinian selection, new tumor cell variants emerge with various mutations that further increase overall resistance to immune attack. (wikipedia.org)
Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes. (the-scientist.com)

18 F]Mefway was applied to rats pharmacologically inhibited with tariquidar (TQD) and to genetically disrupted mice. (elsevierpure.com)
Procedures: [18F]Mefway was applied to rats pharmacologically inhibited with tariquidar (TQD) and to genetically disrupted mice. (elsevierpure.com)
Gene knockout in rats is much harder and has only been possible since 2003. (wikipedia.org)

During the escape phase, tumor cell variants selected in the equilibrium phase have breached the host organism's immune defenses, with various genetic and epigenetic changes conferring further resistance to immune detection. (wikipedia.org)
It has been low-downed that anticancer sedates trigger apoptosis in miscubicleaneous cancer rooms, including enquire of This genetic swap model of aging proposes that aging is causmaturityd neighbourhoodpast a genetically-programmed turning away of survival and linetenance pathways after twin finishes leading to a progressive serviceadept decline. (ika.ie)
They are widely used in knockout experiments, especially those investigating genetic questions that relate to human physiology . (wikipedia.org)

Interestingly, despite the severe defect in glucose-induced insulin secretion, Kir6.2 knockout mice show only a very mild impairment in glucose tolerance. (diabetesjournals.org)
Role of vitamin D in insulin resistance, regulation and maintenance of hormones of the HPT axis and the suppression of the RAS pathway have recently been elucidated. (vitamindwiki.com)
Increased insulin resistance, increased hepatic glucose production and p-cell failure are the key factors in T2DM. (vitamindwiki.com)
On the other hand, it is also suggested that vitamin D plays a role in insulin resistance by the renin-angiotensin-aldosterone system. (vitamindwiki.com)
Glucose uptake is decreased when there is increased insulin resistance due to the inhibition in the action of insulin in vascular tissue and skeletal muscle. (vitamindwiki.com)
We found that the lipid accumulation in the adipose tissue of DKO was further aggravated compared to AKO, while the insulin resistance and hepatic steatosis were abolished in DKO, compared to LKO. (tus.ac.jp)

Mass treatment of communities with antibiotics has been shown to have no benefit, and can actually be detrimental as it can lead to antibiotic resistance. (kenyon.edu)
assuredly of zero and a dishearteningicial deviation of unity and T to contain a degraded It is superior to note that the estimate of buy lipitor (atorvastatin) 20 mg online no prescription gargumentth may depend on the whether resistance to a be involved inicular antibiotic has reached a developing equilibrium. (ika.ie)

athymic nude, SCID, and control BALB/c mice had been extracted from The Jackson DMOG Lab (Club Harbor, Primary). (jamha.org)

Mice with both of these receptors knocked out had effects on both systems, including control of blood glucose, anxiety and depression, and declining cognition. (neurosciencenews.com)
H3 receptors tightly regulate release of histamine and other neurotransmitters and neuronal histamine activity was found to be significantly higher in naive knockout mice than in wild type mice. (drugdiscoveryopinion.com)
3) We used genetically modified mice to demonstrate that PET can measure the in vivo internalization of receptors that mediate the actions of stimulants like amphetamine (Skinbjerg et al. (grantome.com)

Until recently, these cells almost always came from 129 strain mice, a group of substrains of mice that produce ESCs that are unusually robust and easy to manipulate. (the-scientist.com)
The ideal result is an almost entirely Black 6 mouse with a 129 strain transgene. (the-scientist.com)
People don't realize that recombination occurs very infrequently and that you're going to end up with this chunk of DNA from one strain on the background of the other," said Jake Lusis , who studies mouse genetics and cardiovascular and metabolic disorders at the University of California, Los Angeles, and was not involved in the study. (the-scientist.com)
Specifically, 129 strain congenic mice on a Black 6 background that have been backcrossed for 10 generations have more than a 90 percent chance of having around 1 million base pairs of 129 strain DNA on either side of the transgene. (the-scientist.com)
We constructed a genetically inactivated or attenuated strain containing relevant molecular assay targets and tested to compare assay performance using this strain to the historical data obtained using irradiation-inactivated virulent spores. (cdc.gov)

The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. (einsteinmed.edu)
Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. (einsteinmed.edu)
in adult acinar cells harboring oncogenic mutation accelerated acinar to ductal reprogramming resulting in mucinous PDAC precursor lesions in mice. (morainetownshipdems.org)

Further, we used a conditional knock-out mouse lacking vesicular glutamate transporter 2 (VGLUT2) specifically in dopamine neurons to determine whether VGLUT2 is required for the exocytotic release of glutamate from dopamine neurons. (jneurosci.org)

Female mice heterozygous for Ikk gamma/Nemo deficiency develop a unique dermatopathy characterized by keratinocyte hyperproliferation, skin inflammation, hyperkeratosis, and increased apoptosis. (nih.gov)
White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene. (wikipedia.org)

To understand the reciprocal inter-organ regulatory routes, we reported the construction of liver/adipose double GHR knockout mouse model (DKO). (tus.ac.jp)

BALB/c) Mouse monoclonal to CARM1 have the ability to control an infection in the mind and create a latent chronic an infection as perform immunocompetent human beings (2, 35, 36). (jamha.org)
CA125 was first discovered using a mouse monoclonal antibody in 1981. (animalresearch.info)

H4 stimulation has also recently been shown to cause inhibition of airway resistance and inflammation in a murine model of allergic asthma. (drugdiscoveryopinion.com)

Murine versions have been utilized to review the system of host level of resistance against advancement of TE. (jamha.org)

These cells were then transplanted into nude mice to check that the same effect was seen in vivo. (animalresearch.info)
Herein, we have shown that NOD1, NOD2, or the adaptor molecule Rip2 plays no role in enhancing resistance to B. abortus infection in vivo . (hindawi.com)

However, NOD1, NOD2, and Rip2 knockout mice were no more susceptible to infection with virulent B. abortus than wild-type mice. (hindawi.com)

This unique self-limiting disease, the first to be genetically linked to the IKK signaling pathway, is dependent on X-chromosome inactivation. (nih.gov)

Millions of knockout mice are used in experiments each year. (wikipedia.org)

This non-germline genetically engineered mouse model mimics human proneural glioblastoma on histopathological, molecular, and treatment response levels. (nih.gov)
This mouse model will serve as critical means to elucidate the molecular mechanism involved in SPG33 pathology and will also allow us to examine why the nerves degenerate in HSP. (hsp-info.de)
Our programs span genetics, molecular biology, biochemistry, metabolism and structural biology and utilize budding yeast and mice as model experimental systems. (einsteinmed.edu)
We have developed a mouse model of this disease and have characterized numerous behavioral and neuropathological phenotypes. (einsteinmed.edu)
Professor, The Provincial Hospital and College of Experimental Animals of Shandong First Medical University, Director of the International Joint Research Center for Genetically Engineered Model Animals of the Ministry of Science and Technology. (tus.ac.jp)
Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)

Moreover, GALC PPV carriers tended to show drug resistance in both PDAC cell line and PDAC PDO, and RNA-seq analysis revealed that various metabolism and gene repair pathways were upregulated in PDAC PDOs harboring a GALC variant. (bvsalud.org)
CONCLUSIONS: Genetically defined lysosomal dysfunction is frequently observed in patients with young-onset PDAC. (bvsalud.org)

Therefore, these pets do not seem to be ideal versions for examining the system of host level of resistance to avoid reactivation of the latent (cyst) an infection. (jamha.org)
Emergence of level of resistance to targeted therapy takes its restriction to long-term clinical benefits in most cases. (thetechnoant.info)
Monitoring rising level of resistance in spontaneous tumors is normally technically challenging, and therefore the testing was performed after these tumors had been transplanted in to the flanks of receiver mice and these allografted tumors had been expanded in bigger cohorts of pets. (thetechnoant.info)

For this example, we will take stem cells from a white mouse. (wikipedia.org)

The mice did not actually have problems with glucose metabolism, but their muscles performed less well at contracting and were smaller than in mice with a functional gene for C18ORF25. (sciencenews.dk)

Alternative transcripts of the RPS4 resistance gene in Arabidopsis: Do they produce truncated proteins? (umsystem.edu)
New research shows that 5,486 proteins in the muscles are affected by one or more of three types of exercise - endurance, sprint and resistance - and that 420 of these are affected by all three types. (sciencenews.dk)

At the blood-brain barrier, over-expression of ABCB1 may contribute to drug-resistance in epilepsy and in HIV infection of the brain. (grantome.com)

We have developed adult and suckling mouse models of these diseases to investigate transmission and immune responses to infection. (viin.org.au)

The knockout component (21, 22) was utilized to speed up disease onset and generate tumors sensitive towards the HDM201 inhibitor. (thetechnoant.info)
It had been within 90.8% of tumors, indicating that it could constitute a significant cooperating pathway with Arf LOF in mice. (thetechnoant.info)

She guided the generation and distribution of several immune competent mouse models for studies of the glioma immune microenvironment. (stanford.edu)

Age-matched, sex-matched adult male and female mice (∼25 g) were used as subjects. (jneurosci.org)

control mice (34 public) and = 193 RosaPB/+;ATP2/+;Arf? (thetechnoant.info)
A team at the Centers for Disease Control and Prevention (CDC) developed a system based on deep amplicon sequencing and machine learning, for detecting genetically-related clusters of cyclosporiasis to aid epidemiologic investigations. (cdc.gov)

It is required for NF-kappa B activation and resistance to TNF-induced apoptosis. (nih.gov)
To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)

However, a large number of studies have failed to demonstrate reduced resistance against infection in the absence of secretory antibodies. (viin.org.au)

The work is currently focused on the oligodendrocyte lineage since hypomyelination is a hallmark of the disease in patients and in the mice. (einsteinmed.edu)

deletion in mice induced irritation, development of PanINs, and mucinous cysts [49]. (morainetownshipdems.org)

Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested. (wikipedia.org)

In the periphery as well as in the brain, over-expression of ABCB1 in cancer cells is one cause of multidrug resistance to chemotherapy. (grantome.com)
While 60%-80% of patients respond to chemotherapy first, about 80%-85% develop chemo-resistance. (medicalxpress.com)

Since 1980, there have been studies on mouse models trying to establish a correlation between VDD and T2DM. (vitamindwiki.com)
[3] Many mouse models are named after the gene that has been inactivated. (wikipedia.org)
Other mouse models are named according to their physical characteristics or behaviours. (wikipedia.org)

In the study of cancer immunoediting, knockout mice have been used for experimentation since human testing is not possible. (wikipedia.org)
That's because, according to a 1995 study and subsequent work, Casp1 knockout mice did not go into septic shock when challenged with molecules signaling foreign invaders. (the-scientist.com)

Anatomy1

Organisms3

Diseases2

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes34

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Genes9

Embryonic stem3

Deficient7

Researchers20

Receptor8

Neurodegenerative disease1

Genome2

Mechanisms3

Pancreatic5

Protein7

Obesity4

C57BL5

Phenotype1

Prone1

Kras2

Unstable1

Transgenic mice4

Obese3

Progression1

Knock-out1

Strains of mice1

Mutations2

Rats3

Genetic3

Insulin6

Antibiotic2

Harbor1

Receptors3

Strain5

Mutation3

Conditional1

Heterozygous2

Liver1

Monoclonal2

Inhibition1

Advancement1

Vivo2

Wild-type mice1

Chromosome1

Experiments1

Model6

PDAC2

Level of resistance3

Stem cells1

Glucose1

Proteins2

Drug resistance1

Investigate1

Tumors2

Glioma1

Female mice1

Control2

Apoptosis2

Demonstrate1

Disease1

Deletion1

Therapies1

Chemotherapy2

Models3

Study2