• genes
  • The onset of disease is influenced not only by your genes, but also by other natural and environmental external factors. (easydna.ie)
  • There are certain factors (perhaps the types of foods you eat or your lifestyle habits) which are known to be possible triggers for certain diseases by activating the disease-causing genes. (easydna.ie)
  • A Hcs locus, with high phenotypic effects, and various epistatic gene-gene interactions were identified in rats, suggesting a genetic model of predisposition to hepatocarcinogenesis with different subset of low-penetrance genes, at play in different subsets of population, and a major locus. (uniss.it)
  • Identifying variants which control the activity of many genes is a greater challenge than we anticipated but we are developing appropriate tools to uncover them and understand their contribution to disease," comments Panos Deloukas. (medicalxpress.com)
  • A high-quality reference catalogue of the genetic changes that result in the deactivation of human genes has been developed by a team of researchers. (medicalxpress.com)
  • Maybe there are people who are interested in publishing their genetic information on the web to make it available, but those people don't have the opportunity," Though Greshake acknowledges that there are services that allow people to test their own genes and discover inherent predispositions, they are often expensive, or difficult to access. (wikipedia.org)
  • Human leukocyte antigen class II genes are more frequent in patients with Kikuchi disease, suggesting a genetic predisposition to the proposed autoimmune response. (wikipedia.org)
  • coronary
  • The result is enhanced shear stress on vessel walls, and repeated nicotine exposure contributes to accelerated health problems that are a function of chronic vascular injury such as coronary artery disease, acute cardiac ischemic events, and hypertension Studies have shown that nicotine exposure contributes to stroke, peptic ulcer disease, and esophageal reflux. (wikipedia.org)
  • Much of his recent investigative studies have addressed molecular anomalies observed in people with Type 1 diabetes and coronary artery disease (CAD). (wikipedia.org)
  • heritable
  • NAFLD is a heritable and complex trait, the genetic component of which has been explored by a myriad of studies that used different approaches illustrated in Figure 1 . (e-cmh.org)
  • variants
  • An international team of researchers from King's College, Oxford University, Wellcome Trust Sanger Institute and Faculty of Medicine of University of Geneva, has discovered several thousands new genetic variants impacting gene expression some of which are responsible for predisposition to common diseases, bringing closer to the biological interpretation of personal genomes. (medicalxpress.com)
  • With an international team co-led by Professor Tim Spector (Kings College), Professor Mark McCarthy (Oxford University) and Dr. Panos Deloukas (Wellcome Trust Sanger Institute), he publishes a study highlighting thousands of these genetic variants that seem to explain individual differences in gene expression . (medicalxpress.com)
  • The method researchers followed allowed them to uncover nearly 358 variants apparently involved in the predisposition to certain diseases including quantifying the contribution of rare regulatory variants that was previously not possible to identify by conventional analysis methods. (medicalxpress.com)
  • Our work adds to those who have previously demonstrated the contribution of common variants in the predisposition to these disorders", explains Emmanouil Dermitzakis. (medicalxpress.com)
  • Thanks to this new level of knowledge, and if we manage to adapt this methodology to search for these variants in each individual, this will be a powerful tool to help prognose the predisposition to certain diseases and more importantly understand the biological aetiology in order to develop and employ individualized treatments. (medicalxpress.com)
  • This is a hospital based cohort study where subjects diagnosed within twelve months with nonmuscle invasive bladder cancer will be evaluated to determine whether candidate genetic variants are associated with the risk of recurrence and progression. (clinicaltrials.gov)
  • This is a hospital-based cohort study in which subjects with non-muscle invasive bladder cancer diagnosed within the previous 12 months will be evaluated to determine whether candidate genetic variants in patients with superficial bladder cancer can predict the risk of disease recurrence and/or progression, with the goal of modifying surveillance schedules as a function of predicted risk of recurrence or progression. (clinicaltrials.gov)
  • subset
  • In addition to the genetic defects in dystrophin or other cytoskeletal proteins, a subset of dilated cardiomyopathy is linked to enteroviral infection in the heart, especially coxsackievirus B. Enterovirus infections are responsible for about 30% of the cases of acquired dilated cardiomyopathy in humans. (wikipedia.org)
  • etiology
  • Recent epidemiologic studies have re-ignited an old controversy and opinions are forming as to whether mucus hypersecretion is crucial in the etiology of airway disease. (clinicaltrials.gov)
  • Classically recognized white dot syndromes include: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) Birdshot chorioretinopathy Multiple evanescent white dot syndrome (MEWDS) Acute zonal occult outer retinopathy (AZOOR) Multifocal choroiditis and panuveitis (MCP) Punctate inner choroiditis (PIC) Serpiginous choroiditis Specific characteristics regarding the white dots and predicted etiology are presented of selected diseases. (wikipedia.org)
  • genetics
  • In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. (e-cmh.org)
  • Modern human genetics combined with samples donated by the participants in studies such as TwinsUK is making great strides towards finding the genetic culprits behind human disease. (medicalxpress.com)
  • Researchers have developed a valuable mouse genetic blueprint that will accelerate future research and understanding of human genetics. (medicalxpress.com)
  • An accomplished geneticist, writer and lecturer, Dr. Zalloua is a leading authority on the genetics of complex diseases in and among Middle Eastern populations. (wikipedia.org)
  • risk
  • The authors tested for heritability by estimating the relative risk for lumbar disease in relatives and determining a genealogical index of familiality (GIF). (apta.org)
  • First-degree relatives of people with lumbar disc disease had a relative risk of 4.15 of having the disease themselves. (apta.org)
  • How can this genetic test determine my health risk? (easydna.ie)
  • Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain the co-morbidity of these three conditions, we hypothesised that these three long-term, highly prevalent conditions co-occur and may be due to shared familial risk, and/or genetic factors. (duhnnae.com)
  • Genetic disease risk differences between one individual and another are based on complex aetiology. (medicalxpress.com)
  • For patients with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, mucus hypersecretion is now being considered as a risk factor for increased morbidity. (clinicaltrials.gov)
  • It is recommended for subjects with autoimmune diseases or at risk for CD to be screened for CD and to repeat serological screening about every three years to detect cases of clinically silent, late-onset CD. (clinicaltrials.gov)
  • Chewing nicotine gum may increase the risk of heart disease, although this is still debated. (wikipedia.org)
  • Smoking increases the risk of disease and may worsen eye problems. (wikipedia.org)
  • disorders
  • It is a widely explored treatment option for many central nervous system (CNS) disorders including neurodegenerative diseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption (i.e. methamphetamine overdoses). (wikipedia.org)
  • abnormalities
  • People with PBC may also have been diagnosed with another autoimmune disease, such as a rheumatological, endocrinological, gastrointestinal, pulmonary, or dermatological condition, suggesting shared genetic and immune abnormalities. (wikipedia.org)
  • Abnormalities in liver enzyme tests are usually present and elevated gamma-glutamyl transferase and alkaline phosphatase (ALP) are found in early disease. (wikipedia.org)
  • The accumulation is due to various genetic and biochemical abnormalities. (wikipedia.org)
  • diagnostic
  • Hence, knowledge of the disease pathogenesis and predisposing factors is crucial for understanding the disease biology and making decisions on diagnostic or therapeutic interventions, the latter being the main goal of Precision Medicine. (e-cmh.org)
  • gene
  • If you have a family history of breast and ovarian cancer and are looking for a clinical result to confirm if you have the disease causing variant in the gene or not then you need to order a complete BRCA 1 and 2 test. (easydna.ie)
  • In theory, two people could thus share a gene that is perfectly identical and yet show differences in their predisposition to a disease due to genetic differences concerning the regulation (overexpression or underexpression) of this same gene. (medicalxpress.com)
  • To date, no clear genetic defect has been found to point to a single gene cause. (wikipedia.org)
  • scleroderma
  • It has been noted that clinical diagnosis of BXO can be "almost unmistakable," though there are other dermatologic conditions such as lichen planus, localized scleroderma, leukoplakia, vitiligo, and the cutaneous rash of Lyme disease can have a similar appearance. (wikipedia.org)
  • In June 2004, Broadway's wife, Dianne, died after 14 years of battling scleroderma, a rheumatic disease of the connective tissues. (wikipedia.org)
  • interpretation
  • Because of many difficulties and often wrong interpretation of genetic test results, it is recommended that each genetic test result should be consulted with specialist genetic advisory clinic. (cbdna.eu)
  • Human
  • Funded by the US Department of Health & Human Services, the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, and the Division of AIDS. (actgnetwork.org)
  • 1 Hour film featuring my work on the genetic patterns of human migrations in the Middle East, aired on National Geographic Television worldwide and the PBS TV station in the US and Canada. (wikipedia.org)
  • 22 page feature article in the October issue, 2004 that features my study on the genetic patterns of human migrations in the Middle East. (wikipedia.org)
  • Genetic predisposition towards certain human behaviors is scientifically investigated by attempts to identify patterns of human behavior that seem to be invariant over long periods of time and in very different cultures. (wikipedia.org)
  • Reprint edition 1989) (ISBN 0-262-54053-3) Genetic discrimination fact sheet from the National Human Genome Research Institute. (wikipedia.org)
  • progresses
  • As the disease progresses the patient exhibits more serious problems, becoming subject to mood swings and unable to perform complex activities such as driving. (wikipedia.org)
  • evolutionary
  • E. O. Wilson's book on sociobiology and his book Consilience discuss the idea of genetic predisposition to behaviors The field of evolutionary psychology explores the idea that certain behaviors have been selected for during the course of evolution. (wikipedia.org)
  • progression
  • All patients will receive usual care and be followed to determine rates of recurrence and progression of the disease. (clinicaltrials.gov)
  • Neuroprotection aims to prevent or slow disease progression and secondary injuries by halting or at least slowing the loss of neurons. (wikipedia.org)
  • benign
  • Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. (e-cmh.org)
  • The course of the disease is generally benign and self-limiting. (wikipedia.org)
  • aetiology
  • This research revealed parts of the IL12 signaling cascade, particularly IL12A and IL12RB2 polymorphisms, to be important in the aetiology of the disease in addition to the HLA region. (wikipedia.org)
  • signs and symptoms
  • The signs and symptoms of Kikuchi disease are fever, enlargement of the lymph nodes (lymphadenopathy), skin rashes, and headache. (wikipedia.org)
  • The signs and symptoms of Graves' disease virtually all result from the direct and indirect effects of hyperthyroidism, with main exceptions being Graves' ophthalmopathy, goiter, and pretibial myxedema (which are caused by the autoimmune processes of the disease). (wikipedia.org)
  • early
  • By using the phage display libraries technique it is possible to investigate in vivo (intestinal biopsy) early antibody responses in autoimmune disease. (clinicaltrials.gov)
  • It results from a slow, progressive destruction of the small bile ducts of the liver, with the intralobular ducts and the Canals of Hering (intrahepatic ductules) being affected early in the disease. (wikipedia.org)
  • White dots appear early in the disease stages of PIC and MEWDS. (wikipedia.org)
  • The disease was described at least as early as 370 BC by Hippocrates. (wikipedia.org)
  • regulate
  • The research plan is the initial step towards a definitive link between an ubiquitous urban air pollutant, and genetic factors that regulate oxidant-induced airway hypersecretion of mucus. (clinicaltrials.gov)
  • negative
  • An environmental Gram negative alphabacterium - Novosphingobium aromaticivorans has been associated with this disease with several reports suggesting an aetiological role for this organism. (wikipedia.org)
  • Negative environmental influences may block the predisposition (ability) we have to do some things. (wikipedia.org)
  • humans
  • This decellularized valve tissue provides a scaffold with the remaining extracellular matrix (ECM) that can then be used for tissue engineering and valve replacement in humans inflicted with valvular disease. (wikipedia.org)
  • makeup
  • Whilst you cannot alter your genetic makeup, you can alter conditions in your environment. (easydna.ie)
  • After receiving his results, he posted them on Github, hoping to find other users willing to share their personal genetic makeup. (wikipedia.org)
  • discrimination
  • However, at this current state and time, the effects of genetic discrimination are unknown due to the lack of evidence. (wikipedia.org)
  • The Genetic Information Nondiscrimination Act, which was signed into law by President Bush on May 21, 2008, prohibits discrimination in employment and health insurance based on genetic information. (wikipedia.org)
  • however
  • However, this has not been very reliable, because each person has unique genetic characteristics and other factors that are likely to affect what happens to the tumor over time. (clinicaltrials.gov)
  • However, AZOOR may definitely be related to other diseases included in the white dot syndrome group. (wikipedia.org)
  • findings
  • Once you have received your report we recommend that you go over the findings with your doctor or genetic consultant. (easydna.ie)
  • towards
  • you could start making the right lifestyle changes, planning specific health screening and blood tests and work together with a genetic councellor towards a tailored program for disease prevention. (easydna.ie)
  • It is mainly a disease of young adults (20-30 years), with a slight bias towards females. (wikipedia.org)
  • patients
  • Due to the fact that genetic tests are specific type of tests, and their results may have huge influence on patients and their families' personal life, tests on genetic predisposition for neoplasm may only be performed for adult people, who express conscious consent for making such genetic tests. (cbdna.eu)
  • Kikuchi disease is a self-limiting illness which has symptoms which may overlap with Hodgkin's lymphoma leading to misdiagnosis in some patients. (wikipedia.org)
  • alcohol
  • The interviewer will ask each participating mother about her and her child's age, child's gender, her and her child's exposure to chemicals, medical history, places they have lived, places she has worked, family history of disease, reproductive and breast feeding histories, diet, alcohol and tobacco use. (clinicaltrials.gov)