• Molecular
  • This is, to our knowledge, the first molecular genetic characterization of NBAD hydrolase and carcinine hydrolase activity in any organism and is central to the understanding of pigmentation and photoreceptor function. (nih.gov)
  • GRE Subject Biochemistry, Cell and Molecular Biology was a standardized exam provided by ETS (Educational Testing Service) that was discontinued in December 2016. (wikipedia.org)
  • Molecular phylogenetic analysis revealed P. stipticus to have a close genetic relationship with members of the genus Mycena. (wikipedia.org)
  • Reflecting this cross-species genetic complementation method, the gene was called "Excision repair cross-complementing 4" The human ERCC4 gene encodes the XPF protein of 916 amino acids with a molecular mass of about 104,000 daltons. (wikipedia.org)
  • mutants
  • We also find fusions of the ventral neurocranium for all midline mutants tested, which may reveal a hitherto unrecognized function of the midline in influencing differentiation of neural crest cells at their destination. (zfin.org)
  • We have taken a genetic approach to dissecting acquired thermotolerance by characterizing loss-of-function thermotolerance mutants in Arabidopsis. (plantphysiol.org)
  • Eight-two mutants were obtained from 7,239 clones screened using the yeast agglutination test. (nih.gov)
  • Tests involving A1 mutants with various deleted amino acid sequences have shown that editing activity is dependent on residues 14 to 35. (wikipedia.org)
  • proteins
  • An emc allele was identified from a genetic screen designed to identify factors that, when overexpressed, cooperate with mutations in rbf1 , which encodes one of the two Rb proteins found in Drosophila . (biologists.org)
  • Our current results indicate that the genetic determinants such as those involved in the fimbrial biogenesis and regulation, global regulators, transporter proteins, prophage-derived proteins, and enzymes of different functions, to name a few, may play a role in the regulation of type 1 fimbrial expression in response to solid agar and static broth culture conditions. (nih.gov)
  • deleterious
  • When two populations of any sexual organism are separated and kept isolated from each other, the frequencies of deleterious mutations in the two populations will differ over time, by genetic drift. (wikipedia.org)
  • gene
  • ATM, which has a transcript of 12 kilobases, was found to be mutated in AT patients from all complementation groups, indicating that it is probably the sole gene responsible for this disorder. (nih.gov)
  • Complementation will not occur if the mutations are in the same gene. (wikipedia.org)
  • A genetic map can then be created using linkage and genetic markers, and then the gene of interest can be cloned and sequenced. (wikipedia.org)
  • Discovering disease loci using old forward genetic techniques was a very long and difficult process and much of the work went into mapping and cloning the gene through association studies and chromosome walking. (wikipedia.org)
  • Multiple independent complementation groups of Chinese hamster ovary (CHO) cells have been isolated, and this gene restored UV resistance to cells of complementation group 4. (wikipedia.org)
  • Plasmids
  • To test whether a methylation-sensitive restriction system contributes to poor B. burgdorferi transformability, shuttle plasmids were treated with the CpG methylase M.SssI prior to the electroporation of a variety of strains harboring different putative R-M systems. (umassmed.edu)
  • strains
  • Low-passage-number infectious strains of B. burgdorferi exhibit extremely low transformation efficiencies-so low, in fact, as to hinder the genetic study of putative virulence factors. (umassmed.edu)
  • As a control, 16S rRNA was constantly expressed in all the strains tested. (nih.gov)
  • It attributes the poor performance of inbred strains to loss of genetic diversity, with the strains becoming purely homozygous at many loci. (wikipedia.org)
  • arises
  • Further, the selective advantage of complementation that arises from outcrossing may largely account for the general avoidance of inbreeding in nature (e.g. see articles Kin recognition, Inbreeding depression and Incest taboo) [citation needed]. (wikipedia.org)
  • yeast
  • His Ph.D. advisor at MIT was David Botstein, and the title of his thesis was "Genetic analysis of the yeast microtubule cytoskeleton. (wikipedia.org)
  • recombinant
  • To test whether CG12120 possesses these predicted activities, we produced recombinant CG12120 protein using a baculovirus expression system in insect cell culture (Figure 4). (nih.gov)
  • loci
  • Genetic tests demonstrate that Rmr6 encodes a common component required for establishing paramutations at diverse maize loci. (genetics.org)
  • Genetic-linkage studies were able to map the disease loci in cystic fibrosis to chromosome 7 by using protein markers. (wikipedia.org)
  • In general, epistasis is used to denote the departure from 'independence' of the effects of different genetic loci. (wikipedia.org)
  • forward genetic
  • Depending on the region being assessed, forward genetic screens can be classified as illustrated in Figure 2 as: Region Specific screens: Studies are designed specifically to obtain a gradient of phenotypes by generating an allelic series which are helpful in studying the region of interest. (wikipedia.org)
  • variation
  • August Weismann picked up the thread in 1889, arguing that sex served to generate genetic variation, as detailed in the majority of the explanations below. (wikipedia.org)
  • mutant
  • Deletion tests with mutant strands have shown that residues 181 to 210 are integral to mRNA editing, and there is most likely a beta-turn at proline residues 190 and 191. (wikipedia.org)
  • manipulation
  • Biotechnology - new and sometimes controversial branch of biology that studies the manipulation of living matter, including genetic modification and synthetic biology. (wikipedia.org)
  • Evolutionary
  • Since hypotheses for the origins of sex are difficult to test experimentally (outside of Evolutionary computation), most current work has focused on the maintenance of sexual reproduction. (wikipedia.org)
  • data provide
  • These data provide the first direct genetic evidence, to our knowledge, that distinct functions, independent of Hsp synthesis, are required for thermotolerance, including protection of membrane integrity and recovery of protein activity/synthesis. (plantphysiol.org)
  • respectively
  • however, in recent versions of the test, the maximum and minimum reported scores have been 760 (corresponding to the 99 percentile) and 320 (1 percentile) respectively. (wikipedia.org)
  • given
  • A/J inbred mice are widely used to model cancer and for carcinogen testing given their high susceptibility to carcinogen-induced tumors. (jax.org)