Genetic pathogenesis viral morbidity diseases arbovirus infections. Medical search. Frequent questions

and Centers for Disease Control and Prevention, Atlanta Georgia, USA the New York 1999 isolate. (cdc.gov)
The 2012 WNV season in the United States saw a massive spike in the number of neuroinvasive cases and deaths similar to what was seen in the 2002-2003 season, according to the West Nile virus disease cases and deaths reported to the CDC by year and clinical presentation, 1999-2012, by ArboNET (Arboviral Diseases Branch, Centers for Disease Control and Prevention). (mdpi.com)
Centers for Disease Control and Prevention. (cdc.gov)
Electron micrograph courtesy of the Centers for Disease Control and Prevention. (medscape.com)
David Satcher, M.D., Ph.D. Director Centers for Disease Control and Prevention --- Executive Summary "Ingenuity, knowledge, and organization alter but cannot cancel humanity's vulnerability to invasion by parasitic forms of life. (cdc.gov)

Epidemiology, Evolution, and Pathogenesis of H7N9 Influenza Viruses in Five Epidemic Waves since 2013 in China. (cdc.gov)
I was also involved in other projects regarding SARS-CoV-2 variants and disease severity in infants (DOI 10.3389/fmed.2022.896352), Rift Valley fever virus epidemiology in humans and animals in Kenya (DOI 10.1371/journal.pgph.0000505), and dengue virus evolution in Africa (ongoing Ph.D. candidate mentorship). (stanford.edu)
This report summarizes the epidemiology of and risks for infection with TBE virus, provides information on the immunogenicity and safety of TBE vaccine, and summarizes the recommendations of the Advisory Committee on Immunization Practices (ACIP) for use of TBE vaccine among U.S. travelers and laboratory workers. (cdc.gov)
Studies on Molecular Epidemiology of Enteric Pathogens - Genetic characterization of V. cholerae strains. (icmr.nic.in)
Application of decision making tools, particularly mathematical models for forecasting the trend of infection/disease and predicting the long term impact of intervention and selection of appropriate site specific strategy and duration of intervention(s) (Statistical /Mathematical models, economic evaluations, rapid assessment procedures and mapping, sampling protocols, algorithms for morbidity management, molecular epidemiology, DNA fingerprinting for exposure studies). (icmr.nic.in)

This group of viruses have been known to cause significant morbidity and mortality around the world, with the potential to spread quickly and expand their geographical range due to their distinct mode of transmission using arthropods. (encyclopedia.pub)
Although mortality is less but the suffering from the disease is too much, even it may continue for several months. (actascientific.com)
Still, morbidity and mortality are less than Mycoplasma-Associated Steven Johnson's Syndrome (MASJS) and Toxic Epidermal Necrolysis (TEN). (peertechzpublications.org)

Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika virus. (wikipedia.org)
Zika virus infections have been strongly associated with Guillain-Barré syndrome (GBS), which is a rapid onset of muscle weakness caused by the immune system damaging the peripheral nervous system, and which can progress to paralysis. (wikipedia.org)
While both GBS and Zika infection can simultaneously occur in the same individual, it is difficult to definitively identify Zika virus as the cause of GBS. (wikipedia.org)
Travel Grant: 16th International Course on Dengue, Zika, and other Emergent Arboviruses. (stanford.edu)
The goal of this study is to apply semi-holistic approach in determining season-specific risk factors that will likely influence dengue, chikungunya and zika virus disease transmission in Mombasa city, Kenya. (go.ke)
Recently, dengue, chikungunya, and zika viruses have emerged as increasingly important arboviruses that can cause human disease, however no specific treatment or vaccine is available for them. (biomedcentral.com)
This review highlights the current understanding on the pathogenesis, systemic changes and ocular findings, emphasizing the retinal manifestations related to dengue, chikungunya, and zika viruses. (biomedcentral.com)

Individuals with primary immunodeficiency (PID) can excrete polioviruses for prolonged periods, which could act as a source of cryptic transmission of viruses with potential to cause neurological disease. (bvsalud.org)
The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. (encyclopedia.pub)
Arthropod-borne viruses or arboviruses have a unique effect on neutrophil function since viral factors as well as vector factors can affect the activity of these cells. (encyclopedia.pub)
The 12 distinct enveloped RNA viruses that cause most viral hemorrhagic fever (VHF) cases are members of 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. (medscape.com)
Arthropod-borne viruses, or arboviruses, are viruses that are transmitted through the bites of mosquitoes and ticks. (biomedcentral.com)
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
The potential for vaccination against SARS-CoV-2 to be associated with disease enhancement is of theoretical concern, given similar observations with other respiratory viruses in general, and in animal models of highly pathogenic coronaviruses in particular [14] . (cov19longhaulfoundation.org)

Chikungunya virus infection has a clinical presentation that overlaps with that of Ross River virus infection (fever, rash, polyarthritis) and dengue fever transmitted by the same mosquitoes. (medscape.com)
In fact, serologic surveys have demonstrated that outbreaks attributed to dengue in the past have actually turned out to be CHIKV or ZIKV infections. (biomedcentral.com)
DFV is considered as the most serious of these infections, because of the rare but potentially severe dengue shock syndrome" that can lead to death. (biomedcentral.com)

Diarrhoeal Diseases to monitor changing spectrum of enteric pathogens and to identify newer pathogens. (icmr.nic.in)
They serve as the first line of defense against incoming pathogens, quickly mobilizing to the site of infection [ 1 ] . (encyclopedia.pub)
However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). (mdpi.com)

ACIP recommends TBE vaccine for U.S. persons who are moving or traveling to an area where the disease is endemic and will have extensive exposure to ticks based on their planned outdoor activities and itinerary. (cdc.gov)
Arboviral diseases are entities that are transmitted to humans by arthropods such as mosquitoes and ticks. (biomedcentral.com)

Infectious agents that are arthropod-borne (usually mosquitoes) cause many viral hemorrhagic fevers. (medscape.com)
In 1990, we have reported the isolation of a Sindbis-like virus from a pool of Anopheles mosquitoes collected in Xinjiang, China during an arbovirus survey. (biomedcentral.com)
Chikungunya fever (CHIKF) is a viral disease transmitted by mainly two species of mosquitoes - Aedes aegypti and A. albopictus . (actascientific.com)

This review highlights new information regarding the virology, clinical manifestations, 7 nonstructural proteins that likely contribute to viral repli- and pathology of WNV disease, which will provide a new cation. (cdc.gov)
Three different single-nucleotide polymorphisms (SNPs) in human TLR-7 (rs179010, rs5741880, rs3853839) and 1 SNP in TLR-8 (rs3764879) were associated with increased susceptibility to infection and related clinical manifestations. (medscape.com)
Disease severity resulting from infection by these agents varies widely, but the most extreme manifestations include circulatory instability, increased vascular permeability, and diffuse hemorrhage. (medscape.com)
In addition, ocular manifestations of these diseases have become more prevalent over the past few years. (biomedcentral.com)
We reported a case of a young adult admitted with pneumonia and rapidly developed severe mucositis without skin manifestations, which has increased his morbidity and recovery time. (peertechzpublications.org)

A 2017 study reported that Chikungunya infection activates toll-like receptors (TLR), triggering the innate immune system. (medscape.com)
Unleashing the potential of infectious disease genomics (blog post) PHG Foundation, Jul 6, 2017. (cdc.gov)

Using disease modeling, epidemiological, and phylogenetic analysis, we study the genomic evolution and transmission dynamics of H5N1 avian influenza A after 2020. (stanford.edu)

ABSTRACT Chagas disease (CD) is a neglected tropical disease associated with poverty in which patients are surrounded by stigma. (scielo.br)
ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)

IRE1b may also be associated with RIDD, 3 which is closely related to intracellular parasite infections and anti-viral responses at mucosal surface. (distantreader.org)
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)

The goal of this project is to investigate the role of vectors in driving the transmission and dissemination of arboviruses at diverse sites in Kenya and beyond and to provide opportunities for early recognition of arbovirus circulation and mitigate against potential epidemics. (go.ke)
Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. (encyclopedia.pub)

The North American lineages of WNV were characterized by the presence of neuroinvasive and neurovirulent strains causing disease and death in humans, birds and horses. (mdpi.com)

Chikungunya fever is a self-remitting febrile viral illness that has been associated with frequent outbreaks in tropical countries of Africa and Southeast Asia. (medscape.com)
The recent re-emergence and travel-related spread of Chikungunya infection to Europe and the United States has drawn global attention. (medscape.com)
Using a murine model, Lum et al showed that anti-Chikungunya virus antibodies were elicited early in the course of the illness and were directed against the C-terminus of the viral E2 glycoprotein. (medscape.com)
Both natural and Chikungunya virus infection-induced specific antibodies were essential for controlling Chikungunya virus infections. (medscape.com)
Chikungunya virus infection elicited strong innate immunity with an abundant production of proinflammatory markers and cytokines, including high levels of alpha interferon, interleukin (IL)-4, IL10, and gamma interferon. (medscape.com)
The authors speculate that Chikungunya virus is capable of undergoing genetic drifts and could acquire alternate entry mechanisms. (medscape.com)
Several murine models with Chikungunya virus-related joint and neurological diseases are being investigated. (medscape.com)
Chikungunya fever, a re-emerging viral disease affecting both old and new world countries is caused by Chikungunya virus, an RNA virus belonging to Alphaviridae. (actascientific.com)
The name chikungunya means "that which bends up" or "to become controlled"- due to bend down appearance following arthritis, which occurs in this disease [2]. (actascientific.com)
Following this in successive years Chikungunya-like disease was observed in St. Thomas Island, New Orleans and part of South Carolina of the United States in 1827 to 1828 [7]. (actascientific.com)

TBE virus can cause acute neurologic disease, which usually results in hospitalization, often permanent neurologic or cognitive sequelae, and sometimes death. (cdc.gov)
The most recognized clinical manifestation of TBE virus infection is acute neurologic disease, which usually results in hospitalization, often permanent neurologic or cognitive sequelae, and sometimes death. (cdc.gov)
In addition, we review current insights into how the UPR is involved in viral infection at mucosal barriers and potential therapeutic strategies that restore epithelial cell integrity following acute viral infections via cytokine and cellular stress manipulation. (distantreader.org)

SARS-CoV-2 progressed to a global pandemic with substantial consequences due to its high infectivity and transmissibility, and its ability to cause both a severe respiratory illness, and a systemic disease with fatal consequences for vulnerable populations. (cov19longhaulfoundation.org)

Arboviruses are known to cause large-scale epidemics in many parts of the world. (encyclopedia.pub)

The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. (bvsalud.org)

We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. (encyclopedia.pub)

The global expansion of these arboviruses was preceded by the global spread of their vectors. (biomedcentral.com)
This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which a nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)

The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos RJ Chagas. (medscape.com)

Improvements in HRQoL after hospital discharge are independent of imaging improvement, and there seems to be no association between HRQoL after hospital discharge and disease severity on hospital admission. (scielo.br)

Neutrophils during Arboviral Infections" Encyclopedia , https://encyclopedia.pub/entry/11625 (accessed December 10, 2023). (encyclopedia.pub)
In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. (encyclopedia.pub)
Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics. (encyclopedia.pub)
In this review, we highlight the recent advancements in understanding the beneficial and detrimental nature of neutrophils during arboviral infections. (encyclopedia.pub)

However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. (encyclopedia.pub)
It is increasingly recognised that the evolutionary conserved UPR signalling has an important role in mucosal inflammation and infection. (distantreader.org)

BACKGROUND: Late relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. (stanford.edu)
The illnesses caused by the arbovirus have very similar/overlapping clinical presentation with prominent fever, headache, rash, myalgia and arthralgia. (biomedcentral.com)

Clinicians working in urban hospitals or near points of international arrival must be familiar with diseases commonly acquired abroad as well as uncommon but potentially serious conditions such as emerging and re-emerging infectious diseases. (cambridge.org)

We validated the algorithm's predictions by characterizing 646 genetic system variants, encoded in plasmids and genomes, expressed in six gram-positive and gram-negative bacterial hosts. (omictools.com)

The virus has 2 genetic lineages: lineage 1 strains platform for further research into diagnosis, treatment, and are found in North America, Europe, Africa, Asia, and possible prevention of WNV through vaccination. (cdc.gov)
due to WNV infection has increased substantially, and WNV strains from the United States are closely related research into prognosis and possible therapy has expanded. (cdc.gov)
Genetic variation of the virus has been further character- sequences, indicating that the strains in the United States ized and continues to be explored. (cdc.gov)
Cardiac dysrhythmias have been observed in siveness and smaller plaque size of the Texas strains may some North American patients (Centers for Disease be due to mutations in nonstructural proteins that result in Control and Prevention [CDC], unpub. (cdc.gov)
We perform genetic and phenotypic characterisation of the infecting strains, demonstrating intra-host evolution and a neurovirulent phenotype in transgenic mice. (bvsalud.org)
Unraveling the genetic diversity and phylogeny of Leishmania RNA virus 1 strains of infected Leishmania isolates circulating in French Guiana. (cdc.gov)

DFV and ZIKV are asymptomatic in approximately 75% of infections, in contrast to CHIKV where patients are symptomatic in 75-95% of infections [ 1 ]. (biomedcentral.com)

Given that these enhanced responses are triggered by failed attempts to control the infecting virus, VAED typically presents with symptoms related to the target organ of the infection pathogen. (cov19longhaulfoundation.org)
At this time, the pathogenesis, host responses and immunity to SARS-CoV-2 are still being evaluated and are not fully understood. (cov19longhaulfoundation.org)

Persistent bacterial infections and persister cells. (cdc.gov)
Diagnosing these infections is challenging, due to low parasitemia levels during persistent infections and cross-reactivity. (mdpi.com)

For several viral hemorrhagic fevers, person-to-person transmission may occur through direct contact with infected patients, their blood, or their secretions and excretions. (medscape.com)
New cases of vector-borne T cruzi infection usually occur in persons who live in primitive houses in areas where the sylvatic cycle is active. (medscape.com)

These terms refer to the "stooped-over posture" exhibited by individuals with the disease as a consequence of severe chronic incapacitating arthralgias. (medscape.com)
Hence, severe or chronic infections could be attributed to an absence or deregulation of 1 of these pathways. (medscape.com)
[ 13 ] Chronic infection of small field rodents makes rural residents and farmers the most frequently infected, with a strong seasonal predominance for the fall. (medscape.com)
A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)

The roots of this viral illness date back to 1953, when it was first described during an outbreak in a Swahili village in the Newala district of Tanzania, Africa. (medscape.com)
In May 1995, these diseases came to worldwide attention with an outbreak of Ebola virus near the city of Kikwik, Zaire. (medscape.com)

See 11 Travel Diseases to Consider Before and After the Trip , a Critical Images slideshow, to help identify and manage infectious travel diseases. (medscape.com)
Identify immunological parameters for pathogenesis, progress and therapy in infection. (icmr.nic.in)
Since 1987, the National Academy of Science's Institute of Medicine has published three reports, each of which documents, from different perspectives, the urgent need to improve our ability to identify infectious disease threats and respond to them effectively. (cdc.gov)

The natural history of coronavirus infectious disease caused by SARS-CoV-2 (COVID-19), is yet to be fully described. (cov19longhaulfoundation.org)

Prevention involves decreasing mosquito bites in areas where the disease occurs and proper use of condoms. (wikipedia.org)
A. aegypti mosquito is the main vector responsible for the transmission of this disease, which is predominant in tropical weather regions. (biomedcentral.com)

Development of tools for disease surveillance. (icmr.nic.in)
Studies on rotavirus surveillance on disease burden. (icmr.nic.in)
and global surveillance for emerging infections is vital to public health. (cdc.gov)

T cruzi infection in humans occurs in a spotty distribution throughout the range of the sylvatic cycle. (medscape.com)

The virus that causes the disease was first isolated in Africa in 1947. (wikipedia.org)
TBE virus infection is a risk for certain travelers and for laboratory workers who work with the virus. (cdc.gov)
[ 8 ] More recently, imported Marburg virus disease was identified in a Colorado woman who traveled to Uganda. (medscape.com)
The arboviruses include a wide variety of RNA virus including the flaviviruses (genus Flavivirus, one of three genera in the family Flaviviridae) and the alphaviruses (genus Alphavirus, one of two genera in the family Togaviridae). (biomedcentral.com)
On basis of pBR-XJ160, the effects of substitutions within nonstructural protein 1 (nsP1) or nsP2 on the infectivity and pathogenesis of Sindbis virus (SINV) have been investigated. (biomedcentral.com)

Convalescent plasma transfusion consists of passively administered polyclonal antibodies, which generate an immediate immune response and decrease viral load. (bvsalud.org)

TBE vaccine can further reduce infection risk and might be indicated for certain persons who are at higher risk for TBE. (cdc.gov)
This is a Brighton Collaboration Case Definition of the term "Vaccine Associated Enhanced Disease" to be utilized in the evaluation of adverse events following immunization. (cov19longhaulfoundation.org)
Vaccine-associated enhanced diseases (VAED) are modified presentations of clinical infections affecting individuals exposed to a wild-type pathogen after having received a prior vaccination for the same pathogen [1] . (cov19longhaulfoundation.org)
Vaccine-associated enhanced respiratory (VAERD) disease refers to disease with predominant involvement of the lower respiratory tract. (cov19longhaulfoundation.org)
In order to recognize vaccine associated disease enhancement, it is therefore necessary to have a clear understanding of the clinical presentation and usual course of the natural disease. (cov19longhaulfoundation.org)

However, the role of these cells during viral infection is not yet fully understood [ 16 ] . (encyclopedia.pub)

The purpose of this review is to provide an overview of most prevalent arboviruses in Brazil (DFV, ZIKV, CHIKV) regarding the main features, physiopathology, and ocular involvement (Table 1 ). (biomedcentral.com)

Infections in adults have been linked to Guillain-Barré syndrome (GBS). (wikipedia.org)
Both CHIKV and ZIKV related deaths are usually associated with Guillain-Barré syndrome [ 2 ] although recently ten death cases of ZIKV infection unrelated to the Guillain-Barré syndrome have been confirmed in adults [ 2 ]. (biomedcentral.com)

There are numerous arboviruses throughout the world capable of causing human disease spanning different viral families and genera. (biomedcentral.com)

ER stress and activation of the UPR are natural mechanisms by which mucosal epithelial cells combat viral infections. (distantreader.org)
Castorena's research is currently funded by the NIH, and his lab attempts to understand the mechanisms through which a dysfunctional lymphatic system can contribute to the onset and development of cardiovascular diseases. (tulane.edu)

Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection. (omictools.com)

In the current review, the PubMed and Scopus databases were searched for studies aimed at identifying genetic, biochemical, neuroimaging or behavioral markers associated with neurodegeneration in patients with PTSD. (preprints.org)

16,000 WNV disease cases have been reported in contains single-stranded RNA that encodes the capsid (C), the United States. (cdc.gov)

Over the past 5 years, research on WNV envelope (E), and premembrane (prM) proteins, as well as disease has expanded rapidly. (cdc.gov)

aegypti populations in wild, rural, and urban habitats across Kenya: A measure of the risk of emerging infectious disease transmission (KES20,000,000). (go.ke)

Studies on dynamics of disease progression for disease management. (icmr.nic.in)
Investigations on the relationship between hormone levels and progression of disease in women. (icmr.nic.in)
As a disease-associated progression, the years accessed with the other participants should minimize devoted. (plywoodskyscraper.com)

infection in newborns could also lead to brain damage. (wikipedia.org)

We have also confirmed the essential role of E2 glycoprotein, especially the domain of 145-150 (amino acid) aa, in SINV infection through the interaction with cellular heparan sulfate (HS). (biomedcentral.com)

The disease lasts for several days to a week and is usually mild enough that people do not have to go to a hospital. (wikipedia.org)

and a previously unknown hantavirus, producing an often fatal lung infection, was linked to exposure to infected rodents. (cdc.gov)

Organisms3

Diseases3

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Information Science1

Health Care1

Centers for Diseas5

Epidemiology5

Mortality3

Zika7

Viruses7

Dengue3

Pathogens3

Ticks2

Mosquitoes3

Manifestations5

20172

20201

Abstract2

Parasite2

Dissemination2

Neuroinvasive1

Chikungunya10

Acute3

Systemic1

Epidemics1

Severe disease1

Pathology1

Vectors2

Organism1

Severity1

Arboviral4

Inflammation2

Fever2

Potentially1

Variants1

Strains6

Asymptomatic1

Responses2

Persistent2

Occur2

Chronic4

Outbreak2

Identify3

Infectious disease caused1

Mosquito2

Surveillance3

Humans1

Virus5

Antibodies1

Vaccine5

Fully understood1

Brazil1

Adults2

Human1

Mechanisms2

Murine1

Markers1

Cases1

Rapidly1

Populations1

Progression3

Newborns1

Cellular1

Mild1

Exposure1